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Volumn 6, Issue , 2016, Pages

Altered fecal microbiota correlates with liver biochemistry in nonobese patients with non-alcoholic fatty liver disease

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; RNA 16S;

EID: 84984662503     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep32002     Document Type: Article
Times cited : (296)

References (59)
  • 1
    • 78650486196 scopus 로고    scopus 로고
    • Prevalence of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis among a largely middleaged population utilizing ultrasound and liver biopsy: A prospective study
    • Williams, C. D., et al. Prevalence of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis among a largely middleaged population utilizing ultrasound and liver biopsy: a prospective study. Gastroenterology 140, 124-131, doi: 10.1053/j. gastro.2010.09.038 (2011).
    • (2011) Gastroenterology , vol.140 , pp. 124-131
    • Williams, C.D.1
  • 2
    • 56949097660 scopus 로고    scopus 로고
    • Epidemiology of non-alcoholic fatty liver disease in China
    • Fan, J. G. & Farrell, G. C. Epidemiology of non-alcoholic fatty liver disease in China. Journal of hepatology 50, 204-210, doi: 10.1016/j.jhep.2008.10.010 (2009).
    • (2009) Journal of Hepatology , vol.50 , pp. 204-210
    • Fan, J.G.1    Farrell, G.C.2
  • 3
    • 0033038672 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: A spectrum of clinical and pathological severity
    • Matteoni, C. A., et al. Nonalcoholic fatty liver disease: a spectrum of clinical and pathological severity. Gastroenterology 116, 1413-1419 (1999).
    • (1999) Gastroenterology , vol.116 , pp. 1413-1419
    • Matteoni, C.A.1
  • 4
    • 84886298620 scopus 로고    scopus 로고
    • Non-alcoholic steatohepatitis: A microbiota-driven disease
    • Moschen, A. R., Kaser, S. & Tilg, H. Non-alcoholic steatohepatitis: a microbiota-driven disease. Trends in endocrinology and metabolism: TEM 24, 537-545, doi: 10.1016/j.tem.2013.05.009 (2013).
    • (2013) Trends in Endocrinology and Metabolism: TEM , vol.24 , pp. 537-545
    • Moschen, A.R.1    Kaser, S.2    Tilg, H.3
  • 5
    • 78649908827 scopus 로고    scopus 로고
    • The role of the gut microbiota in nonalcoholic fatty liver disease
    • Abu-Shanab, A. & Quigley, E. M. The role of the gut microbiota in nonalcoholic fatty liver disease. Nature reviews. Gastroenterology & hepatology 7, 691-701, doi: 10.1038/nrgastro.2010.172 (2010).
    • (2010) Nature Reviews. Gastroenterology & Hepatology , vol.7 , pp. 691-701
    • Abu-Shanab, A.1    Quigley, E.M.2
  • 7
    • 84930929179 scopus 로고    scopus 로고
    • Who determines the outcomes of HBV exposure?
    • Wang, B. & Li, L. Who determines the outcomes of HBV exposure? Trends in microbiology 23, 328-329, doi: 10.1016/j. tim.2015.04.001 (2015).
    • (2015) Trends in Microbiology , vol.23 , pp. 328-329
    • Wang, B.1    Li, L.2
  • 8
    • 33845901507 scopus 로고    scopus 로고
    • Microbial ecology: Human gut microbes associated with obesity
    • Ley, R. E., Turnbaugh, P. J., Klein, S. & Gordon, J. I. Microbial ecology: human gut microbes associated with obesity. Nature 444, 1022-1023, doi: 10.1038/4441022a (2006).
    • (2006) Nature , vol.444 , pp. 1022-1023
    • Ley, R.E.1    Turnbaugh, P.J.2    Klein, S.3    Gordon, J.I.4
  • 9
    • 58749112734 scopus 로고    scopus 로고
    • A core gut microbiome in obese and lean twins
    • Turnbaugh, P. J., et al. A core gut microbiome in obese and lean twins. Nature 457, 480-484, doi: 10.1038/nature07540 (2009).
    • (2009) Nature , vol.457 , pp. 480-484
    • Turnbaugh, P.J.1
  • 10
    • 84867074831 scopus 로고    scopus 로고
    • A metagenome-wide association study of gut microbiota in type 2 diabetes
    • Qin, J., et al. A metagenome-wide association study of gut microbiota in type 2 diabetes. Nature 490, 55-60, doi: 10.1038/nature11450 (2012).
    • (2012) Nature , vol.490 , pp. 55-60
    • Qin, J.1
  • 11
    • 79960714764 scopus 로고    scopus 로고
    • Characterization of fecal microbial communities in patients with liver cirrhosis
    • Chen, Y., et al. Characterization of fecal microbial communities in patients with liver cirrhosis. Hepatology 54, 562-572, doi: 10.1002/hep.24423 (2011).
    • (2011) Hepatology , vol.54 , pp. 562-572
    • Chen, Y.1
  • 12
    • 84879888338 scopus 로고    scopus 로고
    • Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome
    • Yoshimoto, S., et al. Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome. Nature 499, 97-101, doi: 10.1038/nature12347 (2013).
    • (2013) Nature , vol.499 , pp. 97-101
    • Yoshimoto, S.1
  • 13
    • 84856957894 scopus 로고    scopus 로고
    • Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity
    • Henao-Mejia, J., et al. Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity. Nature 482, 179-185, doi: 10.1038/nature10809 (2012).
    • (2012) Nature , vol.482 , pp. 179-185
    • Henao-Mejia, J.1
  • 14
    • 35948958955 scopus 로고    scopus 로고
    • TLR4 enhances TGF-beta signaling and hepatic fibrosis
    • Seki, E., et al. TLR4 enhances TGF-beta signaling and hepatic fibrosis. Nature medicine 13, 1324-1332, doi: 10.1038/nm1663 (2007).
    • (2007) Nature Medicine , vol.13 , pp. 1324-1332
    • Seki, E.1
  • 15
    • 84884414277 scopus 로고    scopus 로고
    • Intestinal microbiota determines development of non-alcoholic fatty liver disease in mice
    • Le Roy, T., et al. Intestinal microbiota determines development of non-alcoholic fatty liver disease in mice. Gut 62, 1787-1794, doi: 10.1136/gutjnl-2012-303816 (2013).
    • (2013) Gut , vol.62 , pp. 1787-1794
    • Le Roy, T.1
  • 16
    • 84879604697 scopus 로고    scopus 로고
    • Intestinal microbiota in patients with nonalcoholic fatty liver disease
    • Mouzaki, M., et al. Intestinal microbiota in patients with nonalcoholic fatty liver disease. Hepatology 58, 120-127, doi: 10.1002/hep.26319 (2013).
    • (2013) Hepatology , vol.58 , pp. 120-127
    • Mouzaki, M.1
  • 18
    • 84873296091 scopus 로고    scopus 로고
    • Characterization of gut microbiomes in nonalcoholic steatohepatitis (NASH) patients: A connection between endogenous alcohol and NASH
    • Zhu, L., et al. Characterization of gut microbiomes in nonalcoholic steatohepatitis (NASH) patients: a connection between endogenous alcohol and NASH. Hepatology 57, 601-609, doi: 10.1002/hep.26093 (2013).
    • (2013) Hepatology , vol.57 , pp. 601-609
    • Zhu, L.1
  • 19
    • 33748457319 scopus 로고    scopus 로고
    • Prevalence and risk factors of nonalcoholic fatty liver disease in an adult population of Taiwan: Metabolic significance of nonalcoholic fatty liver disease in nonobese adults
    • Chen, C. H., et al. Prevalence and risk factors of nonalcoholic fatty liver disease in an adult population of taiwan: metabolic significance of nonalcoholic fatty liver disease in nonobese adults. Journal of clinical gastroenterology 40, 745-752 (2006).
    • (2006) Journal of Clinical Gastroenterology , vol.40 , pp. 745-752
    • Chen, C.H.1
  • 20
    • 77951493150 scopus 로고    scopus 로고
    • Nonobese population in a developing country has a high prevalence of nonalcoholic fatty liver and significant liver disease
    • Das, K., et al. Nonobese population in a developing country has a high prevalence of nonalcoholic fatty liver and significant liver disease. Hepatology 51, 1593-1602, doi: 10.1002/hep.23567 (2010).
    • (2010) Hepatology , vol.51 , pp. 1593-1602
    • Das, K.1
  • 21
    • 6944227798 scopus 로고    scopus 로고
    • Metabolic significance of nonalcoholic fatty liver disease in nonobese, nondiabetic adults
    • Kim, H. J., et al. Metabolic significance of nonalcoholic fatty liver disease in nonobese, nondiabetic adults. Archives of internal medicine 164, 2169-2175, doi: 10.1001/archinte.164.19.2169 (2004).
    • (2004) Archives of Internal Medicine , vol.164 , pp. 2169-2175
    • Kim, H.J.1
  • 22
    • 84881147421 scopus 로고    scopus 로고
    • Prevalence and risk factors for the development of nonalcoholic fatty liver disease in a nonobese Chinese population: The Zhejiang Zhenhai Study
    • Xu, C., et al. Prevalence and risk factors for the development of nonalcoholic fatty liver disease in a nonobese Chinese population: the Zhejiang Zhenhai Study. The American journal of gastroenterology 108, 1299-1304, doi: 10.1038/ajg.2013.104 (2013).
    • (2013) The American Journal of Gastroenterology , vol.108 , pp. 1299-1304
    • Xu, C.1
  • 23
    • 84941259304 scopus 로고    scopus 로고
    • Prevalence and Severity of Nonalcoholic Fatty Liver Disease in Non-Obese Patients: A Population Study Using Proton-Magnetic Resonance Spectroscopy
    • quiz 1315 doi: 10.1038/ajg.2015.235
    • Wei, J. L., et al. Prevalence and Severity of Nonalcoholic Fatty Liver Disease in Non-Obese Patients: A Population Study Using Proton-Magnetic Resonance Spectroscopy. The American journal of gastroenterology 110, 1306-1314; quiz 1315, doi: 10.1038/ajg.2015.235 (2015).
    • (2015) The American Journal of Gastroenterology , vol.110 , pp. 1306-1314
    • Wei, J.L.1
  • 24
    • 84922610532 scopus 로고    scopus 로고
    • Mapping of the circulating metabolome reveals alpha-ketoglutarate as a predictor of morbid obesityassociated non-alcoholic fatty liver disease
    • Rodriguez-Gallego, E., et al. Mapping of the circulating metabolome reveals alpha-ketoglutarate as a predictor of morbid obesityassociated non-alcoholic fatty liver disease. International journal of obesity 39, 279-287, doi: 10.1038/ijo.2014.53 (2015).
    • (2015) International Journal of Obesity , vol.39 , pp. 279-287
    • Rodriguez-Gallego, E.1
  • 25
    • 84883110880 scopus 로고    scopus 로고
    • Richness of human gut microbiome correlates with metabolic markers
    • Le Chatelier, E., et al. Richness of human gut microbiome correlates with metabolic markers. Nature 500, 541-546, doi: 10.1038/nature12506 (2013).
    • (2013) Nature , vol.500 , pp. 541-546
    • Le Chatelier, E.1
  • 26
    • 73949137604 scopus 로고    scopus 로고
    • Microbiota and SCFA in lean and overweight healthy subjects
    • Schwiertz, A., et al. Microbiota and SCFA in lean and overweight healthy subjects. Obesity 18, 190-195, doi: 10.1038/oby.2009.167 (2010).
    • (2010) Obesity , vol.18 , pp. 190-195
    • Schwiertz, A.1
  • 27
    • 77949393654 scopus 로고    scopus 로고
    • Gut microbiota in human adults with type 2 diabetes differs from non-diabetic adults
    • Larsen, N., et al. Gut microbiota in human adults with type 2 diabetes differs from non-diabetic adults. PloS one 5, e9085, doi: 10.1371/journal.pone.0009085 (2010).
    • (2010) PloS One , vol.5 , pp. e9085
    • Larsen, N.1
  • 28
    • 24044455869 scopus 로고    scopus 로고
    • Genome sequencing in microfabricated high-density picolitre reactors
    • Margulies, M., et al. Genome sequencing in microfabricated high-density picolitre reactors. Nature 437, 376-380, doi: 10.1038/nature03959 (2005).
    • (2005) Nature , vol.437 , pp. 376-380
    • Margulies, M.1
  • 30
    • 0030882260 scopus 로고    scopus 로고
    • N-butyrate downregulates the stimulatory function of peripheral blood-derived antigen-presenting cells: A potential mechanism for modulating T-cell responses by short-chain fatty acids
    • Bohmig, G. A., et al. n-butyrate downregulates the stimulatory function of peripheral blood-derived antigen-presenting cells: a potential mechanism for modulating T-cell responses by short-chain fatty acids. Immunology 92, 234-243 (1997).
    • (1997) Immunology , vol.92 , pp. 234-243
    • Bohmig, G.A.1
  • 31
    • 84898824175 scopus 로고    scopus 로고
    • Interactions between the intestinal microbiome and liver diseases
    • Schnabl, B. & Brenner, D. A. Interactions between the intestinal microbiome and liver diseases. Gastroenterology 146, 1513-1524, doi: 10.1053/j.gastro.2014.01.020 (2014).
    • (2014) Gastroenterology , vol.146 , pp. 1513-1524
    • Schnabl, B.1    Brenner, D.A.2
  • 32
    • 84876294967 scopus 로고    scopus 로고
    • Modulation of the fecal bile acid profile by gut microbiota in cirrhosis
    • Kakiyama, G., et al. Modulation of the fecal bile acid profile by gut microbiota in cirrhosis. Journal of hepatology 58, 949-955, doi: 10.1016/j.jhep.2013.01.003 (2013).
    • (2013) Journal of Hepatology , vol.58 , pp. 949-955
    • Kakiyama, G.1
  • 34
    • 56849106496 scopus 로고    scopus 로고
    • The pervasive effects of an antibiotic on the human gut microbiota, as revealed by deep 16S rRNA sequencing
    • Dethlefsen, L., Huse, S., Sogin, M. L. & Relman, D. A. The pervasive effects of an antibiotic on the human gut microbiota, as revealed by deep 16S rRNA sequencing. PLoS biology 6, e280, doi: 10.1371/journal.pbio.0060280 (2008).
    • (2008) PLoS Biology , vol.6 , pp. e280
    • Dethlefsen, L.1    Huse, S.2    Sogin, M.L.3    Relman, D.A.4
  • 35
    • 33845874101 scopus 로고    scopus 로고
    • An obesity-associated gut microbiome with increased capacity for energy harvest
    • Turnbaugh, P. J., et al. An obesity-associated gut microbiome with increased capacity for energy harvest. Nature 444, 1027-1031, doi: 10.1038/nature05414 (2006).
    • (2006) Nature , vol.444 , pp. 1027-1031
    • Turnbaugh, P.J.1
  • 36
    • 83755186465 scopus 로고    scopus 로고
    • Linkage of gut microbiome with cognition in hepatic encephalopathy. American journal of physiology
    • Bajaj, J. S., et al. Linkage of gut microbiome with cognition in hepatic encephalopathy. American journal of physiology. Gastrointestinal and liver physiology 302, G168-175, doi: 10.1152/ajpgi.00190.2011 (2012).
    • (2012) Gastrointestinal and Liver Physiology , vol.302 , pp. G168-175
    • Bajaj, J.S.1
  • 37
    • 84899474318 scopus 로고    scopus 로고
    • Dysbiosis contributes to fibrogenesis in the course of chronic liver injury in mice
    • De Minicis, S., et al. Dysbiosis contributes to fibrogenesis in the course of chronic liver injury in mice. Hepatology 59, 1738-1749, doi: 10.1002/hep.26695 (2014).
    • (2014) Hepatology , vol.59 , pp. 1738-1749
    • De Minicis, S.1
  • 38
    • 68949148889 scopus 로고    scopus 로고
    • Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease
    • Miele, L., et al. Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease. Hepatology 49, 1877-1887, doi: 10.1002/hep.22848 (2009).
    • (2009) Hepatology , vol.49 , pp. 1877-1887
    • Miele, L.1
  • 39
    • 38449120093 scopus 로고    scopus 로고
    • Lipopolysaccharide-binding protein plasma levels and liver TNF-alpha gene expression in obese patients: Evidence for the potential role of endotoxin in the pathogenesis of non-alcoholic steatohepatitis
    • Ruiz, A. G., et al. Lipopolysaccharide-binding protein plasma levels and liver TNF-alpha gene expression in obese patients: evidence for the potential role of endotoxin in the pathogenesis of non-alcoholic steatohepatitis. Obesity surgery 17, 1374-1380, doi: 10.1007/s11695-007-9243-7 (2007).
    • (2007) Obesity Surgery , vol.17 , pp. 1374-1380
    • Ruiz, A.G.1
  • 40
    • 84900346071 scopus 로고    scopus 로고
    • Lactobacillus rhamnosus GG protects against non-alcoholic fatty liver disease in mice
    • Ritze, Y., et al. Lactobacillus rhamnosus GG protects against non-alcoholic fatty liver disease in mice. PloS one 9, e80169, doi: 10.1371/journal.pone.0080169 (2014).
    • (2014) PloS One , vol.9 , pp. e80169
    • Ritze, Y.1
  • 41
    • 80054873943 scopus 로고    scopus 로고
    • Effect of a probiotic on liver aminotransferases in nonalcoholic fatty liver disease patients: A double blind randomized clinical trial
    • Aller, R., et al. Effect of a probiotic on liver aminotransferases in nonalcoholic fatty liver disease patients: a double blind randomized clinical trial. European review for medical and pharmacological sciences 15, 1090-1095 (2011).
    • (2011) European Review for Medical and Pharmacological Sciences , vol.15 , pp. 1090-1095
    • Aller, R.1
  • 42
    • 20844440555 scopus 로고    scopus 로고
    • Beneficial effects of a probiotic VSL#3 on parameters of liver dysfunction in chronic liver diseases
    • Loguercio, C., et al. Beneficial effects of a probiotic VSL#3 on parameters of liver dysfunction in chronic liver diseases. Journal of clinical gastroenterology 39, 540-543 (2005).
    • (2005) Journal of Clinical Gastroenterology , vol.39 , pp. 540-543
    • Loguercio, C.1
  • 43
    • 84876725499 scopus 로고    scopus 로고
    • Treatment of nonalcoholic steatohepatitis with probiotics. A proof-of-concept study
    • Wong, V. W., et al. Treatment of nonalcoholic steatohepatitis with probiotics. A proof-of-concept study. Annals of hepatology 12, 256-262 (2013).
    • (2013) Annals of Hepatology , vol.12 , pp. 256-262
    • Wong, V.W.1
  • 44
    • 0037309589 scopus 로고    scopus 로고
    • Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease
    • Li, Z., et al. Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease. Hepatology 37, 343-350, doi: 10.1053/jhep.2003.50048 (2003).
    • (2003) Hepatology , vol.37 , pp. 343-350
    • Li, Z.1
  • 45
    • 84954288595 scopus 로고    scopus 로고
    • The severity of nonalcoholic fatty liver disease is associated with gut dysbiosis and shift in the metabolic function of the gut microbiota
    • Boursier, J., et al. The severity of nonalcoholic fatty liver disease is associated with gut dysbiosis and shift in the metabolic function of the gut microbiota. Hepatology 63, 764-775, doi: 10.1002/hep.28356 (2016).
    • (2016) Hepatology , vol.63 , pp. 764-775
    • Boursier, J.1
  • 46
    • 64549089599 scopus 로고    scopus 로고
    • Association of serum uric acid level with non-alcoholic fatty liver disease: A cross-sectional study
    • Li, Y., Xu, C., Yu, C., Xu, L. & Miao, M. Association of serum uric acid level with non-alcoholic fatty liver disease: a cross-sectional study. Journal of hepatology 50, 1029-1034, doi: 10.1016/j.jhep.2008.11.021 (2009).
    • (2009) Journal of Hepatology , vol.50 , pp. 1029-1034
    • Li, Y.1    Xu, C.2    Yu, C.3    Xu, L.4    Miao, M.5
  • 47
  • 48
    • 0034888485 scopus 로고    scopus 로고
    • Systemic uric acid administration increases serum antioxidant capacity in healthy volunteers
    • Waring, W. S., Webb, D. J. & Maxwell, S. R. Systemic uric acid administration increases serum antioxidant capacity in healthy volunteers. Journal of cardiovascular pharmacology 38, 365-371 (2001).
    • (2001) Journal of Cardiovascular Pharmacology , vol.38 , pp. 365-371
    • Waring, W.S.1    Webb, D.J.2    Maxwell, S.R.3
  • 49
    • 77950250064 scopus 로고    scopus 로고
    • Metabolic syndrome and altered gut microbiota in mice lacking Toll-like receptor 5
    • Vijay-Kumar, M., et al. Metabolic syndrome and altered gut microbiota in mice lacking Toll-like receptor 5. Science 328, 228-231, doi: 10.1126/science.1179721 (2010).
    • (2010) Science , vol.328 , pp. 228-231
    • Vijay-Kumar, M.1
  • 50
    • 77949265935 scopus 로고    scopus 로고
    • The environment within: How gut microbiota may influence metabolism and body composition
    • Vrieze, A., et al. The environment within: how gut microbiota may influence metabolism and body composition. Diabetologia 53, 606-613, doi: 10.1007/s00125-010-1662-7 (2010).
    • (2010) Diabetologia , vol.53 , pp. 606-613
    • Vrieze, A.1
  • 51
    • 0037129380 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease
    • Angulo, P. Nonalcoholic fatty liver disease. The New England journal of medicine 346, 1221-1231, doi: 10.1056/NEJMra011775 (2002).
    • (2002) The New England Journal of Medicine , vol.346 , pp. 1221-1231
    • Angulo, P.1
  • 52
    • 84969916129 scopus 로고    scopus 로고
    • Polyomavirus replication and smoking are independent risk factors for bladder cancer after renal transplantation
    • Liu, S., et al. Polyomavirus Replication and Smoking Are Independent Risk Factors for Bladder Cancer After Renal Transplantation. Transplantation, doi: 10.1097/TP.0000000000001260 (2016).
    • (2016) Transplantation
    • Liu, S.1
  • 53
    • 77954235797 scopus 로고    scopus 로고
    • Fitness versus fatness: Moving beyond weight loss in nonalcoholic fatty liver disease
    • Johnson, N. A. & George, J. Fitness versus fatness: moving beyond weight loss in nonalcoholic fatty liver disease. Hepatology 52, 370-381, doi: 10.1002/hep.23711 (2010).
    • (2010) Hepatology , vol.52 , pp. 370-381
    • Johnson, N.A.1    George, J.2
  • 54
    • 34250326350 scopus 로고    scopus 로고
    • Asia-Pacific Working Party on, N. Guidelines for the assessment and management of non-alcoholic fatty liver disease in the Asia-Pacific region: Executive summary
    • Farrell, G. C., Chitturi, S., Lau, G. K. & Sollano, J. D. & Asia-Pacific Working Party on, N. Guidelines for the assessment and management of non-alcoholic fatty liver disease in the Asia-Pacific region: executive summary. Journal of gastroenterology and hepatology 22, 775-777, doi: 10.1111/j.1440-1746.2007.05002.x (2007).
    • (2007) Journal of Gastroenterology and Hepatology , vol.22 , pp. 775-777
    • Farrell, G.C.1    Chitturi, S.2    Lau, G.K.3    Sollano, J.D.4
  • 55
    • 42449155505 scopus 로고    scopus 로고
    • Guidelines for the diagnosis and treatment of nonalcoholic fatty liver diseases
    • Zeng, M. D., et al. Guidelines for the diagnosis and treatment of nonalcoholic fatty liver diseases. Journal of digestive diseases 9, 108-112, doi: 10.1111/j.1751-2980.2008.00331.x (2008).
    • (2008) Journal of Digestive Diseases , vol.9 , pp. 108-112
    • Zeng, M.D.1
  • 56
    • 24144481800 scopus 로고    scopus 로고
    • Spectrum of NAFLD and diagnostic implications of the proposed new normal range for serum ALT in obese women
    • Kunde, S. S., Lazenby, A. J., Clements, R. H. & Abrams, G. A. Spectrum of NAFLD and diagnostic implications of the proposed new normal range for serum ALT in obese women. Hepatology 42, 650-656, doi: 10.1002/hep.20818 (2005).
    • (2005) Hepatology , vol.42 , pp. 650-656
    • Kunde, S.S.1    Lazenby, A.J.2    Clements, R.H.3    Abrams, G.A.4
  • 57
    • 0027460328 scopus 로고
    • Profiling of complex microbial populations by denaturing gradient gel electrophoresis analysis of polymerase chain reaction-amplified genes coding for 16S rRNA
    • Muyzer, G., de Waal, E. C. & Uitterlinden, A. G. Profiling of complex microbial populations by denaturing gradient gel electrophoresis analysis of polymerase chain reaction-amplified genes coding for 16S rRNA. Applied and environmental microbiology 59, 695-700 (1993).
    • (1993) Applied and Environmental Microbiology , vol.59 , pp. 695-700
    • Muyzer, G.1    De Waal, E.C.2    Uitterlinden, A.G.3
  • 58
    • 84863042105 scopus 로고    scopus 로고
    • Metabonomic profiles discriminate hepatocellular carcinoma from liver cirrhosis by ultraperformance liquid chromatography-mass spectrometry
    • Wang, B., et al. Metabonomic profiles discriminate hepatocellular carcinoma from liver cirrhosis by ultraperformance liquid chromatography-mass spectrometry. Journal of proteome research 11, 1217-1227, doi: 10.1021/pr2009252 (2012).
    • (2012) Journal of Proteome Research , vol.11 , pp. 1217-1227
    • Wang, B.1
  • 59
    • 76349111356 scopus 로고    scopus 로고
    • Interactions between gut microbiota, host genetics and diet relevant to development of metabolic syndromes in mice
    • Zhang, C., et al. Interactions between gut microbiota, host genetics and diet relevant to development of metabolic syndromes in mice. The ISME journal 4, 232-241, doi: 10.1038/ismej.2009.112 (2010).
    • (2010) The ISME Journal , vol.4 , pp. 232-241
    • Zhang, C.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.