Fecal microbiome and volatile organic compound metabolome in obese humans with nonalcoholic fatty liver disease

Clinical Gastroenterology and Hepatology

Volumn 11, Issue 7, 2013, Pages 868-875.e3

  Raman, Maitreyi ^a   Ahmed, Iftikhar ^c   Gillevet, Patrick M ^d   Probert, Chris S ^e   Ratcliffe, Norman M ^f   Smith, Steve ^f   Greenwood, Rosemary ^c   Sikaroodi, Masoumeh ^d   Lam, Victor ^a   Crotty, Pam ^a   Bailey, Jennifer ^a   Myers, Robert P ^a   Rioux, Kevin P ^a,b  

^a UNIVERSITY OF CALGARY   (Canada)

^b UNIVERSITY OF CALGARY   (Canada)

^c BRISTOL ROYAL INFIRMARY   (United Kingdom)

^d GEORGE MASON UNIVERSITY   (United States)

^e UNIVERSITY OF LIVERPOOL   (United Kingdom)

^f UNIVERSITY OF THE WEST OF ENGLAND   (United Kingdom)

Author keywords

High Throughput Nucleotide Sequencing; Metabolomics; Microbiota; Nonalcoholic Fatty Liver Disease; Obesity; Volatile Organic Compound

Indexed keywords

VOLATILE ORGANIC COMPOUND;

ADULT; ARTICLE; BIOCHEMISTRY; CASE CONTROL STUDY; CLINICAL ARTICLE; COLON FLORA; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FECES MICROFLORA; FEMALE; FIRMICUTES; HUMAN; LACTOBACILLUS; MALE; MASS FRAGMENTOGRAPHY; METABOLOME; NONALCOHOLIC FATTY LIVER; OBESITY; OBSERVATIONAL STUDY; PHYLUM; PYROSEQUENCING;

EID: 84879245628     PISSN: 15423565     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cgh.2013.02.015     Document Type: Article

References (21)

1. Parnell J.A., Raman M., Rioux K.P., et al. The potential role of prebiotic fibre for treatment and management of non-alcoholic fatty liver disease and associated obesity and insulin resistance. Liver Int 2012, 32:701-711.
2. Ley R.E., Turnbaugh P.J., Klein S., et al. Microbial ecology: human gut microbes associated with obesity. Nature 2006, 444:1022-1023.
3. Turnbaugh P.J., Ley R.E., Mahowald M.A., et al. An obesity-associated gut microbiome with increased capacity for energy harvest. Nature 2006, 444:1027-1031.
4. Cope K., Risby T., Diehl A.M. Increased gastrointestinal ethanol production in obese mice: implications for fatty liver disease pathogenesis. Gastroenterology 2000, 119:1340-1347.
5. Garner C.E., Smith S., De Lacy Costello B., et al. Volatile organic compounds from feces and their potential for diagnosis of gastrointestinal disease. FASEB J 2007, 21:1675-1688.
6. Ahmed I., Smith S., Probert C. Volatile organic compounds as diagnostic faecal biomarkers in inflammatory bowel disease-method development. Gut 2009, 58:A63.
7. Zoetendal E.G., Heilig H.G., Klaassens E.S., et al. Isolation of DNA from bacterial samples of the human gastrointestinal tract. Nat Protoc 2006, 1:870-873.
8. Gillevet P., Sikaroodi M., Keshavarzian A., et al. Quantitative assessment of the human gut microbiome using multitag pyrosequencing. Chem Biodivers 2010, 7:1065-1075.
9. Naqvi A., Rangwala H., Spear G., et al. Analysis of multitag pyrosequence data from human cervical lavage samples. Chem Biodivers 2010, 7:1076-1085.
10. Lozupone C., Knight R. UniFrac: a new phylogenetic method for comparing microbial communities. Appl Environ Microbiol 2005, 71:8228-8235.
11. White J.R., Nagarajan N., Pop M. Statistical methods for detecting differentially abundant features in clinical metagenomic samples. PLoS Comput Biol 2009, 5:e1000352.
12. Cole J.R., Wang Q., Cardenas E., et al. The Ribosomal Database Project: improved alignments and new tools for rRNA analysis. Nucleic Acids Res 2009, 37:D141-D145.
13. Caporaso J.G., Kuczynski J., Stombaugh J., et al. QIIME allows analysis of high-throughput community sequencing data. Nat Methods 2010, 7:335-336.
14. Kallus S.J., Brandt L.J. The intestinal microbiota and obesity. J Clin Gastroenterol 2012, 46:16-24.
15. Spencer M.D., Hamp T.J., Reid R.W., et al. Association between composition of the human gastrointestinal microbiome and development of fatty liver with choline deficiency. Gastroenterology 2011, 140:976-986.
16. Wu G.D., Chen J., Hoffmann C., et al. Linking long-term dietary patterns with gut microbial enterotypes. Science 2011, 334:105-108.
17. Probert C.S., Ahmed I., Khalid T., et al. Volatile organic compounds as diagnostic biomarkers in gastrointestinal and liver diseases. J Gastrointest Liver Dis 2009, 18:337-343.
18. Elgaali H., Hamilton-Kemp T.R., Newman M.C., et al. Comparison of long-chain alcohols and other volatile compounds emitted from food-borne and related Gram positive and gram negative bacteria. J Basic Microbiol 2002, 42:373-380.
19. Zhu L., Baker S.S., Gill C., et al. Characterization of the gut microbiome in non-alcoholic steatohepatitis (NASH) patients: a connection between endogenous alcohol and NASH. Hepatology 2013, 57:601-609.
20. Vos B., Moreno C., Nagy N., et al. Lean non-alcoholic fatty liver disease (lean-NAFLD): a major cause of cryptogenic liver disease. Acta Gastroenterol Belg 2011, 74:389-394.
21. Yazdanian M., Glynn S.L., Wright J.L., et al. Correlating partitioning and Caco-2 cell permeability of structurally diverse small molecular weight compounds. Pharm Res 1998, 15:1490-1494.