Who determines the outcomes of HBV exposure?

Trends in Microbiology

Volumn 23, Issue 6, 2015, Pages 328-329

  Wang, Baohong ^a   Li, Lanjuan ^a  

^a ZHEJIANG UNIVERSITY   (China)

Author keywords

Age; Gut microbiota; HBV; Immunity

Indexed keywords

ANTIBIOTIC AGENT; HEPATITIS B SURFACE ANTIGEN; TOLL LIKE RECEPTOR 4;

AGE; CHRONIC DISEASE; CHRONIC HEPATITIS B; COMMENSAL; DISEASE SEVERITY; DYSBIOSIS; HEPATITIS B; HUMAN; IMMUNOMODULATION; INTESTINE FLORA; MICROBIAL DIVERSITY; NONHUMAN; PERSISTENT VIRUS INFECTION; PRIORITY JOURNAL; PROGNOSIS; SHORT SURVEY; VIRAL CLEARANCE; ANIMAL; IMMUNOLOGY; INTESTINE; MICROBIOLOGY; MICROFLORA;

HEPATITIS B VIRUS;

ANIMALS; HEPATITIS B; HUMANS; INTESTINES; MICROBIOTA;

EID: 84930929179     PISSN: 0966842X     EISSN: 18784380     Source Type: Journal    
DOI: 10.1016/j.tim.2015.04.001     Document Type: Short Survey

References (10)

1. Sandler N.G., et al. Host response to translocated microbial products predicts outcomes of patients with HBV or HCV infection. Gastroenterology 2011, 141:1220-1230.
2. Thio C.L., et al. Chronic viral hepatitis and the human genome. Hepatology 2000, 31:819-827.
3. Wursthorn K., et al. Managing HBV in patients with impaired immunity. Gut 2010, 59:1430-1445.
4. Ma Z., et al. Contribution of Toll-like receptors to the control of hepatitis B virus infection by initiating antiviral innate responses and promoting specific adaptive immune responses. Cell. Mol. Immunol. 2014, 112. 10.1038/cmi.2014.
5. Chou H.H., et al. Age-related immune clearance of hepatitis B virus infection requires the establishment of gut microbiota. Proc. Natl. Acad. Sci. U.S.A. 2015, 112:2175-2180.
6. Li M., et al. Symbiotic gut microbes modulate human metabolic phenotypes. Proc. Natl. Acad. Sci. U.S.A. 2008, 105:2117-2122.
7. Eckburg P.B., et al. Diversity of the human intestinal microbial flora. Science 2005, 308:1635-1638.
8. Qin N., et al. Alterations of the human gut microbiome in liver cirrhosis. Nature 2014, 513:59-64.
9. Seki E., et al. TLR4 enhances TGF-beta signaling and hepatic fibrosis. Nat. Med. 2007, 13:1324-1332.
10. Dapito D.H., et al. Promotion of hepatocellular carcinoma by the intestinal microbiota and TLR4. Cancer Cell 2012, 21:504-516.