메뉴 건너뛰기




Volumn 310, Issue 9, 2016, Pages R866-R874

In vivo and in vitro degradation of peptide YY3–36 to inactive peptide YY3–34 in humans

Author keywords

Degradation; Kinetics; Peptide YY

Indexed keywords

NEUROPEPTIDE Y2 RECEPTOR; PEPTIDE YY; PEPTIDE YY [3-34]; PEPTIDE YY [3-36]; SITAGLIPTIN; UNCLASSIFIED DRUG; GLUCOSE BLOOD LEVEL; PEPTIDE FRAGMENT;

EID: 84984660098     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.00394.2015     Document Type: Article
Times cited : (54)

References (37)
  • 9
    • 0028097051 scopus 로고
    • Complete L-alanine scan of neuropeptide Y reveals ligands binding to Y1 and Y2 receptors with distinguished conformations
    • Beck-Sickinger AG, Weland HA, Wittneben H, Willim KD, Rudolf K, Jung G. Complete L-alanine scan of neuropeptide Y reveals ligands binding to Y1 and Y2 receptors with distinguished conformations. Eur J Biochem 225: 947-958, 1994.
    • (1994) Eur J Biochem , vol.225 , pp. 947-958
    • Beck-Sickinger, A.G.1    Weland, H.A.2    Wittneben, H.3    Willim, K.D.4    Rudolf, K.5    Jung, G.6
  • 10
    • 0026670873 scopus 로고
    • Evidence for a direct inhibitory effect of PYY on insulin secretion in rats
    • Bertrand G, Gross R, Roye M, Ahrkn B, Ribes G. Evidence for a direct inhibitory effect of PYY on insulin secretion in rats. Pancreas 7: 595-600, 1992.
    • (1992) Pancreas , vol.7 , pp. 595-600
    • Bertrand, G.1    Gross, R.2    Roye, M.3    Ahrkn, B.4    Ribes, G.5
  • 12
    • 0024339140 scopus 로고
    • Intrapancreatic localization and effects on insulin and glucagon secretion in the mouse
    • Bottcher G, Ahren B, Lundquist I, Sundler F. Peptide YY: Intrapancreatic localization and effects on insulin and glucagon secretion in the mouse. Pancreas 4: 282-288, 1989.
    • (1989) Pancreas , vol.4 , pp. 282-288
    • Bottcher, G.1    Ahren, B.2    Lundquist, I.3    Sundler, F.4    Peptide, Y.Y.5
  • 13
    • 0035089197 scopus 로고    scopus 로고
    • Increased insulin concentrations and glucose storage in neuropeptide Y Y1 receptor-deficient mice
    • Burcelin R, Brunner HR, Seydoux J, Thorensa B, Pedrazzini T. Increased insulin concentrations and glucose storage in neuropeptide Y Y1 receptor-deficient mice. Peptides 22: 421-427, 2001.
    • (2001) Peptides , vol.22 , pp. 421-427
    • Burcelin, R.1    Brunner, H.R.2    Seydoux, J.3    Thorensa, B.4    Pedrazzini, T.5
  • 14
    • 0028953577 scopus 로고
    • Degradation of glucagon-like peptide-1 by human plasma in vitro yields an N-terminally truncated peptide that is a major endogenous metabolite in vivo
    • Deacon CF, Johnsen AH, Holst JJ. Degradation of glucagon-like peptide-1 by human plasma in vitro yields an N-terminally truncated peptide that is a major endogenous metabolite in vivo. J Clin Endocrinol Metab 80: 952-957, 1995.
    • (1995) J Clin Endocrinol Metab , vol.80 , pp. 952-957
    • Deacon, C.F.1    Johnsen, A.H.2    Holst, J.J.3
  • 15
    • 0033766716 scopus 로고    scopus 로고
    • Degradation of endogenous and exogenous gastric inhibitory polypeptide in healthy and in type 2 diabetic subjects as revealed using a new assay for the intact peptide
    • Deacon CF, Nauck MA, Meier J, Hücking K, Holst JJ. Degradation of endogenous and exogenous gastric inhibitory polypeptide in healthy and in type 2 diabetic subjects as revealed using a new assay for the intact peptide. J Clin Endocrinol Metab 85: 3575-3581, 2000.
    • (2000) J Clin Endocrinol Metab , vol.85 , pp. 3575-3581
    • Deacon, C.F.1    Nauck, M.A.2    Meier, J.3    Hücking, K.4    Holst, J.J.5
  • 18
    • 0024427383 scopus 로고
    • A comparison of intraduodenally and intracolonically administered nutrients on the release of peptide-YY in the dog
    • Greeley GH, Hashimoto T, Izukura M, Gomez G, Jeng J, Hill FLC, Lluis F, Thompson JC. A comparison of intraduodenally and intracolonically administered nutrients on the release of peptide-YY in the dog. Endocrinology 125: 1761-1765, 1989.
    • (1989) Endocrinology , vol.125 , pp. 1761-1765
    • Greeley, G.H.1    Hashimoto, T.2    Izukura, M.3    Gomez, G.4    Jeng, J.5    Hill, F.6    Lluis, F.7    Thompson, J.C.8
  • 20
    • 85011889465 scopus 로고    scopus 로고
    • Assays for peptide products of somatostatin gene expression
    • edited by Conn PM. New York, NY: Academic
    • Holst JJ, Bersani M. Assays for peptide products of somatostatin gene expression. In: Methods in Neurosciences, edited by Conn PM. New York, NY: Academic, 2015, p. 3-22.
    • (2015) Methods in Neurosciences , pp. 3-22
    • Holst, J.J.1    Bersani, M.2
  • 21
    • 0034663977 scopus 로고    scopus 로고
    • Solution structure of monomeric peptide YY supports the functional significance of the PP-fold
    • Keire DA, Kobayashi M, Solomon TE, Reeve JR. Solution structure of monomeric peptide YY supports the functional significance of the PP-fold. Biochemistry 39: 9935-9942, 2000.
    • (2000) Biochemistry , vol.39 , pp. 9935-9942
    • Keire, D.A.1    Kobayashi, M.2    Solomon, T.E.3    Reeve, J.R.4
  • 22
    • 34247533770 scopus 로고    scopus 로고
    • Identification of neuropeptide Y cleavage products in human blood to improve metabolic stability
    • Khan IU, Reppich R, Beck-Sickinger AG. Identification of neuropeptide Y cleavage products in human blood to improve metabolic stability. Biopolymers 88: 182-189, 2007.
    • (2007) Biopolymers , vol.88 , pp. 182-189
    • Khan, I.U.1    Reppich, R.2    Beck-Sickinger, A.G.3
  • 23
    • 0029118049 scopus 로고
    • Degradation of glucose-dependent insulinotropic polypeptide and truncated glucagon-like peptide 1 in vitro and in vivo by dipeptidyl peptidase IV
    • Kieffer TJ, McIntosh CH, Pederson RA. Degradation of glucose-dependent insulinotropic polypeptide and truncated glucagon-like peptide 1 in vitro and in vivo by dipeptidyl peptidase IV. Endocrinology 136: 3585-3596, 1995.
    • (1995) Endocrinology , vol.136 , pp. 3585-3596
    • Kieffer, T.J.1    McIntosh, C.H.2    Pederson, R.A.3
  • 24
    • 0027330240 scopus 로고
    • Y1 and Y2 affinities of the complete series of analogues with single D-residue substitutions
    • Kirby DA, Boublik JH, Rivier JE. Neuropeptide Y: Y1 and Y2 affinities of the complete series of analogues with single D-residue substitutions. J Med Chem 36: 3802-3808, 1993.
    • (1993) J Med Chem , vol.36 , pp. 3802-3808
    • Kirby, D.A.1    Boublik, J.H.2    Rivier, J.E.3    Neuropeptide, Y.4
  • 25
    • 84867026656 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 (GLP-1) receptor agonism or DPP-4 inhibition does not accelerate neoplasia in carcinogen treated mice
    • Kissow H, Hartmann B, Holst JJ, Viby NE, Hansen LS, Rosenkilde MM, Hare KJ, Poulsen SS. Glucagon-like peptide-1 (GLP-1) receptor agonism or DPP-4 inhibition does not accelerate neoplasia in carcinogen treated mice. Regul Pept 179: 91-100, 2012.
    • (2012) Regul Pept , vol.179 , pp. 91-100
    • Kissow, H.1    Hartmann, B.2    Holst, J.J.3    Viby, N.E.4    Hansen, L.S.5    Rosenkilde, M.M.6    Hare, K.J.7    Poulsen, S.S.8
  • 26
    • 0035497743 scopus 로고    scopus 로고
    • Is Galpha16 the optimal tool for fishing ligands of orphan G-protein-coupled receptors?
    • Kostenis E. Is Galpha16 the optimal tool for fishing ligands of orphan G-protein-coupled receptors? Trends Pharmacol Sci 22: 560-564, 2001.
    • (2001) Trends Pharmacol Sci , vol.22 , pp. 560-564
    • Kostenis, E.1
  • 28
    • 41649099750 scopus 로고    scopus 로고
    • Supraphysiological doses of intravenous PYY3-36 cause nausea, but no additional reduction in food intake
    • Le Roux CW, Borg CM, Murphy KG, Vincent RP, Ghatei MA, Bloom SR. Supraphysiological doses of intravenous PYY3-36 cause nausea, but no additional reduction in food intake. Ann Clin Biochem 45: 93-95, 2008.
    • (2008) Ann Clin Biochem , vol.45 , pp. 93-95
    • Le Roux, C.W.1    Borg, C.M.2    Murphy, K.G.3    Vincent, R.P.4    Ghatei, M.A.5    Bloom, S.R.6
  • 29
    • 49949111829 scopus 로고    scopus 로고
    • Molecular recognition of the NPY hormone family by their receptors
    • Lindner D, Stichel J, Beck-Sickinger AG. Molecular recognition of the NPY hormone family by their receptors. Nutrition 24: 907-917, 2008.
    • (2008) Nutrition , vol.24 , pp. 907-917
    • Lindner, D.1    Stichel, J.2    Beck-Sickinger, A.G.3
  • 30
    • 0028349215 scopus 로고
    • Processing and metabolism of peptide-YY: Pivotal roles of dipeptidylpeptidase-IV, aminopeptidase-P, and endopeptidase-24. 11
    • Medeiros MD, Turner AJ. Processing and metabolism of peptide-YY: pivotal roles of dipeptidylpeptidase-IV, aminopeptidase-P, and endopeptidase-24. 11. Endocrinology 134: 2088-2094, 1994.
    • (1994) Endocrinology , vol.134 , pp. 2088-2094
    • Medeiros, M.D.1    Turner, A.J.2
  • 31
    • 22344450701 scopus 로고    scopus 로고
    • High constitutive activity of a virus-encoded seven transmembrane receptor in the absence of the conserved DRY motif (Asp-Arg-Tyr) in transmembrane helix 3
    • Rosenkilde MM, Kledal TN, Schwartz TW. High constitutive activity of a virus-encoded seven transmembrane receptor in the absence of the conserved DRY motif (Asp-Arg-Tyr) in transmembrane helix 3. Mol Pharmacol 68: 11-19, 2005.
    • (2005) Mol Pharmacol , vol.68 , pp. 11-19
    • Rosenkilde, M.M.1    Kledal, T.N.2    Schwartz, T.W.3
  • 33
    • 84889663670 scopus 로고    scopus 로고
    • PYY3-36 and pancreatic polypeptide reduce food intake in an additive manner via distinct hypothalamic dependent pathways in mice
    • Shi YC, Lin Z, Lau J, Zhang H, Yagi M, Kanzler I, Sainsbury A, Herzog H, Lin S. PYY3-36 and pancreatic polypeptide reduce food intake in an additive manner via distinct hypothalamic dependent pathways in mice. Obesity (Silver Spring) 21: E669-E678, 2013.
    • (2013) Obesity (Silver Spring) , vol.21 , pp. E669-E678
    • Shi, Y.C.1    Lin, Z.2    Lau, J.3    Zhang, H.4    Yagi, M.5    Kanzler, I.6    Sainsbury, A.7    Herzog, H.8    Lin, S.9
  • 34
    • 34047216695 scopus 로고    scopus 로고
    • Effects of PYY1-36 and PYY3-36 on appetite, energy intake, energy expenditure, glucose and fat metabolism in obese and lean subjects
    • Sloth B, Holst JJ, Flint A, Gregersen NT, Astrup A. Effects of PYY1-36 and PYY3-36 on appetite, energy intake, energy expenditure, glucose and fat metabolism in obese and lean subjects. Am J Physiol Endocrinol Metab 292: E1062-E1068, 2007.
    • (2007) Am J Physiol Endocrinol Metab , vol.292 , pp. E1062-E1068
    • Sloth, B.1    Holst, J.J.2    Flint, A.3    Gregersen, N.T.4    Astrup, A.5
  • 35
    • 84958813776 scopus 로고    scopus 로고
    • The anorexic hormone Peptide YY3-36 is rapidly metabolized to inactive Peptide YY3-34 in vivo
    • Toräng S, Veedfald S, Rosenkilde MM, Hartmann B, Holst JJ. The anorexic hormone Peptide YY3-36 is rapidly metabolized to inactive Peptide YY3-34 in vivo. Physiol Rep 3: e12455, 2015.
    • (2015) Physiol Rep , vol.3
    • Toräng, S.1    Veedfald, S.2    Rosenkilde, M.M.3    Hartmann, B.4    Holst, J.J.5
  • 36
    • 0037241085 scopus 로고    scopus 로고
    • Similar elimination rates of glucagon-like peptide-1 in obese type 2 diabetic patients and healthy subjects
    • Vilsbøll T, Agersø H, Krarup T, Holst JJ. Similar elimination rates of glucagon-like peptide-1 in obese type 2 diabetic patients and healthy subjects. J Clin Endocrinol Metab 88: 220-224, 2003.
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 220-224
    • Vilsbøll, T.1    Agersø, H.2    Krarup, T.3    Holst, J.J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.