메뉴 건너뛰기




Volumn 3, Issue 7, 2015, Pages

The anorexic hormone peptide yy3-36 is rapidly metabolized to inactive peptide yy3-34 in vivo

Author keywords

Degradation; Kinetics; Peptide YY

Indexed keywords

NEUROMEDIN C; NEUROPEPTIDE Y2 RECEPTOR; PEPTIDE YY; PEPTIDE YY [3-34]; PEPTIDE YY [3-36]; PHOSPHATIDYLINOSITOL; UNCLASSIFIED DRUG;

EID: 84958813776     PISSN: None     EISSN: 2051817X     Source Type: Journal    
DOI: 10.14814/phy2.12455     Document Type: Article
Times cited : (26)

References (21)
  • 1
    • 77954380946 scopus 로고    scopus 로고
    • Twelve weeks treatment with the DPP-4 inhibitor, sitagliptin, prevents degradation of peptide YY and improves glucose and non-glucose induced insulin secretion in patients with type 2 diabetes mellitus
    • Aaboe, K., F. K. Knop, T. Vilsbøll, C. F. Deacon, J. J. Holst, S. Madsbad, et al. 2010. Twelve weeks treatment with the DPP-4 inhibitor, sitagliptin, prevents degradation of peptide YY and improves glucose and non-glucose induced insulin secretion in patients with type 2 diabetes mellitus. Diabetes Obes. Metab. 12:323-333.
    • (2010) Diabetes Obes. Metab , vol.12 , pp. 323-333
    • Aaboe, K.1    Knop, F.K.2    Vilsbøll, T.3    Deacon, C.F.4    Holst, J.J.5    Madsbad, S.6
  • 2
    • 18044365777 scopus 로고    scopus 로고
    • Blockade of the neuropeptide Y Y2 receptor with the specific antagonist BIIE0246 attenuates the effect of endogenous and exogenous peptide YY(3-36) on food intake
    • Abbott, C. R., C. J. Small, A. R. Kennedy, N. M. Neary, A. Sajedi, M. A. Ghatei, et al. 1043. Blockade of the neuropeptide Y Y2 receptor with the specific antagonist BIIE0246 attenuates the effect of endogenous and exogenous peptide YY(3-36) on food intake. Brain Res. 139-144:2005.
    • (2005) Brain Res , vol.1043 , pp. 139-144
    • Abbott, C.R.1    Small, C.J.2    Kennedy, A.R.3    Neary, N.M.4    Sajedi, A.5    Ghatei, M.A.6
  • 3
    • 69949145894 scopus 로고    scopus 로고
    • Kinetic Study of Neuropeptide Y (NPY) Proteolysis in Blood and Identification of NPY3-35: A new peptide generated by plasma kallikrein
    • Abid, K., B. Rochat, P.-G. Lassahn, R. Stöcklin, S. Michalet, N. Brakch, et al. 2009. Kinetic Study of Neuropeptide Y (NPY) Proteolysis in Blood and Identification of NPY3-35: a new peptide generated by plasma kallikrein. J. Biol. Chem. 284:24715-24724.
    • (2009) J. Biol. Chem , vol.284 , pp. 24715-24724
    • Abid, K.1    Rochat, B.2    Lassahn, P.-G.3    St, R.4    Öcklinmichalet, S.5    Brakch, N.6
  • 7
    • 0026601316 scopus 로고
    • Low hepatic clearance of peptide YY (PYY) in the perfused rat liver
    • Beckh, K., H. Mönnikes, S. Loos, R. Arnold, and H. Koop. 1992. Low hepatic clearance of peptide YY (PYY) in the perfused rat liver. Regul. Pept. 37:205-212.
    • (1992) Regul. Pept , vol.37 , pp. 205-212
    • Beckh, K.1    Mönnikes, H.2    Önnikesloos, S.3    Arnold, R.4    Koop, H.5
  • 8
    • 0028916226 scopus 로고
    • Structure-activity relationships of neuropeptide Y analogues with respect to Y1 and Y2 receptors
    • Beck-Sickinger, A. G., and G. Jung. 1995. Structure-activity relationships of neuropeptide Y analogues with respect to Y1 and Y2 receptors. Biopolymers 37:123-142.
    • (1995) Biopolymers , vol.37 , pp. 123-142
    • Beck-Sickinger, A.G.1    Jung, G.2
  • 9
    • 0028097051 scopus 로고
    • Complete L-Alanine scan of neuropeptide Y reveals ligands binding to Y1 and Y2 receptors with distinguished conformations
    • Beck-Sickinger, A. G., H. A. Weland, H. Wittneben, K.-D. Willim, K. Rudolf, and G. Jung. 1994. Complete L-Alanine scan of neuropeptide Y reveals ligands binding to Y1 and Y2 receptors with distinguished conformations. Eur. J. Biochem. 225:947-958.
    • (1994) Eur. J. Biochem , vol.225 , pp. 947-958
    • Beck-Sickinger, A.G.1    Weland, H.A.2    Wittneben, H.3    Willim, K.-D.4    Rudolf, K.5    Jung, G.6
  • 10
    • 0029797540 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 undergoes differential tissue-specific metabolism in the anesthetized pig
    • Deacon, C. F., L. Pridal, L. Klarskov, M. Olesen, and J. J. Holst. 1996. Glucagon-like peptide 1 undergoes differential tissue-specific metabolism in the anesthetized pig. Am. J. Physiol. 271:E458-E464.
    • (1996) Am. J. Physiol , vol.271 , pp. E458-E464
    • Deacon, C.F.1    Pridal, L.2    Klarskov, L.3    Olesen, M.4    Holst, J.J.5
  • 11
    • 0024420577 scopus 로고
    • A new molecular form of PYY: Structural characterization of human PYY(3-36) and PYY(1-36)
    • Eberlein, G. A., V. E. Eysselein, M. Schaeffer, P. Layer, D. Grandt, H. Goebell, et al. 1989. A new molecular form of PYY: structural characterization of human PYY(3-36) and PYY(1-36). Peptides 10:797-803.
    • (1989) Peptides , vol.10 , pp. 797-803
    • Eberlein, G.A.1    Eysselein, V.E.2    Schaeffer, M.3    Layer, P.4    Grandt, D.5    Goebell, H.6
  • 13
    • 0028173653 scopus 로고
    • Two molecular forms of peptide YY (PYY) are abundant in human blood: Characterization of a radioimmunoassay recognizing PYY 1-36 and PYY 3-36. Regul
    • Grandt, D., M. Schimiczek, C. Beglinger, P. Layer, H. Goebell, V. E. Eysselein, et al. 1994. Two molecular forms of peptide YY (PYY) are abundant in human blood: characterization of a radioimmunoassay recognizing PYY 1-36 and PYY 3-36. Regul. Pept. 51:151-159.
    • (1994) Pept , vol.51 , pp. 151-159
    • Grandt, D.1    Schimiczek, M.2    Beglinger, C.3    Layer, P.4    Goebell, H.5    Eysselein, V.E.6
  • 14
    • 0031658489 scopus 로고    scopus 로고
    • Renal tubular transport and metabolism of carboxyamidated and glycine-extended gastrins in pigs
    • Hansen, C. P., F. Stadil, and J. F. Rehfeld. 1998. Renal tubular transport and metabolism of carboxyamidated and glycine-extended gastrins in pigs. Acta Physiol. Scand. 164:29-38.
    • (1998) Acta Physiol. Scand , vol.164 , pp. 29-38
    • Hansen, C.P.1    Stadil, F.2    Rehfeld, J.F.3
  • 15
    • 0036159318 scopus 로고    scopus 로고
    • Structure and receptor binding of PYY analogs
    • Keire, D. A., C. W. Bowers, T. E. Solomon, and J. R. Jr Reeve. 2002. Structure and receptor binding of PYY analogs. Peptides 23:305-321.
    • (2002) Peptides , vol.23 , pp. 305-321
    • Keire, D.A.1    Bowers, C.W.2    Solomon, T.E.3    Reeve, J.R.4
  • 16
    • 34247533770 scopus 로고    scopus 로고
    • Identification of neuropeptide Y cleavage products in human blood to improve metabolic stability
    • Khan, I. U., R. Reppich, and A. G. Beck-Sickinger. 2007. Identification of neuropeptide Y cleavage products in human blood to improve metabolic stability. Biopolymers 88:182-189.
    • (2007) Biopolymers , vol.88 , pp. 182-189
    • Khan, I.U.1    Reppich, R.2    Beck-Sickinger, A.G.3
  • 17
    • 84867026656 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 (GLP-1) receptor agonism or DPP-4 inhibition does not accelerate neoplasia in carcinogen treated mice
    • Kissow, H., B. Hartmann, J. J. Holst, N.-E. Viby, L. S. Hansen, M. M. Rosenkilde, et al. 2012. Glucagon-like peptide-1 (GLP-1) receptor agonism or DPP-4 inhibition does not accelerate neoplasia in carcinogen treated mice. Regul. Pept. 179:91-100.
    • (2012) Regul. Pept , vol.179 , pp. 91-100
    • Kissow, H.1    Hartmann, B.2    Holst, J.J.3    Viby, N.-E.4    Hansen, L.S.5    Rosenkilde, M.M.6
  • 18
    • 0021807092 scopus 로고
    • Renal handling of norepinephrine and epinephrine in the pig
    • Link, L., P. Weidmann, P. Probst, and A. Futterlieb. 1985. Renal handling of norepinephrine and epinephrine in the pig. Pflugers Arch. 405:66-69.
    • (1985) Pflugers Arch , vol.405 , pp. 66-69
    • Link, L.1    Weidmann, P.2    Probst, P.3    Futterlieb, A.4
  • 19
    • 0028349215 scopus 로고
    • Processing and metabolism of peptide-YY: Pivotal roles of dipeptidylpeptidase-IV, aminopeptidase-P, and endopeptidase-24.11
    • Medeiros, M. D., and A. J. Turner. 1994. Processing and metabolism of peptide-YY: pivotal roles of dipeptidylpeptidase-IV, aminopeptidase-P, and endopeptidase-24.11. Endocrinology 134:2088-2094.
    • (1994) Endocrinology , vol.134 , pp. 2088-2094
    • Medeiros, M.D.1    Turner, A.J.2
  • 20
    • 22344450701 scopus 로고    scopus 로고
    • High constitutive activity of a virus-encoded seven transmembrane receptor in the absence of the conserved DRY motif (Asp-Arg-Tyr) in transmembrane helix 3
    • Rosenkilde, M. M., T. N. Kledal, and T. W. Schwartz. 2005. High constitutive activity of a virus-encoded seven transmembrane receptor in the absence of the conserved DRY motif (Asp-Arg-Tyr) in transmembrane helix 3. Mol. Pharmacol. 68:11-19.
    • (2005) Mol. Pharmacol , vol.68 , pp. 11-19
    • Rosenkilde, M.M.1    Kledal, T.N.2    Schwartz, T.W.3
  • 21
    • 0000613769 scopus 로고
    • Isolation and characterization of peptide YY (PYY), a candidate gut hormone that inhibits pancreatic exocrine secretion
    • Tatemoto, K. 1982. Isolation and characterization of peptide YY (PYY), a candidate gut hormone that inhibits pancreatic exocrine secretion. Proc. Natl Acad. Sci. USA 79:2514-2518.
    • (1982) Proc. Natl Acad. Sci. USA , vol.79 , pp. 2514-2518
    • Tatemoto, K.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.