Blunted perception of neural respiratory drive and breathlessness in patients with cystic fibrosis

ERJ Open Research

Volumn 2, Issue 1, 2016, Pages

  Reilly, Charles C ^a,b   Jolley, Caroline J ^a   Elston, Caroline ^b   Moxham, John ^a   Rafferty, Gerrard F ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b KING S COLLEGE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84984602565     PISSN: None     EISSN: 23120541     Source Type: Journal    
DOI: 10.1183/23120541.00057-2015     Document Type: Article

References (42)

1. Sheppard MN, Nicholson AG. The pathology of cystic fibrosis. Curr Diagn Pathol 2002; 8: 50-59.
2. Hart N, Polkey MI, Clément A, et al. Changes in pulmonary mechanics with increasing disease severity in children and young adults with cystic fibrosis. Am J Respir Crit Care Med 2002; 166: 61-66.
3. Regnis J, Donnelly P, Robinson M, et al. Ventilatory mechanics at rest and during exercise in patients with cystic fibrosis. Am J Respir Crit Care Med 1996; 154: 1418-1425.
4. Reilly CC, Ward K, Jolley CJ, et al. Neural respiratory drive, pulmonary mechanics and breathlessness in patients with cystic fibrosis. Thorax 2011; 66: 240-246.
5. Jensen D, O’Donnell DE, Li R, et al. Effects of dead space loading on neuro-muscular and neuro-ventilatory coupling of the respiratory system during exercise in healthy adults: implications for dyspnea and exercise tolerance. Respir Physiol Neurobiol 2011; 179: 219-226.
6. Xiao SC, Lu YR, Guo HX, et al. Effect of expiratory load on neural inspiratory drive. Chin Med J 2012; 125: 3629-3634.
7. Luo YM, Li RF, Jolley C, et al. Neural respiratory drive in patients with COPD during exercise tests. Respiration 2011; 81: 294-301.
8. O’Donnell DE, Banzett RB, Carrieri-Kohlman V, et al. Pathophysiology of dyspnea in chronic obstructive pulmonary disease: a roundtable. Proc Am Thorac Soc 2007; 4: 145-168.
9. Qin YY, Steier J, Jolley C, et al. Efficiency of neural drive during exercise in patients with COPD and healthy subjects. Chest 2010; 138: 1309-1315.
10. Jolley CJ, Luo YM, Steier J, et al. Neural respiratory drive and breathlessness in COPD. Eur Respir J 2015; 45: 355-364.
11. Grønseth R, Vollmer WM, Hardie JA, et al. Predictors of dyspnoea prevalence: results from the BOLD study. Eur Respir J 2014; 43: 1610-1620.
12. Miller MR, Hankinson J, Brusasco V, et al. Standardisation of spirometry. Eur Respir J 2005; 26: 319-338.
13. Wanger J, Clausen JL, Coates A, et al. Standardisation of the measurement of lung volumes. Eur Respir J 2005; 26: 511-522.
14. Jolley CJ, Luo Y-M, Steier J, et al. Neural respiratory drive in healthy subjects and in COPD. Eur Respir J 2009; 33: 289-297.
15. Duiverman ML, van Eykern LA, Vennik PW, et al. Reproducibility and responsiveness of a noninvasive EMG technique of the respiratory muscles in COPD patients and in healthy subjects. J Appl Physiol 2004; 96: 1723-1729.
16. Maarsingh EJ, van Eykern LA, Sprikkelman AB, et al. Respiratory muscle activity measured with a noninvasive EMG technique: technical aspects and reproducibility. J Appl Physiol 2000; 88: 1955-1961.
17. Reilly CC, Ward K, Jolley CJ, et al. Neural respiratory drive, pulmonary mechanics and breathlessness in patients with cystic fibrosis. Thorax 2011; 66: 240-246.
18. Hutchison AA, Wozniak JA, Choi HG, et al. Respiratory muscle activities after birth in asphyxiated preterm lambs. Acta Paediatr 1994; 83: 241-248.
19. Mador MJ, Rodis A, Magalang UJ. Reproducibility of Borg scale measurements of dyspnea during exercise in patients with COPD. Chest 1995; 107: 1590-1597.
20. Martínez Francés ME, Perpiñá Tordera M, Belloch Fuster A, et al. ¿Cómo valorar la percepción de la disnea inducida en la EPOC? [How can we assess the perception of induced dyspnea in chronic obstructive pulmonary disease?]. Arch Bronconeumol 2004; 40: 149-154.
21. Polkey MI, Kyroussis D, Hamnegard CH, et al. Diaphragm strength in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1996; 154: 1310-1317.
22. Rodriguez-Raecke R, Ihle K, Ritter C, et al. Neuronal differences between chronic low back pain and depression regarding long-term habituation to pain. Eur J Pain 2014; 18: 701-711.
23. Wan L, Van Diest I, De Peuter S, et al. Repeated breathlessness experiences induced by hypercapnia: differential effects on intensity and unpleasantness. Chest 2009; 135: 455-461.
24. Crombez G, Vervaet L, Baeyens F, et al. Do pain expectancies cause pain in chronic low back patients? A clinical investigation. Behav Res Ther 1996; 34: 919-925.
25. Wan L, Van Diest I, De Peuter S, et al. Repeated experiences of air hunger and ventilatory behavior in response to hypercapnia in the standardized rebreathing test: effects of anxiety. Biol Psychol 2008; 77: 223-232.
26. Chapleau MW, Hajduczok G, Abboud FM. Peripheral and central mechanisms of baroreflex resetting. Clin Exp Pharmacol Physiol Suppl 1989; 15: 31-43.
27. Hudson AL, Laveneziana P. Do we “drive” dyspnoea? Eur Respir J 2015; 45: 301-304.
28. Guenette JA, Chin RC, Cheng S, et al. Mechanisms of exercise intolerance in Global Initiative for Chronic Obstructive Lung Disease grade1 COPD. Eur Respir J 2014; 44: 1177-1187.
29. Barnes PJ. Blunted perception and death from asthma. N Engl J Med 1994; 330: 1383-1384.
30. Feldman JM, McQuaid EL, Klein RB, et al. Symptom perception and functional morbidity across a 1-year follow-up in pediatric asthma. Pediatr Pulmonol 2007; 42: 339-347.
31. von Leupoldt A, Vovk A, Bradley MM, et al. Habituation in neural processing and subjective perception of respiratory sensations. Psychophysiology 2011; 48: 808-812.
32. Davenport PW, Cruz M, Stecenko AA, et al. Respiratory-related evoked potentials in children with life-threatening asthma. Am J Respir Crit Care Med 2000; 161: 1830-1835.
33. Fauroux B, Renault F, Boelle PY, et al. Impaired cortical processing of inspiratory loads in children with chronic respiratory defects. Respir Res 2007; 8: 61.
34. von Leupoldt A, Brassen S, Baumann HJ, et al. Structural brain changes related to disease duration in patients with asthma. PloS One 2011; 6: e23739.
35. Geha PY, Baliki MN, Harden RN, et al. The brain in chronic CRPS pain: abnormal gray-white matter interactions in emotional and autonomic regions. Neuron 2008; 60: 570-581.
36. May A. Chronic pain may change the structure of the brain. Pain 2008; 137: 7-15.
37. Gandevia SC, Gorman RB, McKenzie DK, et al. Effects of increased ventilatory drive on motor unit firing rates in human inspiratory muscles. Am J Respir Crit Care Med 1999; 160: 1598-1603.
38. Reilly CC, Jolley CJ, Ward K, et al. Neural respiratory drive measured during inspiratory threshold loading and acute hypercapnia in healthy individuals. Exp Physiol 2013; 98: 1190-1198.
39. Decramer M, De Troyer A. Respiratory changes in parasternal intercostal length. J Appl Physiol Respir Environ Exerc Physiol 1984; 57: 1254-1260.
40. Decramer M, Xi JT, Reid MB, et al. Relationship between diaphragm length and abdominal dimensions. J Appl Physiol 1986; 61: 1815-1820.
41. Murphy PB, Kumar A, Reilly C, et al. Neural respiratory drive as a physiological biomarker to monitor change during acute exacerbations of COPD. Thorax 2011; 66: 602-608.
42. Laviolette L, Laveneziana P. Dyspnoea: a multidimensional and multidisciplinary approach. Eur Respir J 2014; 43: 1750-1762.