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Volumn 310, Issue 11, 2016, Pages L1199-L1205

Phosphorylation inactivation of endothelial nitric oxide synthesis in pulmonary arterial hypertension

Author keywords

Endothelial cells; Nitric oxide; Protein kinases

Indexed keywords

ALANINE; ASPARTIC ACID; ENDOTHELIAL NITRIC OXIDE SYNTHASE; IONOMYCIN; N(G) NITROARGININE METHYL ESTER; PROPRANOLOL; PROTEIN KINASE C ALPHA; SERINE; THREONINE; TYROSINE; NITRIC OXIDE; NOS3 PROTEIN, HUMAN; PROTEIN KINASE C;

EID: 84984596207     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00092.2016     Document Type: Article
Times cited : (35)

References (55)
  • 1
    • 0037772382 scopus 로고    scopus 로고
    • Compensatory phosphorylation and protein-protein interactions revealed by loss of function and gain of function mutants of multiple serine phosphorylation sites in endothelial nitric-oxide synthase
    • Bauer PM, Fulton D, Boo YC, Sorescu GP, Kemp BE, Jo H, Sessa WC. Compensatory phosphorylation and protein-protein interactions revealed by loss of function and gain of function mutants of multiple serine phosphorylation sites in endothelial nitric-oxide synthase. J Biol Chem 278: 14841-14849, 2003.
    • (2003) J Biol Chem , vol.278 , pp. 14841-14849
    • Bauer, P.M.1    Fulton, D.2    Boo, Y.C.3    Sorescu, G.P.4    Kemp, B.E.5    Jo, H.6    Sessa, W.C.7
  • 3
    • 0042388672 scopus 로고    scopus 로고
    • Flow-dependent regulation of endothelial nitric oxide synthase: Role of protein kinases
    • Boo YC, Jo H. Flow-dependent regulation of endothelial nitric oxide synthase: role of protein kinases. Am J Physiol Cell Physiol 285: C499-C508, 2003.
    • (2003) Am J Physiol Cell Physiol , vol.285 , pp. C499-C508
    • Boo, Y.C.1    Jo, H.2
  • 4
    • 84875097290 scopus 로고    scopus 로고
    • Role of PKCalpha-p38 MAPK-Gialpha axis in peroxynitrite-mediated inhibition of beta-adrenergic response in pulmonary artery smooth muscle cells
    • Chakraborti S, Roy S, Chowdhury A, Mandal A, Chakraborti T. Role of PKCalpha-p38 MAPK-Gialpha axis in peroxynitrite-mediated inhibition of beta-adrenergic response in pulmonary artery smooth muscle cells. Cell Signal 25: 512-526, 2013.
    • (2013) Cell Signal , vol.25 , pp. 512-526
    • Chakraborti, S.1    Roy, S.2    Chowdhury, A.3    Mandal, A.4    Chakraborti, T.5
  • 5
    • 0036791014 scopus 로고    scopus 로고
    • Adenoviral gene transfer of endothelial nitric-oxide synthase (ENOS) partially restores normal pulmonary arterial pressure in eNOS-deficient mice
    • Champion HC, Bivalacqua TJ, Greenberg SS, Giles TD, Hyman AL, Kadowitz PJ. Adenoviral gene transfer of endothelial nitric-oxide synthase (eNOS) partially restores normal pulmonary arterial pressure in eNOS-deficient mice. Proc Natl Acad Sci USA 99: 13248-13253, 2002.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 13248-13253
    • Champion, H.C.1    Bivalacqua, T.J.2    Greenberg, S.S.3    Giles, T.D.4    Hyman, A.L.5    Kadowitz, P.J.6
  • 7
    • 0030889046 scopus 로고    scopus 로고
    • Mutation of Glu-361 in human endothelial nitric-oxide synthase selectively abolishes L-arginine binding without perturbing the behavior of heme and other redox centers
    • Chen PF, Tsai AL, Berka V, Wu KK. Mutation of Glu-361 in human endothelial nitric-oxide synthase selectively abolishes L-arginine binding without perturbing the behavior of heme and other redox centers. J Biol Chem 272: 6114-6118, 1997.
    • (1997) J Biol Chem , vol.272 , pp. 6114-6118
    • Chen, P.F.1    Tsai, A.L.2    Berka, V.3    Wu, K.K.4
  • 11
    • 0033542476 scopus 로고    scopus 로고
    • Activation of nitric oxide synthase in endothelial cells by Aktdependent phosphorylation
    • Dimmeler S, Fleming I, Fisslthaler B, Hermann C, Busse R, Zeiher AM. Activation of nitric oxide synthase in endothelial cells by Aktdependent phosphorylation. Nature 399: 601-605, 1999.
    • (1999) Nature , vol.399 , pp. 601-605
    • Dimmeler, S.1    Fleming, I.2    Fisslthaler, B.3    Hermann, C.4    Busse, R.5    Zeiher, A.M.6
  • 13
    • 0033694694 scopus 로고    scopus 로고
    • Nitric oxide synthase in pulmonary hypertension: Lessons from knockout mice
    • Fagan KA, McMurtry I, Rodman DM. Nitric oxide synthase in pulmonary hypertension: lessons from knockout mice. Physiol Res 49: 539-548, 2000.
    • (2000) Physiol Res , vol.49 , pp. 539-548
    • Fagan, K.A.1    McMurtry, I.2    Rodman, D.M.3
  • 14
    • 0242552817 scopus 로고    scopus 로고
    • Cyclic GMP-dependent protein kinases and the cardiovascular system: Insights from genetically modified mice
    • Feil R, Lohmann SM, de Jonge H, Walter U, Hofmann F. Cyclic GMP-dependent protein kinases and the cardiovascular system: insights from genetically modified mice. Circ Res 93: 907-916, 2003.
    • (2003) Circ Res , vol.93 , pp. 907-916
    • Feil, R.1    Lohmann, S.M.2    De Jonge, H.3    Walter, U.4    Hofmann, F.5
  • 15
    • 0032960992 scopus 로고    scopus 로고
    • Activation of nitric oxide synthase by beta 2-adrenoceptors in human umbilical vein endothelium in vitro
    • Ferro A, Queen LR, Priest RM, Xu B, Ritter JM, Poston L, Ward JP. Activation of nitric oxide synthase by beta 2-adrenoceptors in human umbilical vein endothelium in vitro. Br J Pharmacol 126: 1872-1880, 1999.
    • (1999) Br J Pharmacol , vol.126 , pp. 1872-1880
    • Ferro, A.1    Queen, L.R.2    Priest, R.M.3    Xu, B.4    Ritter, J.M.5    Poston, L.6    Ward, J.P.7
  • 16
    • 0033566864 scopus 로고    scopus 로고
    • Signal transduction of eNOS activation
    • Fleming I, Busse R. Signal transduction of eNOS activation. Cardiovasc Res 43: 532-541, 1999.
    • (1999) Cardiovasc Res , vol.43 , pp. 532-541
    • Fleming, I.1    Busse, R.2
  • 21
    • 0029055964 scopus 로고
    • Reduced expression of endothelial nitric oxide synthase in the lungs of patients with pulmonary hypertension
    • Giaid A, Saleh D. Reduced expression of endothelial nitric oxide synthase in the lungs of patients with pulmonary hypertension. N Engl J Med 333: 214-221, 1995.
    • (1995) N Engl J Med , vol.333 , pp. 214-221
    • Giaid, A.1    Saleh, D.2
  • 23
    • 73949089031 scopus 로고    scopus 로고
    • Storage lesion in banked blood due to hemolysis-dependent disruption of nitric oxide homeostasis
    • Gladwin MT, Kim-Shapiro DB. Storage lesion in banked blood due to hemolysis-dependent disruption of nitric oxide homeostasis. Curr Opin Hematol 16: 515-523, 2009.
    • (2009) Curr Opin Hematol , vol.16 , pp. 515-523
    • Gladwin, M.T.1    Kim-Shapiro, D.B.2
  • 24
    • 0034698050 scopus 로고    scopus 로고
    • Reconstitution of an endothelial nitric-oxide synthase (ENOS), hsp90, and caveolin-1 complex in vitro. Evidence that hsp90 facilitates calmodulin stimulated displacement of eNOS from caveolin-1
    • Gratton JP, Fontana J, O’Connor DS, Garcia-Cardena G, McCabe TJ, Sessa WC. Reconstitution of an endothelial nitric-oxide synthase (eNOS), hsp90, and caveolin-1 complex in vitro. Evidence that hsp90 facilitates calmodulin stimulated displacement of eNOS from caveolin-1. J Biol Chem 275: 22268-22272, 2000.
    • (2000) J Biol Chem , vol.275 , pp. 22268-22272
    • Gratton, J.P.1    Fontana, J.2    O’Connor, D.S.3    Garcia-Cardena, G.4    McCabe, T.J.5    Sessa, W.C.6
  • 25
  • 27
    • 0035844241 scopus 로고    scopus 로고
    • Reciprocal phosphorylation and regulation of endothelial nitric-oxide synthase in response to bradykinin stimulation
    • Harris MB, Ju H, Venema VJ, Liang H, Zou R, Michell BJ, Chen ZP, Kemp BE, Venema RC. Reciprocal phosphorylation and regulation of endothelial nitric-oxide synthase in response to bradykinin stimulation. J Biol Chem 276: 16587-16591, 2001.
    • (2001) J Biol Chem , vol.276 , pp. 16587-16591
    • Harris, M.B.1    Ju, H.2    Venema, V.J.3    Liang, H.4    Zou, R.5    Michell, B.J.6    Chen, Z.P.7    Kemp, B.E.8    Venema, R.C.9
  • 32
    • 36349023095 scopus 로고    scopus 로고
    • Epinephrine regulation of the endothelial nitric-oxide synthase: Roles of RAC1 and beta3-adrenergic receptors in endothelial NO signaling
    • Kou R, Michel T. Epinephrine regulation of the endothelial nitric-oxide synthase: roles of RAC1 and beta3-adrenergic receptors in endothelial NO signaling. J Biol Chem 282: 32719-32729, 2007.
    • (2007) J Biol Chem , vol.282 , pp. 32719-32729
    • Kou, R.1    Michel, T.2
  • 33
    • 0242666181 scopus 로고    scopus 로고
    • Phosphorylation of threonine 497 in endothelial nitric-oxide synthase coordinates the coupling of L-arginine metabolism to efficient nitric oxide production
    • Lin MI, Fulton D, Babbitt R, Fleming I, Busse R, Pritchard KA Jr, Sessa WC. Phosphorylation of threonine 497 in endothelial nitric-oxide synthase coordinates the coupling of L-arginine metabolism to efficient nitric oxide production. J Biol Chem 278: 44719-44726, 2003.
    • (2003) J Biol Chem , vol.278 , pp. 44719-44726
    • Lin, M.I.1    Fulton, D.2    Babbitt, R.3    Fleming, I.4    Busse, R.5    Pritchard, K.A.6    Sessa, W.C.7
  • 34
    • 0030920365 scopus 로고    scopus 로고
    • The first 35 amino acids and fatty acylation sites determine the molecular targeting of endothelial nitric oxide synthase into the Golgi region of cells: A green fluorescent protein study
    • Liu J, Hughes TE, Sessa WC. The first 35 amino acids and fatty acylation sites determine the molecular targeting of endothelial nitric oxide synthase into the Golgi region of cells: a green fluorescent protein study. J Cell Biol 137: 1525-1535, 1997.
    • (1997) J Cell Biol , vol.137 , pp. 1525-1535
    • Liu, J.1    Hughes, T.E.2    Sessa, W.C.3
  • 37
    • 0031856005 scopus 로고    scopus 로고
    • High expression of endothelial nitric oxide synthase in plexiform lesions of pulmonary hypertension
    • Mason NA, Springall DR, Burke M, Pollock J, Mikhail G, Yacoub MH, Polak JM. High expression of endothelial nitric oxide synthase in plexiform lesions of pulmonary hypertension. J Pathol 185: 313-318, 1998.
    • (1998) J Pathol , vol.185 , pp. 313-318
    • Mason, N.A.1    Springall, D.R.2    Burke, M.3    Pollock, J.4    Mikhail, G.5    Yacoub, M.H.6    Polak, J.M.7
  • 38
    • 0041810555 scopus 로고    scopus 로고
    • Regulation of endothelial nitric oxide synthase by protein kinase C
    • Matsubara M, Hayashi N, Jing T, Titani K. Regulation of endothelial nitric oxide synthase by protein kinase C. J Biochem 133: 773-781, 2003.
    • (2003) J Biochem , vol.133 , pp. 773-781
    • Matsubara, M.1    Hayashi, N.2    Jing, T.3    Titani, K.4
  • 39
    • 0034054493 scopus 로고    scopus 로고
    • Enhanced electron flux and reduced calmodulin dissociation may explain “calcium-independent” eNOS activation by phosphorylation
    • McCabe TJ, Fulton D, Roman LJ, Sessa WC. Enhanced electron flux and reduced calmodulin dissociation may explain “calcium-independent” eNOS activation by phosphorylation. J Biol Chem 275: 6123-6128, 2000.
    • (2000) J Biol Chem , vol.275 , pp. 6123-6128
    • McCabe, T.J.1    Fulton, D.2    Roman, L.J.3    Sessa, W.C.4
  • 40
    • 0035947574 scopus 로고    scopus 로고
    • Coordinated control of endothelial nitric-oxide synthase phosphorylation by protein kinase C and the cAMP-dependent protein kinase
    • Michell BJ, Chen Z, Tiganis T, Stapleton D, Katsis F, Power DA, Sim AT, Kemp BE. Coordinated control of endothelial nitric-oxide synthase phosphorylation by protein kinase C and the cAMP-dependent protein kinase. J Biol Chem 276: 17625-17628, 2001.
    • (2001) J Biol Chem , vol.276 , pp. 17625-17628
    • Michell, B.J.1    Chen, Z.2    Tiganis, T.3    Stapleton, D.4    Katsis, F.5    Power, D.A.6    Sim, A.T.7    Kemp, B.E.8
  • 41
    • 0036829884 scopus 로고    scopus 로고
    • Identification of regulatory sites of phosphorylation of the bovine endothelial nitric-oxide synthase at serine 617 and serine 635
    • Michell BJ, Harris MB, Chen ZP, Ju H, Venema VJ, Blackstone MA, Huang W, Venema RC, Kemp BE. Identification of regulatory sites of phosphorylation of the bovine endothelial nitric-oxide synthase at serine 617 and serine 635. J Biol Chem 277: 42344-42351, 2002.
    • (2002) J Biol Chem , vol.277 , pp. 42344-42351
    • Michell, B.J.1    Harris, M.B.2    Chen, Z.P.3    Ju, H.4    Venema, V.J.5    Blackstone, M.A.6    Huang, W.7    Venema, R.C.8    Kemp, B.E.9
  • 42
    • 0027752805 scopus 로고
    • The L-arginine-nitric oxide pathway
    • Moncada S, Higgs A. The L-arginine-nitric oxide pathway. N Engl J Med 329: 2002-2012, 1993.
    • (1993) N Engl J Med , vol.329 , pp. 2002-2012
    • Moncada, S.1    Higgs, A.2
  • 44
    • 0035722661 scopus 로고    scopus 로고
    • High levels of nitric oxide in individuals with pulmonary hypertension receiving epoprostenol therapy
    • Ozkan M, Dweik RA, Laskowski D, Arroliga AC, Erzurum SC. High levels of nitric oxide in individuals with pulmonary hypertension receiving epoprostenol therapy. Lung 179: 233-243, 2001.
    • (2001) Lung , vol.179 , pp. 233-243
    • Ozkan, M.1    Dweik, R.A.2    Laskowski, D.3    Arroliga, A.C.4    Erzurum, S.C.5
  • 46
    • 0031005025 scopus 로고    scopus 로고
    • Effects of intracellular tyrosine residue mutation and carboxyl terminus truncation on signal transduction and internalization of the rat bradykinin B2 receptor
    • Prado GN, Taylor L, Polgar P. Effects of intracellular tyrosine residue mutation and carboxyl terminus truncation on signal transduction and internalization of the rat bradykinin B2 receptor. J Biol Chem 272: 14638-14642, 1997.
    • (1997) J Biol Chem , vol.272 , pp. 14638-14642
    • Prado, G.N.1    Taylor, L.2    Polgar, P.3
  • 49
    • 0030955626 scopus 로고    scopus 로고
    • Pulmonary vasoconstriction and hypertension in mice with targeted disruption of the endothelial nitric oxide synthase (NOS 3) gene
    • Steudel W, Ichinose F, Huang PL, Hurford WE, Jones RC, Bevan JA, Fishman MC, Zapol WM. Pulmonary vasoconstriction and hypertension in mice with targeted disruption of the endothelial nitric oxide synthase (NOS 3) gene. Circ Res 81: 34-41, 1997.
    • (1997) Circ Res , vol.81 , pp. 34-41
    • Steudel, W.1    Ichinose, F.2    Huang, P.L.3    Hurford, W.E.4    Jones, R.C.5    Bevan, J.A.6    Fishman, M.C.7    Zapol, W.M.8
  • 50
    • 0032102283 scopus 로고    scopus 로고
    • Sustained pulmonary hypertension and right ventricular hypertrophy after chronic hypoxia in mice with congenital deficiency of nitric oxide synthase 3
    • Steudel W, Scherrer-Crosbie M, Bloch KD, Weimann J, Huang PL, Jones RC, Picard MH, Zapol WM. Sustained pulmonary hypertension and right ventricular hypertrophy after chronic hypoxia in mice with congenital deficiency of nitric oxide synthase 3. J Clin Invest 101: 2468-2477, 1998.
    • (1998) J Clin Invest , vol.101 , pp. 2468-2477
    • Steudel, W.1    Scherrer-Crosbie, M.2    Bloch, K.D.3    Weimann, J.4    Huang, P.L.5    Jones, R.C.6    Picard, M.H.7    Zapol, W.M.8
  • 51
    • 0032930417 scopus 로고    scopus 로고
    • Mammalian nitric oxide synthases
    • Stuehr DJ. Mammalian nitric oxide synthases. Biochim Biophys Acta 1411: 217-230, 1999.
    • (1999) Biochim Biophys Acta , vol.1411 , pp. 217-230
    • Stuehr, D.J.1
  • 53
    • 0032533159 scopus 로고    scopus 로고
    • Arginine metabolism: Nitric oxide and beyond
    • Wu G, Morris SM Jr. Arginine metabolism: nitric oxide and beyond. Biochem J 336: 1-17, 1998.
    • (1998) Biochem J , vol.336 , pp. 1-17
    • Wu, G.1    Morris, S.M.2


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