Insulin increases sympathetic nerve activity in part by suppression of tonic inhibitory neuropeptide y inputs into the paraventricular nucleus in female rats

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 311, Issue 1, 2016, Pages R97-R103

  Cassaglia, Priscila A ^a   Shi, Zhigang ^a   Brooks, Virginia L ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

Arcuate nucleus; NPY; PVN; SNA; MSH

Indexed keywords

ALPHA INTERMEDIN; CHLORALOSE; INSULIN; N ACETYL ALPHA INTERMEDIN[4-10]CYCLO[4 NORLEUCINE 5 ASPARTIC ACID 7 [3 (2 NAPHTHYL)ALANINE] 10 LYSINAMIDE]; N2 DIPHENYLACETYL N (4 UREIDOMETHYLBENZYL)ARGININAMIDE; NEUROPEPTIDE Y; ANTIDIABETIC AGENT; ARGININE; INTERMEDIN; MELANOCORTIN 3 RECEPTOR; MELANOCORTIN 3 RECEPTOR, RAT; MELANOCORTIN 4 RECEPTOR; MELANOCORTIN RECEPTOR TYPE 4, RAT; NEUROPEPTIDE Y RECEPTOR; NEUROPEPTIDE Y-Y1 RECEPTOR;

ANIMAL EXPERIMENT; ARCUATE NUCLEUS; ARTICLE; CONTROLLED STUDY; FEMALE; HEART RATE; HYPOTHALAMIC PARAVENTRICULAR NUCLEUS; LUMBAR SYMPATHETIC NERVE ACTIVITY; NONHUMAN; PRESSORECEPTOR REFLEX; PRIORITY JOURNAL; RAT; SYMPATHETIC FUNCTION; SYMPATHETIC NERVE; ADRENERGIC SYSTEM; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; BLOOD PRESSURE; DRUG EFFECTS; MICROINJECTION; SPRAGUE DAWLEY RAT;

ANIMALS; ARGININE; BAROREFLEX; BLOOD PRESSURE; FEMALE; HEART RATE; HYPOGLYCEMIC AGENTS; INSULIN; MELANOCYTE-STIMULATING HORMONES; MICROINJECTIONS; NEUROPEPTIDE Y; PARAVENTRICULAR HYPOTHALAMIC NUCLEUS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, MELANOCORTIN, TYPE 3; RECEPTOR, MELANOCORTIN, TYPE 4; RECEPTORS, NEUROPEPTIDE Y; SYMPATHETIC NERVOUS SYSTEM;

EID: 84984595869     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.00054.2016     Document Type: Article

References (19)

1. Brooks VL, Dampney RA, Heesch CM. Pregnancy and the endocrine regulation of the baroreceptor reflex. Am J Physiol Regul Integr Comp Physiol 299: R439-R451, 2010.
2. Brooks VL, Shi Z, Holwerda SW, Fadel PJ. Obesity-induced increases in sympathetic nerve activity: Sex matters. Auton Neurosci 187: 18-26, 2015.
3. Cassaglia PA, Hermes SM, Aicher SA, Brooks VL. Insulin acts in the arcuate nucleus to increase lumbar sympathetic nerve activity and baroreflex function in rats. J Physiol 589: 1643-1662, 2011.
4. Cassaglia PA, Shi Z, Li B, Reis WL, Clute-Reinig NM, Stern JE, Brooks VL. Neuropeptide Y acts in the paraventricular nucleus to suppress sympathetic nerve activity and its baroreflex regulation. J Physiol 592: 1655-1675, 2014.
5. Charkoudian N, Wallin BG. Sympathetic neural activity to the cardiovascular system: integrator of systemic physiology and interindividual characteristics. Compr Physiol 4: 825-850, 2014.
6. Kawabe T, Kawabe K, Sapru HN. Cardiovascular responses to chemical stimulation of the hypothalamic arcuate nucleus in the rat: role of the hypothalamic paraventricular nucleus. PLoS One 7: e45180, 2012.
7. Lee SJ, Kirigiti M, Lindsley SR, Loche A, Madden CJ, Morrison SF, Smith MS, Grove KL. Efferent projections of neuropeptide Y-expressing neurons of the dorsomedial hypothalamus in chronic hyperphagic models. J Comp Neurol 521: 1891-1914, 2013.
8. Luckett BS, Frielle JL, Wolfgang L, Stocker SD. Arcuate nucleus injection of an anti-insulin affibody prevents the sympathetic response to insulin. Am J Physiol Heart Circ Physiol 304: H1538-H1546, 2013.
9. Paxinos G, Watson C. The Rat Brain in Sterotaxic Coordinates. San Diego: Academic Press, 2007.
10. Qiu J, Zhang C, Borgquist A, Nestor CC, Smith AW, Bosch MA, Ku S, Wagner EJ, Ronnekleiv OK, Kelly MJ. Insulin excites anorexigenic proopiomelanocortin neurons via activation of canonical transient receptor potential channels. Cell Metab 19: 682-693, 2014.
11. Rahmouni K, Morgan DA, Morgan GM, Liu X, Sigmund CD, Mark AL, Haynes WG. Hypothalamic PI3K and MAPK differentially mediate regional sympathetic activation to insulin. J Clin Invest 114: 652-658, 2004.
12. Shi YC, Lau J, Lin Z, Zhang H, Zhai L, Sperk G, Heilbronn R, Mietzsch M, Weger S, Huang XF, Enriquez RF, Baldock PA, Zhang L, Sainsbury A, Herzog H, Lin S. Arcuate NPY controls sympathetic output and BAT function via a relay of tyrosine hydroxylase neurons in the PVN. Cell Metab 17: 236-248, 2013.
13. Shi Z, Brooks VL. Leptin differentially increases sympathetic nerve activity and its baroreflex regulation in female rats: role of oestrogen. J Physiol 593: 1633-1647, 2015.
14. Shi Z, Cassaglia PA, Gotthardt LC, Brooks VL. Hypothalamic paraventricular and arcuate nuclei contribute to elevated sympathetic nerve activity in pregnant rats: roles of neuropeptide Y and α-melanocytestimulating hormone. Hypertension 66: 1191-1198, 2015.
15. Shi Z, Li B, Brooks VL. Role of the paraventricular nucleus of the hypothalamus in the sympathoexcitatory effects of leptin. Hypertension 66: 1034-1041, 2015.
16. Stanley BG, Leibowitz SF. Neuropeptide Y injected in the paraventricular hypothalamus: a powerful stimulant of feeding behavior. Proc Natl Acad Sci USA 82: 3940-3943, 1985.
17. Steiner JL, Bardgett ME, Wolfgang L, Lang CH, Stocker SD. Glucocorticoids attenuate the central sympathoexcitatory actions of insulin. J Neurophysiol 112: 2597-2604, 2014.
18. Stocker SD, Gordon KW. Glutamate receptors in the hypothalamic paraventricular nucleus contribute to insulin-induced sympathoexcitation. J Neurophysiol 113: 1302-1309, 2015.
19. Ward KR, Bardgett JF, Wolfgang L, Stocker SD. Sympathetic response to insulin is mediated by melanocortin 3/4 receptors in the hypothalamic paraventricular nucleus. Hypertension 57: 435-441, 2011.