메뉴 건너뛰기




Volumn 199, Issue 5, 2009, Pages 742-749

Hepatitis B virus basal core promoter mutation and DNA load correlate with expression of hepatitis B core antigen in patients with chronic hepatitis B

Author keywords

[No Author keywords available]

Indexed keywords

HEPATITIS B CORE ANTIGEN; HEPATITIS B(E) ANTIGEN; VIRUS DNA;

EID: 84984550857     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/596655     Document Type: Article
Times cited : (27)

References (49)
  • 1
    • 0036293243 scopus 로고    scopus 로고
    • Global control of hepatitis B virus infection
    • Kao JH, Chen DS. Global control of hepatitis B virus infection. Lancet Infect Dis 2002; 2:395-403.
    • (2002) Lancet Infect Dis , vol.2 , pp. 395-403
    • Kao, J.H.1    Chen, D.S.2
  • 2
    • 0028916425 scopus 로고
    • Hepatitis B virus immunopathogenesis
    • Chisari FV, Ferrari C. Hepatitis B virus immunopathogenesis. Annu Rev Immunol 1995; 13:29-60.
    • (1995) Annu Rev Immunol , vol.13 , pp. 29-60
    • Chisari, F.V.1    Ferrari, C.2
  • 3
    • 0023269196 scopus 로고
    • Biologic and prognostic significance of hepatocyte hepatitis B core antigen expression in the natural course of chronic hepatitis B virus infection
    • Hsu HC, Su IJ, Lai MY, et al. Biologic and prognostic significance of hepatocyte hepatitis B core antigen expression in the natural course of chronic hepatitis B virus infection. J Hepatol 1987; 5:45-50.
    • (1987) J Hepatol , vol.5 , pp. 45-50
    • Hsu, H.C.1    Su, I.J.2    Lai, M.Y.3
  • 4
    • 0021950657 scopus 로고
    • Prognostic value of hepatitis B core antigen (HBcAg) expression in the liver of children with chronic hepatitis type B
    • Bortolotti F, Alberti A, Cadrobbi P, Rugge M, Armigliato M, Realdi G. Prognostic value of hepatitis B core antigen (HBcAg) expression in the liver of children with chronic hepatitis type B. Liver 1985; 5:40-7.
    • (1985) Liver , vol.5 , pp. 40-47
    • Bortolotti, F.1    Alberti, A.2    Cadrobbi, P.3    Rugge, M.4    Armigliato, M.5    Realdi, G.6
  • 5
    • 0344643443 scopus 로고    scopus 로고
    • Nuclear localization of hepatitis B core antigen and its relations to liver injury, hepatocyte proliferation, and viral load
    • Serinoz E, Varli M, Erden E, et al. Nuclear localization of hepatitis B core antigen and its relations to liver injury, hepatocyte proliferation, and viral load. J Clin Gastroenterol 2003; 36:269-72.
    • (2003) J Clin Gastroenterol , vol.36 , pp. 269-272
    • Serinoz, E.1    Varli, M.2    Erden, E.3
  • 6
    • 0023203608 scopus 로고
    • Intrahepatic distribution of hepatitis B surface and core antigens in chronic hepatitis B virus infection: Hepatocyte with cytoplasmic/membranous hepatitis B core antigen as a possible target for immune hepatocytolysis
    • Chu CM, Liaw YF. Intrahepatic distribution of hepatitis B surface and core antigens in chronic hepatitis B virus infection: hepatocyte with cytoplasmic/membranous hepatitis B core antigen as a possible target for immune hepatocytolysis. Gastroenterology 1987; 92:220-5.
    • (1987) Gastroenterology , vol.92 , pp. 220-225
    • Chu, C.M.1    Liaw, Y.F.2
  • 7
    • 0031060085 scopus 로고    scopus 로고
    • The degrees of hepatocyte nuclear but not cytoplasmic expression of hepatitis B core antigen reflects the level of viral replication in chronic hepatitis B virus infection
    • Chu CM, Yeh CT, Chien RN, Sheen IS, Liaw YF. The degrees of hepatocyte nuclear but not cytoplasmic expression of hepatitis B core antigen reflects the level of viral replication in chronic hepatitis B virus infection. J Clin Microbiol 1997; 35:102-5.
    • (1997) J Clin Microbiol , vol.35 , pp. 102-105
    • Chu, C.M.1    Yeh, C.T.2    Chien, R.N.3    Sheen, I.S.4    Liaw, Y.F.5
  • 8
    • 0028823206 scopus 로고
    • Subcellular localization of hepatitis B core antigen in relation to hepatocyte regeneration in chronic hepatitis B
    • Chu CM, Yeh CT, Sheen IS, Liaw YF. Subcellular localization of hepatitis B core antigen in relation to hepatocyte regeneration in chronic hepatitis B. Gastroenterology 1995; 109:1926-32.
    • (1995) Gastroenterology , vol.109 , pp. 1926-1932
    • Chu, C.M.1    Yeh, C.T.2    Sheen, I.S.3    Liaw, Y.F.4
  • 9
    • 0024328735 scopus 로고
    • Change of intrahepatic expression of hepatitis B core antigen during the clinical course of type-B chronic hepatitis
    • Franca ST, Kiyosawa K, Imai Y, et al. Change of intrahepatic expression of hepatitis B core antigen during the clinical course of type-B chronic hepatitis. Scand J Gastroenterol 1989; 24:454-60.
    • (1989) Scand J Gastroenterol , vol.24 , pp. 454-460
    • Franca, S.T.1    Kiyosawa, K.2    Imai, Y.3
  • 10
    • 0022377012 scopus 로고
    • Cytoplasmic (but not nuclear) hepatitis B virus (HBV) core antigen reflects HBV DNA synthesis at the level of the infected hepatocyte
    • Gowans EJ, Burrel CJ, Jilbert AR, Marmion BP. Cytoplasmic (but not nuclear) hepatitis B virus (HBV) core antigen reflects HBV DNA synthesis at the level of the infected hepatocyte. Intervirology 1985; 24:220-5.
    • (1985) Intervirology , vol.24 , pp. 220-225
    • Gowans, E.J.1    Burrel, C.J.2    Jilbert, A.R.3    Marmion, B.P.4
  • 11
    • 0028338553 scopus 로고
    • Detection of precore hepatitis B virus mutants in asymptomatic HBsAg-positive family members
    • Akarca US, Greene S, Lok ASF. Detection of precore hepatitis B virus mutants in asymptomatic HBsAg-positive family members. Hepatology 1994; 19:1366-70.
    • (1994) Hepatology , vol.19 , pp. 1366-1370
    • Akarca, U.S.1    Greene, S.2    Lok, A.S.F.3
  • 12
    • 0033020624 scopus 로고    scopus 로고
    • High prevalence of 1762(T) 1764(A) mutations in the basal core promoter of hepatitis B virus isolated from Black Africans with hepatocellular carcinoma compared with asymptomatic carriers
    • Baptista M, Kramvis A, Kew MC. High prevalence of 1762(T) 1764(A) mutations in the basal core promoter of hepatitis B virus isolated from Black Africans with hepatocellular carcinoma compared with asymptomatic carriers. Hepatology 1999; 29:946-53.
    • (1999) Hepatology , vol.29 , pp. 946-953
    • Baptista, M.1    Kramvis, A.2    Kew, M.C.3
  • 13
    • 0025729803 scopus 로고
    • Wild-type and e antigen-minus hepatitis B viruses and course of chronic hepatitis
    • Brunetto MR, Giarin MM, Oliveri F, et al. Wild-type and e antigen-minus hepatitis B viruses and course of chronic hepatitis. Proc Natl Acad Sci USA 1991; 88:4186-90.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 4186-4190
    • Brunetto, M.R.1    Giarin, M.M.2    Oliveri, F.3
  • 14
    • 0029817029 scopus 로고    scopus 로고
    • Effect of a naturally occurring mutation in the hepatitis B virus basal core promoter on precore gene expression and viral replication
    • Buckwold VE, Xu Z, Chen M, Yen TSB, Ou JH. Effect of a naturally occurring mutation in the hepatitis B virus basal core promoter on precore gene expression and viral replication. J Virol 1996; 70:5845-51.
    • (1996) J Virol , vol.70 , pp. 5845-5851
    • Buckwold, V.E.1    Xu, Z.2    Chen, M.3    Yen, T.S.B.4    Ou, J.H.5
  • 15
    • 84984559410 scopus 로고    scopus 로고
    • Genotypes and clinical phenotypes of hepatitis B virus in patients with chronic hepatitis B virus infection
    • Kao JH, Chen PJ, Lai MY, Chen DS. Genotypes and clinical phenotypes of hepatitis B virus in patients with chronic hepatitis B virus infection. J Clin Microbiol 2002; 40:1207-9.
    • (2002) J Clin Microbiol , vol.40 , pp. 1207-1209
    • Kao, J.H.1    Chen, P.J.2    Lai, M.Y.3    Chen, D.S.4
  • 16
    • 84984535720 scopus 로고    scopus 로고
    • Hepatitis B genotypes correlate with clinical outcomes in patients with chronic hepatitis B
    • Kao JH, Chan PJ, Lai MY, Chen DS. Hepatitis B genotypes correlate with clinical outcomes in patients with chronic hepatitis B. Gastroenterology 2000; 118:554-9.
    • (2000) Gastroenterology , vol.118 , pp. 554-559
    • Kao, J.H.1    Chan, P.J.2    Lai, M.Y.3    Chen, D.S.4
  • 17
    • 84984549253 scopus 로고    scopus 로고
    • Basal core promoter mutations of hepatitis B virus and increase the risk of hepatocellular carcinoma in hepatitis B carriers
    • Kao JH, Chen PJ, Lai MY, Chen DS. Basal core promoter mutations of hepatitis B virus and increase the risk of hepatocellular carcinoma in hepatitis B carriers. Gastroenterology 2003; 124:327-34.
    • (2003) Gastroenterology , vol.124 , pp. 327-334
    • Kao, J.H.1    Chen, P.J.2    Lai, M.Y.3    Chen, D.S.4
  • 18
    • 84983726628 scopus 로고    scopus 로고
    • Hepatitis B genotypes and the response to interferon therapy
    • Kao JH, Wu NH, Chen PJ, Lai MY, Chen DS. Hepatitis B genotypes and the response to interferon therapy. J Hepatol 2000; 33:998-1002.
    • (2000) J Hepatol , vol.33 , pp. 998-1002
    • Kao, J.H.1    Wu, N.H.2    Chen, P.J.3    Lai, M.Y.4    Chen, D.S.5
  • 19
    • 0348047588 scopus 로고    scopus 로고
    • Hepatitis B virus genotypes and hepatocellular carcinoma in Taiwan
    • Kao JH. Hepatitis B virus genotypes and hepatocellular carcinoma in Taiwan. Intervirology 2003; 46:400-7.
    • (2003) Intervirology , vol.46 , pp. 400-407
    • Kao, J.H.1
  • 20
    • 84984539148 scopus 로고    scopus 로고
    • High prevalence and mapping of pre-S deletion in hepatitis B virus carriers with progressive liver diseases
    • Chen BF, Liu CJ, Chow GW, Chen PJ, Kao JH, Chen DS. High prevalence and mapping of pre-S deletion in hepatitis B virus carriers with progressive liver diseases. Gastroenterology 2006; 130:1153-68.
    • (2006) Gastroenterology , vol.130 , pp. 1153-1168
    • Chen, B.F.1    Liu, C.J.2    Chow, G.W.3    Chen, P.J.4    Kao, J.H.5    Chen, D.S.6
  • 21
    • 84984559412 scopus 로고    scopus 로고
    • Role of hepatitis B viral load and basal core promoter mutation in hepatocellular carcinoma in hepatitis B carriers
    • Liu CJ, Chen BF, Chen PJ, et al. Role of hepatitis B viral load and basal core promoter mutation in hepatocellular carcinoma in hepatitis B carriers. J Infect Dis 2006; 193:1258-65.
    • (2006) J Infect Dis , vol.193 , pp. 1258-1265
    • Liu, C.J.1    Chen, B.F.2    Chen, P.J.3
  • 22
    • 33645989765 scopus 로고    scopus 로고
    • Interferon alpha-2b with and without ribavirin in the treatment of hepatitis B e antigen-positive chronic hepatitis B: A randomized study
    • Liu CJ, Lai MY, Chao YC, et al. Interferon alpha-2b with and without ribavirin in the treatment of hepatitis B e antigen-positive chronic hepatitis B: a randomized study. Hepatology 2006; 43:742-9.
    • (2006) Hepatology , vol.43 , pp. 742-749
    • Liu, C.J.1    Lai, M.Y.2    Chao, Y.C.3
  • 23
    • 84984569467 scopus 로고    scopus 로고
    • Role of hepatitis B virus precore/core promoter mutations and serum viral load on non-cirrhotic hepatocellular carcinoma: A case control study
    • Liu CJ, Chen BF, Chen PJ, et al. Role of hepatitis B virus precore/core promoter mutations and serum viral load on non-cirrhotic hepatocellular carcinoma: a case control study. J Infect Dis 2006; 194:594-9.
    • (2006) J Infect Dis , vol.194 , pp. 594-599
    • Liu, C.J.1    Chen, B.F.2    Chen, P.J.3
  • 24
    • 84984535989 scopus 로고    scopus 로고
    • Viral factors correlate with hepatitis B e antigen seroconversion in patients with chronic hepatitis B
    • Liu CJ, Chen PJ, Lai MY, et al. Viral factors correlate with hepatitis B e antigen seroconversion in patients with chronic hepatitis B. Liver Int 2006; 26:949-55.
    • (2006) Liver Int , vol.26 , pp. 949-955
    • Liu, C.J.1    Chen, P.J.2    Lai, M.Y.3
  • 25
    • 0031984485 scopus 로고    scopus 로고
    • Wild-type levels of pregenomic RNA and replication but reduced pre-C RNA and e-antigen synthesis of hepatitis B virus with C(1653)A-T, A(1762)A-T and G(1764)G-A mutations in the core promoter
    • Gunther S, Piwon N, Will H. Wild-type levels of pregenomic RNA and replication but reduced pre-C RNA and e-antigen synthesis of hepatitis B virus with C(1653)A-T, A(1762)A-T and G(1764)G-A mutations in the core promoter. J Gen Virol 1998; 79:375-80.
    • (1998) J Gen Virol , vol.79 , pp. 375-380
    • Gunther, S.1    Piwon, N.2    Will, H.3
  • 27
    • 0025739721 scopus 로고
    • Mutations in the precore region of hepatitis B virus DNA in patients with fulminant hepatitis and severe hepatitis
    • Omata M, Ehata T, Yokosuka O, Hosoda K, Ohno M. Mutations in the precore region of hepatitis B virus DNA in patients with fulminant hepatitis and severe hepatitis. N Engl J Med 1991; 324:1699-704.
    • (1991) N Engl J Med , vol.324 , pp. 1699-1704
    • Omata, M.1    Ehata, T.2    Yokosuka, O.3    Hosoda, K.4    Ohno, M.5
  • 28
    • 0028222146 scopus 로고
    • Mutations in the pre-core region of hepatitis B virus serve to enhance the stability of the secondary structure of the pre-genome encapsidation signal
    • Lok ASF, Akarca U, Greene S. Mutations in the pre-core region of hepatitis B virus serve to enhance the stability of the secondary structure of the pre-genome encapsidation signal. Proc Natl Acad Sci USA 1994; 91:4077-81.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 4077-4081
    • Lok, A.S.F.1    Akarca, U.2    Greene, S.3
  • 29
    • 0030589455 scopus 로고    scopus 로고
    • Reduced precore transcription and enhanced core-pregenome transcription of hepatitis B virus RNA after replacement of the precore-core promoter with sequences associated with e antigen-seronegative persistent infections
    • Moriyama K, Okamoto H, Tsuda F, Mayumi M. Reduced precore transcription and enhanced core-pregenome transcription of hepatitis B virus RNA after replacement of the precore-core promoter with sequences associated with e antigen-seronegative persistent infections. Virology 1996; 226:269-80.
    • (1996) Virology , vol.226 , pp. 269-280
    • Moriyama, K.1    Okamoto, H.2    Tsuda, F.3    Mayumi, M.4
  • 30
    • 0027992963 scopus 로고
    • Hepatitis B virus with mutations in the core promoter for an e antigen-negative phenotype in carriers with antibody to e antigen
    • Okamoto H, Tsuda F, Akahane Y, et al. Hepatitis B virus with mutations in the core promoter for an e antigen-negative phenotype in carriers with antibody to e antigen. J Virol 1994; 68:8102-10.
    • (1994) J Virol , vol.68 , pp. 8102-8110
    • Okamoto, H.1    Tsuda, F.2    Akahane, Y.3
  • 31
    • 0032979682 scopus 로고    scopus 로고
    • Different hepatitis B virus genotypes are associated with different mutations in the core promoter and precore regions during hepatitis B e antigen seroconversion
    • Chan HLY, Hussain M, Lok ASF. Different hepatitis B virus genotypes are associated with different mutations in the core promoter and precore regions during hepatitis B e antigen seroconversion. Hepatology 1999;29:976-84.
    • (1999) Hepatology , vol.29 , pp. 976-984
    • Chan, H.L.Y.1    Hussain, M.2    Lok, A.S.F.3
  • 32
    • 0035196637 scopus 로고    scopus 로고
    • A case-control study for clinical molecular biological differences between hepatitis B viruses of genotypes B and C
    • Orito E, Mizokami M, Sakugawa H, et al. A case-control study for clinical molecular biological differences between hepatitis B viruses of genotypes B and C. Hepatology 2001; 33:218-23.
    • (2001) Hepatology , vol.33 , pp. 218-223
    • Orito, E.1    Mizokami, M.2    Sakugawa, H.3
  • 33
    • 0037942914 scopus 로고    scopus 로고
    • Genome replication, virion secretion, and e antigen expression of naturally occurring hepatitis B virus core promoter mutants
    • Parekh S, Zoulim F, Ahn SH, et al. Genome replication, virion secretion, and e antigen expression of naturally occurring hepatitis B virus core promoter mutants. J Virol 2003; 77:6601-12.
    • (2003) J Virol , vol.77 , pp. 6601-6612
    • Parekh, S.1    Zoulim, F.2    Ahn, S.H.3
  • 34
    • 0038216605 scopus 로고    scopus 로고
    • The effects of hepatitis B virus core promoter mutations on hepatitis B core antigen distribution in hepatocytes as detected by laser-assisted microdissection
    • Kawai K, Horiike N, Michitaka K, Onji M. The effects of hepatitis B virus core promoter mutations on hepatitis B core antigen distribution in hepatocytes as detected by laser-assisted microdissection. J Hepatol 2003; 38:635-41.
    • (2003) J Hepatol , vol.38 , pp. 635-641
    • Kawai, K.1    Horiike, N.2    Michitaka, K.3    Onji, M.4
  • 35
    • 0032978859 scopus 로고    scopus 로고
    • Cytoplasmic expression of hepatitis B core antigen in chronic hepatitis B virus infection: Role of precore stop mutants
    • Park YN, Han KH, Kim KS, Chung JP, Kim S, Park C. Cytoplasmic expression of hepatitis B core antigen in chronic hepatitis B virus infection: role of precore stop mutants. Liver 1999; 19:199-205.
    • (1999) Liver , vol.19 , pp. 199-205
    • Park, Y.N.1    Han, K.H.2    Kim, K.S.3    Chung, J.P.4    Kim, S.5    Park, C.6
  • 36
    • 0036178339 scopus 로고    scopus 로고
    • Viral genotype and hepatitis B virus DNA levels are correlated with histological liver damage in HBeAg-negative chronic hepatitis B virus infection
    • Chan HL, Tsang SW, Liew CT, et al. Viral genotype and hepatitis B virus DNA levels are correlated with histological liver damage in HBeAg-negative chronic hepatitis B virus infection. Am J Gastroenterol 2002;97:406-12.
    • (2002) Am J Gastroenterol , vol.97 , pp. 406-412
    • Chan, H.L.1    Tsang, S.W.2    Liew, C.T.3
  • 37
    • 84984548773 scopus 로고    scopus 로고
    • Origin of serum hepatitis B virus in acute exacerbation: Comparison with HBV in the liver and from other exacerbation
    • Liu CJ, Kao JH, Wang HY, et al. Origin of serum hepatitis B virus in acute exacerbation: comparison with HBV in the liver and from other exacerbation. Hepatology 2004;40:310-7.
    • (2004) Hepatology , vol.40 , pp. 310-317
    • Liu, C.J.1    Kao, J.H.2    Wang, H.Y.3
  • 38
    • 84984585828 scopus 로고    scopus 로고
    • A prospective study characterizing full-length hepatitis B virus genomes during acute exacerbation
    • Liu CJ, Chen PJ, Lai MY, et al. A prospective study characterizing full-length hepatitis B virus genomes during acute exacerbation. Gastroenterology 2003; 124:80-90.
    • (2003) Gastroenterology , vol.124 , pp. 80-90
    • Liu, C.J.1    Chen, P.J.2    Lai, M.Y.3
  • 39
    • 0019813866 scopus 로고
    • Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis
    • Knodell RG, Ishak KG, Black WC, et al. Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis. Hepatology 1981; 1:431-5.
    • (1981) Hepatology , vol.1 , pp. 431-435
    • Knodell, R.G.1    Ishak, K.G.2    Black, W.C.3
  • 40
    • 40349113699 scopus 로고    scopus 로고
    • Core promoter mutations of hepatitis B virus and hepatocellular carcinoma: The story beyond A1762T/G1764A mutations
    • Liu CJ, Kao JH. Core promoter mutations of hepatitis B virus and hepatocellular carcinoma: the story beyond A1762T/G1764A mutations. J Gastroenterol Hepatol 2008; 23:347-50.
    • (2008) J Gastroenterol Hepatol , vol.23 , pp. 347-350
    • Liu, C.J.1    Kao, J.H.2
  • 41
    • 33646773989 scopus 로고    scopus 로고
    • The degrees of hepatocyte cytoplasmic expression of hepatitis B core antigen correlate with histologic activity of liver disease in the young patients with chronic hepatitis B infection
    • Kim TH, Cho EY, Oh HJ, et al. The degrees of hepatocyte cytoplasmic expression of hepatitis B core antigen correlate with histologic activity of liver disease in the young patients with chronic hepatitis B infection. J Korean Med Sci 2006; 21:279-83.
    • (2006) J Korean Med Sci , vol.21 , pp. 279-283
    • Kim, T.H.1    Cho, E.Y.2    Oh, H.J.3
  • 42
    • 0028813109 scopus 로고
    • Phosphorylation and nuclear localization of the hepatitis B virus core protein: Significance of serine in the three repeated SPRRR motifs
    • Liao W, Ou JH. Phosphorylation and nuclear localization of the hepatitis B virus core protein: significance of serine in the three repeated SPRRR motifs. J Virol 1995; 69:1025-9.
    • (1995) J Virol , vol.69 , pp. 1025-1029
    • Liao, W.1    Ou, J.H.2
  • 43
    • 0025251613 scopus 로고
    • The arginine-rich domain of hepatitis B virus precore and core proteins contains a signal for nuclear transport
    • Yeh CT, Liaw YF, Ou JH. The arginine-rich domain of hepatitis B virus precore and core proteins contains a signal for nuclear transport. J Virol 1990; 64:6141-7.
    • (1990) J Virol , vol.64 , pp. 6141-6147
    • Yeh, C.T.1    Liaw, Y.F.2    Ou, J.H.3
  • 44
    • 0027255244 scopus 로고
    • Cell cycle regulation of nuclear localization of hepatitis B virus core protein
    • Yeh CT, Wong SW, Fung YK, Ou JH. Cell cycle regulation of nuclear localization of hepatitis B virus core protein. Proc Natl Acad Sci USA 1993; 90:6459-63.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 6459-6463
    • Yeh, C.T.1    Wong, S.W.2    Fung, Y.K.3    Ou, J.H.4
  • 45
    • 0033526794 scopus 로고    scopus 로고
    • Roles of the three major phosphorylation sites of hepatitis B virus core protein in viral replication
    • Lan YT, Li J, Liao WY, Ou JH. Roles of the three major phosphorylation sites of hepatitis B virus core protein in viral replication. Virology 1999;259:342-8.
    • (1999) Virology , vol.259 , pp. 342-348
    • Lan, Y.T.1    Li, J.2    Liao, W.Y.3    Ou, J.H.4
  • 46
    • 0036019518 scopus 로고    scopus 로고
    • Hepatitis B viral genotypes: Clinical relevance and molecular characteristics
    • Kao JH. Hepatitis B viral genotypes: clinical relevance and molecular characteristics. J Gastroenterol Hepatol 2002; 17:643-50.
    • (2002) J Gastroenterol Hepatol , vol.17 , pp. 643-650
    • Kao, J.H.1
  • 48
    • 0034916337 scopus 로고    scopus 로고
    • Hepatitis B virus mutants and fulminant hepatitis B: Fitness plus phenotype
    • Bartholomeusz A, Locarnini S. Hepatitis B virus mutants and fulminant hepatitis B: fitness plus phenotype. Hepatology 2001; 34:432-5.
    • (2001) Hepatology , vol.34 , pp. 432-435
    • Bartholomeusz, A.1    Locarnini, S.2
  • 49
    • 34547972612 scopus 로고    scopus 로고
    • Correlation of hepatitis B core antigen and beta-catenin expression on hepatocytes in chronic hepatitis B virus infection: Relevance to the severity of liver damage and viral replication
    • Kim CW, Yoon SK, Jung ES, et al. Correlation of hepatitis B core antigen and beta-catenin expression on hepatocytes in chronic hepatitis B virus infection: relevance to the severity of liver damage and viral replication. J Gastroenterol Hepatol 2007; 22:1534-42.
    • (2007) J Gastroenterol Hepatol , vol.22 , pp. 1534-1542
    • Kim, C.W.1    Yoon, S.K.2    Jung, E.S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.