Mitochondrial polymerase gamma dysfunction and aging cause cardiac nuclear DNA methylation changes

Physiological Genomics

Volumn 48, Issue 4, 2016, Pages 274-280

  Koczor, Christopher A ^a   Ludlow, Ivan ^a   Fields, Earl ^a   Jiao, Zhe ^a   Ludaway, Tomika ^a   Russ, Rodney ^a   Lewis, William ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Aging; Cardiomyopathy; DNA methylation; Mitochondria

Indexed keywords

CELL NUCLEUS DNA; DNA DIRECTED DNA POLYMERASE; MITOCHONDRIAL DNA; POLG PROTEIN, MOUSE;

AGING; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DNA METHYLATION; DOWN REGULATION; E BOX ELEMENT; ECHOCARDIOGRAPHY; ELECTROCARDIOGRAM; GENE AMPLIFICATION; GENE EXPRESSION; HEART EJECTION FRACTION; HEART FUNCTION; HEART LEFT VENTRICLE HYPERTROPHY; MITOCHONDRIAL DNA DISORDER; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; UPREGULATION; ANIMAL; C57BL MOUSE; ELECTROCARDIOGRAPHY; FEMALE; GENE EXPRESSION PROFILING; GENETICS; HEART; HEART FAILURE; HEART MITOCHONDRION; MALE; METABOLISM; PHYSIOLOGY; TRANSGENIC MOUSE;

AGING; ANIMALS; DNA METHYLATION; DNA, MITOCHONDRIAL; DNA-DIRECTED DNA POLYMERASE; ELECTROCARDIOGRAPHY; FEMALE; GENE EXPRESSION PROFILING; HEART; HEART FAILURE; HYPERTROPHY, LEFT VENTRICULAR; MALE; MICE, INBRED C57BL; MICE, TRANSGENIC; MITOCHONDRIA, HEART;

EID: 84983778363     PISSN: 10948341     EISSN: 15312267     Source Type: Journal    
DOI: 10.1152/physiolgenomics.00099.2015     Document Type: Article

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