Blockade of αeβ7 integrin suppresses accumulation of CD8 + and Th9 lymphocytes from patients with IBD in the inflamed gut in vivo

Gut

Volumn 66, Issue 11, 2017, Pages 1936-1948

  Zundler, Sebastian ^a   Schillinger, Daniela ^a   Fischer, Anika ^a   Atreya, Raja ^a   López Posadas, Rocío ^a   Watson, Alastair ^b   Neufert, Clemens ^a   Atreya, Imke ^a   Neurath, Markus F ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b UNIVERSITY OF EAST ANGLIA   (United Kingdom)

Author keywords

ADHESION MOLECULES; ANTIBODY TARGETED THERAPY; INFLAMMATORY BOWEL DISEASE; INTEGRINS; INTESTINAL T CELLS

Indexed keywords

ALPHA INTEGRIN; ALPHA4BETA7 INTEGRIN; ALPHAEBETA7 INTEGRIN; BUTYRIC ACID; DEXTRAN SULFATE; ETROLIZUMAB; T LYMPHOCYTE RECEPTOR; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; VEDOLIZUMAB; BIOLOGICAL MARKER; GASTROINTESTINAL AGENT; INTEGRIN; INTEGRIN ALPHA4BETA7; INTEGRIN ALPHAEBETA7; MONOCLONAL ANTIBODY;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL ADHESION ASSAY; CELL CULTURE; CONTROLLED STUDY; DRUG EFFECT; DRUG RETENTION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; INFLAMMATORY BOWEL DISEASE; LYMPHOCYTE ACTIVATION; LYMPHOCYTE HOMING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TH17 CELL; TH2 CELL; TH9 CELL; ADULT; ANIMAL; ANTAGONISTS AND INHIBITORS; DRUG EFFECTS; FEMALE; HELPER CELL; IMMUNOLOGY; INFLAMMATORY BOWEL DISEASES; KNOCKOUT MOUSE; MALE; METABOLISM; MIDDLE AGED; T LYMPHOCYTE;

ADULT; ANIMALS; ANTIBODIES, MONOCLONAL, HUMANIZED; BIOMARKERS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; FEMALE; FLOW CYTOMETRY; GASTROINTESTINAL AGENTS; HUMANS; IMMUNOHISTOCHEMISTRY; INFLAMMATORY BOWEL DISEASES; INTEGRINS; MALE; MICE; MICE, KNOCKOUT; MIDDLE AGED; T-LYMPHOCYTES; T-LYMPHOCYTES, HELPER-INDUCER;

EID: 84983688440     PISSN: 00175749     EISSN: 14683288     Source Type: Journal    
DOI: 10.1136/gutjnl-2016-312439     Document Type: Article

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