Cardiac angiotensin-(1–12) expression and systemic hypertension in rats expressing the human angiotensinogen gene

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 310, Issue 8, 2016, Pages H995-H1002

  Ferrario, Carlos M ^a   VonCannon, Jessica ^a   Jiao, Yan ^a   Ahmad, Sarfaraz ^a   Bader, Michael ^b   Dell’Italia, Louis J ^c   Groban, Leanne ^a   Varagic, Jasmina ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

^b MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^c University of Alabama at Birmingham   (United States)

Author keywords

Angiotensin converting enzyme inhibitors; Angiotensin II; Angiotensin (1 12); Angiotensinogen; Cardiac angiotensins; Chymase; Renin

Indexed keywords

ANGIOTENSIN; ANGIOTENSIN (1-12); ANGIOTENSIN CONVERTING ENZYME 2; ANGIOTENSINOGEN; CHYMASE; DIPEPTIDYL CARBOXYPEPTIDASE; UNCLASSIFIED DRUG; AGT PROTEIN, HUMAN; ANGIOTENSIN-(1-12), HUMAN; PEPTIDE FRAGMENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERIAL PRESSURE; ARTICLE; CARDIAC MUSCLE CELL; CONTROLLED STUDY; ECHOCARDIOGRAPHY; ENZYME ACTIVITY; EXPERIMENTAL HYPERTENSION; GENE EXPRESSION; HEART FUNCTION; HEART RATE; HEART VENTRICLE HYPERTROPHY; HEART WEIGHT; HUMAN; IMMUNOFLUORESCENCE; MALE; MUSCULOSKELETAL SYSTEM PARAMETERS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SYSTOLIC BLOOD PRESSURE; TIBIAL LENGTH RATIO; TRANSGENIC RAT; ANIMAL; BLOOD; CARDIAC MUSCLE; CARDIOMEGALY; DIAGNOSTIC IMAGING; DISEASE MODEL; ECHOGRAPHY; GENETICS; GENOTYPE; HEART LEFT VENTRICLE FUNCTION; HOMOZYGOTE; HYDROLYSIS; HYPERTENSION; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PHENOTYPE; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; SPRAGUE DAWLEY RAT; TIME FACTOR;

ANGIOTENSINOGEN; ANIMALS; ARTERIAL PRESSURE; CARDIOMEGALY; DISEASE MODELS, ANIMAL; GENOTYPE; HEART RATE; HOMOZYGOTE; HUMANS; HYDROLYSIS; HYPERTENSION; MALE; MYOCARDIUM; PEPTIDE FRAGMENTS; PHENOTYPE; RATS, SPRAGUE-DAWLEY; RATS, TRANSGENIC; RENIN-ANGIOTENSIN SYSTEM; TIME FACTORS; ULTRASONOGRAPHY; VENTRICULAR FUNCTION, LEFT;

EID: 84983643567     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00833.2015     Document Type: Article

References (40)

1. Ahmad S, Simmons T, Varagic J, Moniwa N, Chappell MC, Ferrario CM. Chymase-dependent generation of angiotensin II from angiotensin- (1-12) in human atrial tissue. PLoS One 6: e28501, 2011.
2. Ahmad S, Varagic J, Groban L, Dell’Italia LJ, Nagata S, Kon ND, Ferrario CM. Angiotensin-(1-12): a chymase-mediated cellular angiotensin II substrate. Curr Hypertens Rep 16: 429, 2014.
3. Ahmad S, Varagic J, Westwood BM, Chappell MC, Ferrario CM. Uptake and metabolism of the novel peptide angiotensin-(1-12) by neonatal cardiac myocytes. PLoS One 6: e15759, 2011.
4. Ahmad S, Wei CC, Tallaj J, Dell’Italia LJ, Moniwa N, Varagic J, Ferrario CM. Chymase mediates angiotensin-(1-12) metabolism in normal human hearts. J Am Soc Hypertens 7: 128-136, 2013.
5. Baker KM, Chernin MI, Schreiber T, Sanghi S, Haiderzaidi S, Booz GW, Dostal DE, Kumar R. Evidence of a novel intracrine mechanism in angiotensin II-induced cardiac hypertrophy. Regul Pept 120: 5-13, 2004.
6. Baker KM, Kumar R. Intracellular angiotensin II induces cell proliferation independent of AT1 receptor. Am J Physiol Cell Physiol 291: C995-C1001, 2006.
7. Becari C, Oliveira EB, Salgado MC. Alternative pathways for angiotensin II generation in the cardiovascular system. Braz J Med Biol Res 44: 914-919, 2011.
8. Bohlender J, Ganten D, Luft FC. Rats transgenic for human renin and human angiotensinogen as a model for gestational hypertension. J Am Soc Nephrol 11: 2056-2061, 2000.
9. Bohlender J, Menard J, Ganten D, Luft FC. Angiotensinogen concentrations and renin clearance: implications for blood pressure regulation. Hypertension 35: 780-786, 2000.
10. Bohlender J, Menard J, Luft FC, Ganten D. Dose effects of human renin in rats transgenic for human angiotensinogen. Hypertension 29: 1031-1038, 1997.
11. Bohlender J, Menard J, Wagner J, Luft FC, Ganten D. Human renin-dependent hypertension in rats transgenic for human angiotensinogen. Hypertension 27: 535-540, 1996.
12. De Mello WC. Intracrine action of angiotensin II in the intact ventricle of the failing heart: angiotensin II changes cardiac excitability from within. Mol Cell Biochem 358: 309-315, 2011.
13. De Mello WC, Gerena Y. Further studies on the effects of intracrine and extracellular angiotensin II on the regulation of heart cell volume. On the influence of aldosterone and spironolactone. Regul Pept 165: 200-205, 2010.
14. Dell’Italia LJ, Husain A. Dissecting the role of chymase in angiotensin II formation and heart and blood vessel diseases. Curr Opin Cardiol 17: 374-379, 2002.
15. Ferrario CM, Ahmad S, Nagata S, Simington SW, Varagic J, Kon N, Dell’Italia LJ. An evolving story of angiotensin-II-forming pathways in rodents and humans. Clin Sci (Lond) 126: 461-469, 2014.
16. Ferrario CM, Jessup J, Chappell MC, Averill DB, Brosnihan KB, Tallant EA, Diz DI, Gallagher PE. Effect of angiotensin-converting enzyme inhibition and angiotensin II receptor blockers on cardiac angiotensin- converting enzyme 2. Circulation 111: 2605-2610, 2005.
17. Ferrario CM, Trask AJ, Jessup JA. Advances in biochemical and functional roles of angiotensin-converting enzyme 2 and angiotensin-(1-7) in regulation of cardiovascular function. Am J Physiol Heart Circ Physiol 289: H2281-H2290, 2005.
18. Ferrario CM, Varagic J, Habibi J, Nagata S, Kato J, Chappell MC, Trask AJ, Kitamura K, Whaley-Connell A, Sowers JR. Differential regulation of angiotensin-(1-12) in plasma and cardiac tissue in response to bilateral nephrectomy. Am J Physiol Heart Circ Physiol 296: H1184-H1192, 2009.
19. Ganten D, Wagner J, Zeh K, Bader M, Michel JB, Paul M, Zimmermann F, Ruf P, Hilgenfeldt U, Ganten U. Species specificity of renin kinetics in transgenic rats harboring the human renin and angiotensinogen genes. Proc Natl Acad Sci USA 89: 7806-7810, 1992.
20. Garg R, Yusuf S. Overview of randomized trials of angiotensin-converting enzyme inhibitors on mortality and morbidity in patients with heart failure. Collaborative Group on ACE Inhibitor Trials. JAMA 273: 1450-1456, 1995.
21. Husain A. The chymase-angiotensin system in humans. J Hypertens 11: 1155-1159, 1993.
22. Kumar R, Thomas CM, Yong QC, Chen W, Baker KM. The intracrine renin-angiotensin system. Clin Sci (Lond) 123: 273-284, 2012.
23. Kumar R, Yong QC, Thomas CM, Baker KM. Intracardiac intracellular angiotensin system in diabetes. Am J Physiol Regul Integr Comp Physiol 302: R510-R517, 2012.
24. Moniwa N, Varagic J, Ahmad S, VonCannon JL, Ferrario CM. Restoration of the blood pressure circadian rhythm by direct renin inhibition and blockade of angiotensin II receptors in mRen2 Lewis hypertensive rats. Ther Adv Cardiovasc Dis 6: 15-29, 2012.
25. Moniwa N, Varagic J, Simington SW, Ahmad S, Nagata S, VonCannon JL, Ferrario CM. Primacy of angiotensin converting enzyme in angiotensin-(1-12) metabolism. Am J Physiol Heart Circ Physiol 305: H644-H650, 2013.
26. Nagata S, Kato J, Sasaki K, Minamino N, Eto T, Kitamura K. Isolation and identification of proangiotensin-12, a possible component of the renin-angiotensin system. Biochem Biophys Res Commun 350: 1026-1031, 2006.
27. Nagata S, Varagic J, Kon ND, Wang H, Groban L, Simington SW, Ahmad S, Dell’Italia LJ, VonCannon JL, Deal D, Ferrario CM. Differential expression of the angiotensin-(1-12)/chymase axis in human atrial tissue. Ther Adv Cardiovasc Dis 9: 168-180, 2015.
28. Ong HT, Ong LM, Ho JJ. Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin-receptor blockers (ARBs) in patients at high risk of cardiovascular events: a meta-analysis of 10 randomised placebocontrolled trials. ISRN Cardiol 2013: 478-597, 2013.
29. Prosser HC, Forster ME, Richards AM, Pemberton CJ. Cardiac chymase converts rat proangiotensin-12 (PA12) to angiotensin II: effects of PA12 upon cardiac haemodynamics. Cardiovasc Res 82: 40-50, 2009.
30. Singh VP, Baker KM, Kumar R. Activation of the intracellular reninangiotensin system in cardiac fibroblasts by high glucose: role in extracellular matrix production. Am J Physiol Heart Circ Physiol 294: H1675-H1684, 2008.
31. Singh VP, Le B, Khode R, Baker KM, Kumar R. Intracellular angiotensin II production in diabetic rats is correlated with cardiomyocyte apoptosis, oxidative stress, and cardiac fibrosis. Diabetes 57: 3297-3306, 2008.
32. St John SM, Pfeffer MA, Moye L, Plappert T, Rouleau JL, Lamas G, Rouleau J, Parker JO, Arnold MO, Sussex B, Braunwald E. Cardiovascular death and left ventricular remodeling two years after myocardial infarction: baseline predictors and impact of long-term use of captopril: information from the Survival and Ventricular Enlargement (SAVE) trial. Circulation 96: 3294-3299, 1997.
33. Trask AJ, Jessup JA, Chappell MC, Ferrario CM. Angiotensin-(1-12) is an alternate substrate for angiotensin peptide production in the heart. Am J Physiol Heart Circ Physiol 294: H2242-H2247, 2008.
34. Urata H, Kinoshita A, Misono KS, Bumpus FM, Husain A. Identification of a highly specific chymase as the major angiotensin II-forming enzyme in the human heart. J Biol Chem 265: 22348-22357, 1990.
35. Varagic J, Ahmad S, Brosnihan KB, Groban L, Chappell MC, Tallant EA, Gallagher PE, Ferrario CM. Decreased cardiac Ang-(1-7) is associated with salt-induced cardiac remodeling and dysfunction. Ther Adv Cardiovasc Dis 4: 17-25, 2010.
36. Varagic J, Ahmad S, VonCannon JL, Moniwa N, Brosnihan KB, Wysocki J, Batlle D, Ferrario CM. Predominance of AT(1) blockade over mas-mediated angiotensin-(1-7) mechanisms in the regulation of blood pressure and renin-angiotensin system in mRen2 Lewis rats. Am J Hypertens 26: 583-590, 2013.
37. Varagic J, Trask AJ, Jessup JA, Chappell MC, Ferrario CM. New angiotensins. J Mol Med (Berl) 86: 663-671, 2008.
38. Wang H, Jessup JA, Zhao Z, Da SJ, Lin M, MacNamara LM, Ahmad S, Chappell MC, Ferrario CM, Groban L. Characterization of the cardiac renin angiotensin system in oophorectomized and estrogen-replete mRen2 Lewis rats. PLoS One 8: e76992, 2013.
39. Wei CC, Hase N, Inoue Y, Bradley EW, Yahiro E, Li M, Naqvi N, Powell PC, Shi K, Takahashi Y, Saku K, Urata H, Dell’Italia LJ, Husain A. Mast cell chymase limits the cardiac efficacy of Ang I-converting enzyme inhibitor therapy in rodents. J Clin Invest 120: 1229-1239, 2010.
40. Wei CC, Tian B, Perry G, Meng QC, Chen YF, Oparil S, Dell’Italia LJ. Differential ANG II generation in plasma and tissue of mice with decreased expression of the ACE gene. Am J Physiol Heart Circ Physiol 282: H2254-H2258, 2002.