RNF122 suppresses antiviral type I interferon production by targeting RIG-I CARDs to mediate RIG-I degradation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 34, 2016, Pages 9581-9586

  Wang, Wendie ^a   Jiang, Minghong ^a   Liu, Shuo ^a   Zhang, Shikun ^a   Liu, Wei ^a   Ma, Yuanwu ^b   Zhang, Lianfeng ^b   Zhang, Jiyan ^c   Cao, Xuetao ^a,d  

^a INSTITUTE OF BASIC MEDICAL SCIENCES   (China)

^b BEIJING HOSPITAL   (China)

^c INSTITUTE OF BASIC MEDICAL SCIENCES   (China)

^d SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

E3 ligase; Innate immunity; RIG I; RNF122; Type I interferon

Indexed keywords

RETINOIC ACID INDUCIBLE PROTEIN I; RING FINGER PROTEIN; RING FINGER PROTEIN 122; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; INTERFERON; MEMBRANE PROTEIN; NERVE PROTEIN; PROTEASOME; ROBO3 PROTEIN, MOUSE; SMALL INTERFERING RNA; UBIQUITIN PROTEIN LIGASE;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; CELL PROLIFERATION; EMBRYO; GENE ACTIVATION; HEK293 CELL LINE; HUMAN; HUMAN CELL; IMMUNOCOMPETENT CELL; IMMUNOFLUORESCENCE; IMMUNOPRECIPITATION; INNATE IMMUNITY; INTERFERON PRODUCTION; L929 CELL LINE; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; RING FINGER MOTIF; RNA VIRUS; RNA VIRUS INFECTION; SIGNAL TRANSDUCTION; UBIQUITINATION; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; DEFICIENCY; GENE EXPRESSION REGULATION; GENETICS; GROWTH, DEVELOPMENT AND AGING; IMMUNOLOGY; KNOCKOUT MOUSE; MACROPHAGE; METABOLISM; PROTEIN DOMAIN; SENDAI VIRUS; VESICULOVIRUS; VIROLOGY;

ANIMALS; GENE EXPRESSION REGULATION; IMMUNITY, INNATE; INTERFERON TYPE I; MACROPHAGES; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; NERVE TISSUE PROTEINS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEOLYSIS; RNA, SMALL INTERFERING; SENDAI VIRUS; SIGNAL TRANSDUCTION; UBIQUITIN-PROTEIN LIGASES; VESICULOVIRUS;

EID: 84983604685     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1604277113     Document Type: Article

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