Simvastatin attenuates liver injury in rodents with biliary cirrhosis submitted to hemorrhage/resuscitation

Shock

Volumn 47, Issue 3, 2017, Pages 370-377

  Meireles, Cintia Zimmermann ^a,b   Pasarin, Marcos ^a   Lozano, Juan Jose ^c   García Calderó, Héctor ^a,c   Gracia Sancho, Jordi ^a,c   García Pagán, Juan Carlos ^a,c   Bosch, Jaime ^a,c,d   Abraldes, Juan G ^a,c,e  

^a UNIVERSITY OF BARCELONA   (Spain)

^b FEDERAL UNIVERSITY OF SANTA CATARINA   (Brazil)

^c INSTITUTO DE SALUD CARLOS III   (Spain)

^d UNIVERSITY OF BERN   (Switzerland)

^e UNIVERSITY OF ALBERTA   (Canada)

Author keywords

3 hydroxy 3 methylglutaryl coenzyme; Abbreviations Ach; acetylcholine; acute on chronic liver failure; acute variceal bleeding; alanine transferase; ALT; AoCLF; aspartate transferase; AST; AVB; CBDL; citrate phosphate dextrose; common biliar duct ligation; CPD; GAPDH; Gene Set Enrichment Analysis; glyceraldehyde 3 phosphate dehydrogenase; GSEA; H E; H R; hematoxylin and eosin; hemorrhage resuscitation; HMG CoA; IL1B; IL6; interleukin 1b; interleukin 6; Limma; linear models for microarray data; liposaccharide; LPS; MAP; mean arterial pressure; MELD; methoxamine; model end liver disease; Mtx; PCR; real time polymerase chain reaction; ribonucleic acid; RNA; TLR4; toll like receptor 4

Indexed keywords

3 HYDROXY 3 METHYLGLUTARYL COENZYME A; ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; CEFTRIAXONE; SIMVASTATIN; TRANSCRIPTOME; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBIOTIC THERAPY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILIARY CIRRHOSIS; BILIRUBIN BLOOD LEVEL; CLINICAL ASSESSMENT; CLINICAL EVALUATION; CONTROLLED STUDY; ENDOTHELIAL DYSFUNCTION; EX VIVO STUDY; FUNCTIONAL ASSESSMENT; HEMORRHAGIC SHOCK; HYPOVOLEMIC SHOCK; IN VIVO STUDY; LIVER HEMORRHAGE; LIVER INJURY; LIVER PERFUSION; LIVER PROTECTION; LIVER WEIGHT; MALE; MICROCIRCULATION; NONHUMAN; PORTAL HYPERTENSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; RESUSCITATION; SHAM PROCEDURE; SINGLE DRUG DOSE; SPLEEN WEIGHT; VASODILATATION; ANIMAL; DRUG EFFECTS; GASTROINTESTINAL HEMORRHAGE; INJURIES; LIVER; LIVER CIRRHOSIS; METABOLISM;

ANIMALS; GASTROINTESTINAL HEMORRHAGE; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; LIVER; LIVER CIRRHOSIS; LIVER CIRRHOSIS, BILIARY; MALE; RATS; SIMVASTATIN;

EID: 84983567970     PISSN: 10732322     EISSN: 15400514     Source Type: Journal    
DOI: 10.1097/SHK.0000000000000734     Document Type: Article

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