Mechanosensing by the α 6-integrin confers an invasive fibroblast phenotype and mediates lung fibrosis

Nature Communications

Volumn 7, Issue , 2016, Pages

  Chen, Huaping ^a   Qu, Jing ^a   Huang, Xiangwei ^a   Kurundkar, Ashish ^a   Zhu, Lanyan ^b   Yang, Naiheng ^a   Venado, Aida ^a,c   Ding, Qiang ^a   Liu, Gang ^a   Antony, Veena B ^a   Thannickal, Victor J ^a   Zhou, Yong ^a  

^a University of Alabama at Birmingham   (United States)

^b CENTRAL SOUTH UNIVERSITY   (China)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA6 INTEGRIN; COLLAGEN TYPE 4; GELATINASE A; GELATINASE B; PROTEIN C FOS; PROTEIN C JUN; BLEOMYCIN; RHO KINASE;

ANATOMY; ANTIBIOTICS; CELLS AND CELL COMPONENTS; EXPERIMENTAL STUDY; GENE EXPRESSION; PHENOTYPE; PROTEIN; RODENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL ADHESION; CONTROLLED STUDY; DNA BINDING; EXPERIMENTAL PULMONARY FIBROSIS; FEMALE; FIBROSING ALVEOLITIS; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN TISSUE; HYDROGEL; IN VITRO STUDY; IN VIVO STUDY; LUNG FIBROBLAST; LUNG LAVAGE; MESENCHYME CELL; MOUSE; MYOFIBROBLAST; NONHUMAN; PHENOTYPE; PROMOTER REGION; PROTEIN EXPRESSION; UPREGULATION; ANIMAL; BASEMENT MEMBRANE; BIOLOGICAL MODEL; C57BL MOUSE; EXTRACELLULAR MATRIX; FIBROBLAST; GENE DELETION; GENETICS; LUNG; LUNG FIBROSIS; MECHANOTRANSDUCTION; METABOLISM; PATHOLOGY;

MUS;

ANIMALS; BASEMENT MEMBRANE; BLEOMYCIN; CELL ADHESION; EXTRACELLULAR MATRIX; FIBROBLASTS; GENE DELETION; HUMANS; INTEGRIN ALPHA6; LUNG; MECHANOTRANSDUCTION, CELLULAR; MICE, INBRED C57BL; MODELS, BIOLOGICAL; MYOFIBROBLASTS; PHENOTYPE; PROTO-ONCOGENE PROTEINS C-FOS; PULMONARY FIBROSIS; RHO-ASSOCIATED KINASES; UP-REGULATION;

EID: 84983288553     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms12564     Document Type: Article

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