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Volumn 89, Issue 2, 2016, Pages 123-134

Analytical challenges of extracellular vesicle detection: A comparison of different techniques

Author keywords

Detection techniques; Dynamic light scattering; Electron microscopy; Exosomes; Extracellular vesicles; Flow cytometry; Microparticles; Nanoparticle tracking analysis

Indexed keywords

ANIMAL; ATOMIC FORCE MICROSCOPY; COMPARATIVE STUDY; ELECTRON MICROSCOPY; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; HUMAN; MEMBRANE MICROPARTICLE; PHYSIOLOGY; PROCEDURES; ULTRASTRUCTURE;

EID: 84983200491     PISSN: 15524922     EISSN: 15524930     Source Type: Journal    
DOI: 10.1002/cyto.a.22795     Document Type: Review
Times cited : (177)

References (90)
  • 4
    • 84926632470 scopus 로고    scopus 로고
    • Exosomes: Vehicles of intercellular signaling, biomarkers, and vectors of cell therapy
    • Kourembanas S. Exosomes: Vehicles of intercellular signaling, biomarkers, and vectors of cell therapy. Ann Rev Physiol 2014.
    • (2014) Ann Rev Physiol
    • Kourembanas, S.1
  • 5
    • 0014082202 scopus 로고
    • The nature and significance of platelet products in human plasma
    • Wolf P. The nature and significance of platelet products in human plasma. Br J Haematol 1967;13:269-288.
    • (1967) Br J Haematol , vol.13 , pp. 269-288
    • Wolf, P.1
  • 6
    • 0014139523 scopus 로고
    • Electron microscopic observations on the excretion of cell-wall material by Vibrio cholerae
    • Chatterjee SN, Das J. Electron microscopic observations on the excretion of cell-wall material by Vibrio cholerae. J Gen Microbiol 1967;49:1-11.
    • (1967) J Gen Microbiol , vol.49 , pp. 1-11
    • Chatterjee, S.N.1    Das, J.2
  • 7
    • 77749309281 scopus 로고    scopus 로고
    • Virulence and immunomodulatory roles of bacterial outer membrane vesicles
    • Ellis TN, Kuehn MJ. Virulence and immunomodulatory roles of bacterial outer membrane vesicles. Microbiol Mol Biol Rev 2010;74:81-94.
    • (2010) Microbiol Mol Biol Rev , vol.74 , pp. 81-94
    • Ellis, T.N.1    Kuehn, M.J.2
  • 9
    • 84904704297 scopus 로고    scopus 로고
    • Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles
    • Colombo M, Raposo G, Thery C. Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles. Annu Rev Cell Dev Biol 2014;30:255-289.
    • (2014) Annu Rev Cell Dev Biol , vol.30 , pp. 255-289
    • Colombo, M.1    Raposo, G.2    Thery, C.3
  • 10
    • 84949934993 scopus 로고    scopus 로고
    • As we wait: Coping with an imperfect nomenclature for extracellular vesicles
    • jev.v2i0.20389. eCollection 2013.
    • Gould SJ, Raposo G. As we wait: Coping with an imperfect nomenclature for extracellular vesicles. J Extracell Vesicles 2013;2:10-3402. /jev.v2i0.20389. eCollection 2013.
    • (2013) J Extracell Vesicles , vol.2 , pp. 10-3402
    • Gould, S.J.1    Raposo, G.2
  • 12
    • 79958045842 scopus 로고    scopus 로고
    • A new microparticle size calibration standard for use in measuring smaller microparticles using a new flow cytometer
    • Chandler WL, Yeung W, Tait JF. A new microparticle size calibration standard for use in measuring smaller microparticles using a new flow cytometer. J Thromb Haemost 2011;9:1216-1224.
    • (2011) J Thromb Haemost , vol.9 , pp. 1216-1224
    • Chandler, W.L.1    Yeung, W.2    Tait, J.F.3
  • 13
    • 80051579721 scopus 로고    scopus 로고
    • More on: Calibration for the measurement of microparticles: Value of calibrated polystyrene beads for flow cytometry-based sizing of biological microparticles
    • author reply 1681-2.
    • Robert S, Poncelet P, Lacroix R, Raoult D, Dignat-George F. More on: Calibration for the measurement of microparticles: Value of calibrated polystyrene beads for flow cytometry-based sizing of biological microparticles. J Thromb Haemost 2011;9:1676-1678. author reply 1681-2.
    • (2011) J Thromb Haemost , vol.9 , pp. 1676-1678
    • Robert, S.1    Poncelet, P.2    Lacroix, R.3    Raoult, D.4    Dignat-George, F.5
  • 15
    • 78149316960 scopus 로고    scopus 로고
    • Questionnaire on Microparticle Detection and Characterization: A retrospective analysis.
    • Sydney, Australia. Vascular Biology Working Group Standatization Sub Committee International Society of Thrombosis and Hemostasis, Sydney, Australia.
    • Dignat-Goerge F. Questionnaire on Microparticle Detection and Characterization: A retrospective analysis. Vascular Biology Working Group. Standatization Sub Committee international Society of Thrombosis and Hemostasis; 2005, Sydney, Australia. Vascular Biology Working Group. Standatization Sub Committee International Society of Thrombosis and Hemostasis, Sydney, Australia. 2005.
    • (2005) Vascular Biology Working Group Standatization Sub Committee international Society of Thrombosis and Hemostasis, 2005
    • Dignat-Goerge, F.1
  • 16
    • 84898680460 scopus 로고    scopus 로고
    • Extracellular vesicles from blood plasma: Determination of their morphology, size, phenotype and concentration
    • Arraud N, Linares R, Tan S, Gounou C, Pasquet JM, Mornet S, Brisson AR. Extracellular vesicles from blood plasma: Determination of their morphology, size, phenotype and concentration. J Thromb Haemost 2014;12:614-627.
    • (2014) J Thromb Haemost , vol.12 , pp. 614-627
    • Arraud, N.1    Linares, R.2    Tan, S.3    Gounou, C.4    Pasquet, J.M.5    Mornet, S.6    Brisson, A.R.7
  • 17
    • 79251591623 scopus 로고    scopus 로고
    • Detection and isolation of cell-derived microparticles are compromised by protein complexes resulting from shared biophysical parameters
    • Gyorgy B, Modos K, Pallinger E, Paloczi K, Pasztoi M, Misjak P, Deli MA, Sipos A, Szalai A, Voszka I, et al. Detection and isolation of cell-derived microparticles are compromised by protein complexes resulting from shared biophysical parameters. Blood 2011;117:e39-e48.
    • (2011) Blood , vol.117 , pp. e39-e48
    • Gyorgy, B.1    Modos, K.2    Pallinger, E.3    Paloczi, K.4    Pasztoi, M.5    Misjak, P.6    Deli, M.A.7    Sipos, A.8    Szalai, A.9    Voszka, I.10
  • 18
    • 84873873127 scopus 로고    scopus 로고
    • Calcium-phosphate microprecipitates mimic microparticles when examined with flow cytometry
    • Larson MC, Luthi MR, Hogg N, Hillery CA. Calcium-phosphate microprecipitates mimic microparticles when examined with flow cytometry. Cytometry A 2013;83A:242-250.
    • (2013) Cytometry A , vol.83A , pp. 242-250
    • Larson, M.C.1    Luthi, M.R.2    Hogg, N.3    Hillery, C.A.4
  • 19
  • 20
    • 82155195863 scopus 로고    scopus 로고
    • Fluorescent particles in the antibody solution result in false TF- and CD14-positive microparticles in flow cytometric analysis
    • Aass HC, Ovstebo R, Troseid AM, Kierulf P, Berg JP, Henriksson CE. Fluorescent particles in the antibody solution result in false TF- and CD14-positive microparticles in flow cytometric analysis. Cytometry A 2011;79A:990-999.
    • (2011) Cytometry A , vol.79A , pp. 990-999
    • Aass, H.C.1    Ovstebo, R.2    Troseid, A.M.3    Kierulf, P.4    Berg, J.P.5    Henriksson, C.E.6
  • 24
    • 84899738700 scopus 로고    scopus 로고
    • Procoagulant, tissue factor-bearing microparticles in bronchoalveolar lavage of interstitial lung disease patients: An observational study
    • Novelli F, Neri T, Tavanti L, Armani C, Noce C, Falaschi F, Bartoli ML, Martino F, Palla A, Celi A, et al. Procoagulant, tissue factor-bearing microparticles in bronchoalveolar lavage of interstitial lung disease patients: An observational study. PLoS One 2014;9:e95013
    • (2014) PLoS One , vol.9 , pp. e95013
    • Novelli, F.1    Neri, T.2    Tavanti, L.3    Armani, C.4    Noce, C.5    Falaschi, F.6    Bartoli, M.L.7    Martino, F.8    Palla, A.9    Celi, A.10
  • 26
    • 41149172340 scopus 로고    scopus 로고
    • Phase I clinical trial of autologous ascites-derived exosomes combined with GM-CSF for colorectal cancer
    • Dai S, Wei D, Wu Z, Zhou X, Wei X, Huang H, Li G. Phase I clinical trial of autologous ascites-derived exosomes combined with GM-CSF for colorectal cancer. Mol Ther 2008;16:782-790.
    • (2008) Mol Ther , vol.16 , pp. 782-790
    • Dai, S.1    Wei, D.2    Wu, Z.3    Zhou, X.4    Wei, X.5    Huang, H.6    Li, G.7
  • 28
    • 79952513429 scopus 로고    scopus 로고
    • Pre-analytical and analytical issues in the analysis of blood microparticles
    • Yuana Y, Bertina RM, Osanto S. Pre-analytical and analytical issues in the analysis of blood microparticles. Thromb Haemost 2011;105:396-408.
    • (2011) Thromb Haemost , vol.105 , pp. 396-408
    • Yuana, Y.1    Bertina, R.M.2    Osanto, S.3
  • 29
    • 52249096984 scopus 로고    scopus 로고
    • Characterizing blood microparticles: Technical aspects and challenges
    • Shet AS. Characterizing blood microparticles: Technical aspects and challenges. Vasc Health Risk Manag 2008;4:769-774.
    • (2008) Vasc Health Risk Manag , vol.4 , pp. 769-774
    • Shet, A.S.1
  • 31
    • 51849135441 scopus 로고    scopus 로고
    • Flow cytometric measurement of microparticles: Pitfalls and protocol modifications
    • Shah MD, Bergeron AL, Dong JF, Lopez JA. Flow cytometric measurement of microparticles: Pitfalls and protocol modifications. Platelets 2008;19:365-372.
    • (2008) Platelets , vol.19 , pp. 365-372
    • Shah, M.D.1    Bergeron, A.L.2    Dong, J.F.3    Lopez, J.A.4
  • 32
    • 84898677689 scopus 로고    scopus 로고
    • Circulating microparticles: Challenges and perspectives of flow cytometric assessment
    • Shantsila E, Montoro-Garcia S, Gallego P, Lip GY. Circulating microparticles: Challenges and perspectives of flow cytometric assessment. Thromb Haemost 2014;111:1009-1014.
    • (2014) Thromb Haemost , vol.111 , pp. 1009-1014
    • Shantsila, E.1    Montoro-Garcia, S.2    Gallego, P.3    Lip, G.Y.4
  • 34
    • 84882757926 scopus 로고    scopus 로고
    • The ISTH SSC Workshop. Standardization of pre-analytical variables in plasma microparticle determination: Results of the International Society on Thrombosis and Haemostasis SSC Collaborative workshop
    • Lacroix R, Judicone C, Mooberry M, Boucekine M, Key NS, Dignat-George F. The ISTH SSC Workshop. Standardization of pre-analytical variables in plasma microparticle determination: Results of the International Society on Thrombosis and Haemostasis SSC Collaborative workshop. J Thromb Haemost 2013;
    • (2013) J Thromb Haemost
    • Lacroix, R.1    Judicone, C.2    Mooberry, M.3    Boucekine, M.4    Key, N.S.5    Dignat-George, F.6
  • 35
    • 85016448020 scopus 로고    scopus 로고
    • Minimal experimental requirements for definition of extracellular vesicles and their functions: A position statement from the International society for Extracellular Vesicles
    • Joetvall J, Hill AF, Hochberg F, Buzas E, Vizio Di, Gardiner D, Gho C, Kurochkin YS, Mathivanan IV, Quesenberry S, et al. Minimal experimental requirements for definition of extracellular vesicles and their functions: A position statement from the International society for Extracellular Vesicles. J Extracell Vesicles 2014;3:26913.
    • (2014) J Extracell Vesicles , vol.3 , pp. 26913
    • Joetvall, J.1    Hill, A.F.2    Hochberg, F.3    Buzas, E.4    Vizio, D.5    Gardiner, D.6    Gho, C.7    Kurochkin, Y.S.8    Mathivanan, I.V.9    Quesenberry, S.10
  • 36
    • 84873407266 scopus 로고    scopus 로고
    • Microparticle counts in platelet-rich and platelet-free plasma, effect of centrifugation and sample-processing protocols
    • Chandler WL. Microparticle counts in platelet-rich and platelet-free plasma, effect of centrifugation and sample-processing protocols. Blood Coagul Fibrinolysis 2013;24:125-132.
    • (2013) Blood Coagul Fibrinolysis , vol.24 , pp. 125-132
    • Chandler, W.L.1
  • 37
    • 67651163574 scopus 로고    scopus 로고
    • Centrifugation is a crucial step impacting microparticle measurement
    • author reply 227-8.
    • Dignat-George F, Freyssinet JM, Key NS. Centrifugation is a crucial step impacting microparticle measurement. Platelets 2009;20:225-226. author reply 227-8.
    • (2009) Platelets , vol.20 , pp. 225-226
    • Dignat-George, F.1    Freyssinet, J.M.2    Key, N.S.3
  • 40
    • 58849112565 scopus 로고    scopus 로고
    • Recovery and composition of microparticles after snap-freezing depends on thawing temperature
    • Trummer A, De Rop C, Tiede A, Ganser A, Eisert R. Recovery and composition of microparticles after snap-freezing depends on thawing temperature. Blood Coagul Fibrinolysis 2009;20:52-56.
    • (2009) Blood Coagul Fibrinolysis , vol.20 , pp. 52-56
    • Trummer, A.1    De Rop, C.2    Tiede, A.3    Ganser, A.4    Eisert, R.5
  • 41
    • 84958663989 scopus 로고    scopus 로고
    • Microparticle analysis in disorders of hemostasis and thrombosis
    • Mooberry MJ, Key NS. Microparticle analysis in disorders of hemostasis and thrombosis. Cytometry A 2016;89A:111-122.
    • (2016) Cytometry A , vol.89A , pp. 111-122
    • Mooberry, M.J.1    Key, N.S.2
  • 42
    • 0027266776 scopus 로고
    • Flow cytometry instrumentation in research and clinical laboratories
    • Bogh LD, Duling TA. Flow cytometry instrumentation in research and clinical laboratories. Clin Lab Sci 1993;6:167-173.
    • (1993) Clin Lab Sci , vol.6 , pp. 167-173
    • Bogh, L.D.1    Duling, T.A.2
  • 44
    • 80051601807 scopus 로고    scopus 로고
    • More on: Calibration for the measurement of microparticles: needs, interests, and limitations of calibrated polystyrene beads for flow cytometry-based quantification of biological microparticles
    • Mullier F, Bailly N, Chatelain C, Dogne JM, Chatelain B. More on: Calibration for the measurement of microparticles: needs, interests, and limitations of calibrated polystyrene beads for flow cytometry-based quantification of biological microparticles. J Thromb Haemostasis 2011; 1679-1681.
    • (2011) J Thromb Haemostasis , pp. 1679-1681
    • Mullier, F.1    Bailly, N.2    Chatelain, C.3    Dogne, J.M.4    Chatelain, B.5
  • 48
    • 84874109683 scopus 로고    scopus 로고
    • A trigger channel threshold artifact in nanoparticle analysis
    • Nolan JP, Stoner SA. A trigger channel threshold artifact in nanoparticle analysis. Cytometry A 2013;83A:301-305.
    • (2013) Cytometry A , vol.83A , pp. 301-305
    • Nolan, J.P.1    Stoner, S.A.2
  • 49
    • 84866781675 scopus 로고    scopus 로고
    • Fluorescent labeling of nano-sized vesicles released by cells and subsequent quantitative and qualitative analysis by high-resolution flow cytometry
    • Van der Vlist EJ, Nolte-'t Hoen EN, Stoorvogel W, Arkesteijn GJ, Wauben MH. Fluorescent labeling of nano-sized vesicles released by cells and subsequent quantitative and qualitative analysis by high-resolution flow cytometry. Nature Protocols 2012;7:1311-1326.
    • (2012) Nature Protocols , vol.7 , pp. 1311-1326
    • Van der Vlist, E.J.1    Nolte-'t Hoen, E.N.2    Stoorvogel, W.3    Arkesteijn, G.J.4    Wauben, M.H.5
  • 51
    • 84958677280 scopus 로고    scopus 로고
    • Fluorescence triggering: A general strategy for enumerating and phenotyping extracellular vesicles by flow cytometry
    • Arraud N, Gounou C, Turpin D, Brisson AR. Fluorescence triggering: A general strategy for enumerating and phenotyping extracellular vesicles by flow cytometry. Cytometry A 2016;89A:184-195.
    • (2016) Cytometry A , vol.89A , pp. 184-195
    • Arraud, N.1    Gounou, C.2    Turpin, D.3    Brisson, A.R.4
  • 53
    • 0000836619 scopus 로고
    • Characterization of potentiometric membrane dyes
    • Loew LM. Characterization of potentiometric membrane dyes. Adv Chem Ser 1994;235:151.
    • (1994) Adv Chem Ser , vol.235 , pp. 151
    • Loew, L.M.1
  • 54
    • 0032189880 scopus 로고    scopus 로고
    • Resolution of dimly fluorescent particles: A practical measure of fluorescence sensitivity
    • Chase ES, Hoffman RA. Resolution of dimly fluorescent particles: A practical measure of fluorescence sensitivity. Cytometry 1998;33:267-279.
    • (1998) Cytometry , vol.33 , pp. 267-279
    • Chase, E.S.1    Hoffman, R.A.2
  • 55
    • 84902277709 scopus 로고    scopus 로고
    • Cutting-edge analysis of extracellular microparticles using ImageStream(X) imaging flow cytometry
    • Headland SE, Jones HR, D'Sa AS, Perretti M, Norling LV. Cutting-edge analysis of extracellular microparticles using ImageStream(X) imaging flow cytometry. Sci Rep 2014;4:5237.
    • (2014) Sci Rep , vol.4 , pp. 5237
    • Headland, S.E.1    Jones, H.R.2    D'Sa, A.S.3    Perretti, M.4    Norling, L.V.5
  • 58
    • 0004310121 scopus 로고
    • Means for counting particles suspended in a fluid
    • October 20
    • Coulter WI. Means for counting particles suspended in a fluid. October 20, 1953: US patent 2, 656, 508.
    • (1953)
    • Coulter, W.I.1
  • 60
    • 84876489927 scopus 로고    scopus 로고
    • Wallace Coulter's life and his impact on the world
    • Simson E. Wallace Coulter's life and his impact on the world. Int J Lab Hematol 2013;35:230-236.
    • (2013) Int J Lab Hematol , vol.35 , pp. 230-236
    • Simson, E.1
  • 61
    • 78149304704 scopus 로고    scopus 로고
    • Impedance-based flow cytometry for the measurement of microparticles
    • Zwicker JI. Impedance-based flow cytometry for the measurement of microparticles. Semin Thromb Hemost 2010;36:819-823.
    • (2010) Semin Thromb Hemost , vol.36 , pp. 819-823
    • Zwicker, J.I.1
  • 63
    • 84905485531 scopus 로고    scopus 로고
    • Characterization and deep sequencing analysis of exosomal and non-exosomal miRNA in human urine
    • Cheng L, Sun X, Scicluna BJ, Coleman BM, Hill AF. Characterization and deep sequencing analysis of exosomal and non-exosomal miRNA in human urine. Kidney Int 2014;86:433-444.
    • (2014) Kidney Int , vol.86 , pp. 433-444
    • Cheng, L.1    Sun, X.2    Scicluna, B.J.3    Coleman, B.M.4    Hill, A.F.5
  • 66
    • 84928400353 scopus 로고    scopus 로고
    • Single-particle cryo-EM at crystallographic resolution
    • Cheng Y. Single-particle cryo-EM at crystallographic resolution. Cell 2015;161:450-457.
    • (2015) Cell , vol.161 , pp. 450-457
    • Cheng, Y.1
  • 68
    • 77951762023 scopus 로고    scopus 로고
    • Structural-mechanical characterization of nanoparticle exosomes in human saliva, using correlative AFM, FESEM, and force spectroscopy
    • Sharma S, Rasool HI, Palanisamy V, Mathisen C, Schmidt M, Wong DT, Gimzewski JK. Structural-mechanical characterization of nanoparticle exosomes in human saliva, using correlative AFM, FESEM, and force spectroscopy. ACS Nano 2010;4:1921-1926.
    • (2010) ACS Nano , vol.4 , pp. 1921-1926
    • Sharma, S.1    Rasool, H.I.2    Palanisamy, V.3    Mathisen, C.4    Schmidt, M.5    Wong, D.T.6    Gimzewski, J.K.7
  • 70
    • 0033179130 scopus 로고    scopus 로고
    • Platelet-derived microparticles on synthetic surfaces observed by atomic force microscopy and fluorescence microscopy
    • Siedlecki CA, Wang IW, Higashi JM, Kottke-Marchant K, Marchant RE. Platelet-derived microparticles on synthetic surfaces observed by atomic force microscopy and fluorescence microscopy. Biomaterials 1999;20:1521-1529.
    • (1999) Biomaterials , vol.20 , pp. 1521-1529
    • Siedlecki, C.A.1    Wang, I.W.2    Higashi, J.M.3    Kottke-Marchant, K.4    Marchant, R.E.5
  • 71
    • 85012272454 scopus 로고    scopus 로고
    • Characterisation of tissue factor-bearing extracellular vesicles with AFM: Comparison of air-tapping-mode AFM and liquid Peak Force AFM
    • 2:10.3402/jev.v2i0.21045. eCollection 2013.
    • Hardij J, Cecchet F, Berquand A, Gheldof D, Chatelain C, Mullier F, Chatelain B, Dogne JM. Characterisation of tissue factor-bearing extracellular vesicles with AFM: Comparison of air-tapping-mode AFM and liquid Peak Force AFM. J Extracell Vesicles 2013; 2:10.3402/jev.v2i0.21045. eCollection 2013.
    • (2013) J Extracell Vesicles
    • Hardij, J.1    Cecchet, F.2    Berquand, A.3    Gheldof, D.4    Chatelain, C.5    Mullier, F.6    Chatelain, B.7    Dogne, J.M.8
  • 72
    • 84865436657 scopus 로고    scopus 로고
    • Determination of the size distribution of blood microparticles directly in plasma using atomic force microscopy and microfluidics
    • Ashcroft BA, de Sonneville J, Yuana Y, Osanto S, Bertina R, Kuil ME, Oosterkamp TH. Determination of the size distribution of blood microparticles directly in plasma using atomic force microscopy and microfluidics. Biomed Microdevices 2012;14:641-649.
    • (2012) Biomed Microdevices , vol.14 , pp. 641-649
    • Ashcroft, B.A.1    de Sonneville, J.2    Yuana, Y.3    Osanto, S.4    Bertina, R.5    Kuil, M.E.6    Oosterkamp, T.H.7
  • 73
    • 77953291167 scopus 로고    scopus 로고
    • Critical evaluation of Nanoparticle Tracking Analysis (NTA) by NanoSight for the measurement of nanoparticles and protein aggregates
    • Filipe V, Hawe A, Jiskoot W. Critical evaluation of Nanoparticle Tracking Analysis (NTA) by NanoSight for the measurement of nanoparticles and protein aggregates. Pharm Res 2010;27:796-810.
    • (2010) Pharm Res , vol.27 , pp. 796-810
    • Filipe, V.1    Hawe, A.2    Jiskoot, W.3
  • 75
    • 84951247824 scopus 로고
    • A study of Brownian motion using light scattering
    • Clark N, Lunack J, Benedek G. A study of Brownian motion using light scattering. Am J Physiol 1970;38:575-585.
    • (1970) Am J Physiol , vol.38 , pp. 575-585
    • Clark, N.1    Lunack, J.2    Benedek, G.3
  • 76
    • 0038161224 scopus 로고    scopus 로고
    • Revisiting the method of cumulants for the analysis of dynamic light-scattering data
    • Frisken BJ. Revisiting the method of cumulants for the analysis of dynamic light-scattering data. Appl Opt 2001;40:4087-4091.
    • (2001) Appl Opt , vol.40 , pp. 4087-4091
    • Frisken, B.J.1
  • 77
    • 84904313207 scopus 로고    scopus 로고
    • Particle size distribution of exosomes and microvesicles determined by transmission electron microscopy, flow cytometry, nanoparticle tracking analysis, and resistive pulse sensing
    • van der Pol E, Coumans FA, Grootemaat AE, Gardiner C, Sargent IL, Harrison P, Sturk A, van Leeuwen TG, Nieuwland R. Particle size distribution of exosomes and microvesicles determined by transmission electron microscopy, flow cytometry, nanoparticle tracking analysis, and resistive pulse sensing. J Thromb Haemost 2014;12:1182-1192.
    • (2014) J Thromb Haemost , vol.12 , pp. 1182-1192
    • van der Pol, E.1    Coumans, F.A.2    Grootemaat, A.E.3    Gardiner, C.4    Sargent, I.L.5    Harrison, P.6    Sturk, A.7    van Leeuwen, T.G.8    Nieuwland, R.9
  • 85
    • 34249726598 scopus 로고    scopus 로고
    • Miniaturized asymmetrical flow field-flow fractionation: application to biological vesicles
    • Oh S, Kang D, Ahn SM, Simpson RJ, Lee BH, Moon MH. Miniaturized asymmetrical flow field-flow fractionation: application to biological vesicles. J Sep Sci 2007;30:1082-1087.
    • (2007) J Sep Sci , vol.30 , pp. 1082-1087
    • Oh, S.1    Kang, D.2    Ahn, S.M.3    Simpson, R.J.4    Lee, B.H.5    Moon, M.H.6
  • 90
    • 0026013242 scopus 로고
    • Vesicle sizing: Number distributions by dynamic light scattering
    • Hallett FR, Watton J, Krygsman P. Vesicle sizing: Number distributions by dynamic light scattering. Biophys J 1991;59:357-362.
    • (1991) Biophys J , vol.59 , pp. 357-362
    • Hallett, F.R.1    Watton, J.2    Krygsman, P.3


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