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Angewandte Chemie - International Edition

Volumn 54, Issue 49, 2015, Pages 14898-14902

A visible-light-mediated radical smiles rearrangement and its application to the synthesis of a difluoro-substituted spirocyclic ORL-1 antagonist

(5) Douglas, James J a,b Albright, Haley a Sevrin, Martin J a Cole, Kevin P b Stephenson, Corey R J a

a UNIVERSITY OF MICHIGAN (United States)

b ELI LILLY AND COMPANY (United States)

Author keywords

catalysis; heterocycles; photocatalysis; radical reactions; rearrangement

Indexed keywords

CATALYSIS; PHOTOCATALYSIS; REACTION KINETICS;

CATALYST LOADINGS; HETEROCYCLES; OPIOID RECEPTORS; RADICAL REACTIONS; REARRANGEMENT; SMILES REARRANGEMENT; STRATEGIC BENEFITS; SYNTHETIC SEQUENCE;

LIGHT;

FREE RADICAL; HETEROCYCLIC COMPOUND; NOCICEPTIN RECEPTOR; OPIATE RECEPTOR; SPIRO COMPOUND;

CHEMICAL STRUCTURE; CHEMISTRY; LIGHT; METABOLISM; RADIATION RESPONSE; SYNTHESIS;

FREE RADICALS; HETEROCYCLIC COMPOUNDS; LIGHT; MOLECULAR STRUCTURE; RECEPTORS, OPIOID; SPIRO COMPOUNDS;

EID: 84983157637 PISSN: 14337851 EISSN: 15213773 Source Type: Journal
DOI: 10.1002/anie.201507369 Document Type: Article

Times cited : (152)

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