Early rehabilitation aggravates brain damage after stroke via enhanced activation of nicotinamide adenine dinucleotide phosphate oxidase (NOX)

Brain Research

Volumn 1648, Issue , 2016, Pages 266-276

  Shen, Jiamei ^a,b   Huber, Mitchell ^b   Zhao, Ethan Y ^b   Peng, Changya ^b   Li, Fengwu ^a   Li, Xiaorong ^a   Geng, Xiaokun ^a,b   Ding, Yuchuan ^a,b  

^a CAPITAL MEDICAL UNIVERSITY   (China)

^b WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Exercise; Glut 1; Glut 3; Hyperglycolysis; Lactic acidosis; Timing

Indexed keywords

GLUCOSE TRANSPORTER 1; GLUCOSE TRANSPORTER 3; GLYCOPROTEIN GP 91; LACTIC ACID; PROTEIN P47; PROTEIN P67; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; CYBB PROTEIN, RAT; MEMBRANE PROTEIN; NEUTROPHIL CYTOSOL FACTOR 67K; NEUTROPHIL CYTOSOLIC FACTOR 1; P22-PHOX PROTEIN, RAT; PHOSPHOPROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BRAIN DAMAGE; BRAIN ISCHEMIA; CONTROLLED STUDY; ENZYME ACTIVATION; EXERCISE; GLYCOLYSIS; HYPERGLYCOLYSIS; LACTIC ACIDOSIS; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SUBUNIT; RAT; ROTAROD TEST; SPRAGUE DAWLEY RAT; ANIMAL; BRAIN CORTEX; BRAIN INJURIES; COMPLICATION; ENZYMOLOGY; METABOLISM; STROKE;

ANIMALS; APOPTOSIS; BRAIN INJURIES; CEREBRAL CORTEX; GLUCOSE TRANSPORTER TYPE 1; GLUCOSE TRANSPORTER TYPE 3; LACTIC ACID; MALE; MEMBRANE GLYCOPROTEINS; NADPH OXIDASE; PHOSPHOPROTEINS; PHYSICAL CONDITIONING, ANIMAL; RATS; RATS, SPRAGUE-DAWLEY; ROTAROD PERFORMANCE TEST; STROKE;

EID: 84983001789     PISSN: 00068993     EISSN: 18726240     Source Type: Journal    
DOI: 10.1016/j.brainres.2016.08.001     Document Type: Article

References (36)

1. Andreollo, N.A., Santos, E.F., Araujo, M.R., Lopes, L.R., Rat's age versus human's age: what is the relationship?. Arq. Bras. Cir. Dig. 25 (2012), 49–51.
2. Bedard, K., Krause, K.H., The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. Physiol. Rev. 87 (2007), 245–313.
3. Bergsneider, M., Hovda, D.A., Shalmon, E., Kelly, D.F., Vespa, P.M., Martin, N.A., Phelps, M.E., McArthur, D.L., Caron, M.J., Kraus, J.F., Becker, D.P., Cerebral hyperglycolysis following severe traumatic brain injury in humans: a positron emission tomography study. J. Neurosurg. 86 (1997), 241–251.
4. Bokoch, G.M., Knaus, U.G., NADPH oxidases: not just for leukocytes anymore!. Trends Biochem Sci. 28 (2003), 502–508.
5. Ding, Y., Li, J., Clark, J., Diaz, F.G., Rafols, J.A., Synaptic plasticity in thalamic nuclei enhanced by motor skill training in rat with transient middle cerebral artery occlusion. Neurol. Res 25 (2003), 189–194.
6. Ding, Y., Li, J., Luan, X., Ding, Y.H., Lai, Q., Rafols, J.A., Phillis, J.W., Clark, J.C., Diaz, F.G., Exercise pre-conditioning reduces brain damage in ischemic rats that may be associated with regional angiogenesis and cellular overexpression of neurotrophin. Neuroscience 124 (2004), 583–591.
7. Ding, Y.H., Li, J., Zhou, Y., Rafols, J.A., Clark, J.C., Ding, Y., Cerebral angiogenesis and expression of angiogenic factors in aging rats after exercise. Curr. Neurovasc. Res. 3 (2006), 15–23.
8. Dornbos, D. 3rd, Zwagerman, N., Guo, M., Ding, J.Y., Peng, C., Esmail, F., Sikharam, C., Geng, X., Guthikonda, M., Ding, Y., Preischemic exercise reduces brain damage by ameliorating metabolic disorder in ischemia/reperfusion injury. J. Neurosci. Res. 91 (2013), 818–827.
9. Fu, P., Peng, C., Ding, J.Y., Asmaro, K., Sullivan, J.M., Guthikonda, M., Ding, Y., Acute administration of ethanol reduces apoptosis following ischemic stroke in rats. Neurosci. Res. 76 (2013), 93–97.
10. Geng, X., Fu, P., Ji, X., Peng, C., Fredrickson, V., Sy, C., Meng, R., Ling, F., Du, H., Tan, X., Huttemann, M., Guthikonda, M., Ding, Y., Synergetic neuroprotection of normobaric oxygenation and ethanol in ischemic stroke through improved oxidative mechanism. Stroke 44 (2013), 1418–1425.
11. Geng, X., Parmar, S., Li, X., Peng, C., Ji, X., Chakraborty, T., Li, W.A., Du, H., Tan, X., Ling, F., Guthikonda, M., Rafols, J.A., Ding, Y., Reduced apoptosis by combining normobaric oxygenation with ethanol in transient ischemic stroke. Brain Res. 1531 (2013), 17–24.
12. Groemping, Y., Rittinger, K., Activation and assembly of the NADPH oxidase: a structural perspective. Biochem. J. 386 (2005), 401–416.
13. Hotting, K., Roder, B., Beneficial effects of physical exercise on neuroplasticity and cognition. Neurosci. Biobehav. Rev. 37 (2013), 2243–2257.
14. Hsu, J.E., Jones, T.A., Time-sensitive enhancement of motor learning with the less-affected forelimb after unilateral sensorimotor cortex lesions in rats. Eur. J. Neurosci. 22 (2005), 2069–2080.
15. Humm, J.L., Kozlowski, D.A., James, D.C., Gotts, J.E., Schallert, T., Use-dependent exacerbation of brain damage occurs during an early post-lesion vulnerable period. Brain Res. 783 (1998), 286–292.
16. Kinni, H., Guo, M., Ding, J.Y., Konakondla, S., Dornbos, D. 3rd, Tran, R., Guthikonda, M., Ding, Y., Cerebral metabolism after forced or voluntary physical exercise. Brain Res. 1388 (2011), 48–55.
17. Kochanski, R., Peng, C., Higashida, T., Geng, X., Huttemann, M., Guthikonda, M., Ding, Y., Neuroprotection conferred by post-ischemia ethanol therapy in experimental stroke: an inhibitory effect on hyperglycolysis and NADPH oxidase activation. J. Neurochem. 126 (2013), 113–121.
18. Kozlowski, D.A., James, D.C., Schallert, T., Use-dependent exaggeration of neuronal injury after unilateral sensorimotor cortex lesions. J. Neurosci. 16 (1996), 4776–4786.
19. Kruyt, N.D., Biessels, G.J., Devries, J.H., Roos, Y.B., Hyperglycemia in acute ischemic stroke: pathophysiology and clinical management. Nat. Rev. Neurol. 6 (2010), 145–155.
20. Lee, S.U., Kim, D.Y., Park, S.H., Choi, D.H., Park, H.W., Han, T.R., Mild to moderate early exercise promotes recovery from cerebral ischemia in rats. Can. J. Neurol. Sci. 36 (2009), 443–449.
21. Li, W.A., Moore-Langston, S., Chakraborty, T., Rafols, J.A., Conti, A.C., Ding, Y., Hyperglycemia in stroke and possible treatments. Neurol. Res 35 (2013), 479–491.
22. Longa, E.Z., Weinstein, P.R., Carlson, S., Cummins, R., Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke 20 (1989), 84–91.
23. Matsuda, F., Sakakima, H., Yoshida, Y., The effects of early exercise on brain damage and recovery after focal cerebral infarction in rats. Acta Physiol. 201 (2011), 275–287.
24. Park, J.W., Bang, M.S., Kwon, B.S., Park, Y.K., Kim, D.W., Shon, S.M., Jeong, S.W., Lee, D.K., Kim, D.E., Early treadmill training promotes motor function after hemorrhagic stroke in rats. Neurosci. Lett. 471 (2010), 104–108.
25. Risedal, A., Zeng, J., Johansson, B.B., Early training may exacerbate brain damage after focal brain ischemia in the rat. J. Cereb. Blood Flow. Metab. 19 (1999), 997–1003.
26. Schurr, A., Lactate, glucose and energy metabolism in the ischemic brain (Review). Int. J. Mol. Med. 10 (2002), 131–136.
27. Serrano, F., Kolluri, N.S., Wientjes, F.B., Card, J.P., Klann, E., NADPH oxidase immunoreactivity in the mouse brain. Brain Res. 988 (2003), 193–198.
28. Shao, B., Bayraktutan, U., Hyperglycaemia promotes human brain microvascular endothelial cell apoptosis via induction of protein kinase C-ssI and prooxidant enzyme NADPH oxidase. Redox Biol. 2 (2014), 694–701.
29. Sorce, S., Krause, K.H., NOX enzymes in the central nervous system: from signaling to disease. Antioxid. Redox Signal 11 (2009), 2481–2504.
30. Steultjens, E., Jellema, S., Early applied stroke carers training programme was not more effective than usual care. Aust. Occup. Ther. J. 61 (2014), 210–211.
31. Suh, S.W., Shin, B.S., Ma, H., Van Hoecke, M., Brennan, A.M., Yenari, M.A., Swanson, R.A., Glucose and NADPH oxidase drive neuronal superoxide formation in stroke. Ann. Neurol. 64 (2008), 654–663.
32. Takeya, R., Ueno, N., Kami, K., Taura, M., Kohjima, M., Izaki, T., Nunoi, H., Sumimoto, H., Novel human homologues of p47phox and p67phox participate in activation of superoxide-producing NADPH oxidases. J. Biol. Chem, 290, 2015, 6003.
33. Tamakoshi, K., Ishida, A., Takamatsu, Y., Hamakawa, M., Nakashima, H., Shimada, H., Ishida, K., Motor skills training promotes motor functional recovery and induces synaptogenesis in the motor cortex and striatum after intracerebral hemorrhage in rats. Behav. Brain Res. 260 (2014), 34–43.
34. Tang, X.N., Cairns, B., Kim, J.Y., Yenari, M.A., NADPH oxidase in stroke and cerebrovascular disease. Neurol. Res. 34 (2012), 338–345.
35. Tang, X.N., Cairns, B., Kim, J.Y., Yenari, M.A., NADPH Oxidase in stroke and cerebrovascular disease. Neurol. Res., 2012.
36. Wang, F., Wang, Y., Geng, X., Asmaro, K., Peng, C., Sullivan, J.M., Ding, J.Y., Ji, X., Ding, Y., Neuroprotective effect of acute ethanol administration in a rat with transient cerebral ischemia. Stroke 43 (2012), 205–210.