Randomised, double-blind, placebo-controlled trial with azithromycin selects for anti-inflammatory microbial metabolites in the emphysematous lung

Thorax

Volumn 72, Issue 1, 2017, Pages 13-22

  Segal, Leopoldo N ^a,b   Clemente, Jose C ^c   Wu, Benjamin G ^a   Wikoff, William R ^d   Gao, Zhan ^b   Li, Yonghua ^a   Ko, Jane P ^b   Rom, William N ^a,b   Blaser, Martin J ^b   Weiden, Michael D ^a,b  

^a BELLEVUE HOSPITAL CENTER   (United States)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Bronchoscopy; COPD Mechanisms

Indexed keywords

AZITHROMYCIN; CXCL1 CHEMOKINE; GLYCOLIC ACID; INDOLEACETIC ACID; INTERLEUKIN 12P40; INTERLEUKIN 13; LINOLEIC ACID; PLACEBO; RNA 16S; TUMOR NECROSIS FACTOR; ANTIINFECTIVE AGENT; CXCL1 PROTEIN, HUMAN; CYTOKINE; GLYCOLIC ACID DERIVATIVE; INDOLEACETIC ACID DERIVATIVE;

ACIDIMICROBIALES; ADULT; ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL LOAD; BIFIDOBACTERIUM; BRADYRHIZOBIACEAE; BRONCHOALVEOLAR LAVAGE FLUID; CELL COUNT; CELL DIFFERENTIATION; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOPHAGA; DRUG EFFICACY; DRUG RESPONSE; FEMALE; GENE SEQUENCE; HUMAN; LUNG EMPHYSEMA; LUNG MICROBIOME; MACROPHAGE; MALE; METABOLOMICS; MICROBIOME; NEISSERIA; PNEUMONIA; RALSTONIA; RANDOMIZED CONTROLLED TRIAL; RHODOSPIRILLACEAE; TISSIERELLACEAE; TREATMENT DURATION; AGED; CHEMISTRY; DOUBLE BLIND PROCEDURE; DRUG EFFECTS; INFLAMMATION; LUNG; LUNG ALVEOLUS MACROPHAGE; METABOLISM; METABOLOME; MICROBIOLOGY; MICROFLORA; MIDDLE AGED;

AGED; ANTI-BACTERIAL AGENTS; AZITHROMYCIN; BRONCHOALVEOLAR LAVAGE FLUID; CHEMOKINE CXCL1; CYTOKINES; DOUBLE-BLIND METHOD; FEMALE; GLYCOLATES; HUMANS; INDOLEACETIC ACIDS; INFLAMMATION; INTERLEUKIN-12 SUBUNIT P40; INTERLEUKIN-13; LINOLEIC ACID; LUNG; MACROPHAGES, ALVEOLAR; MALE; METABOLOME; MICROBIOTA; MIDDLE AGED; PULMONARY EMPHYSEMA; RNA, RIBOSOMAL, 16S; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84982938369     PISSN: 00406376     EISSN: 14683296     Source Type: Journal    
DOI: 10.1136/thoraxjnl-2016-208599     Document Type: Article

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