메뉴 건너뛰기




Volumn 18, Issue 10, 2016, Pages

Update on the Management of Pancreatic Cancer in Older Adults

Author keywords

Chemoradiation; Chemotherapy; Comprehensive geriatric assessment; Frailty scores; Geriatric oncology; Novel therapies; Older adults; Pancreatic adenocarcinoma; Radiation; Surgery; Symptom management; Toxicity scores; Update

Indexed keywords

CAPECITABINE; CISPLATIN; ERLOTINIB; FLUOROURACIL; FOLINIC ACID; GEMCITABINE; GIMERACIL PLUS OTERACIL POTASSIUM PLUS TEGAFUR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR VACCINE; IRINOTECAN; NIVOLUMAB; OXALIPLATIN; PACLITAXEL; PEMBROLIZUMAB; ANTINEOPLASTIC AGENT;

EID: 84982840502     PISSN: 15233790     EISSN: 15346269     Source Type: Journal    
DOI: 10.1007/s11912-016-0547-4     Document Type: Review
Times cited : (8)

References (105)
  • 2
    • 84982825092 scopus 로고    scopus 로고
    • Howlader N, Noone A, Krapcho M, Garshell J, Miller D, Altekruse S, et al. SEER Cancer Statistics Review, 1975–2012, National Cancer Institute. Bethesda, MD, based on November 2014 SEER data submission, posted to the SEER website, April 2015. [Internet]. [cited 2016 Feb 7]. Available from
    • Howlader N, Noone A, Krapcho M, Garshell J, Miller D, Altekruse S, et al. SEER Cancer Statistics Review, 1975–2012, National Cancer Institute. Bethesda, MD, based on November 2014 SEER data submission, posted to the SEER website, April 2015. [Internet]. [cited 2016 Feb 7]. Available from: http://seer.cancer.gov/csr/1975_2012/.
  • 3
    • 30744467177 scopus 로고    scopus 로고
    • Population aging and cancer: a cross-national concern
    • Yancik R. Population aging and cancer: a cross-national concern. Cancer J Sudbury Mass. 2005;11:437–41.
    • (2005) Cancer J Sudbury Mass , vol.11 , pp. 437-441
    • Yancik, R.1
  • 4
    • 77951636925 scopus 로고    scopus 로고
    • Cancer in the oldest old: making better treatment decisions
    • PID: 20308651
    • Hanson LC, Muss HB. Cancer in the oldest old: making better treatment decisions. J Clin Oncol. 2010;28:1975–6.
    • (2010) J Clin Oncol , vol.28 , pp. 1975-1976
    • Hanson, L.C.1    Muss, H.B.2
  • 5
    • 84907045086 scopus 로고    scopus 로고
    • Pancreatic adenocarcinoma
    • COI: 1:CAS:528:DC%2BC2cXhs1Olt7rK, PID: 25207767
    • Ryan DP, Hong TS, Bardeesy N. Pancreatic adenocarcinoma. N Engl J Med. 2014;371:1039–49.
    • (2014) N Engl J Med , vol.371 , pp. 1039-1049
    • Ryan, D.P.1    Hong, T.S.2    Bardeesy, N.3
  • 6
    • 84982788564 scopus 로고    scopus 로고
    • Jan 3]
    • Cancer of the pancreas—SEER Stat Fact Sheets [Internet]. [cited 2016 Jan 3]. Available from: http://seer.cancer.gov/statfacts/html/pancreas.html.
    • (2016) Available from:
  • 8
    • 84994479573 scopus 로고    scopus 로고
    • Disparities by race, age, and sex in the improvement of survival for major cancers: results from the National Cancer Institute Surveillance, Epidemiology, and End Results (SEER) Program in the United States, 1990 to 2010
    • PID: 26182310
    • Zeng C, Wen W, Morgans AK, Pao W, Shu X-O, Zheng W. Disparities by race, age, and sex in the improvement of survival for major cancers: results from the National Cancer Institute Surveillance, Epidemiology, and End Results (SEER) Program in the United States, 1990 to 2010. JAMA Oncol. 2015;1:88–96.
    • (2015) JAMA Oncol , vol.1 , pp. 88-96
    • Zeng, C.1    Wen, W.2    Morgans, A.K.3    Pao, W.4    Shu, X.-O.5    Zheng, W.6
  • 9
    • 84944153570 scopus 로고    scopus 로고
    • Underuse of surgical resection among elderly patients with early-stage pancreatic cancer
    • PID: 26138347
    • He W, Zhao H, Chan W, Lopez D, Shroff RT, Giordano SH. Underuse of surgical resection among elderly patients with early-stage pancreatic cancer. Surgery. 2015;158:1226–34.
    • (2015) Surgery , vol.158 , pp. 1226-1234
    • He, W.1    Zhao, H.2    Chan, W.3    Lopez, D.4    Shroff, R.T.5    Giordano, S.H.6
  • 10
    • 84874108357 scopus 로고    scopus 로고
    • Evidence for treatment and survival disparities by age in pancreatic adenocarcinoma: a population-based analysis
    • PID: 22836862
    • Amin S, Lucas AL, Frucht H. Evidence for treatment and survival disparities by age in pancreatic adenocarcinoma: a population-based analysis. Pancreas. 2013;42:249–53.
    • (2013) Pancreas , vol.42 , pp. 249-253
    • Amin, S.1    Lucas, A.L.2    Frucht, H.3
  • 12
    • 84904267009 scopus 로고    scopus 로고
    • Trajectory of care and use of multimodality therapy in older patients with pancreatic adenocarcinoma
    • PID: 24851723
    • Parmar AD, Vargas GM, Tamirisa NP, Sheffield KM, Riall TS. Trajectory of care and use of multimodality therapy in older patients with pancreatic adenocarcinoma. Surgery. 2014;156:280–9.
    • (2014) Surgery , vol.156 , pp. 280-289
    • Parmar, A.D.1    Vargas, G.M.2    Tamirisa, N.P.3    Sheffield, K.M.4    Riall, T.S.5
  • 15
    • 16544371710 scopus 로고    scopus 로고
    • Enrollment of elderly patients in clinical trials for cancer drug registration: a 7-year experience by the US Food and Drug Administration
    • Talarico L, Chen G, Pazdur R. Enrollment of elderly patients in clinical trials for cancer drug registration: a 7-year experience by the US Food and Drug Administration. J Clin Oncol Off J Am Soc Clin Oncol. 2004;22:4626–31.
    • (2004) J Clin Oncol Off J Am Soc Clin Oncol , vol.22 , pp. 4626-4631
    • Talarico, L.1    Chen, G.2    Pazdur, R.3
  • 16
    • 2642573558 scopus 로고    scopus 로고
    • Participation in cancer clinical trials: race-, sex-, and age-based disparities
    • COI: 1:CAS:528:DC%2BD2cXkvVeqsL4%3D, PID: 15187053
    • Murthy VH, Krumholz HM, Gross CP. Participation in cancer clinical trials: race-, sex-, and age-based disparities. JAMA. 2004;291:2720–6.
    • (2004) JAMA , vol.291 , pp. 2720-2726
    • Murthy, V.H.1    Krumholz, H.M.2    Gross, C.P.3
  • 18
    • 38949167506 scopus 로고    scopus 로고
    • Clinical pharmacology of cancer therapies in older adults
    • COI: 1:CAS:528:DC%2BD1cXhs1Krsbw%3D, PID: 18256586
    • Hurria A, Lichtman SM. Clinical pharmacology of cancer therapies in older adults. Br J Cancer. 2008;98:517–22.
    • (2008) Br J Cancer , vol.98 , pp. 517-522
    • Hurria, A.1    Lichtman, S.M.2
  • 19
    • 0037441772 scopus 로고    scopus 로고
    • Can older cancer patients tolerate chemotherapy? A prospective pilot study
    • PID: 12569613
    • Chen H, Cantor A, Meyer J, Beth Corcoran M, Grendys E, Cavanaugh D, et al. Can older cancer patients tolerate chemotherapy? A prospective pilot study. Cancer. 2003;97:1107–14.
    • (2003) Cancer , vol.97 , pp. 1107-1114
    • Chen, H.1    Cantor, A.2    Meyer, J.3    Beth Corcoran, M.4    Grendys, E.5    Cavanaugh, D.6
  • 20
    • 84878994076 scopus 로고    scopus 로고
    • Improved targeting of cancer care for older patients: a systematic review of the utility of comprehensive geriatric assessment
    • PID: 24070464
    • Ramjaun A, Nassif MO, Krotneva S, Huang AR, Meguerditchian AN. Improved targeting of cancer care for older patients: a systematic review of the utility of comprehensive geriatric assessment. J Geriatr Oncol. 2013;4:271–81.
    • (2013) J Geriatr Oncol , vol.4 , pp. 271-281
    • Ramjaun, A.1    Nassif, M.O.2    Krotneva, S.3    Huang, A.R.4    Meguerditchian, A.N.5
  • 21
    • 34249774066 scopus 로고    scopus 로고
    • Comprehensive geriatric assessment for older patients with cancer
    • Extermann M, Hurria A. Comprehensive geriatric assessment for older patients with cancer. J Clin Oncol Off J Am Soc Clin Oncol. 2007;25:1824–31.
    • (2007) J Clin Oncol Off J Am Soc Clin. Oncol , vol.25 , pp. 1824-1831
    • Extermann, M.1    Hurria, A.2
  • 22
  • 23
    • 84928764575 scopus 로고    scopus 로고
    • The impact of comprehensive geriatric assessment interventions on tolerance to chemotherapy in older people
    • COI: 1:STN:280:DC%2BC2MjjslKgsA%3D%3D, PID: 25871332, This study showed that geriatrician-delivered geriatric assessment improves completion rates of chemotherapy, fewer treatment modifications, and decreased toxicity
    • Kalsi T, Babic-Illman G, Ross PJ, Maisey NR, Hughes S, Fields P, et al. The impact of comprehensive geriatric assessment interventions on tolerance to chemotherapy in older people. Br J Cancer. 2015;112:1435–44. This study showed that geriatrician-delivered geriatric assessment improves completion rates of chemotherapy, fewer treatment modifications, and decreased toxicity.
    • (2015) Br J Cancer , vol.112 , pp. 1435-1444
    • Kalsi, T.1    Babic-Illman, G.2    Ross, P.J.3    Maisey, N.R.4    Hughes, S.5    Fields, P.6
  • 24
    • 84899487178 scopus 로고    scopus 로고
    • Geriatric assessment improves prediction of surgical outcomes in older adults undergoing pancreaticoduodenectomy: a prospective cohort study
    • PID: 24096757, This is a prospective outcome study which showed that the geriatric assessment prospectively and independently predicted adverse surgical outcomes in older patients undergoing pancreaticoduodenectomy
    • Dale W, Hemmerich J, Kamm A, Posner MC, Matthews JB, Rothman R, et al. Geriatric assessment improves prediction of surgical outcomes in older adults undergoing pancreaticoduodenectomy: a prospective cohort study. Ann Surg. 2014;259:960–5. This is a prospective outcome study which showed that the geriatric assessment prospectively and independently predicted adverse surgical outcomes in older patients undergoing pancreaticoduodenectomy.
    • (2014) Ann Surg , vol.259 , pp. 960-965
    • Dale, W.1    Hemmerich, J.2    Kamm, A.3    Posner, M.C.4    Matthews, J.B.5    Rothman, R.6
  • 26
    • 84938996361 scopus 로고    scopus 로고
    • Estimating the risk of chemotherapy toxicity in older patients with cancer: the role of the Vulnerable Elders Survey-13 (VES-13)
    • PID: 26088748
    • Luciani A, Biganzoli L, Colloca G, Falci C, Castagneto B, Floriani I, et al. Estimating the risk of chemotherapy toxicity in older patients with cancer: the role of the Vulnerable Elders Survey-13 (VES-13). J Geriatr Oncol. 2015;6:272–9.
    • (2015) J Geriatr Oncol , vol.6 , pp. 272-279
    • Luciani, A.1    Biganzoli, L.2    Colloca, G.3    Falci, C.4    Castagneto, B.5    Floriani, I.6
  • 28
    • 84921495723 scopus 로고    scopus 로고
    • Screening tools for multidimensional health problems warranting a geriatric assessment in older cancer patients: an update on SIOG recommendations†
    • COI: 1:STN:280:DC%2BC2cfivFyisw%3D%3D, This is the latest SIOG recommendation on screening tools for frailty in older cancer patients. It is also a good systemic review of studies comparing various screening tools with the comprehensive geriatric assessment and with each other
    • Decoster L, Van Puyvelde K, Mohile S, Wedding U, Basso U, Colloca G, et al. Screening tools for multidimensional health problems warranting a geriatric assessment in older cancer patients: an update on SIOG recommendations†. Ann Oncol Off J Eur Soc Med Oncol ESMO. 2015;26:288–300. This is the latest SIOG recommendation on screening tools for frailty in older cancer patients. It is also a good systemic review of studies comparing various screening tools with the comprehensive geriatric assessment and with each other.
    • (2015) Ann Oncol Off J Eur Soc Med Oncol ESMO , vol.26 , pp. 288-300
    • Decoster, L.1    Van Puyvelde, K.2    Mohile, S.3    Wedding, U.4    Basso, U.5    Colloca, G.6
  • 29
    • 84862575323 scopus 로고    scopus 로고
    • Predicting the risk of chemotherapy toxicity in older patients: the Chemotherapy Risk Assessment Scale for High-Age Patients (CRASH) score
    • PID: 22072065
    • Extermann M, Boler I, Reich RR, Lyman GH, Brown RH, DeFelice J, et al. Predicting the risk of chemotherapy toxicity in older patients: the Chemotherapy Risk Assessment Scale for High-Age Patients (CRASH) score. Cancer. 2012;118:3377–86.
    • (2012) Cancer , vol.118 , pp. 3377-3386
    • Extermann, M.1    Boler, I.2    Reich, R.R.3    Lyman, G.H.4    Brown, R.H.5    DeFelice, J.6
  • 30
    • 84897893781 scopus 로고    scopus 로고
    • Adjuvant therapy for pancreatic cancer
    • Goodman MD, Saif MW. Adjuvant therapy for pancreatic cancer. JOP J Pancreas. 2014;15:87–90.
    • (2014) JOP J Pancreas , vol.15 , pp. 87-90
    • Goodman, M.D.1    Saif, M.W.2
  • 31
    • 84955743598 scopus 로고    scopus 로고
    • Clinicopathological features of 15 occult and 178 clinical pancreatic ductal adenocarcinomas in 8339 autopsied elderly patients
    • Matsuda Y, Ishiwata T, Yachida S, Suzuki A, Hamashima Y, Hamayasu H, et al. Clinicopathological features of 15 occult and 178 clinical pancreatic ductal adenocarcinomas in 8339 autopsied elderly patients. Pancreas. 2016;45:234–40.
    • (2016) Pancreas , vol.45 , pp. 234-240
    • Matsuda, Y.1    Ishiwata, T.2    Yachida, S.3    Suzuki, A.4    Hamashima, Y.5    Hamayasu, H.6
  • 32
    • 28044467767 scopus 로고    scopus 로고
    • Management strategies for patients with hereditary pancreatic cancer
    • PID: 16107246
    • Brentnall TA. Management strategies for patients with hereditary pancreatic cancer. Curr Treat Options Oncol. 2005;6:437–45.
    • (2005) Curr Treat Options Oncol , vol.6 , pp. 437-445
    • Brentnall, T.A.1
  • 33
  • 34
    • 79954853231 scopus 로고    scopus 로고
    • Resection benefits older adults with locoregional pancreatic cancer despite greater short-term morbidity and mortality
    • PID: 21453378
    • Riall TS, Sheffield KM, Kuo Y-F, Townsend CM, Goodwin JS. Resection benefits older adults with locoregional pancreatic cancer despite greater short-term morbidity and mortality. J Am Geriatr Soc. 2011;59:647–54.
    • (2011) J Am Geriatr Soc , vol.59 , pp. 647-654
    • Riall, T.S.1    Sheffield, K.M.2    Kuo, Y.-F.3    Townsend, C.M.4    Goodwin, J.S.5
  • 35
    • 70350058926 scopus 로고    scopus 로고
    • What is the effect of age on pancreatic resection?
    • PID: 19845182
    • Riall TS. What is the effect of age on pancreatic resection? Adv Surg. 2009;43:233–49.
    • (2009) Adv Surg , vol.43 , pp. 233-249
    • Riall, T.S.1
  • 36
    • 33747507299 scopus 로고    scopus 로고
    • One thousand consecutive pancreaticoduodenectomies
    • PID: 16794383
    • Cameron JL, Riall TS, Coleman J, Belcher KA. One thousand consecutive pancreaticoduodenectomies. Ann Surg. 2006;244:10–5.
    • (2006) Ann Surg , vol.244 , pp. 10-15
    • Cameron, J.L.1    Riall, T.S.2    Coleman, J.3    Belcher, K.A.4
  • 37
    • 84925822210 scopus 로고    scopus 로고
    • Two thousand consecutive pancreaticoduodenectomies
    • PID: 25724606
    • Cameron JL, He J. Two thousand consecutive pancreaticoduodenectomies. J Am Coll Surg. 2015;220:530–6.
    • (2015) J Am Coll Surg , vol.220 , pp. 530-536
    • Cameron, J.L.1    He, J.2
  • 38
    • 0028805061 scopus 로고
    • Pancreatic or liver resection for malignancy is safe and effective for the elderly
    • COI: 1:STN:280:DyaK28%2FisFWitw%3D%3D, PID: 7574924
    • Fong Y, Blumgart LH, Fortner JG, Brennan MF. Pancreatic or liver resection for malignancy is safe and effective for the elderly. Ann Surg. 1995;222:426–34.
    • (1995) Ann Surg , vol.222 , pp. 426-434
    • Fong, Y.1    Blumgart, L.H.2    Fortner, J.G.3    Brennan, M.F.4
  • 39
    • 84872157016 scopus 로고    scopus 로고
    • Pancreatectomy for adenocarcinoma in elderly patients: postoperative outcomes and long term results: a study of the French Surgical Association
    • COI: 1:STN:280:DC%2BC38bptVKnsg%3D%3D, PID: 22999411, Large study composing of more than 900 patients in Europe with pancreatic cancer undergoing pancreatectomy showing similar postoperative mortality and morbidity rates in patients of three age groups: <70, 70–79, and ≥80 years
    • Turrini O, Paye F, Bachellier P, Sauvanet A, Sa Cunha A, Le Treut YP, et al. Pancreatectomy for adenocarcinoma in elderly patients: postoperative outcomes and long term results: a study of the French Surgical Association. Eur J Surg Oncol. 2013;39:171–8. Large study composing of more than 900 patients in Europe with pancreatic cancer undergoing pancreatectomy showing similar postoperative mortality and morbidity rates in patients of three age groups: <70, 70–79, and ≥80 years.
    • (2013) Eur J Surg Oncol , vol.39 , pp. 171-178
    • Turrini, O.1    Paye, F.2    Bachellier, P.3    Sauvanet, A.4    Sa Cunha, A.5    Le Treut, Y.P.6
  • 42
    • 84984549329 scopus 로고    scopus 로고
    • Outcome of pancreaticoduodenectomy in octogenarians: single institution’s experience and review of the literature
    • COI: 1:STN:280:DC%2BC2MbnslWjtg%3D%3D, PID: 26117303
    • Beltrame V, Gruppo M, Pastorelli D, Pedrazzoli S, Merigliano S, Sperti C. Outcome of pancreaticoduodenectomy in octogenarians: single institution’s experience and review of the literature. J Visc Surg. 2015;152:279–84.
    • (2015) J Visc Surg , vol.152 , pp. 279-284
    • Beltrame, V.1    Gruppo, M.2    Pastorelli, D.3    Pedrazzoli, S.4    Merigliano, S.5    Sperti, C.6
  • 46
    • 84863418364 scopus 로고    scopus 로고
    • Discharge disposition after pancreatic resection for malignancy: analysis of national trends
    • PID: 22321039
    • Shah BC, Smith LM, Ullrich F, Are C. Discharge disposition after pancreatic resection for malignancy: analysis of national trends. HPB. 2012;14:201–8.
    • (2012) HPB , vol.14 , pp. 201-208
    • Shah, B.C.1    Smith, L.M.2    Ullrich, F.3    Are, C.4
  • 47
    • 36148953846 scopus 로고    scopus 로고
    • Outcomes in octogenarians undergoing high-risk cancer operation: a national study
    • PID: 18035254
    • Finlayson E, Fan Z, Birkmeyer JD. Outcomes in octogenarians undergoing high-risk cancer operation: a national study. J Am Coll Surg. 2007;205:729–34.
    • (2007) J Am Coll Surg , vol.205 , pp. 729-734
    • Finlayson, E.1    Fan, Z.2    Birkmeyer, J.D.3
  • 49
    • 79960087885 scopus 로고    scopus 로고
    • Adjuvant chemoradiation therapy after pancreaticoduodenectomy in elderly patients with pancreatic adenocarcinoma
    • PID: 20643511
    • Horowitz DP, Hsu CC, Wang J, Makary MA, Winter JM, Robinson R, et al. Adjuvant chemoradiation therapy after pancreaticoduodenectomy in elderly patients with pancreatic adenocarcinoma. Int J Radiat Oncol Biol Phys. 2011;80:1391–7.
    • (2011) Int J Radiat Oncol Biol Phys , vol.80 , pp. 1391-1397
    • Horowitz, D.P.1    Hsu, C.C.2    Wang, J.3    Makary, M.A.4    Winter, J.M.5    Robinson, R.6
  • 52
    • 12144287320 scopus 로고    scopus 로고
    • A randomized trial of chemoradiotherapy and chemotherapy after resection of pancreatic cancer
    • COI: 1:CAS:528:DC%2BD2cXit12rtr8%3D, PID: 15028824
    • Neoptolemos JP, Stocken DD, Friess H, Bassi C, Dunn JA, Hickey H, et al. A randomized trial of chemoradiotherapy and chemotherapy after resection of pancreatic cancer. N Engl J Med. 2004;350:1200–10.
    • (2004) N Engl J Med , vol.350 , pp. 1200-1210
    • Neoptolemos, J.P.1    Stocken, D.D.2    Friess, H.3    Bassi, C.4    Dunn, J.A.5    Hickey, H.6
  • 53
    • 84885462618 scopus 로고    scopus 로고
    • Adjuvant chemotherapy with gemcitabine and long-term outcomes among patients with resected pancreatic cancer: the CONKO-001 randomized trial
    • COI: 1:CAS:528:DC%2BC3sXhs1Cnt7zJ, PID: 24104372, This trial established that adjuvant chemotherapy with gemcitabine provides survival benefit in the adjuvant setting
    • Oettle H, Neuhaus P, Hochhaus A, Hartmann JT, Gellert K, Ridwelski K, et al. Adjuvant chemotherapy with gemcitabine and long-term outcomes among patients with resected pancreatic cancer: the CONKO-001 randomized trial. JAMA. 2013;310:1473–81. This trial established that adjuvant chemotherapy with gemcitabine provides survival benefit in the adjuvant setting.
    • (2013) JAMA , vol.310 , pp. 1473-1481
    • Oettle, H.1    Neuhaus, P.2    Hochhaus, A.3    Hartmann, J.T.4    Gellert, K.5    Ridwelski, K.6
  • 54
    • 77956416112 scopus 로고    scopus 로고
    • Adjuvant chemotherapy with fluorouracil plus folinic acid vs gemcitabine following pancreatic cancer resection: a randomized controlled trial
    • COI: 1:CAS:528:DC%2BC3cXhtFequ7nE, PID: 20823433
    • Neoptolemos JP, Stocken DD, Bassi C, Ghaneh P, Cunningham D, Goldstein D, et al. Adjuvant chemotherapy with fluorouracil plus folinic acid vs gemcitabine following pancreatic cancer resection: a randomized controlled trial. JAMA. 2010;304:1073–81.
    • (2010) JAMA , vol.304 , pp. 1073-1081
    • Neoptolemos, J.P.1    Stocken, D.D.2    Bassi, C.3    Ghaneh, P.4    Cunningham, D.5    Goldstein, D.6
  • 55
    • 84980392144 scopus 로고    scopus 로고
    • ESPAC-4: a multicenter, international, open-label randomized controlled phase III trial of adjuvant combination chemotherapy of gemcitabine (GEM) and capecitabine (CAP) versus monotherapy gemcitabine in patients with resected pancreatic ductal adenocarcinoma
    • This large randomized study showed superiority of adjuvant gemcitabine with capecitabine over gemcitabine alone and may change standard of care
    • Neoptolemos JP, Palmer D, Ghaneh P, Valle JW, Cunningham D, Wadsley J, et al. ESPAC-4: a multicenter, international, open-label randomized controlled phase III trial of adjuvant combination chemotherapy of gemcitabine (GEM) and capecitabine (CAP) versus monotherapy gemcitabine in patients with resected pancreatic ductal adenocarcinoma. ASCO Meet Abstr. 2016;34:LBA4006. This large randomized study showed superiority of adjuvant gemcitabine with capecitabine over gemcitabine alone and may change standard of care.
    • (2016) ASCO Meet Abstr , vol.34 , pp. LBA4006
    • Neoptolemos, J.P.1    Palmer, D.2    Ghaneh, P.3    Valle, J.W.4    Cunningham, D.5    Wadsley, J.6
  • 56
    • 84982784622 scopus 로고    scopus 로고
    • Safety and feasibility of S-1 adjuvant chemotherapy for pancreatic cancer in elderly patients
    • Murakawa M, Aoyama T, Katayama Y, Asari M, Sawazaki S, Yamaoku K, et al. Safety and feasibility of S-1 adjuvant chemotherapy for pancreatic cancer in elderly patients. ASCO Meet Abstr. 2015;33:486.
    • (2015) ASCO Meet Abstr , vol.33 , pp. 486
    • Murakawa, M.1    Aoyama, T.2    Katayama, Y.3    Asari, M.4    Sawazaki, S.5    Yamaoku, K.6
  • 57
    • 0021867923 scopus 로고
    • Pancreatic cancer. Adjuvant combined radiation and chemotherapy following curative resection
    • COI: 1:STN:280:DyaL2M3ltFSnsQ%3D%3D
    • Kalser MH, Ellenberg SS. Pancreatic cancer. Adjuvant combined radiation and chemotherapy following curative resection. Arch Surg Chic Ill 1960. 1985;120:899–903.
    • (1985) Arch Surg Chic Ill 1960 , vol.120 , pp. 899-903
    • Kalser, M.H.1    Ellenberg, S.S.2
  • 58
    • 40449113435 scopus 로고    scopus 로고
    • Fluorouracil vs gemcitabine chemotherapy before and after fluorouracil-based chemoradiation following resection of pancreatic adenocarcinoma: a randomized controlled trial
    • COI: 1:CAS:528:DC%2BD1cXjtVSltL0%3D, PID: 18319412
    • Regine WF, Winter KA, Abrams RA, Safran H, Hoffman JP, Konski A, et al. Fluorouracil vs gemcitabine chemotherapy before and after fluorouracil-based chemoradiation following resection of pancreatic adenocarcinoma: a randomized controlled trial. JAMA. 2008;299:1019–26.
    • (2008) JAMA , vol.299 , pp. 1019-1026
    • Regine, W.F.1    Winter, K.A.2    Abrams, R.A.3    Safran, H.4    Hoffman, J.P.5    Konski, A.6
  • 59
    • 84898677292 scopus 로고    scopus 로고
    • Optimal duration and timing of adjuvant chemotherapy after definitive surgery for ductal adenocarcinoma of the pancreas: ongoing lessons from the ESPAC-3 study
    • This study showed that completion of all 6 cycles of adjuvant chemotherapy was more important than timing of adjuvant therapy
    • Valle JW, Palmer D, Jackson R, Cox T, Neoptolemos JP, Ghaneh P, et al. Optimal duration and timing of adjuvant chemotherapy after definitive surgery for ductal adenocarcinoma of the pancreas: ongoing lessons from the ESPAC-3 study. J Clin Oncol Off J Am Soc Clin Oncol. 2014;32:504–12. This study showed that completion of all 6 cycles of adjuvant chemotherapy was more important than timing of adjuvant therapy.
    • (2014) J Clin Oncol Off J Am Soc Clin Oncol , vol.32 , pp. 504-512
    • Valle, J.W.1    Palmer, D.2    Jackson, R.3    Cox, T.4    Neoptolemos, J.P.5    Ghaneh, P.6
  • 60
    • 34247252488 scopus 로고    scopus 로고
    • Systematic review, including meta-analyses, on the management of locally advanced pancreatic cancer using radiation/combined modality therapy
    • COI: 1:CAS:528:DC%2BD2sXkt1Gqtb4%3D, PID: 17406358
    • Sultana A, Tudur Smith C, Cunningham D, Starling N, Tait D, Neoptolemos JP, et al. Systematic review, including meta-analyses, on the management of locally advanced pancreatic cancer using radiation/combined modality therapy. Br J Cancer. 2007;96:1183–90.
    • (2007) Br J Cancer , vol.96 , pp. 1183-1190
    • Sultana, A.1    Tudur Smith, C.2    Cunningham, D.3    Starling, N.4    Tait, D.5    Neoptolemos, J.P.6
  • 61
    • 0142121292 scopus 로고    scopus 로고
    • Treatment of locally advanced pancreatic cancer in the real world: population-based practices and effectiveness
    • Krzyzanowska MK, Weeks JC, Earle CC. Treatment of locally advanced pancreatic cancer in the real world: population-based practices and effectiveness. J Clin Oncol Off J Am Soc Clin Oncol. 2003;21:3409–14.
    • (2003) J Clin Oncol Off J Am Soc Clin Oncol , vol.21 , pp. 3409-3414
    • Krzyzanowska, M.K.1    Weeks, J.C.2    Earle, C.C.3
  • 62
    • 23844511851 scopus 로고    scopus 로고
    • Chemoradiotherapy for locally advanced pancreatic carcinoma in elderly patients
    • COI: 1:CAS:528:DC%2BD2MXnvFyms70%3D, PID: 16020973
    • Morizane C, Okusaka T, Ito Y, Ueno H, Ikeda M, Takezako Y, et al. Chemoradiotherapy for locally advanced pancreatic carcinoma in elderly patients. Oncology. 2005;68:432–7.
    • (2005) Oncology , vol.68 , pp. 432-437
    • Morizane, C.1    Okusaka, T.2    Ito, Y.3    Ueno, H.4    Ikeda, M.5    Takezako, Y.6
  • 63
    • 80755143456 scopus 로고    scopus 로고
    • Gemcitabine alone versus gemcitabine plus radiotherapy in patients with locally advanced pancreatic cancer: an Eastern Cooperative Oncology Group trial
    • COI: 1:CAS:528:DC%2BC3MXhs1CisLzN
    • Loehrer PJ, Feng Y, Cardenes H, Wagner L, Brell JM, Cella D, et al. Gemcitabine alone versus gemcitabine plus radiotherapy in patients with locally advanced pancreatic cancer: an Eastern Cooperative Oncology Group trial. J Clin Oncol Off J Am Soc Clin Oncol. 2011;29:4105–12.
    • (2011) J Clin Oncol Off J Am Soc Clin Oncol , vol.29 , pp. 4105-4112
    • Loehrer, P.J.1    Feng, Y.2    Cardenes, H.3    Wagner, L.4    Brell, J.M.5    Cella, D.6
  • 64
    • 84884556143 scopus 로고    scopus 로고
    • Comparison of chemoradiotherapy (CRT) and chemotherapy (CT) in patients with a locally advanced pancreatic cancer (LAPC) controlled after 4 months of gemcitabine with or without erlotinib: final results of the international phase III LAP 07 study
    • This is the largest phase III trial to date comparing chemoradiotherapy to chemotherapy alone in locally advanced disease. This study showed no survival benefit with chemoradiation
    • Hammel P, Huguet F, Van Laethem J-L, Goldstein D, Glimelius B, Artru P, et al. Comparison of chemoradiotherapy (CRT) and chemotherapy (CT) in patients with a locally advanced pancreatic cancer (LAPC) controlled after 4 months of gemcitabine with or without erlotinib: final results of the international phase III LAP 07 study. ASCO Meet Abstr. 2013;31:LBA4003. This is the largest phase III trial to date comparing chemoradiotherapy to chemotherapy alone in locally advanced disease. This study showed no survival benefit with chemoradiation.
    • (2013) ASCO Meet Abstr , vol.31 , pp. LBA4003
    • Hammel, P.1    Huguet, F.2    Van Laethem, J.-L.3    Goldstein, D.4    Glimelius, B.5    Artru, P.6
  • 66
    • 84879117793 scopus 로고    scopus 로고
    • SBRT in unresectable advanced pancreatic cancer: preliminary results of a mono-institutional experience
    • Tozzi A, Comito T, Alongi F, Navarria P, Iftode C, Mancosu P, et al. SBRT in unresectable advanced pancreatic cancer: preliminary results of a mono-institutional experience. Radiat Oncol Lond Engl. 2013;8:148.
    • (2013) Radiat Oncol Lond Engl , vol.8 , pp. 148
    • Tozzi, A.1    Comito, T.2    Alongi, F.3    Navarria, P.4    Iftode, C.5    Mancosu, P.6
  • 68
    • 84880635783 scopus 로고    scopus 로고
    • Stereotactic body radiation therapy for locally advanced and borderline resectable pancreatic cancer is effective and well tolerated
    • This is one of the larger series on the effectiveness of SBRT in locally advanced and borderline resectable pancreatic cancer
    • Chuong MD, Springett GM, Freilich JM, Park CK, Weber JM, Mellon EA, et al. Stereotactic body radiation therapy for locally advanced and borderline resectable pancreatic cancer is effective and well tolerated. Int J Radiat Oncol. 2013;86:516–22. This is one of the larger series on the effectiveness of SBRT in locally advanced and borderline resectable pancreatic cancer.
    • (2013) Int J Radiat Oncol , vol.86 , pp. 516-522
    • Chuong, M.D.1    Springett, G.M.2    Freilich, J.M.3    Park, C.K.4    Weber, J.M.5    Mellon, E.A.6
  • 69
    • 67649207663 scopus 로고    scopus 로고
    • Pretreatment assessment of resectable and borderline resectable pancreatic cancer: expert consensus statement
    • PID: 19396496
    • Callery MP, Chang KJ, Fishman EK, Talamonti MS, William Traverso L, Linehan DC. Pretreatment assessment of resectable and borderline resectable pancreatic cancer: expert consensus statement. Ann Surg Oncol. 2009;16:1727–33.
    • (2009) Ann Surg Oncol , vol.16 , pp. 1727-1733
    • Callery, M.P.1    Chang, K.J.2    Fishman, E.K.3    Talamonti, M.S.4    William Traverso, L.5    Linehan, D.C.6
  • 70
    • 43049106807 scopus 로고    scopus 로고
    • Borderline resectable pancreatic cancer: the importance of this emerging stage of disease
    • PID: 18471707
    • Katz MHG, Pisters PWT, Evans DB, Sun CC, Lee JE, Fleming JB, et al. Borderline resectable pancreatic cancer: the importance of this emerging stage of disease. J Am Coll Surg. 2008;206:833–46.
    • (2008) J Am Coll Surg , vol.206 , pp. 833-846
    • Katz, M.H.G.1    Pisters, P.W.T.2    Evans, D.B.3    Sun, C.C.4    Lee, J.E.5    Fleming, J.B.6
  • 72
    • 80052293264 scopus 로고    scopus 로고
    • Neoadjuvant therapy in pancreatic adenocarcinoma: a meta-analysis of phase II trials
    • PID: 21878232
    • Assifi MM, Lu X, Eibl G, Reber HA, Li G, Hines OJ. Neoadjuvant therapy in pancreatic adenocarcinoma: a meta-analysis of phase II trials. Surgery. 2011;150:466–73.
    • (2011) Surgery , vol.150 , pp. 466-473
    • Assifi, M.M.1    Lu, X.2    Eibl, G.3    Reber, H.A.4    Li, G.5    Hines, O.J.6
  • 73
    • 84947023760 scopus 로고    scopus 로고
    • Use of neoadjuvant therapy in patients 75 years of age and older with pancreatic cancer
    • PID: 26243342, This study showed that older patients can derive similar benefits from neoadjuvant therapy compared to younger patients in resectable or borderline resectable pancreatic cancer
    • Miura JT, Krepline AN, George B, Ritch PS, Erickson BA, Johnston FM, et al. Use of neoadjuvant therapy in patients 75 years of age and older with pancreatic cancer. Surgery. 2015;158:1545–55. This study showed that older patients can derive similar benefits from neoadjuvant therapy compared to younger patients in resectable or borderline resectable pancreatic cancer.
    • (2015) Surgery , vol.158 , pp. 1545-1555
    • Miura, J.T.1    Krepline, A.N.2    George, B.3    Ritch, P.S.4    Erickson, B.A.5    Johnston, F.M.6
  • 74
    • 84861465672 scopus 로고    scopus 로고
    • A retrospective study of neoadjuvant FOLFIRINOX in unresectable or borderline-resectable locally advanced pancreatic adenocarcinoma
    • COI: 1:CAS:528:DC%2BC38XhtFamsrnF, PID: 22642850
    • Hosein PJ, Macintyre J, Kawamura C, Maldonado JC, Ernani V, Loaiza-Bonilla A, et al. A retrospective study of neoadjuvant FOLFIRINOX in unresectable or borderline-resectable locally advanced pancreatic adenocarcinoma. BMC Cancer. 2012;12:199.
    • (2012) BMC Cancer , vol.12 , pp. 199
    • Hosein, P.J.1    Macintyre, J.2    Kawamura, C.3    Maldonado, J.C.4    Ernani, V.5    Loaiza-Bonilla, A.6
  • 75
    • 84896486447 scopus 로고    scopus 로고
    • Neoadjuvant FOLFIRINOX for borderline resectable pancreas cancer: a new treatment paradigm?
    • COI: 1:CAS:528:DC%2BC2cXosFCktLw%3D, PID: 24569947
    • Christians KK, Tsai S, Mahmoud A, Ritch P, Thomas JP, Wiebe L, et al. Neoadjuvant FOLFIRINOX for borderline resectable pancreas cancer: a new treatment paradigm? Oncologist. 2014;19:266–74.
    • (2014) Oncologist , vol.19 , pp. 266-274
    • Christians, K.K.1    Tsai, S.2    Mahmoud, A.3    Ritch, P.4    Thomas, J.P.5    Wiebe, L.6
  • 77
    • 84923848673 scopus 로고    scopus 로고
    • Neoadjuvant modified (m) FOLFIRINOX for locally advanced unresectable (LAPC) and borderline resectable (BRPC) adenocarcinoma of the pancreas
    • PID: 25358667, Although effective, FOLFIRINOX has significant toxicity. This study described the experience with a modified FOLFIRINOX regimen in the neoadjuvant setting and showed that it is an effective and well-tolerated regimen
    • Blazer M, Wu C, Goldberg RM, Phillips G, Schmidt C, Muscarella P, et al. Neoadjuvant modified (m) FOLFIRINOX for locally advanced unresectable (LAPC) and borderline resectable (BRPC) adenocarcinoma of the pancreas. Ann Surg Oncol. 2015;22:1153–9. Although effective, FOLFIRINOX has significant toxicity. This study described the experience with a modified FOLFIRINOX regimen in the neoadjuvant setting and showed that it is an effective and well-tolerated regimen.
    • (2015) Ann Surg Oncol , vol.22 , pp. 1153-1159
    • Blazer, M.1    Wu, C.2    Goldberg, R.M.3    Phillips, G.4    Schmidt, C.5    Muscarella, P.6
  • 78
    • 84964684411 scopus 로고    scopus 로고
    • Preoperative modified FOLFIRINOX (mFOLFIRINOX) followed by chemoradiation (CRT) for borderline resectable (BLR) pancreatic cancer (PDAC): initial results from Alliance Trial A021101
    • Katz MHG, Shi Q, Ahmad SA, Herman JM, Marsh R de w, Collisson EA, et al. Preoperative modified FOLFIRINOX (mFOLFIRINOX) followed by chemoradiation (CRT) for borderline resectable (BLR) pancreatic cancer (PDAC): initial results from Alliance Trial A021101. ASCO Meet Abstr. 2015;33:4008.
    • (2015) ASCO Meet Abstr , vol.33 , pp. 4008
    • Katz, M.H.G.1    Shi, Q.2    Ahmad, S.A.3    Herman, J.M.4    Marsh, R.5    Collisson, E.A.6
  • 79
    • 84997177984 scopus 로고    scopus 로고
    • Phase II study of preoperation mFOLFIRINOX and chemoradiation for high-risk resectable and borderline resectable pancreatic adenocarcinoma
    • Varadhachary GR, Fleming JB, Crane CH, Fogelman DR, Shroff RT, Lee JE, et al. Phase II study of preoperation mFOLFIRINOX and chemoradiation for high-risk resectable and borderline resectable pancreatic adenocarcinoma. ASCO Meet Abstr. 2015;33:362.
    • (2015) ASCO Meet Abstr , vol.33 , pp. 362
    • Varadhachary, G.R.1    Fleming, J.B.2    Crane, C.H.3    Fogelman, D.R.4    Shroff, R.T.5    Lee, J.E.6
  • 80
    • 84939456074 scopus 로고    scopus 로고
    • Capello M, Lee M, Wang H, Babel I, Katz MH, Fleming JB, et al. Carboxylesterase 2 as a determinant of response to irinotecan and neoadjuvant FOLFIRINOX therapy in pancreatic ductal adenocarcinoma. J Natl Cancer Inst. 2015;107:djv132
    • Capello M, Lee M, Wang H, Babel I, Katz MH, Fleming JB, et al. Carboxylesterase 2 as a determinant of response to irinotecan and neoadjuvant FOLFIRINOX therapy in pancreatic ductal adenocarcinoma. J Natl Cancer Inst. 2015;107:djv132.
  • 81
    • 84927132764 scopus 로고    scopus 로고
    • Intensified neoadjuvant chemotherapy with nab-paclitaxel plus gemcitabine followed by FOLFIRINOX in a patient with locally advanced unresectable pancreatic cancer
    • COI: 1:CAS:528:DC%2BC2cXitVymsr%2FF, PID: 25408659
    • Kunzmann V, Herrmann K, Bluemel C, Kapp M, Hartlapp I, Steger U. Intensified neoadjuvant chemotherapy with nab-paclitaxel plus gemcitabine followed by FOLFIRINOX in a patient with locally advanced unresectable pancreatic cancer. Case Rep Oncol. 2014;7:648–55.
    • (2014) Case Rep Oncol , vol.7 , pp. 648-655
    • Kunzmann, V.1    Herrmann, K.2    Bluemel, C.3    Kapp, M.4    Hartlapp, I.5    Steger, U.6
  • 82
    • 84982853217 scopus 로고    scopus 로고
    • Mar 4]
    • Trial to investigate intensified neoadjuvant chemotherapy in locally advanced pancreatic cancer—full text view—ClinicalTrials.gov [Internet]. [cited 2016 Mar 4]. Available from: https://clinicaltrials.gov/ct2/show/NCT02125136.
    • (2016) Available from:
  • 83
    • 84925874126 scopus 로고    scopus 로고
    • Prognostic factors in metastatic pancreatic cancer: older patients are associated with reduced overall survival
    • COI: 1:CAS:528:DC%2BC3sXht1WktL%2FF, PID: 24649248
    • Tas F, Sen F, Keskin S, Kilic L, Yildiz I. Prognostic factors in metastatic pancreatic cancer: older patients are associated with reduced overall survival. Mol Clin Oncol. 2013;1:788–92.
    • (2013) Mol Clin Oncol , vol.1 , pp. 788-792
    • Tas, F.1    Sen, F.2    Keskin, S.3    Kilic, L.4    Yildiz, I.5
  • 84
    • 41149162302 scopus 로고    scopus 로고
    • Tolerance and efficacy of gemcitabine and gemcitabine-based regimens in elderly patients with advanced pancreatic cancer
    • PID: 18362833
    • Maréchal R, Demols A, Gay F, de Maertelaer V, Arvanitaki M, Hendlisz A, et al. Tolerance and efficacy of gemcitabine and gemcitabine-based regimens in elderly patients with advanced pancreatic cancer. Pancreas. 2008;36:e16–21.
    • (2008) Pancreas , vol.36 , pp. e16-e21
    • Maréchal, R.1    Demols, A.2    Gay, F.3    de Maertelaer, V.4    Arvanitaki, M.5    Hendlisz, A.6
  • 85
    • 79958728624 scopus 로고    scopus 로고
    • Role of chemotherapy in the very elderly patients with metastatic pancreatic cancer—a Veterans Affairs Cancer Registry analysis
    • Aldoss IT, Tashi T, Gonsalves W, Kalaiah RK, Fang X, Silberstein P, et al. Role of chemotherapy in the very elderly patients with metastatic pancreatic cancer—a Veterans Affairs Cancer Registry analysis. J Geriatr Oncol. 2011;2:209–14.
    • (2011) J Geriatr Oncol , vol.2 , pp. 209-214
    • Aldoss, I.T.1    Tashi, T.2    Gonsalves, W.3    Kalaiah, R.K.4    Fang, X.5    Silberstein, P.6
  • 86
    • 8244254377 scopus 로고    scopus 로고
    • Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial
    • COI: 1:CAS:528:DyaK2sXlsFKksLY%3D
    • Burris HA, Moore MJ, Andersen J, Green MR, Rothenberg ML, Modiano MR, et al. Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial. J Clin Oncol Off J Am Soc Clin Oncol. 1997;15:2403–13.
    • (1997) J Clin Oncol Off J Am Soc Clin Oncol , vol.15 , pp. 2403-2413
    • Burris, H.A.1    Moore, M.J.2    Andersen, J.3    Green, M.R.4    Rothenberg, M.L.5    Modiano, M.R.6
  • 87
    • 79955921754 scopus 로고    scopus 로고
    • FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer
    • COI: 1:CAS:528:DC%2BC3MXlvF2jsrw%3D, PID: 21561347
    • Conroy T, Desseigne F, Ychou M, Bouché O, Guimbaud R, Bécouarn Y, et al. FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer. N Engl J Med. 2011;364:1817–25.
    • (2011) N Engl J Med , vol.364 , pp. 1817-1825
    • Conroy, T.1    Desseigne, F.2    Ychou, M.3    Bouché, O.4    Guimbaud, R.5    Bécouarn, Y.6
  • 88
    • 84969323019 scopus 로고    scopus 로고
    • Safety and efficacy of modified dose-attenuated FOLFIRINOX chemotherapy in patients over 65 years with advanced pancreatic adenocarcinoma
    • This study suggested that in older adults, the modified FOLFIRINOX regimen can be a reasonable option in advanced pancreatic cancer
    • Alessandretti MB, Moreira RB, Brandao EP, Gomes JR, Amarante MPF, Lino ADR, et al. Safety and efficacy of modified dose-attenuated FOLFIRINOX chemotherapy in patients over 65 years with advanced pancreatic adenocarcinoma. ASCO Meet Abstr. 2015;33:468. This study suggested that in older adults, the modified FOLFIRINOX regimen can be a reasonable option in advanced pancreatic cancer.
    • (2015) ASCO Meet Abstr , vol.33 , pp. 468
    • Alessandretti, M.B.1    Moreira, R.B.2    Brandao, E.P.3    Gomes, J.R.4    Amarante, M.P.F.5    Lino, A.D.R.6
  • 89
    • 84982787731 scopus 로고    scopus 로고
    • Feb 15]
    • Efficacy and tolerance evaluation in FOLFIRINOX dose adjusted in elderly patients with a metastatic pancreatic cancer—full text view—ClinicalTrials.gov [Internet]. [cited 2016 Feb 15]. Available from: https://clinicaltrials.gov/ct2/show/NCT02143219.
    • (2016) Available from:
  • 90
    • 84886741654 scopus 로고    scopus 로고
    • Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine
    • This is a phase III randomized study which showed survival benefit of adding nab-paclitaxel to gemcitabine and is one of the most important recent trials, along with the FOLFIRINOX study by Conroy et al., to have changed the paradigm of treatment in advanced pancreatic cancer
    • Von Hoff DD, Ervin T, Arena FP, Chiorean EG, Infante J, Moore M, et al. Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine. N Engl J Med. 2013;369:1691–703. This is a phase III randomized study which showed survival benefit of adding nab-paclitaxel to gemcitabine and is one of the most important recent trials, along with the FOLFIRINOX study by Conroy et al., to have changed the paradigm of treatment in advanced pancreatic cancer.
    • (2013) N Engl J Med , vol.369 , pp. 1691-1703
    • Von Hoff, D.D.1    Ervin, T.2    Arena, F.P.3    Chiorean, E.G.4    Infante, J.5    Moore, M.6
  • 91
    • 84982789685 scopus 로고    scopus 로고
    • Nab-paclitaxel (Nab-P) and gemcitabine (G) as first-line chemotherapy (CT) in advanced pancreatic cancer (APDAC) elderly patients (pts): a “real-life” study
    • Giordano G, Vaccaro V, Lucchini E, Musettini G, Bertocchi P, Bergamo F, et al. Nab-paclitaxel (Nab-P) and gemcitabine (G) as first-line chemotherapy (CT) in advanced pancreatic cancer (APDAC) elderly patients (pts): a “real-life” study. ASCO Meet Abstr. 2015;33:424.
    • (2015) ASCO Meet Abstr , vol.33 , pp. 424
    • Giordano, G.1    Vaccaro, V.2    Lucchini, E.3    Musettini, G.4    Bertocchi, P.5    Bergamo, F.6
  • 92
    • 84962628352 scopus 로고    scopus 로고
    • Modified gemcitabine and nab-paclitaxel in patients with metastatic pancreatic cancer (MPC): a single-institution experience
    • Krishna K, Blazer MA, Wei L, Ahn DH, Wu CS-Y, Ciombor KK, et al. Modified gemcitabine and nab-paclitaxel in patients with metastatic pancreatic cancer (MPC): a single-institution experience. ASCO Meet Abstr. 2015;33:366.
    • (2015) ASCO Meet Abstr , vol.33 , pp. 366
    • Krishna, K.1    Blazer, M.A.2    Wei, L.3    Ahn, D.H.4    Wu, C.S.-Y.5    Ciombor, K.K.6
  • 93
    • 84871723767 scopus 로고    scopus 로고
    • Impact of FOLFIRINOX compared with gemcitabine on quality of life in patients with metastatic pancreatic cancer: results from the PRODIGE 4/ACCORD 11 randomized trial
    • COI: 1:CAS:528:DC%2BC3sXitFalt7k%3D
    • Gourgou-Bourgade S, Bascoul-Mollevi C, Desseigne F, Ychou M, Bouché O, Guimbaud R, et al. Impact of FOLFIRINOX compared with gemcitabine on quality of life in patients with metastatic pancreatic cancer: results from the PRODIGE 4/ACCORD 11 randomized trial. J Clin Oncol Off J Am Soc Clin Oncol. 2013;31:23–9.
    • (2013) J Clin Oncol Off J Am Soc Clin Oncol , vol.31 , pp. 23-29
    • Gourgou-Bourgade, S.1    Bascoul-Mollevi, C.2    Desseigne, F.3    Ychou, M.4    Bouché, O.5    Guimbaud, R.6
  • 94
    • 84959459386 scopus 로고    scopus 로고
    • Nanoliposomal irinotecan with fluorouracil and folinic acid in metastatic pancreatic cancer after previous gemcitabine-based therapy (NAPOLI-1): a global, randomised, open-label, phase 3 trial
    • COI: 1:CAS:528:DC%2BC2MXhvV2jsrzF, This phase III study of 417 patients showed survival benefit of adding nanoliposomal irinotecan in combination with fluorouracil and folinic acid in patients previously treated with gemcitabine-based therapy. This study led to the approval of nanoliposomal irinotecan by the FDA for this indication
    • Wang-Gillam A, Li C-P, Bodoky G, Dean A, Shan Y-S, Jameson G, et al. Nanoliposomal irinotecan with fluorouracil and folinic acid in metastatic pancreatic cancer after previous gemcitabine-based therapy (NAPOLI-1): a global, randomised, open-label, phase 3 trial. Lancet Lond Engl. 2016;387:545–57. This phase III study of 417 patients showed survival benefit of adding nanoliposomal irinotecan in combination with fluorouracil and folinic acid in patients previously treated with gemcitabine-based therapy. This study led to the approval of nanoliposomal irinotecan by the FDA for this indication.
    • (2016) Lancet Lond Engl , vol.387 , pp. 545-557
    • Wang-Gillam, A.1    Li, C.-P.2    Bodoky, G.3    Dean, A.4    Shan, Y.-S.5    Jameson, G.6
  • 95
    • 84942988759 scopus 로고    scopus 로고
    • Nab-paclitaxel plus gemcitabine for metastatic pancreatic adenocarcinoma after Folfirinox failure: an AGEO prospective multicentre cohort
    • COI: 1:CAS:528:DC%2BC2MXhsFGiurnP, PID: 26372701
    • Portal A, Pernot S, Tougeron D, Arbaud C, Bidault AT, de la Fouchardière C, et al. Nab-paclitaxel plus gemcitabine for metastatic pancreatic adenocarcinoma after Folfirinox failure: an AGEO prospective multicentre cohort. Br J Cancer. 2015;113:989–95.
    • (2015) Br J Cancer , vol.113 , pp. 989-995
    • Portal, A.1    Pernot, S.2    Tougeron, D.3    Arbaud, C.4    Bidault, A.T.5    de la Fouchardière, C.6
  • 96
    • 84962474657 scopus 로고    scopus 로고
    • PANOVA: a pilot study of TTFields concomitant with gemcitabine for front-line therapy in patients with advanced pancreatic adenocarcinoma
    • Rivera F, Gallego J, Guillen C, Benavides M, Lopez-Martin JA, Betticher DC, et al. PANOVA: a pilot study of TTFields concomitant with gemcitabine for front-line therapy in patients with advanced pancreatic adenocarcinoma. ASCO Meet Abstr. 2016;34:269.
    • (2016) ASCO Meet Abstr , vol.34 , pp. 269
    • Rivera, F.1    Gallego, J.2    Guillen, C.3    Benavides, M.4    Lopez-Martin, J.A.5    Betticher, D.C.6
  • 97
    • 84929431322 scopus 로고    scopus 로고
    • Safety and survival with GVAX pancreas prime and Listeria monocytogenes-expressing mesothelin (CRS-207) boost vaccines for metastatic pancreatic cancer
    • COI: 1:CAS:528:DC%2BC2MXhtVaqtL7O
    • Le DT, Wang-Gillam A, Picozzi V, Greten TF, Crocenzi T, Springett G, et al. Safety and survival with GVAX pancreas prime and Listeria monocytogenes-expressing mesothelin (CRS-207) boost vaccines for metastatic pancreatic cancer. J Clin Oncol Off J Am Soc Clin Oncol. 2015;33:1325–33.
    • (2015) J Clin Oncol Off J Am Soc Clin Oncol , vol.33 , pp. 1325-1333
    • Le, D.T.1    Wang-Gillam, A.2    Picozzi, V.3    Greten, T.F.4    Crocenzi, T.5    Springett, G.6
  • 98
    • 84982866559 scopus 로고    scopus 로고
    • Neoadjuvant/adjuvant GVAX pancreas vaccine (with CY) with or without nivolumab trial for surgically resectable pancreatic cancer—full text view—ClinicalTrials.gov [Internet]. [cited 2016 Mar 3]. Available from
    • Neoadjuvant/adjuvant GVAX pancreas vaccine (with CY) with or without nivolumab trial for surgically resectable pancreatic cancer—full text view—ClinicalTrials.gov [Internet]. [cited 2016 Mar 3]. Available from: https://clinicaltrials.gov/ct2/show/NCT02451982?term=pancreatic+pd1&rank=2.
  • 99
    • 84982864247 scopus 로고    scopus 로고
    • Safety study of nivolumab with nab-paclitaxel plus or minus gemcitabine in pancreatic cancer, nab-paclitaxel/carboplatin in stage IIIb/IV non-small cell lung cancer or nab-paclitaxel in recurrent metastatic breast cancer—full text view—ClinicalTrials.gov [Internet]. [cited 2016 Mar 3]. Available from
    • Safety study of nivolumab with nab-paclitaxel plus or minus gemcitabine in pancreatic cancer, nab-paclitaxel/carboplatin in stage IIIb/IV non-small cell lung cancer or nab-paclitaxel in recurrent metastatic breast cancer—full text view—ClinicalTrials.gov [Internet]. [cited 2016 Mar 3]. Available from: https://clinicaltrials.gov/ct2/show/NCT02309177?term=pancreatic+pd1&rank=5.
  • 100
    • 84982864248 scopus 로고    scopus 로고
    • Mar 3]
    • Safety and immunological effect of pembrolizumab in resectable or borderline resectable pancreatic cancer—full text view—ClinicalTrials.gov [Internet]. [cited 2016 Mar 3]. Available from: https://clinicaltrials.gov/ct2/show/NCT02305186.
    • (2016) Available from:
  • 101
    • 84982812469 scopus 로고    scopus 로고
    • Mar 3]
    • WHO | WHO’s cancer pain ladder for adults [Internet]. WHO. [cited 2016 Mar 3]. Available from: http://www.who.int/cancer/palliative/painladder/en/.
    • (2016) Available from:
  • 102
    • 80052997944 scopus 로고    scopus 로고
    • Randomized, double-blind, controlled trial of early endoscopic ultrasound-guided celiac plexus neurolysis to prevent pain progression in patients with newly diagnosed, painful, inoperable pancreatic cancer
    • Wyse JM, Carone M, Paquin SC, Usatii M, Sahai AV. Randomized, double-blind, controlled trial of early endoscopic ultrasound-guided celiac plexus neurolysis to prevent pain progression in patients with newly diagnosed, painful, inoperable pancreatic cancer. J Clin Oncol Off J Am Soc Clin Oncol. 2011;29:3541–6.
    • (2011) J Clin Oncol Off J Am Soc Clin Oncol , vol.29 , pp. 3541-3546
    • Wyse, J.M.1    Carone, M.2    Paquin, S.C.3    Usatii, M.4    Sahai, A.V.5
  • 103
    • 33645458244 scopus 로고    scopus 로고
    • Long-term outcome of biliary and duodenal stents in palliative treatment of patients with unresectable adenocarcinoma of the head of pancreas
    • PID: 16635221
    • Maire F, Hammel P, Ponsot P, Aubert A, O’Toole D, Hentic O, et al. Long-term outcome of biliary and duodenal stents in palliative treatment of patients with unresectable adenocarcinoma of the head of pancreas. Am J Gastroenterol. 2006;101:735–42.
    • (2006) Am J Gastroenterol , vol.101 , pp. 735-742
    • Maire, F.1    Hammel, P.2    Ponsot, P.3    Aubert, A.4    O’Toole, D.5    Hentic, O.6
  • 104
    • 84995804523 scopus 로고    scopus 로고
    • Endoscopic stenting versus operative gastrojejunostomy for malignant gastric outlet obstruction-a systematic review and meta-analysis of randomized and non-randomized trials
    • PID: 24772336
    • Nagaraja V, Eslick GD, Cox MR. Endoscopic stenting versus operative gastrojejunostomy for malignant gastric outlet obstruction-a systematic review and meta-analysis of randomized and non-randomized trials. J Gastrointest Oncol. 2014;5:92–8.
    • (2014) J Gastrointest Oncol , vol.5 , pp. 92-98
    • Nagaraja, V.1    Eslick, G.D.2    Cox, M.R.3
  • 105
    • 43449115194 scopus 로고    scopus 로고
    • Development and validation of a predictive model for chemotherapy-associated thrombosis
    • COI: 1:CAS:528:DC%2BD1cXmtlaiur8%3D, PID: 18216292
    • Khorana AA, Kuderer NM, Culakova E, Lyman GH, Francis CW. Development and validation of a predictive model for chemotherapy-associated thrombosis. Blood. 2008;111:4902–7.
    • (2008) Blood , vol.111 , pp. 4902-4907
    • Khorana, A.A.1    Kuderer, N.M.2    Culakova, E.3    Lyman, G.H.4    Francis, C.W.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.