Clinicopathological Features of 15 Occult and 178 Clinical Pancreatic Ductal Adenocarcinomas in 8339 Autopsied Elderly Patients

Pancreas

Volumn 45, Issue 2, 2016, Pages 234-240

  Matsuda, Yoko ^a   Ishiwata, Toshiyuki ^b   Yachida, Shinichi ^c   Suzuki, Akemi ^a   Hamashima, Yuri ^a   Hamayasu, Hideki ^a   Yoshimura, Hisashi ^b   Honma, Naoko ^a   Aida, Junko ^a   Takubo, Kaiyo ^a   Arai, Tomio ^a  

^a Tokyo Metropolitan Institute of Gerontology   (Japan)

^b NIPPON MEDICAL SCHOOL   (Japan)

^c NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

Author keywords

aging; autopsy; occult cancer; pancreatic cancer

Indexed keywords

HYALIN; MUCIN 1; MUCIN 2;

ADIPOSE TISSUE; ADVANCED CANCER; AGE; AGED; ARTICLE; AUTOPSY; CANCER SIZE; CANCER SURVIVAL; CLINICAL FEATURE; DISTANT METASTASIS; FEMALE; GERIATRIC PATIENT; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INCIDENTAL FINDING; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; MICROSCOPY; NERVE PLEXUS; OCCULT CANCER; PANCREAS ADENOCARCINOMA; PANCREAS NECROSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RETROSPECTIVE STUDY; STROMA; TUMOR INVASION; TUMOR NECROSIS; VERY ELDERLY; DISEASE COURSE; MIDDLE AGED; PANCREAS; PANCREAS CARCINOMA; PANCREAS TUMOR; PATHOLOGY; STATISTICS AND NUMERICAL DATA; SURVIVAL ANALYSIS; TUMOR VOLUME;

AGE FACTORS; AGED; AGED, 80 AND OVER; AUTOPSY; CARCINOMA, PANCREATIC DUCTAL; DISEASE PROGRESSION; FEMALE; HUMANS; MALE; MIDDLE AGED; NEOPLASM INVASIVENESS; PANCREAS; PANCREATIC NEOPLASMS; RETROSPECTIVE STUDIES; SURVIVAL ANALYSIS; TUMOR BURDEN;

EID: 84955743598     PISSN: 08853177     EISSN: 15364828     Source Type: Journal    
DOI: 10.1097/MPA.0000000000000447     Document Type: Article

References (26)

1. Siegel R, Ma J, Zou Z, Cancer statistics, 2014. CA Cancer J Clin. 2014; 64: 9-29.
2. Warshaw AL, Fernández-del Castillo C,. Pancreatic carcinoma. N Engl J Med. 1992; 326: 455-465.
3. Bidoli E, Fratino L, Bruzzone S, Time trends of cancer mortality among elderly in Italy, 1970-2008: an observational study. BMC Cancer. 2012; 12: 443.
4. Foundation for Promotion of Cancer Research. Available at: http://ganjoho.jp/data/professional/statistics/backnumber/2013/cancer-statistics-2013.pdf. Accessed April 28, 2014.
5. Pandol S, Gukovskaya A, Edderkaoui M, Epidemiology, risk factors, and the promotion of pancreatic cancer: role of the stellate cell. J Gastroenterol Hepatol. 2012; 27 (suppl 2): 127-134.
6. Lillemoe KD, Yeo CJ, Cameron JL,. Pancreatic cancer: state-of-the-art care. CA Cancer J Clin. 2000; 50: 241-268.
7. Arai T, Takubo K,. Clinicopathological and molecular characteristics of gastric and colorectal carcinomas in the elderly. Pathol Int. 2007; 57: 303-314.
8. DePinho RA,. The age of cancer. Nature. 2000; 408: 248-254.
9. Yachida S, Jones S, Bozic I, Distant metastasis occurs late during the genetic evolution of pancreatic cancer. Nature. 2010; 467: 1114-1117.
10. Arai T, Sakurai U, Sawabe M, Pathologic characteristics of malignant neoplasms occurring in the elderly. Gan To Kagaku Ryoho. 2011; 38: 1571-1576.
11. DeGregori J,. Challenging the axiom: does the occurrence of oncogenic mutations truly limit cancer development with age? Oncogene. 2012; 32: 1869-1875.
12. Ahrendt SA, Pitt HA,. Surgical management of pancreatic cancer. Oncology (Williston Park). 2002; 16: 725-734.
13. Iacobuzio-Donahue CA, Fu B, Yachida S, DPC4 gene status of the primary carcinoma correlates with patterns of failure in patients with pancreatic cancer. J Clin Oncol. 2009; 27: 1806-1813.
14. Hruban RH, Boffetta P, Hiraoka N, Tumours of the pancreas. In: Bosman FT, Carneiro F, Hruban RH, eds. Who Classification of Tumours of the Digestive System. Lyon: IARC Press; 2010.
15. Arai T, Sawabe M, Takubo K, Multiple colorectal cancers in the elderly: a retrospective study of both surgical and autopsy cases. J Gastroenterol. 2001; 36: 748-752.
16. Winter JM, Tang LH, Klimstra DS, A novel survival-based tissue microarray of pancreatic cancer validates MUC1 and mesothelin as biomarkers. PLoS One. 2012; 7: e40157.
17. Matsuda Y, Hagio M, Naito Z, Clinicopathological features of 30 autopsy cases of pancreatic carcinoma. J Nippon Med Sch. 2012; 79: 459-467.
18. Mao C, Domenico DR, Kim K, Observations on the developmental patterns and the consequences of pancreatic exocrine adenocarcinoma. Findings of 154 autopsies. Arch Surg. 1995; 130: 125-134.
19. Ogren M, Bergqvist D, Wåhlander K, Trousseau's syndrome-what is the evidence? A population-based autopsy study. Thromb Haemost. 2006; 95: 541-545.
20. Campbell PJ, Yachida S, Mudie LJ, The patterns and dynamics of genomic instability in metastatic pancreatic cancer. Nature. 2010; 467: 1109-1113.
21. Tas F, Sen F, Keskin S, Prognostic factors in metastatic pancreatic cancer: older patients are associated with reduced overall survival. Mol Clin Oncol. 2013; 1: 788-792.
22. Sehgal R, Alsharedi M, Larck C, Pancreatic cancer survival in elderly patients treated with chemotherapy. Pancreas. 2014; 43: 306-310.
23. Madura JA, Jarman BT, Doherty MG, Adenosquamous carcinoma of the pancreas. Arch Surg. 1999; 134: 599-603.
24. Boyd CA, Benarroch-Gampel J, Sheffield KM, 415 patients with adenosquamous carcinoma of the pancreas: a population-based analysis of prognosis and survival. J Surg Res. 2012; 174: 12-19.
25. Paal E, Thompson LD, Frommelt RA, A clinicopathologic and immunohistochemical study of 35 anaplastic carcinomas of the pancreas with a review of the literature. Ann Diagn Pathol. 2001; 5: 129-140.
26. Krasinskas AM, Moser AJ, Saka B, KRAS mutant allele-specific imbalance is associated with worse prognosis in pancreatic cancer and progression to undifferentiated carcinoma of the pancreas. Mod Pathol. 2013; 26: 1346-1354.