Effective molecular targeting of CDK4/6 and IGF-1R in a rare FUS-ERG fusion CDKN2A-deletion doxorubicin-resistant Ewing's sarcoma patient-derived orthotopic xenograft (PDOX) nudemouse model

Oncotarget

Volumn 7, Issue 30, 2016, Pages 47556-47564

  Murakami, Takashi ^a,b,c   Singh, Arun S ^d   Kiyuna, Tasuku ^a   Dry, Sarah M ^d   Li, Yunfeng ^d   James, Aaron W ^d   Igarashi, Kentaro ^a   Kawaguchi, Kei ^a   DeLong, Jonathan C ^b   Zhang, Yong ^a   Hiroshima, Yukihiko ^c   Russell, Tara ^d   Eckardt, Mark A ^d,e   Yanagawa, Jane ^d   Federman, Noah ^d   Matsuyama, Ryusei ^c   Chishima, Takashi ^c   Tanaka, Kuniya ^c   Bouvet, Michael ^b   Endo, Itaru ^c   Eilber, Fritz C ^d,f   Hoffman, Robert M ^a,b,f,g   more..

^a ANTICANCER INC   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^c YOKOHAMA CITY UNIVERSITY   (Japan)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

^g PDOX LLC   (United States)

Author keywords

Ewing's sarcoma; Linsitinib; Palbocicib; Patient derived orthotopic xenograft; PDOX

Indexed keywords

CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE 6; CYCLIN DEPENDENT KINASE INHIBITOR 2A; DOXORUBICIN; LINSITINIB; PALBOCICLIB; SOMATOMEDIN; SOMATOMEDIN RECEPTOR; 3-(8-AMINO-1-(2-PHENYLQUINOLIN-7-YL)IMIDAZO(1,5-A)PYRAZIN-3-YL)-1-METHYLCYCLOBUTANOL; CDKN2A PROTEIN, HUMAN; CYCLIN DEPENDENT KINASE INHIBITOR 2C; IMIDAZOLE DERIVATIVE; ONCOPROTEIN; PIPERAZINE DERIVATIVE; PYRAZINE DERIVATIVE; PYRIDINE DERIVATIVE; RNA BINDING PROTEIN FUS; SOMATOMEDIN C RECEPTOR; TLS-ERG FUSION PROTEIN, HUMAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER INHIBITION; CONTROLLED STUDY; DRUG EFFICACY; EWING SARCOMA; FEMALE; HISTOPATHOLOGY; MOLECULARLY TARGETED THERAPY; MOUSE; NONHUMAN; TUMOR GROWTH; TUMOR VOLUME; XENOGRAFT; ANIMAL; ANTAGONISTS AND INHIBITORS; BONE TUMOR; DRUG RESISTANCE; DRUG SCREENING; GENETICS; HUMAN; PATHOLOGY;

ANIMALS; BONE NEOPLASMS; CYCLIN-DEPENDENT KINASE 4; CYCLIN-DEPENDENT KINASE 6; CYCLIN-DEPENDENT KINASE INHIBITOR P18; DOXORUBICIN; DRUG RESISTANCE, NEOPLASM; FEMALE; HUMANS; IMIDAZOLES; MICE; MOLECULAR TARGETED THERAPY; ONCOGENE PROTEINS, FUSION; PIPERAZINES; PYRAZINES; PYRIDINES; RECEPTOR, IGF TYPE 1; RNA-BINDING PROTEIN FUS; SARCOMA, EWING; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84982812991     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.9879     Document Type: Article

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