Successful fluorescence-guided surgery on human colon cancer patient-derived orthotopic xenograft mouse models using a fluorophore-conjugated anti-CEA antibody and a portable imaging system

Journal of Laparoendoscopic and Advanced Surgical Techniques

Volumn 24, Issue 4, 2014, Pages 241-247

  Hiroshima, Yukihiko ^a,b,c   Maawy, Ali ^b   Metildi, Cristina A ^b   Zhang, Yong ^a   Uehara, Fuminari ^a,b   Miwa, Shinji ^a,b   Yano, Shuya ^a,b   Sato, Sho ^c   Murakami, Takashi ^c   Momiyama, Masashi ^c   Chishima, Takashi ^c   Tanaka, Kuniya ^c   Bouvet, Michael ^b   Endo, Itaru ^c   Hoffman, Robert M ^a,b  

^a ANTICANCER INC   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c YOKOHAMA CITY UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALEXAFLUOR 488; CARCINOEMBRYONIC ANTIGEN; CARCINOEMBRYONIC ANTIGEN MONOCLONAL ANTIBODY; CARCINOEMBRYONIC ANTIGEN MONOCLONAL ANTIBODY ALEXAFLUOR 488 CONJUGATE; FLUORESCENT DYE; UNCLASSIFIED DRUG; ALEXA 488 HYDRAZIDE; ANTIIDIOTYPIC ANTIBODY; HYDRAZINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CAMERA; CANCER CELL; CANCER MODEL; CANCER PATIENT; COLON CANCER; DRUG CONJUGATION; FLUORESCENCE; FLUORESCENCE GUIDED SURGERY; FROZEN SECTION; HISTOLOGY; HUMAN; HUMAN TISSUE; IMAGING SYSTEM; LAPAROTOMY; MAJOR CLINICAL STUDY; MICROSCOPY; MOUSE; NONHUMAN; NUDE MOUSE; OPERATING ROOM; ORTHOTOPIC TRANSPLANTATION; PORTABLE EQUIPMENT; PORTABLE IMAGING SYSTEM; PREOPERATIVE PERIOD; PRIORITY JOURNAL; SINGLE DRUG DOSE; SURGICAL TECHNOLOGY; TREATMENT OUTCOME; ANIMAL; COLONIC NEOPLASMS; COMPUTER ASSISTED SURGERY; DISEASE MODEL; FEMALE; FLUORESCENCE IMAGING; IMMUNOLOGY; PATHOLOGY; PROCEDURES; SCID MOUSE; XENOGRAFT;

ANIMALS; ANTIBODIES, ANTI-IDIOTYPIC; CARCINOEMBRYONIC ANTIGEN; COLONIC NEOPLASMS; DISEASE MODELS, ANIMAL; FEMALE; HUMANS; HYDRAZINES; MICE; MICE, NUDE; MICE, SCID; OPTICAL IMAGING; SURGERY, COMPUTER-ASSISTED; TRANSPLANTATION, HETEROLOGOUS;

EID: 84897407935     PISSN: 10926429     EISSN: 15579034     Source Type: Journal    
DOI: 10.1089/lap.2013.0418     Document Type: Article

References (36)

1. Andreoni B, Chiappa A, Bertani E, et al. Surgical outcomes for colon and rectal cancer over a decade: Results from a consecutive monocentric experience in 902 unselected patients. World J Surg Oncol 2007;5:73.
2. Bouvet M, Hoffman RM. Glowing tumors make for better detection and resection. Sci Transl Med 2011;3(110): 110fs110.
3. Ruo L, Guillem JG. Surgical management of primary colorectal cancer. Surg Oncol 1998;7:153-163.
4. Fujiwara T, Kagawa S, Kishimoto H, et al. Enhanced antitumor efficacy of telomerase-selective oncolytic adenoviral agent OBP-401 with docetaxel: Preclinical evaluation of chemovirotherapy. Int J Cancer 2006;119:432-440.
5. Kishimoto H, Kojima T, Watanabe Y, et al. In vivo imaging of lymph node metastasis with telomerase-specific replication- selective adenovirus. Nat Med 2006;12:1213-1219.
6. Kishimoto H, Zhao M, Hayashi K, et al. In vivo internal tumor illumination by telomerase-dependent adenoviral GFP for precise surgical navigation. Proc Natl Acad Sci U S A 2009;106:14514-14517.
7. Metildi CA, Kaushal S, Snyder CS, Hoffman RM, Bouvet M. Fluorescence-guided surgery of human colon cancer increases complete resection resulting in cures in an orthotopic nude mouse model. J Surg Res 2013;179:87-93.
8. Metildi CA, Kaushal S, Hardamon CR, et al. Fluorescenceguided surgery allows for more complete resection of pancreatic cancer, resulting in longer disease-free survival compared with standard surgery in orthotopic mouse models. J Am Coll Surg 2012;215:126-135; discussion 135-136.
9. Stepp H, Beck T, Pongratz T, et al. ALA and malignant glioma: Fluorescence-guided resection and photodynamic treatment. J Environ Pathol Toxicol Oncol 2007; 26:157-164.
10. Fu X, Guadagni F, Hoffman RM. A metastatic nude-mouse model of human pancreatic cancer constructed orthotopically with histologically intact patient specimens. Proc Natl Acad Sci U S A 1992;89:5645-5649.
11. Fu X, Hoffman RM. Human ovarian carcinoma metastatic models constructed in nude mice by orthotopic transplantation of histologically-intact patient specimens. Anticancer Res 1993;13:283-286.
12. Fu XY, Besterman JM, Monosov A, Hoffman RM. Models of human metastatic colon cancer in nude mice orthotopically constructed by using histologically intact patient specimens. Proc Natl Acad Sci U S A 1991;88:9345-9349.
13. Suetsugu A, Hassanein MK, Reynoso J, et al. The cyan fluorescent protein nude mouse as a host for multicolorcoded imaging models of primary and metastatic tumor microenvironments. Anticancer Res 2012;32:31-38.
14. Suetsugu A, Katz M, Fleming J, et al. Multi-color palette of fluorescent proteins for imaging the tumor microenvironment of orthotopic tumorgraft mouse models of clinical pancreatic cancer specimens. J Cell Biochem 2012;113: 2290-2295.
15. Suetsugu A, Katz M, Fleming J, et al. Non-invasive fluorescent- protein imaging of orthotopic pancreatic-cancerpatient tumorgraft progression in nude mice. Anticancer Res 2012;32:3063-3067.
16. Yang M, Luiken G, Baranov E, Hoffman RM. Facile whole-body imaging of internal fluorescent tumors in mice with an LED flashlight. Biotechniques 2005;39:170-172.
17. Kim MP, Evans DB, Wang H, Abbruzzese JL, Fleming JB, Gallick GE. Generation of orthotopic and heterotopic human pancreatic cancer xenografts in immunodeficient mice. Nat Protoc 2009;4:1670-1680.
18. Kim MP, Truty MJ, Choi W, et al. Molecular profiling of direct xenograft tumors established from human pancreatic adenocarcinoma after neoadjuvant therapy. Ann Surg Oncol 2012;19(Suppl 3):S395-403.
19. An Z, Wang X, Willmott N, et al. Conversion of highly malignant colon cancer from an aggressive to a controlled disease by oral administration of a metalloproteinase inhibitor. Clin Exp Metastasis 1997;15:184-195.
20. Furukawa T, Kubota T, Watanabe M, et al. Immunochemotherapy prevents human colon cancer metastasis after orthotopic onplantation of histologically-intact tumor tissue in nude mice. Anticancer Res 1993;13:287-291.
21. Hoffman RM. Orthotopic metastatic mouse models for anticancer drug discovery and evaluation: A bridge to the clinic. Invest New Drugs 1999;17:343-359.
22. Wang X, Fu X, Brown PD, Crimmin MJ, Hoffman RM. Matrix metalloproteinase inhibitor BB-94 (batimastat) inhibits human colon tumor growth and spread in a patientlike orthotopic model in nude mice. Cancer Res 1994;54: 4726-4728.
23. Kaushal S, McElroy MK, Luiken GA, et al. Fluorophoreconjugated anti-CEA antibody for the intraoperative imaging of pancreatic and colorectal cancer. J Gastrointest Surg 2008;12:1938-1950.
24. Yamauchi K,YangM, Jiang P, et al.Development of real-time subcellular dynamic multicolor imaging of cancer celltrafficking in live mice with a variable-magnification wholemouse imaging system. Cancer Res 2006;66:4208-4214.
25. Uchugonova A, Zhao M, Weinigel M, et al. Multiphoton tomography visualizes collagen fibers in the tumor microenvironment that maintain cancer-cell anchorage and shape. J Cell Biochem 2013;114:99-102.
26. Fu X, Hoffman RM. Human ovarian carcinoma metastatic models constructed in nude mice by orthotopic transplantation of histologically-intact patient specimens. Anticancer Res 1993;13:283-286.
27. Fu X, Le P, Hoffman RM. A metastatic-orthotopic transplant nude-mouse model of human patient breast cancer. Anticancer Res 1993;13:901-904.
28. Furukawa T, Kubota T, Watanabe M, et al. Orthotopic transplantation of histologically intact clinical specimens of stomach cancer to nude mice: Correlation of metastatic sites in mouse and individual patient donors. Int J Cancer 1993;53:608-612.
29. Bertotti A, Migliardi G, Galimi F, et al. A molecularly annotated platform of patient-derived xenografts (''xenopatients'') identifies HER2 as an effective therapeutic target in cetuximab-resistant colorectal cancer. Cancer Discov 2011;1:508-523.
30. Talmadge JE, Singh RK, Fidler IJ, Raz A. Murine models to evaluate novel and conventional therapeutic strategies for cancer. Am J Pathol 2007;170:793-804.
31. McElroy M, Kaushal S, Luiken GA, et al. Imaging of primary and metastatic pancreatic cancer using a fluorophore- conjugated anti-CA19-9 antibody for surgical navigation. World J Surg 2008;32:1057-1066.
32. Nguyen QT, Olson ES, Aguilera TA, et al. Surgery with molecular fluorescence imaging using activatable cellpenetrating peptides decreases residual cancer and improves survival. Proc Natl Acad Sci U S A 2010;107:4317-4322.
33. Stummer W, Pichlmeier U, Meinel T, Wiestler OD, Zanella F, Reulen HJ. Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: A randomised controlled multicentre phase III trial. Lancet Oncol 2006;7:392-401.
34. Urano Y, Sakabe M, Kosaka N, et al. Rapid cancer detection by topically spraying a gamma-glutamyltranspeptidaseactivated fluorescent probe. Sci Transl Med 2011;3:110-119.
35. van Dam GM, Themelis G, Crane LM, et al. Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-alpha targeting: First in-human results. Nat Med 2011;17:1315-1319.
36. Sakuma S, Yano T, Masaoka Y, et al. Detection of early colorectal cancer imaged with peanut agglutinin-immobilized fluorescent nanospheres having surface poly(N-vinylacetamide) chains. Eur J Pharm Biopharm 2010;74:451-460.