Resveratrol inhibits renal interstitial fibrosis in diabetic nephropathy by regulating AMPK/NOX4/ROS pathway

Journal of Molecular Medicine

Volumn 94, Issue 12, 2016, Pages 1359-1371

  He, Ting ^a   Xiong, Jiachuan ^a   Nie, Ling ^a   Yu, Yanlin ^a   Guan, Xu ^a   Xu, Xinli ^a   Xiao, Tangli ^a   Yang, Ke ^a   Liu, Liang ^a   Zhang, Daohai ^a   Huang, Yunjian ^a   Zhang, Jingbo ^a   Wang, Junping ^a   Sharma, Kumar ^b,c   Zhao, Jinghong ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c VA SAN DIEGO HEALTHCARE SYSTEM   (United States)

Author keywords

AMPK; Diabetic nephropathy; ERK 1 2; NOX; Reactive oxygen species; Resveratrol

Indexed keywords

ALBUMIN; ALPHA SMOOTH MUSCLE ACTIN; CALVASCULIN; CREATINE; FIBRONECTIN; GLUCOSE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; RESVERATROL; SMALL INTERFERING RNA; ANTIOXIDANT; MAPK1 PROTEIN, MOUSE; NOX4 PROTEIN, MOUSE; STILBENE DERIVATIVE;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CELL PROLIFERATION; CONTROLLED STUDY; DIABETIC NEPHROPATHY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; GLUCOSE BLOOD LEVEL; IN VIVO STUDY; KIDNEY FIBROSIS; MALE; MOUSE; MYOFIBROBLAST; NONHUMAN; PROTEIN EXPRESSION; RENAL INTERSTITIAL FIBROSIS; SIGNAL TRANSDUCTION; THERAPY EFFECT; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CELL DIFFERENTIATION; CELL LINE; CYTOLOGY; DRUG EFFECTS; FIBROBLAST; FIBROSIS; GENE EXPRESSION REGULATION; GENETICS; KIDNEY; METABOLISM; PATHOLOGY; RAT;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; ANTIOXIDANTS; CELL DIFFERENTIATION; CELL LINE; CELL PROLIFERATION; DIABETIC NEPHROPATHIES; FIBROBLASTS; FIBROSIS; GENE EXPRESSION REGULATION; GLUCOSE; KIDNEY; MALE; MICE, INBRED C57BL; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MYOFIBROBLASTS; NADPH OXIDASE 4; RATS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; STILBENES;

EID: 84982802686     PISSN: 09462716     EISSN: 14321440     Source Type: Journal    
DOI: 10.1007/s00109-016-1451-y     Document Type: Article

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