Polycystic ovary syndrome and psychiatric disorders: Co-morbidity and heritability in a nationwide Swedish cohort

Psychoneuroendocrinology

Volumn 73, Issue , 2016, Pages 196-203

  Cesta, Carolyn E ^a   Månsson, Mattias ^a   Palm, Camilla ^a   Lichtenstein, Paul ^a   Iliadou, Anastasia N ^a   Landén, Mikael ^a,b  

^a KAROLINSKA INSTITUTE   (Sweden)

^b UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

Androgens; Epidemiology; Polycystic ovary syndrome; Psychiatric disorders; Sibling analysis

Indexed keywords

ADULT; ALCOHOLISM; ANOREXIA; ANXIETY DISORDER; ARTICLE; ASPERGER SYNDROME; ATTENTION DEFICIT DISORDER; AUTISM; BIPOLAR DISORDER; BULIMIA; COHORT ANALYSIS; COMORBIDITY; CONTROLLED STUDY; DEPRESSION; EATING DISORDER; FEMALE; GENDER DYSPHORIA; HERITABILITY; HUMAN; MALE; MENTAL DISEASE; OBSESSIVE COMPULSIVE DISORDER; OVARY POLYCYSTIC DISEASE; PERSONALITY DISORDER; POPULATION RESEARCH; PRIORITY JOURNAL; RISK; SCHIZOPHRENIA; SIBLING; SOCIAL PHOBIA; SUICIDE; TIC; TRANSSEXUALISM; ADOLESCENT; GENETICS; REGISTER; STATISTICS AND NUMERICAL DATA; SWEDEN; YOUNG ADULT;

ADOLESCENT; ADULT; COHORT STUDIES; COMORBIDITY; FEMALE; HUMANS; MENTAL DISORDERS; POLYCYSTIC OVARY SYNDROME; REGISTRIES; SIBLINGS; SWEDEN; YOUNG ADULT;

EID: 84982798930     PISSN: 03064530     EISSN: 18733360     Source Type: Journal    
DOI: 10.1016/j.psyneuen.2016.08.005     Document Type: Article

References (44)

1. Algars, M., Huang, L., Von Holle, A.F., Peat, C.M., Thornton, L.M., Lichtenstein, P., Bulik, C.M., Binge eating and menstrual dysfunction. J. Psychosom. Res. 76 (2014), 19–22.
2. Altinok, M.L., Glintborg, D., Depont Christensen, R., Hallas, J., Andersen, M., Prescription of antidepressants is increased in Danish patients with polycystic ovary syndrome and is associated with hyperandrogenism: a population-based cohort study. Clin. Endocrinol. (Oxf.) 80 (2014), 884–889.
3. Baba, T., Endo, T., Honnma, H., Kitajima, Y., Hayashi, T., Ikeda, H., Masumori, N., Kamiya, H., Moriwaka, O., Saito, T., Association between polycystic ovary syndrome and female-to-male transsexuality. Hum. Reprod. 22 (2007), 1011–1016.
4. Bosinski, H.A., Peter, M., Bonatz, G., Arndt, R., Heidenreich, M., Sippell, W.G., Wille, R., A higher rate of hyperandrogenic disorders in female-to-male transsexuals. Psychoneuroendocrinology 22 (1997), 361–380.
5. Cotrufo, P., Monteleone, P., d'Istria, M., Fuschino, A., Serino, I., Maj, M., Aggressive behavioral characteristics and endogenous hormones in women with Bulimia nervosa. Neuropsychobiology 42 (2000), 58–61.
6. Dumesic, D.A., Goodarzi, M.O., Chazenbalk, G.D., Abbott, D.H., Intrauterine environment and polycystic ovary syndrome. Semin. Reprod. Med. 32 (2014), 159–165.
7. Elsenbruch, S., Benson, S., Hahn, S., Tan, S., Mann, K., Pleger, K., Kimmig, R., Janssen, O.E., Determinants of emotional distress in women with polycystic ovary syndrome. Hum. Reprod. 21 (2006), 1092–1099.
8. Glintborg, D., Hass Rubin, K., Nybo, M., Abrahamsen, B., Andersen, M., Morbidity and medicine prescriptions in a nationwide Danish population of patients diagnosed with polycystic ovary syndrome. Eur. J. Endocrinol. 172 (2015), 627–638.
9. Hart, R., Doherty, D.A., The potential implications of a PCOS diagnosis on a woman's long-term health using data linkage. J. Clin. Endocrinol. Metab., 2014 jc20143886.
10. Herguner, S., Harmanci, H., Toy, H., Attention deficit-hyperactivity disorder symptoms in women with polycystic ovary syndrome. Int. J. Psychiatry Med., 2015.
11. Hollinrake, E., Abreu, A., Maifeld, M., Van Voorhis, B.J., Dokras, A., Increased risk of depressive disorders in women with polycystic ovary syndrome. Fertil. Steril. 87 (2007), 1369–1376.
12. Hung, J.H., Hu, L.Y., Tsai, S.J., Yang, A.C., Huang, M.W., Chen, P.M., Wang, S.L., Lu, T., Shen, C.C., Risk of psychiatric disorders following polycystic ovary syndrome: a nationwide population-based cohort study. PLoS One, 9, 2014, e97041.
13. Ingudomnukul, E., Baron-Cohen, S., Wheelwright, S., Knickmeyer, R., Elevated rates of testosterone-related disorders in women with autism spectrum conditions. Horm. Behav. 51 (2007), 597–604.
14. Joffe, H., Cohen, L.S., Suppes, T., McLaughlin, W.L., Lavori, P., Adams, J.M., Hwang, C.H., Hall, J.E., Sachs, G.S., Valproate is associated with new-onset oligoamenorrhea with hyperandrogenism in women with bipolar disorder. Biol. Psychiatry 59 (2006), 1078–1086.
15. Kahsar-Miller, M.D., Nixon, C., Boots, L.R., Go, R.C., Azziz, R., Prevalence of polycystic ovary syndrome (PCOS) in first-degree relatives of patients with PCOS. Fertil. Steril. 75 (2001), 53–58.
16. Klipstein, K.G., Goldberg, J.F., Screening for bipolar disorder in women with polycystic ovary syndrome: a pilot study. J. Affect. Disord. 91 (2006), 205–209.
17. Koponen, H., Jokelainen, J., Keinanen-Kiukaanniemi, S., Kumpusalo, E., Vanhala, M., Metabolic syndrome predisposes to depressive symptoms: a population-based 7-year follow-up study. J. Clin. Psychiatry 69 (2008), 178–182.
18. Kowalczyk, R., Skrzypulec, V., Lew-Starowicz, Z., Nowosielski, K., Grabski, B., Merk, W., Psychological gender of patients with polycystic ovary syndrome. Acta Obstet. Gynecol. Scand. 91 (2012), 710–714.
19. Legro, R.S., Driscoll, D., Strauss, J.F. 3rd, Fox, J., Dunaif, A., Evidence for a genetic basis for hyperandrogenemia in polycystic ovary syndrome. Proc. Natl. Acad. Sci. U. S. A. 95, 1998, 14956–14960.
20. Liu, D.M., Torchen, L.C., Sung, Y., Paparodis, R., Legro, R.S., Grebe, S.K., Singh, R.J., Taylor, R.L., Dunaif, A., Evidence for gonadotrophin secretory and steroidogenic abnormalities in brothers of women with polycystic ovary syndrome. Hum. Reprod. 29 (2014), 2764–2772.
21. Ludvigsson, J.F., Andersson, E., Ekbom, A., Feychting, M., Kim, J.L., Reuterwall, C., Heurgren, M., Olausson, P.O., External review and validation of the Swedish national inpatient register. BMC Public Health, 11, 2011, 450.
22. Luppino, F.S., de Wit, L.M., Bouvy, P.F., Stijnen, T., Cuijpers, P., Penninx, B.W., Zitman, F.G., Overweight, obesity, and depression: a systematic review and meta-analysis of longitudinal studies. Arch. Gen. Psychiatry 67 (2010), 220–229.
23. Mansson, M., Holte, J., Landin-Wilhelmsen, K., Dahlgren, E., Johansson, A., Landen, M., Women with polycystic ovary syndrome are often depressed or anxious—a case control study. Psychoneuroendocrinology 33 (2008), 1132–1138.
24. March, W.A., Moore, V.M., Willson, K.J., Phillips, D.I., Norman, R.J., Davies, M.J., The prevalence of polycystic ovary syndrome in a community sample assessed under contrasting diagnostic criteria. Hum. Reprod. 25 (2010), 544–551.
25. Markham, J.A., Sex steroids and schizophrenia. Rev. Endocr. Metab. Disord. 13 (2012), 187–207.
26. McCluskey, S., Evans, C., Lacey, J.H., Pearce, J.M., Jacobs, H., Polycystic ovary syndrome and bulimia. Fertil. Steril. 55 (1991), 287–291.
27. Monteleone, P., Luisi, M., Colurcio, B., Casarosa, E., Monteleone, P., Ioime, R., Genazzani, A.R., Maj, M., Plasma levels of neuroactive steroids are increased in untreated women with anorexia nervosa or bulimia nervosa. Psychosom. Med. 63 (2001), 62–68.
28. Morgan, J.F., McCluskey, S.E., Brunton, J.N., Hubert Lacey, J., Polycystic ovarian morphology and bulimia nervosa: a 9-year follow-up study. Fertil. Steril. 77 (2002), 928–931.
29. Mueller, A., Gooren, L.J., Naton-Schotz, S., Cupisti, S., Beckmann, M.W., Dittrich, R., Prevalence of polycystic ovary syndrome and hyperandrogenemia in female-to-male transsexuals. J. Clin. Endocrinol. Metab. 93 (2008), 1408–1411.
30. Norman, R.J., Dewailly, D., Legro, R.S., Hickey, T.E., Polycystic ovary syndrome. Lancet 370 (2007), 685–697.
31. Rasgon, N.L., Rao, R.C., Hwang, S., Altshuler, L.L., Elman, S., Zuckerbrow-Miller, J., Korenman, S.G., Depression in women with polycystic ovary syndrome: clinical and biochemical correlates. J. Affect. Disord. 74 (2003), 299–304.
32. Rassi, A., Veras, A.B., dos Reis, M., Pastore, D.L., Bruno, L.M., Bruno, R.V., de Avila, M.A., Nardi, A.E., Prevalence of psychiatric disorders in patients with polycystic ovary syndrome. Compr. Psychiatry 51 (2010), 599–602.
33. Reynolds-May, M.F., Kenna, H.A., Marsh, W., Stemmle, P.G., Wang, P., Ketter, T.A., Rasgon, N.L., Evaluation of reproductive function in women treated for bipolar disorder compared to healthy controls. Bipolar Disord. 16 (2014), 37–47.
34. Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group, Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil. Steril. 81 (2004), 19–25.
35. Sahingoz, M., Uguz, F., Gezginc, K., Korucu, D.G., Axis I and axis II diagnoses in women with PCOS. Gen. Hosp. Psychiatry 35 (2013), 508–511.
36. Scaruffi, E., Gambineri, A., Cattaneo, S., Turra, J., Vettor, R., Mioni, R., Personality and psychiatric disorders in women affected by polycystic ovary syndrome. Front. Endocrinol. (Lausanne), 5, 2014, 185.
37. Sellgren, C., Landen, M., Lichtenstein, P., Hultman, C.M., Langstrom, N., Validity of bipolar disorder hospital discharge diagnoses: file review and multiple register linkage in Sweden. Acta Psychiatr. Scand. 124 (2011), 447–453.
38. Sundblad, C., Bergman, L., Eriksson, E., High levels of free testosterone in women with bulimia nervosa. Acta Psychiatr. Scand. 90 (1994), 397–398.
39. Sundblad, C., Landen, M., Eriksson, T., Bergman, L., Eriksson, E., Effects of the androgen antagonist flutamide and the serotonin reuptake inhibitor citalopram in bulimia nervosa. J. Clin. Psychopharmacol. 25 (2005), 85–88.
40. Teede, H., Deeks, A., Moran, L., Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan. BMC Med., 8, 2010, 41.
41. Torchen, L.C., Kumar, A., Kalra, B., Savjani, G., Sisk, R., Legro, R.S., Dunaif, A., Increased antimullerian hormone levels and other reproductive endocrine changes in adult male relatives of women with polycystic ovary syndrome. Fertil. Steril., 2016.
42. Weber, B., Lewicka, S., Deuschle, M., Colla, M., Heuser, I., Testosterone, androstenedione and dihydrotestosterone concentrations are elevated in female patients with major depression. Psychoneuroendocrinology 25 (2000), 765–771.
43. Weiner, C.L., Primeau, M., Ehrmann, D.A., Androgens and mood dysfunction in women: comparison of women with polycystic ovarian syndrome to healthy controls. Psychosom. Med. 66 (2004), 356–362.
44. de Bruin, E.I., Verheij, F., Wiegman, T., Ferdinand, R.F., Differences in finger length ratio between males with autism, pervasive developmental disorder-not otherwise specified, ADHD, and anxiety disorders. Dev. Med. Child Neurol. 48 (2006), 962–965.