CDH1 rs9929218 variant at 16q22.1 contributes to colorectal cancer susceptibility

Oncotarget

Volumn 7, Issue 30, 2016, Pages 47278-47286

  Han, Peng ^a   Liu, Guiyou ^b   Lu, Xin ^c   Cao, Minmin ^c   Yan, Youling ^c   Zou, Jing ^c   Li, Xiaobo ^a   Wang, Guangyu ^a  

^a HARBIN MEDICAL UNIVERSITY   (China)

^b Chinese Academy of Sciences   (China)

^c First Hospital of Harbin   (China)

Author keywords

Colorectal cancer; eQTL; Genome wide association study; Meta analysis; Rs9929218

Indexed keywords

CADHERIN; CADHERIN 1; UNCLASSIFIED DRUG; CDH1 PROTEIN, HUMAN;

ARTICLE; CANCER SUSCEPTIBILITY; CDH1 GENE; CHROMOSOME 16Q; CHROMOSOME VARIANT; COLORECTAL CANCER; FUNCTIONAL ASSESSMENT; GENE; GENETIC ASSOCIATION; GENETIC HETEROGENEITY; GENETIC REGULATION; GENETIC SCREENING; GENETIC SUSCEPTIBILITY; HUMAN; MAJOR CLINICAL STUDY; MCOLN2 GENE; META ANALYSIS (TOPIC); PROTEIN EXPRESSION; RP11 354M1.2 GENE; SAMPLE SIZE; SYSTEMATIC REVIEW; VALIDATION STUDY; ZFP90 GENE; CHROMOSOME 16; COLORECTAL TUMOR; GENETIC PREDISPOSITION; GENETICS; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; META ANALYSIS; PATHOLOGY; PROCEDURES; SINGLE NUCLEOTIDE POLYMORPHISM;

CADHERINS; CHROMOSOMES, HUMAN, PAIR 16; COLORECTAL NEOPLASMS; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HUMANS; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 84982797766     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.9758     Document Type: Article

References (50)

1. Quan B, Qi X, Yu Z, Jiang Y, Liao M, Wang G, Feng R, Zhang L, Chen Z, Jiang Q and Liu G. Pathway analysis of genome-wide association study and transcriptome data highlights new biological pathways in colorectal cancer. Mol Genet Genomics. 2015; 290:603-610.
2. Liao M, Wang G, Quan B, Qi X, Yu Z, Feng R, Zhang L, Jiang Y, Zhang Y and Liu G. Analyzing large-scale samples confirms the association between rs16892766 polymorphism and colorectal cancer susceptibility. Sci Rep. 2015; 5:7957.
3. He D, Ma L, Feng R, Zhang L, Jiang Y, Zhang Y and Liu G. Analyzing large-scale samples highlights significant association between rs10411210 polymorphism and colorectal cancer. Biomed Pharmacother. 2015; 74:164-168.
4. Liu G, Jiang Y, Wang P, Feng R, Jiang N, Chen X, Song H and Chen Z. Cell adhesion molecules contribute to Alzheimer's disease: multiple pathway analyses of two genome-wide association studies. J Neurochem. 2012; 120:190-198.
5. Liu G, Jiang Y, Chen X, Zhang R, Ma G, Feng R, Zhang L, Liao M, Miao Y, Chen Z, Zeng R and Li K. Measles contributes to rheumatoid arthritis: evidence from pathway and network analyses of genome-wide association studies. PLoS One. 2013; 8:e75951.
6. Liu G, Yao L, Liu J, Jiang Y, Ma G, Chen Z, Zhao B and Li K. Cardiovascular disease contributes to Alzheimer's disease: evidence from large-scale genome-wide association studies. Neurobiol Aging. 2014; 35:786-792.
7. Shang H, Liu G, Jiang Y, Fu J, Zhang B, Song R and Wang W. Pathway analysis of two amyotrophic lateral sclerosis GWAS highlights shared genetic signals with Alzheimer's disease and Parkinson's disease. Mol Neurobiol. 2015; 51:361-369.
8. Xiang Z, Xu M, Liao M, Jiang Y, Jiang Q, Feng R, Zhang L, Ma G, Wang G, Chen Z, Zhao B, Sun T, Li K and Liu G. Integrating Genome-Wide Association Study and Brain Expression Data Highlights Cell Adhesion Molecules and Purine Metabolism in Alzheimer's Disease. Mol Neurobiol. 2015; 52:514-521.
9. Zhao X, Gu J, Li M, Xi J, Sun W, Song G and Liu G. Pathway analysis of body mass index genome-wide association study highlights risk pathways in cardiovascular disease. Sci Rep. 2015; 5:13025.
10. Jiang Q, Jin S, Jiang Y, Liao M, Feng R, Zhang L, Liu G and Hao J. Alzheimer's Disease Variants with the Genome-Wide Significance are Significantly Enriched in Immune Pathways and Active in Immune Cells. Mol Neurobiol. 2016.
11. Wei J, Li M, Gao F, Zeng R, Liu G and Li K. Multiple analyses of large-scale genome-wide association study highlight new risk pathways in lumbar spine bone mineral density. Oncotarget. 2016. doi: 10.18632/oncotarget.8948.
12. Liu G and Li K. CHCHD2 and Parkinson's disease. Lancet Neurol. 2015; 14:679-680.
13. Li K, Jiang Q, Xu A and Liu G. REST rs3796529 variant does not confer susceptibility to Alzheimer's disease. Ann Neurol. 2015; 78:835-836.
14. Jiang Q and Liu G. REST rs3796529 variant does not influence human subcortical brain structures. Ann Neurol. 2016; 79:334-335.
15. Liu G. No association of TREM1 rs6910730 and TREM2 rs7759295 with Alzheimer disease. Ann Neurol. 2015; 78:659.
16. Houlston RS, Webb E, Broderick P, Pittman AM, Di Bernardo MC, Lubbe S, Chandler I, Vijayakrishnan J, Sullivan K, Penegar S, Carvajal-Carmona L, Howarth K, Jaeger E, et al. Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer. Nat Genet. 2008; 40:1426-1435.
17. Ho JW, Choi SC, Lee YF, Hui TC, Cherny SS, Garcia-Barcelo MM, Carvajal-Carmona L, Liu R, To SH, Yau TK, Chung CC, Yau CC, Hui SM, et al. Replication study of SNP associations for colorectal cancer in Hong Kong Chinese. Br J Cancer. 2011; 104:369-375.
18. Xiong F, Wu C, Bi X, Yu D, Huang L, Xu J, Zhang T, Zhai K, Chang J, Tan W, Cai J and Lin D. Risk of genome-wide association study-identified genetic variants for colorectal cancer in a Chinese population. Cancer Epidemiol Biomarkers Prev. 2010; 19:1855-1861.
19. Zhang B, Jia WH, Matsuda K, Kweon SS, Matsuo K, Xiang YB, Shin A, Jee SH, Kim DH, Cai Q, Long J, Shi J, Wen W, et al. Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk. Nat Genet. 2014; 46:533-542.
20. He J, Wilkens LR, Stram DO, Kolonel LN, Henderson BE, Wu AH, Le Marchand L and Haiman CA. Generalizability and epidemiologic characterization of eleven colorectal cancer GWAS hits in multiple populations. Cancer Epidemiol Biomarkers Prev. 2011; 20:70-81.
21. Hutter CM, Chang-Claude J, Slattery ML, Pflugeisen BM, Lin Y, Duggan D, Nan H, Lemire M, Rangrej J, Figueiredo JC, Jiao S, Harrison TA, Liu Y, et al. Characterization of gene-environment interactions for colorectal cancer susceptibility loci. Cancer Res. 2012; 72:2036-2044.
22. Wang H, Haiman CA, Burnett T, Fortini BK, Kolonel LN, Henderson BE, Signorello LB, Blot WJ, Keku TO, Berndt SI, Newcomb PA, Pande M, Amos CI, et al. Fine-mapping of genome-wide association study-identified risk loci for colorectal cancer in African Americans. Hum Mol Genet. 2013; 22:5048-5055.
23. Kupfer SS, Anderson JR, Hooker S, Skol A, Kittles RA, Keku TO, Sandler RS and Ellis NA. Genetic heterogeneity in colorectal cancer associations between African and European americans. Gastroenterology. 2010; 139:1677-1685, 1685 e1671-1678.
24. von Holst S, Picelli S, Edler D, Lenander C, Dalen J, Hjern F, Lundqvist N, Lindforss U, Pahlman L, Smedh K, Tornqvist A, Holm J, Janson M, et al. Association studies on 11 published colorectal cancer risk loci. Br J Cancer. 2010; 103:575-580.
25. Mates IN, Csiki I, Mates D, Constantinescu V, Badea P, Dinu D, Constantin A and Constantinoiu S. Association of common genetic variants with colorectal cancer risk in a Romanian sample. Chirurgia (Bucur). 2010; 105:749-757.
26. Closa A, Cordero D, Sanz-Pamplona R, Sole X, Crous-Bou M, Pare-Brunet L, Berenguer A, Guino E, Lopez-Doriga A, Guardiola J, Biondo S, Salazar R and Moreno V. Identification of candidate susceptibility genes for colorectal cancer through eQTL analysis. Carcinogenesis. 2014; 35:2039-2046.
27. Liu G, Bao X and Wang R. Expression quantitative trait loci regulate HNF4A and PTBP1 expression in human brains. Proc Natl Acad Sci U S A. 2015; 112:E3975.
28. Bao X, Liu G, Jiang Y, Jiang Q, Liao M, Feng R, Zhang L, Ma G, Zhang S, Chen Z, Zhao B, Wang R and Li K. Cell adhesion molecule pathway genes are regulated by cisregulatory SNPs and show significantly altered expression in Alzheimer's disease brains. Neurobiol Aging. 2015; 36:2904 e2901-2907.
29. Liu G, Liu Y, Jiang Q, Jiang Y, Feng R, Zhang L, Chen Z, Li K and Liu J. Convergent Genetic and Expression Datasets Highlight TREM2 in Parkinson's Disease Susceptibility. Mol Neurobiol. 2015.
30. Kupfer SS, Skol AD, Hong E, Ludvik A, Kittles RA, Keku TO, Sandler RS and Ellis NA. Shared and independent colorectal cancer risk alleles in TGFbeta-related genes in African and European Americans. Carcinogenesis. 2014; 35:2025-2030.
31. Carvajal-Carmona LG, Cazier JB, Jones AM, Howarth K, Broderick P, Pittman A, Dobbins S, Tenesa A, Farrington S, Prendergast J, Theodoratou E, Barnetson R, Conti D, et al. Fine-mapping of colorectal cancer susceptibility loci at 8q23.3, 16q22.1 and 19q13.11: refinement of association signals and use of in silico analysis to suggest functional variation and unexpected candidate target genes. Hum Mol Genet. 2011; 20:2879-2888.
32. Gogele M, Minelli C, Thakkinstian A, Yurkiewich A, Pattaro C, Pramstaller PP, Little J, Attia J and Thompson JR. Methods for meta-analyses of genome-wide association studies: critical assessment of empirical evidence. Am J Epidemiol. 2012; 175:739-749.
33. Liu G, Zhang L, Feng R, Liao M, Jiang Y, Chen Z, Zhao B and Li K. Lack of association between PICALM rs3851179 polymorphism and Alzheimer's disease in Chinese population and APOEepsilon4-negative subgroup. Neurobiol Aging. 2013; 34:1310 e1319-1310.
34. Liu G, Zhang S, Cai Z, Ma G, Zhang L, Jiang Y, Feng R, Liao M, Chen Z, Zhao B and Li K. PICALM gene rs3851179 polymorphism contributes to Alzheimer's disease in an Asian population. Neuromolecular Med. 2013; 15:384-388.
35. Liu G, Xu Y, Jiang Y, Zhang L, Feng R and Jiang Q. PICALM rs3851179 Variant Confers Susceptibility to Alzheimer's Disease in Chinese Population. Mol Neurobiol. 2016.
36. Liu G, Zhang S, Cai Z, Li Y, Cui L, Ma G, Jiang Y, Zhang L, Feng R, Liao M, Chen Z, Zhao B and Li K. BIN1 gene rs744373 polymorphism contributes to Alzheimer's disease in East Asian population. Neurosci Lett. 2013; 544:47-51.
37. Liu G, Wang H, Liu J, Li J, Li H, Ma G, Jiang Y, Chen Z, Zhao B and Li K. The CLU gene rs11136000 variant is significantly associated with Alzheimer's disease in Caucasian and Asian populations. Neuromolecular Med. 2014; 16:52-60.
38. Liu G, Li F, Zhang S, Jiang Y, Ma G, Shang H, Liu J, Feng R, Zhang L, Liao M, Zhao B and Li K. Analyzing large-scale samples confirms the association between the ABCA7 rs3764650 polymorphism and Alzheimer's disease susceptibility. Mol Neurobiol. 2014; 50:757-764.
39. Shen N, Chen B, Jiang Y, Feng R, Liao M, Zhang L, Li F, Ma G, Chen Z, Zhao B, Li K and Liu G. An Updated Analysis with 85, 939 Samples Confirms the Association Between CR1 rs6656401 Polymorphism and Alzheimer's Disease. Mol Neurobiol. 2015; 51:1017-1023.
40. Zhang S, Zhang D, Jiang Y, Wu L, Shang H, Liu J, Feng R, Liao M, Zhang L, Liu Y, Liu G and Li K. CLU rs2279590 polymorphism contributes to Alzheimer's disease susceptibility in Caucasian and Asian populations. J Neural Transm (Vienna). 2015; 122:433-439.
41. Chen H, Wu G, Jiang Y, Feng R, Liao M, Zhang L, Ma G, Chen Z, Zhao B, Li K, Yu C and Liu G. Analyzing 54, 936 Samples Supports the Association Between CD2AP rs9349407 Polymorphism and Alzheimer's Disease Susceptibility. Mol Neurobiol. 2015; 52:1-7.
42. Li X, Shen N, Zhang S, Liu J, Jiang Q, Liao M, Feng R, Zhang L, Wang G, Ma G, Zhou H, Chen Z, Jiang Y, Zhao B, Li K and Liu G. CD33 rs3865444 Polymorphism Contributes to Alzheimer's Disease Susceptibility in Chinese, European, and North American Populations. Mol Neurobiol. 2015; 52:414-421.
43. Zhang S, Li X, Ma G, Jiang Y, Liao M, Feng R, Zhang L, Liu J, Wang G, Zhao B, Jiang Q, Li K and Liu G. CLU rs9331888 Polymorphism Contributes to Alzheimer's Disease Susceptibility in Caucasian But Not East Asian Populations. Mol Neurobiol. 2016; 53:1446-1451.
44. Chen G, Fu X, Wang G, Liu G and Bai X. Genetic Variant rs10757278 on Chromosome 9p21 Contributes to Myocardial Infarction Susceptibility. Int J Mol Sci. 2015; 16:11678-11688.
45. Li Y, Song D, Jiang Y, Wang J, Feng R, Zhang L, Wang G, Chen Z, Wang R, Jiang Q and Liu G. CR1 rs3818361 Polymorphism Contributes to Alzheimer's Disease Susceptibility in Chinese Population. Mol Neurobiol. 2015.
46. Liu G and Jiang Q. Alzheimer's disease CD33 rs3865444 variant does not contribute to cognitive performance. Proc Natl Acad Sci U S A. 2016; 113:E1589-1590.
47. Song F, Khan KS, Dinnes J and Sutton AJ. Asymmetric funnel plots and publication bias in meta-analyses of diagnostic accuracy. Int J Epidemiol. 2002; 31:88-95.
48. Westra HJ, Peters MJ, Esko T, Yaghootkar H, Schurmann C, Kettunen J, Christiansen MW, Fairfax BP, Schramm K, Powell JE, Zhernakova A, Zhernakova DV, Veldink JH, et al. Systematic identification of trans eQTLs as putative drivers of known disease associations. Nat Genet. 2013; 45:1238-1243.
49. Human genomics. The Genotype-Tissue Expression (GTEx) pilot analysis: multitissue gene regulation in humans. Science. 2015; 348:648-660.
50. Li FX, Yang XX, Hu NY, Du HY, Ma Q and Li M. Singlenucleotide polymorphism associations for colorectal cancer in southern chinese population. Chin J Cancer Res. 2012; 24:29-35.