The neurotrophin receptor p75 mediates gp120-induced loss of synaptic spines in aging mice

Neurobiology of Aging

Volumn 46, Issue , 2016, Pages 160-168

  Bachis, Alessia ^a   Wenzel, Erin ^a   Boelk, Allyssia ^a   Becker, Jodi ^b   Mocchetti, Italo ^a  

^a GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Aging; Hippocampus; HIV; p75NTR; proBDNF; TrkB

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; GLYCOPROTEIN GP 120; NEUROTROPHIN RECEPTOR P75; NERVE GROWTH FACTOR RECEPTOR;

ADULT; AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL LOSS; CELL STRUCTURE; CONTROLLED STUDY; DENDRITIC SPINE; ENZYME ACTIVATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE DELETION; HIPPOCAMPUS; HIV ASSOCIATED DEMENTIA; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; STAINING; SYNAPTIC TRANSMISSION; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; COMPLICATION; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; METABOLISM; MOLECULARLY TARGETED THERAPY; NEUROCOGNITIVE DISORDERS; PATHOLOGY; PHYSIOLOGY; SYNAPSE; TRANSGENIC MOUSE; VIROLOGY;

AGING; ANIMALS; BRAIN-DERIVED NEUROTROPHIC FACTOR; DENDRITIC SPINES; HIPPOCAMPUS; HIV ENVELOPE PROTEIN GP120; HIV INFECTIONS; HIV-1; HUMANS; MALE; MICE, INBRED C57BL; MICE, TRANSGENIC; MOLECULAR TARGETED THERAPY; NEUROCOGNITIVE DISORDERS; RECEPTOR, NERVE GROWTH FACTOR; SYNAPSES;

EID: 84982719861     PISSN: 01974580     EISSN: 15581497     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2016.07.001     Document Type: Article

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