Transgenic models in the study of AIDS dementia complex

Current Topics in Microbiology and Immunology

Volumn 206, Issue , 1996, Pages 223-241

  Toggas, S M ^a   Mucke, L ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

VIRUS PROTEIN;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ANIMAL MODEL; DEMENTIA; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MOUSE; NEUROPATHOLOGY; NONHUMAN; PRIORITY JOURNAL; REPORTER GENE; REVIEW; TRANSGENIC MOUSE;

ANIMALIA; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; MUS MUSCULUS;

EID: 0030029081     PISSN: 0070217X     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-3-642-85208-4_12     Document Type: Review

References (89)

1. Appleman ME, Marshall DW, Brey RL, Houk RW, Beatty DC, Winn RE, Melcher GP, Wise MG, Sumaya CV, Boswell RN (1988) Cerebrospinal fluid abnormalities in patients without AIDS who are seropositive for the human immunodeficiency virus. J Infect Dis 158. 193-199
2. Bakker CE, Verheij C, Willemsen R, van der Heim R, Oerlemans F, Vermey M, Bygrave A, Hoogeveen AT, Oostra BA, Reyniers E, De Boulle K, D'Hooge R, Cras P, van Velzen D, Nagels G, Martin J-J, De Deyn PP, Darby JK, Willems PJ (1994) Fmr 1 knockout mice a model to study fragile X mental retardation Cell 78: 23-33
3. Benos DJ, Hahn BH, Bubien JK, Ghosh SK, Mashburn NA. Chaikin MA, Shaw GM, Benveniste EN (1994) Envelope glycoprotein gp120 of human immunodeficiency virus type 1 alters ion transport in astrocytes, implications for AIDS dementia complex Proc Natl Acad Sci USA 91 494-498
4. 2 microglobulin in patients infected with human immunodeficiency virus. Neurology 39: 830-834
5. Brew BJ, Bhalla RB, Paul M, Gallardo H, McArthur JC, Schwartz MK, Price RW (1990) Cerebrospinal fluid neopterin in human immunodeficiency virus type 1 infection Ann Neurol 28: 556-560
6. Budka H (1992) Cerebral pathology in AIDS: a new nomenclature and pathogenetic concepts. Curr Opinion Neurol Neurosurg 5: 917-923
7. Cadet JL, Sheng P, Ali S, Rothman R, Carlson E, Epstein C (1994) Attenuation of methamphetamine-induced neurotoxicity in copper/zinc superoxide dismutase transgenic mice. J Neurochem 62. 380-383
8. Campbell IL, Abraham CR, Masliah E, Kemper P, Inglis JD, Oldstone MBA, Mucke L (1993a) Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin 6. Proc Natl Acad Sci USA 90 10061-10065
9. Campbell IL, Mucke L, Sandberg K (1993b) Cerebral overexpression of interteukin-6 or Interferon-α1 induces distinct neuropathology in transgenic mice (Abstr). Soc Neurosci Abstr 19: 98.2
10. Chan PH, Chu L, Chen SF, Carlson EJ, Epstein CJ {1994) Attenuation of glutamate-induced neuronal swelling and toxicity in transgenic mice overexpressing human CuZn-superoxide dismutase Acta Neurochir Suppl (Wiar) 51: 245-247
11. Chiang C-S, Stalder A, Samimi A, Campbell IL (1994) Reactive gliosis as a consequence of interleukin-6 expression in the brain. Studies in transgenic mice Dev Neurosci 16: 212-221
12. Corboy JR, Buzy JM, Zink MC, Clements JE (1992) Expression directed from HIV long terminal repeats in the central nervous system of transgenic mice. Science 258: 1804-1808
13. Dawson VL, Dawson TM, Uhl GR, Snyder SH (1993) Human immunodeficiency virus type 1 coat protein neurotoxicity mediated by nitric oxide in primary cortical cultures. Proc Natl Acad Sci USA 90: 3256-3259
14. Elovaara I, Poutiainen E, Raininko R, Valanne L, Virta A, Valle SL, Lahdevirta J, Iivanainen M (1990) Mild brain atrophy in early HIV infection: the lack of association with cognitive deficits and HIV-specific intrathecal immune response. J Neurol Sci 99: 121-136
15. Emilie D, Peuchmaur M, Maillot MC, Crevon MC, Brousse N, Delfraissy JF, Dormont J, Galanaud P (1990) Production of interteukins in human immunodeficiency virus-1-replicating lymph nodes J Clin Invest 86 148-159
16. Epstein LG, Gendelman HE (1993) Human immunodeficiency virus type 1 infection of the nervous system: pathogenetic mechanisms. Ann Neurol 33: 429-436
17. Freed EO, Myers DJ, Risser R (1989) Mutational analysis of the cleavage sequence of the human immunodeficiency virus type 1 envelope glycoprotein precursor gp160. J Virol 63: 4670-4675
18. Furth PA, St Onge L, Böger H, Gruss P, Gossen M, Kistner A, Bujard H, Henninghausen L (1994) Temporal control of gene expression in transgenic mice by a tetracycline-responsive promoter Proc Natl Acad Sci 91: 9302-9306
19. Gallo P, Frei K, Rordorf C, Lazdins J, Tavolato B, Fontana A (1989) Human immunodeficiency virus type 1 (HIV-1) infection of the central nervous system: an evaluation of cytokmes in cerebrospinal fluid J Neuroimmunol 23: 109-116
20. Gelbard HA, Nottet HSLM, Swindells S, Jett M, Dzenko KA, Genis P, White R, Wang L, Choi Y-B, Zhang D, Lipton SA, Tourtellotte WW, Epstein LG, Gendelman HE (1994) Platelet-activating factor: a candidate human immunodeficiency virus type 1-induced neurotoxin. J Virol 68 4628-4635
21. Geleziunas R, Schipper HM, Wainberg MA (1992) Pathogenesis and therapy of HlV-1 infection of the central nervous system AIDS 6: 1411-1426
22. Genis P, Jett M, Bernton EW, Boyle T, Gelbard HA, Dzenko K, Keane RW, Resnick L, Mizrachi Y, Volsky DJ, Epstein LG, Gendelman HE (1992) Cytokines and arachidonic acid metabolites produced during human immunodeficiency virus (HIV)-infected macrophage-astroglia interactions: Implications for the neuropathogenests of HIV disease. J Exp Med 176: 1703-1718
23. Giulian D, Vaca K, Noonan CA (1990) Secretion of neurotoxin by mononuclear phagocytes infected with HIV-1. Science 250: 1593-1596
24. Giulian D, Wendt E, Vaca K, Noonan CA (1993) The envelope glycoprotein of human immunodeficiency virus type 1 stimulates release of neurotoxins from monocytes. Proc Natl Acad Sci USA 90: 2769-2773
25. Giowa JR, Panlilio LV, Brenneman DE, Gozes I, Fridkin M, Hill JM (1992) Learning impairment following intracerebral administration of the HIV envelope protein gp120 or a VIP antagonist. Brain Res 570: 49-53
26. Gossen M, Bujard H (1992) Tight control of gene expression in mammalian cells by tetracycline-responsive promoters Proc Natl Acad Sci USA 89: 5547-5551
27. Gossen M, Bonin AL, Bujard H (1993) Control of gene activity in higher eukaryotic cells by prokaryotic regulatory elements Trends Biochem Sci 18. 471-475
28. Goudsmit J, Paul DA, Lange JMA, Speelman H, van der Noordaa J, van der Helm HJ, de Wolf F, Epstein LG, Krone WJA, Oleske JM, Coutinho RA (1986) Expression of human immunodeficiency virus antigen (HIV-Ag) in serum and cerebrospinal fluid during acute and chronic infection. Lancet 2 177-180
29. Heyes MP, Brew BJ, Martin A, Price RW, Salazar AM, Sidtis JJ, Yergey JA, Mouradian MM, Sadler AE, Keilp J (1991) Quinolinic acid in cerebrospinal fluid and serum in HIV-1 infection: relationship to clinical and neurological status. Ann Neurol 29: 202-209
30. Hill JM, Mervus RF, Avidor R, Moody TW, Brenneman DE (1993) HIV envelope protein-induced neuronal damage and retardation of behavioral development inrat neonates Brain Res 603: 222-233
31. Ho DD, Rota TR, Schooley RT, Kaplan JC, Allan JD, Groopman JE, Resnick L, Felsenstein D, Andrews CA, Hirsch MS (1985) Isolation of HTLV-III from cerebrospinal fluid and neural tissues of patients with neurologic syndromes related to the acquired immunodeficiency syndrome N Engl J Med 313: 1493-1497
32. Hurtrel M, Ganiere JP, Guelfi JF, Chakrabarti L, Maire MA, Gray F, Montagnier L, Hurtrel B (1992) Comparison of early and late feline immunodeficiency virus encephalopathies. AIDS 6: 399-406
33. Johnson WB, Ruppe MD, Rockenstein EM, Price J, Sarthy VP, Verderber LC, Mucke L (1995) Indicator expression directed by regulatory sequences of the glial fibrillary acidic protein (GFAP) gene: in vivo comparison of distinct GFAP-lacZ transgenes. Glia 13: 174-184
34. Kay DG, Gravel C, Pothier F, Laperriere A, Robitaille Y, Jolicoeur P (1993) Neurological disease induced in transgenic mice expressing the env gene of the Cas-Br-E murine retrovirus. Proc Natl Acad Sci USA 90: 4538-4542
35. Keilhoff G, Wolf G (1992) Memantine prevents quinolinic acid-induced hippocampal damage. Eur J Pharmacol 219: 451-454
36. Kekow J, Wachsman W, McCutchan JA, Cronin M, Carson D, Lotz M (1990) Transforming growth factor β and noncytopathic mechanisms of immunodeficiency in human immunodeficiency virus infection Proc Natl Acad Sci USA 87: 8321-8325
37. Kimes AS, London ED, Szabo G, Raymon L, Tabakoff B (1991) Reduction of cerebral glucose utilization by HIV envelope glycoprotein gp-120. Exp Neurol 112: 224-228
38. Koch JA, Ruprecht RM (1992) Animal models for anti-AIDS therapy. Antiviral Res 19: 81-109
39. Koyanagi Y, Miles S, Mitsuyasu RT, Merrill JE, Vinters HV, Chen ISY (1987) Dual infection of the central nervous system by AIDS viruses with distinct cellular tropisms. Science 236: 819-822
40. Lackner AA, Dandekar S, Gardner MB (1991) Neurobiology of simian and feline immunodeficiency virus infections. Brain Pathol 1: 201-212
41. Leonard JM, Abramczuk JW, Pezen DS, Rutledge R, Belcher JH, Hakim F, Shearer G, Lamperth L, Travis W, Fredrickson T (1988) Development of disease and virus recovery in transgenic mice containing HIV proviral DNA. Science 242: 1665-1670
42. Levi G, Patrizio M, Bernardo A, Petrucci TC, Agresti C (1993) Human immunodeficiency virus coat protein gp120 inhibits the β-adrenergic regulation of astroglial and microglial functions Proc Natl Acad Sci USA 90 1541-1545
43. Lipton SA (1992a) Memantine prevents HIV coat protein-induced neuronal injury in vitro. Neurology 42. 1403-1405
44. Lipton SA (1992b) Requirement for macrophages in neuronal injury induced by HIV envelope protein gp120. NeuroReport 3: 913-915
45. Lipton SA (1992c) Models of neuronal injury in AIDS another role for the NMDA receptor? Trends Neurosci 15: 75-79
46. Lipton SA (1994) HIV-related neuronal injury: potential therapeutic intervention with calcium channel antagonists and NMDA antagonists Mol Neurobiol 8: 181-196
47. Mabrouk K, Van Rietschoten J, Vives E, Darbon H, Rochat H, Sabatier J-M (1991) Lethal neurotoxicity in mice of the basic domains of HIV and SIV rev proteins FEBS Lett 289: 13-17
48. MacDonald MC, Robertson HA, Wilkinson M (1993) Age- and dose-related NMDA induction of Fos-like immunoreactivity and c-fos mRNA in the arcuate nucleus of immature female rats Dev Brain Res 73 193-198
49. Marshall DW, Brey RL, Cahill WT, Houk RW, Zajac RA, Boswell RN (1988) Spectrum of cerebrospinal fluid findings in various stages of human immunodeficiency virus infection Arch Neurol 45: 954-958
50. Masliah E, Achim CL, Ge N, DeTeresa R, Terry RD, Wiley CA (1992) Spectrum of human immunodeficiency virus-associated neocortical damage. Ann Neurol 32: 321-329
51. Mattson MP, Cheng B, Culwell AR, Esch FS, Lieberburg I, Rydel RE (1993) Evidence for excitoprotective and intraneuronal calcium- regulating roles for secreted forms of the β-amyloid precursor protein. Neuron 10: 243-254
52. McArthur JC, Cohen BA, Farzedegan H, Cornblath DR, Selnes OA, Ostrow D, Johnson RT, Phair J, Polk BF (1988) Cerebrospinal fluid abnormalities in homosexual men with and without neuropsychiatric findings. Ann Neurol 23 suppl: S34-S37
53. Merrill JE, Chen IS (1991) HIV-1, macrophages, glial cells, and cytokines in AIDS nervous system disease. FASEB J 5 2391-2397
54. Merrill JE, Koyanagi Y, Zack J, Thomas L, Martin F, Chen IS (1992) Induction of interleukin-1 and tumor necrosis factor alpha in brain cultures by human immunodeficiency virus type 1. J Virol 66: 2217-2225
55. Moster DE, Gulizia RJ, Baird SM, Wilson DB, Spector DH, Spector SA (1991) Human immunodeficiency virus infection of human-PBL-SCID mice. Science 251: 791-794
56. Mucke L, Eddleston M (1993) Astrocytes in infectious and immune-mediated diseases of the central nervous system. FASEB J 7 1226-1232
57. Mucke L, Rockenstein EM (1993) Prolonged delivery of transgene products to specific brain regions by migratory astrocyte grafts. Transgenics 1: 3-9
58. Mucke L, Forss-Petter S, Goldgaber D, Johnson W, Picard E, Rockenstein E, Abraham C (1992) Transgenic models to study the pathogenic role of mutated and non-mutated forms of human amyloid proteins in the development of Alzheimer's disease (AD). Neurobiol Aging 13 Suppl 1: S101
59. Mucke L, Abraham CR, Ruppe MD, Rockenstein EM, Toggas SM, Alford M, Masliah E (1995a) Protection against HIV-1 gp120-induced brain damage by neuronal expression of human amyloid precursor protein. J Exp Med 181. 1551-1556
60. Mucke L, Masliah E, Campbell IL (1995b) Transgenic models to assess the neuropathogenic potential of HIV-1 proteins and cytokines. Springer, Berlin Heidelberg New York (Current Topics in Microbioiogy and Immunology, Vol. 202: 187-205)
61. Muller WEG, Schröder HC, Ushijima H, Dapper J, Bormann J (1992) gp120 of HIV-1 induced apoptosis in rat cortical cell cultures: prevention by memantine Eur J Pharmacol 226: 209-214
62. Namikawa R, Kaneshima H, Lieberman M, Weissman IL, McCune JM (1988) Infection of SCID-hu mouse by HIV-1 Science 242 1684-1686
63. Oliver CN, Starke-Reed PE, Stadtman ER, Liu GJ, Carney JM, Floyd RA (1990) Oxidative damage to brasn proteins, loss of glutamine synthetase activity, and production of free radicals during ischemia/reperfusion-induced injury to gerbil brain Proc Natl Acad Sci USA 87: 5144-5147
64. Passman RS, Fishman GI (1994) Regulated expression of foreign genes in vivo after germline transfer. J Clin Invest 94: 2421-2425
65. Pietraforte D, Tritarelli E, Testa U, Minetti M (1994) gp120 HIV envelope glycoprotein increases the production of nitrtc oxide in human monocyte-derived macrophages. J Leukocyte Biol 55: 175-182
66. Price RW, Perry SW (eds) (1994) HIV, AIDS, and the brain Raven, New York
67. Przedborski S, Kostic V, Jackson-Lewis V, Naini AB, Simonetti S, Fahn S, Carlson E, Epstein CJ, Cadet JL (1992) Transgenic mice wtth increased Cu/Zn-superoxide dismutase activity are resistant to N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity J Neurosci 12. 1658-1667
68. Pulliam L, West D. Haigwood N, Swanson RA (1993) HIV-1 envelope gp120 alters astrocytes in human brain cultures AIDS Res Hum Retroviruses 9. 439-444
69. Resnick L, Berger JR, Shapshak P, Tourtellote WW (1988) Early penetration of the blood-brain barrier by HIV Neurology 38: 9-14
70. Rosenberg ZF, Fauci AS (1990) Immunopathogenetic mechanisms of HIV infection: cytokine induction of HIV expression. Immunol Today 11: 176-180
71. Sabatier J-M, Vives E, Mabrouk K, Benjouad A, Rochat H, Duval A, Hue B, Bahraoui E (1991) Evidence for neurotoxic activity of tat from human immunodeficiency virus type 1. J Virol 65: 961-967
72. Saito Y, Sharer LR, Epstein LG, Michaels J, Mintz M, Louder M, Golding K, Cvetkovich TA, Blumberg BM (1994) Overexpression of nef as a marker for restricted HIV-1 infection of astrocytes in postmortem pediatric central nervous tissues. Neurology 44: 474-481
73. Schneider J, Kaaden O, Copeland TD, Oroszlan S, Hunsmann G (1986) Shedding and interspecies type sero-reactivity of the envelope glycopolypeptide gp120 of the human immunodeficiency virus. J Gen Virol 67: 2533-2538
74. Seif el Nasr M, Peruche B, Rossberg C, Mennel HD, Krieglstain J (1990) Neuroprotective effect of memantine demonstrated in vivo and in vitro. Eur J Pharmacol 185 19-24
75. Sharer LR (1992) Pathology of HIV-1 infection of the central nervous system. A review. J Neuropathol Exp Neurol 51: 3-11
76. Small JA, Bieberich C, Ghotbi Z, Hess J, Scangos GA, Clements JE (1989) The visna virus long terminal repeat directs expression of a reporter gene in activated macrophages, lymphocytes, and the central nervous system of transgenic mice. J Virol 63: 1891-1896
77. Spencer DC, Price RW (1992) Human immunodeficiency virus and the central nervous system Annu Rev Microbiol 46: 655-693
78. Sundar SK, Cierpial MA, Kamaraju LS, Long S, Hsieh S, Lorenz C, Aaron M, Ritchie JC, Weiss JM (1991) Human immunodeficiency virus glycoprotein (gp120) infused into rat brain induces interleukin 1 to elevate pituitary-adrenal activity and decrease peripheral cellular immune responses. Proc Natl Acad Sci USA 88: 11246-11250
79. Tardy M, Fages C, Riol H, LePrince G, Rataboul P, Charriere-Bertrand C, Nunez J (1989) Developmental expression of the glial fibrillary acidic protein mRNA in the central nervous system and in cultured astrocytes. J Neurochern 52: 162-167
80. Toggas SM, Masliah E, Rockenstein EM, Rail GF, Abraham CR, Mucke L (1994) Central nervous system damage produced by expression of the HIV-1 coat protein gp120 in transgenic mice. Nature 367 188-193
81. Toggas SM, Masliah E, Mucke L (1995) Prevention of HIV-1 gp120-induced neuronal damage in the central nervous system of transgenic mice by the NMDA receptor antagonist rnemantine Brain Res (in press)
82. Tornatore C, Chandra R, Berger JR, Major EO (1994) HIV-1 infection of subcortical astrocytes in the pediatric central nervous system. Neurology 44: 481-487
83. Tyor WR, Glass JD, Griffin JW, Becker PS, McArthur JC, Bezman L, Griffin DE (1992) Cytokine expression in the brain during the acquired immunodeficiency syndrome. Ann Neurol 31: 349-360
84. Tyor WR, Power C, Gendelman HE, Markham RB (1993) A model of human immunodeficiency virus encephalitis in scid mice. Proc Natl Acad Sci USA 90: 8658-8662
85. Vitkovic L, Kalebic T, da Cunha A, Fauci AS (1990) Astrocyte-conditioned medium stimulates HIV-1 expression in a chronically infected promonocyte clone. J Neuroimmunol 30: 153-160
86. Wahl SM, Allen JB, McCartney-Francis N, Morganti-Kossmann MC, Kossmann T, Ellingsworth L, Mai UE, Mergenhagen SE, Orenstein JM (1991) Macrophage- and astrocyte-derived transforming growth factor beta as a mediator of central nervous system dysfunction in acquired immune deficiency syndrome J Exp Med 173: 981-991
87. Wesselingh SL, Power C, Glass JD, Tyor WR, McArthur JC, Farber JM, Griffin JW, Griffin DE (1993) Intracerebral cytokine messenger RNA expression in acquired immunodeficiency syndrome dementia. Ann Neurol 33: 576-582
88. Wyss-Coray T, Feng L, Masliah E, Ruppe MD, Lee HS, Toggas SM, Rockenstein EM, Mucke L (1995) Increased central nervous system production of extracellular matrix components and development of hydrocephalus in transgenic mice overexpressing transforming growth factor-β1. Am J Pathol 147: 53-67
89. Yang G, Chan PH, Chen J, Carlson E, Chen SF, Weinstein P, Epstein CJ, Kamii H (1994) Human copper-zinc superoxide dismutase transgenic mice are highly resistant to reperfusion injury after focal cerebral ischemia. Stroke 25: 165-170