Activation of proinflammatory signaling by 4-hydroxynonenal- Src adducts in aged kidneys

Oncotarget

Volumn 7, Issue 32, 2016, Pages 50864-50874

  Jang, Eun Ji ^a   Kim, Dae Hyun ^a   Lee, Bonggi ^a   Lee, Eun Kyeong ^a   Chung, Ki Wung ^a   Moon, Kyoung Mi ^a   Kim, Min Jo ^a   An, Hye Jin ^a   Jeong, Ji Won ^a   Kim, Ye Ra ^a   Yu, Byung Pal ^b   Chung, Hae Young ^a  

^a Pusan National University   (South Korea)

^b UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

4 HNE; Aged kidney; Cell senescence; Gerotarget; Inflammation; Src

Indexed keywords

4 HYDROXYNONENAL; CYCLOOXYGENASE 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN TYROSINE KINASE; TRANSCRIPTION FACTOR AP 1; 4-HYDROXY-2-NONENAL; ALDEHYDE;

AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL AGING; CELL CULTURE TECHNIQUE; CONTROLLED STUDY; DISEASE COURSE; ENZYME INDUCTION; EXPERIMENTAL STUDY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; KIDNEY PARENCHYMA; MALE; NEPHRITIS; NONHUMAN; PATHOGENESIS; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION; UMBILICAL VEIN ENDOTHELIAL CELL; UPREGULATION; ANIMAL; INFLAMMATION; KIDNEY; METABOLISM; PATHOLOGY; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

AGING; ALDEHYDES; ANIMALS; CELLULAR SENESCENCE; HUMANS; INFLAMMATION; KIDNEY; MALE; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; SRC-FAMILY KINASES;

EID: 84982273179     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.10854     Document Type: Article

References (25)

1. Esterbauer H, Schaur RJ, Zollner H. Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes. Free Radic Biol Med. 1991; 11: 81-128.
2. Chiarpotto E, Biasi F, Scavazza A, Camandola S, Dianzani MU, Poli G. Metabolism of 4-hydroxy-2-nonenal and aging. Bioche Biophys Res Commun. 1995; 207: 477-484.
3. Wang DS, Iwata N, Hama E, Saido TC, Dickson DW. Oxidized neprilysin in aging and Alzheimer's disease brains. Biochem Biophys Res Commun. 2003; 310: 236-241.
4. Lee JH, Jung KJ, Kim JW, Kim HJ, Yu BP, Chung HY. Suppression of apoptosis by calorie restriction in aged kidney. Exp Gerontol. 2004; 39: 1361-1368.
5. Uchida K. 4-Hydroxy-2-nonenal: a product and mediator of oxidative stress. Prog Lipid Res. 2003; 42: 318-343.
6. Toyokuni S, Uchida K, Okamoto K, Hattori-Nakakuki Y, Hiai H, Stadtman ER. Formation of 4-hydroxy-2-nonenalmodified proteins in the renal proximal tubules of rats treated with a renal carcinogen, ferric nitrilotriacetate. Proc Natl Acad Sci USA. 1994; 91: 2616-2620.
7. Hamilton RFJr, Li L, Eschenbacher WL, Szweda L, Holian A. Potential involvement of 4-hydroxynonenal in the response of human lung cells to ozone. Am J Physiol. 1998; 274: 8-16.
8. Compton CN, Franko AP, Murray MT, Diebel LN, Dulchavsky SA. Signaling of apoptotic lung injury by lipid hydroperoxides. J Trauma. 1998; 44: 783-788.
9. Uchida K. Role of reactive aldehyde in cardiovascular diseases. Free Radic Biol Med. 2000; 28: 1685-1696.
10. Yu BP. Aging and oxidative stress: modulation by dietary restriction. Free Radic Biol Med. 1996; 21: 651-668.
11. Chung HY, Kim HJ, Kim JW, Yu BP. The inflammation hypothesis of aging: molecular modulation by calorie restriction. Ann N Y Acad Sci. 2001; 928: 327-335.
12. Chung HY, Kim HJ, Kim KW, Choi JS, Yu BP. Molecular inflammation hypothesis of aging based on the anti-aging mechanism of calorie restriction. Microsc Res Tech. 2002; 59: 264-272.
13. Kumagai T, Matsukawa N, Kaneko Y, Kusumi Y, Mitsumata M, Uchida K. A lipid peroxidation-derived inflammatory mediator: identification of 4-hydroxy-2-nonenal as a potential inducer of cyclooxygenase-2 in macrophages. J Biol Chem. 2004; 279:48389-96.
14. Jung KJ, Lee EK, Yu BP, Chung HY. Significance of protein tyrosine kinase/protein tyrosine phosphatase balance in the regulation of NF-kappaB signaling in the inflammatory process and aging. Free Radic Biol Med. 2009; 47: 983-991.
15. Jang EJ, Jeong HO, Park D, Kim DH, Choi YJ, Chung KW, Park MH, Yu BP, Chung HY. Src tyrosine kinase activation by 4-Hydroxynonenal upregulates p38/AP-1 signaling and COX-2 expression in endothelial cells. Plos One. 2015; 10: e0129244.
16. Moreau R, Heath SH, Doneanu CE, Lindsay JG, Hagen TM. Age-related increase in 4-hydroxynonenal adduction to rat heart alpha-ketoglutarate dehydrogenase does not cause loss of its catalytic activity. Antioxid Redox Signal. 2003; 5: 517-527.
17. Volkel W, Sicilia T, Pahler A, Gsell W, Tatschner T, Jellinger K, Leblhuber F, Riederer P, Lutz WK. Gotz ME. Increased brain level s of 4-hydroxy-2-nonenal glutathione conjugates in severe Alzheimer's disease. Neurochemi stry International. 2006; 48: 679-686.
18. Siems W1, Carluccio F, Grune T, Jakstadt M, Quast S, Hampl H, Sommerburg O. Elevated serum concentration of cardiotoxic lipid peroxidation products in chronic renal failure in relation to severity of renal anemia. Clin Nephrol. 2002; 58 Suppl 1:S20-5.
19. Leonarduzzi G, Robbesyn F. Poli G. Signaling kinases modulated by 4-hydroxynonenal. Free Radic Bioi Med. 2004; 37: 1694-1702.
20. Uchida K. Role of reactive aldehyde in cardiovascular diseases. Free Radic Bioi Med. 2000; 28: 1685-1696.
21. Kim CH, Zou Y, Kim DH, Kim ND, Yu BP, Chung HY. Proteomic analysis of nitrated and 4-hydroxy-2-nonenalmodified serum proteins during aging. J Gerontol A Biol Sci Med Sci. 2006; 61: 332-338.
22. Negre-Salvayre A, Vieira O, Escargueil-Blanc I, Salvayre R. Oxidized LDL and 4-hydroxynonenal modulate tyrosine kinase receptor activity. Mol Aspects Med. 2003; 24: 251-261.
23. Zhang H, Forman HJ. 4-Hydroxynonenal activates Src through a non-canonical pathway that involves EGFR/ PTP1B. Free Radic Biol Med. 2015; 89: 701-707.
24. Kim JM, Lee EK, Kim DH, Yu BP, Chung HY. Kaempferol modulates pro-inflammatory NF-kappaB activation by suppressing advanced glycation endproducts-induced NADPH oxidase. Age (Dordr). 2010; 32: 197-208.
25. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 1970; 227: 680-685.