Src tyrosine kinase activation by 4-hydroxynonenal upregulates p38, ERK/AP-1 signaling and COX-2 expression in YPEN-1 cells

PLoS ONE

Volumn 10, Issue 10, 2015, Pages

  Jang, Eun Ji ^a   Jeong, Hyoung Oh ^a   Park, Daeui ^a   Kim, Dae Hyun ^a   Choi, Yeon Ja ^a   Chung, Ki Wung ^a   Park, Min Hi ^a   Yu, Byung Pal ^b   Chung, Hae Young ^a  

^a Pusan National University   (South Korea)

^b UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 HYDROXYNONENAL; CYCLOOXYGENASE 2; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN TYROSINE KINASE; SYNAPTOPHYSIN; TRANSCRIPTION FACTOR AP 1; 4-HYDROXY-2-NONENAL; ALDEHYDE; MITOGEN ACTIVATED PROTEIN KINASE P38; PTGS2 PROTEIN, RAT; SMALL INTERFERING RNA;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVATION; MALE; MOLECULAR DOCKING; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; UPREGULATION; ANIMAL; BINDING SITE; CELL NUCLEUS; CHEMISTRY; CYTOSOL; DRUG EFFECTS; GENE EXPRESSION REGULATION; INFLAMMATION; LIQUID CHROMATOGRAPHY; METABOLISM; OXIDATIVE STRESS; PHOSPHORYLATION; TANDEM MASS SPECTROMETRY; TUMOR CELL LINE;

ALDEHYDES; ANIMALS; BINDING SITES; CELL LINE, TUMOR; CELL NUCLEUS; CHROMATOGRAPHY, LIQUID; CYCLOOXYGENASE 2; CYTOSOL; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENE EXPRESSION REGULATION, ENZYMOLOGIC; INFLAMMATION; MOLECULAR DOCKING SIMULATION; OXIDATIVE STRESS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; RATS; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; SRC-FAMILY KINASES; TANDEM MASS SPECTROMETRY; TRANSCRIPTION FACTOR AP-1; UP-REGULATION;

EID: 84949024631     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0129244     Document Type: Article

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