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Volumn 127, Issue 14, 2016, Pages 1790-1802

Polycomb-dependent epigenetic landscape in adult T-cell leukemia

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MICRORNA; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR EZH2; TRANSCRIPTOME; TUMOR SUPPRESSOR PROTEIN; EZH2 PROTEIN, HUMAN; POLYCOMB REPRESSIVE COMPLEX 2; TAX PROTEIN; TAX PROTEIN, HUMAN T-LYMPHOTROPHIC VIRUS 1; TUMOR PROTEIN;

EID: 84982171111     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2015-08-662593     Document Type: Article
Times cited : (123)

References (60)
  • 1
    • 0042175289 scopus 로고    scopus 로고
    • Human T lymphotropic virus type-I and adult T-cell leukemia in Japan
    • Yamaguchi K, Watanabe T. Human T lymphotropic virus type-I and adult T-cell leukemia in Japan. Int J Hematol. 2002;76(Suppl 2):240-245.
    • (2002) Int J Hematol. , vol.76 , pp. 240-245
    • Yamaguchi, K.1    Watanabe, T.2
  • 2
    • 36849051298 scopus 로고    scopus 로고
    • VCAP-AMP-VECP compared with biweekly CHOP for adult T-cell leukemialymphoma: Japan Clinical Oncology Group Study JCOG9801
    • Tsukasaki K, Utsunomiya A, Fukuda H, et al; Japan Clinical Oncology Group Study JCOG9801. VCAP-AMP-VECP compared with biweekly CHOP for adult T-cell leukemialymphoma: Japan Clinical Oncology Group Study JCOG9801. J Clin Oncol. 2007;25(34):5458-5464.
    • (2007) J Clin Oncol. , vol.25 , Issue.34 , pp. 5458-5464
    • Tsukasaki, K.1    Utsunomiya, A.2    Fukuda, H.3
  • 3
    • 58549103931 scopus 로고    scopus 로고
    • Definition, prognostic factors, treatment, and response criteria of adult T-cell leukemia-lymphoma: A proposal from an international consensus meeting
    • Tsukasaki K, Hermine O, Bazarbachi A, et al. Definition, prognostic factors, treatment, and response criteria of adult T-cell leukemia-lymphoma: a proposal from an international consensus meeting. J Clin Oncol. 2009;27(3):453-459.
    • (2009) J Clin Oncol. , vol.27 , Issue.3 , pp. 453-459
    • Tsukasaki, K.1    Hermine, O.2    Bazarbachi, A.3
  • 4
    • 77957962485 scopus 로고    scopus 로고
    • Meta-analysis on the use of zidovudine and interferon-alfa in adult T-cell leukemia/lymphoma showing improved survival in the leukemic subtypes
    • Bazarbachi A, Plumelle Y, Carlos Ramos J, et al. Meta-analysis on the use of zidovudine and interferon-alfa in adult T-cell leukemia/lymphoma showing improved survival in the leukemic subtypes. J Clin Oncol. 2010;28(27):4177-4183.
    • (2010) J Clin Oncol. , vol.28 , Issue.27 , pp. 4177-4183
    • Bazarbachi, A.1    Plumelle, Y.2    Carlos Ramos, J.3
  • 5
    • 84863745306 scopus 로고    scopus 로고
    • Prognostic index for acute- and lymphoma-type adult T-cell leukemia/lymphoma
    • Katsuya H, Yamanaka T, Ishitsuka K, et al. Prognostic index for acute- and lymphoma-type adult T-cell leukemia/lymphoma. J Clin Oncol. 2012;30(14):1635-1640.
    • (2012) J Clin Oncol. , vol.30 , Issue.14 , pp. 1635-1640
    • Katsuya, H.1    Yamanaka, T.2    Ishitsuka, K.3
  • 7
    • 13144276369 scopus 로고    scopus 로고
    • Proliferation of adult T cell leukemia/lymphoma cells is associated with the constitutive activation of JAK/STAT proteins
    • Takemoto S, Mulloy JC, Cereseto A, et al. Proliferation of adult T cell leukemia/lymphoma cells is associated with the constitutive activation of JAK/STAT proteins. Proc Natl Acad Sci USA. 1997;94(25):13897-13902.
    • (1997) Proc Natl Acad Sci USA , vol.94 , Issue.25 , pp. 13897-13902
    • Takemoto, S.1    Mulloy, J.C.2    Cereseto, A.3
  • 8
    • 0035877991 scopus 로고    scopus 로고
    • Comparative genomic hybridization analysis in adult T-cell leukemia/lymphoma: Correlation with clinical course
    • Tsukasaki K, Krebs J, Nagai K, et al. Comparative genomic hybridization analysis in adult T-cell leukemia/lymphoma: correlation with clinical course. Blood. 2001;97(12):3875-3881.
    • (2001) Blood , vol.97 , Issue.12 , pp. 3875-3881
    • Tsukasaki, K.1    Krebs, J.2    Nagai, K.3
  • 9
    • 27144476790 scopus 로고    scopus 로고
    • Dual targeting of transformed and untransformed HTLV-1-infected T cells by DHMEQ, a potent and selective inhibitor of NF-kappaB, as a strategy for chemoprevention and therapy of adult T-cell leukemia
    • Watanabe M, Ohsugi T, Shoda M, et al. Dual targeting of transformed and untransformed HTLV-1-infected T cells by DHMEQ, a potent and selective inhibitor of NF-kappaB, as a strategy for chemoprevention and therapy of adult T-cell leukemia. Blood. 2005;106(7):2462-2471.
    • (2005) Blood , vol.106 , Issue.7 , pp. 2462-2471
    • Watanabe, M.1    Ohsugi, T.2    Shoda, M.3
  • 10
    • 33744464235 scopus 로고    scopus 로고
    • Identification of subtype-specific genomic alterations in aggressive adult T-cell leukemia/lymphoma
    • Oshiro A, Tagawa H, Ohshima K, et al. Identification of subtype-specific genomic alterations in aggressive adult T-cell leukemia/lymphoma. Blood. 2006;107(11):4500-4507.
    • (2006) Blood , vol.107 , Issue.11 , pp. 4500-4507
    • Oshiro, A.1    Tagawa, H.2    Ohshima, K.3
  • 11
    • 84862907856 scopus 로고    scopus 로고
    • Polycomb-mediated loss of miR-31 activates NIK-dependent NF-κB pathway in adult T cell leukemia and other cancers
    • Yamagishi M, Nakano K, Miyake A, et al. Polycomb-mediated loss of miR-31 activates NIK-dependent NF-κB pathway in adult T cell leukemia and other cancers. Cancer Cell. 2012;21(1):121-135.
    • (2012) Cancer Cell. , vol.21 , Issue.1 , pp. 121-135
    • Yamagishi, M.1    Nakano, K.2    Miyake, A.3
  • 12
    • 84875830301 scopus 로고    scopus 로고
    • Molecular hallmarks of adult T cell leukemia
    • Yamagishi M, Watanabe T. Molecular hallmarks of adult T cell leukemia. Front Microbiol. 2012;3:334.
    • (2012) Front Microbiol. , vol.3 , pp. 334
    • Yamagishi, M.1    Watanabe, T.2
  • 13
    • 84919702854 scopus 로고    scopus 로고
    • Loss of NDRG2 expression activates PI3K-AKT signalling via PTEN phosphorylation in ATLL and other cancers
    • Nakahata S, Ichikawa T, Maneesaay P, et al. Loss of NDRG2 expression activates PI3K-AKT signalling via PTEN phosphorylation in ATLL and other cancers. Nat Commun. 2014;5:3393.
    • (2014) Nat Commun. , vol.5 , pp. 3393
    • Nakahata, S.1    Ichikawa, T.2    Maneesaay, P.3
  • 14
    • 84923362619 scopus 로고    scopus 로고
    • Integrative analysis of 111 reference human epigenomes
    • Kundaje A, Meuleman W, Ernst J, et al; Roadmap Epigenomics Consortium. Integrative analysis of 111 reference human epigenomes. Nature. 2015;518(7539):317-330.
    • (2015) Nature , vol.518 , Issue.7539 , pp. 317-330
    • Kundaje, A.1    Meuleman, W.2    Ernst, J.3
  • 15
    • 84881086323 scopus 로고    scopus 로고
    • Cancer as a dysregulated epigenome allowing cellular growth advantage at the expense of the host
    • Timp W, Feinberg AP. Cancer as a dysregulated epigenome allowing cellular growth advantage at the expense of the host. Nat Rev Cancer. 2013;13(7):497-510.
    • (2013) Nat Rev Cancer , vol.13 , Issue.7 , pp. 497-510
    • Timp, W.1    Feinberg, A.P.2
  • 16
    • 77957154350 scopus 로고    scopus 로고
    • Throwing the cancer switch: Reciprocal roles of polycomb and trithorax proteins
    • Mills AA. Throwing the cancer switch: reciprocal roles of polycomb and trithorax proteins. Nat Rev Cancer. 2010;10(10):669-682.
    • (2010) Nat Rev Cancer , vol.10 , Issue.10 , pp. 669-682
    • Mills, A.A.1
  • 17
    • 78751662908 scopus 로고    scopus 로고
    • The Polycomb complex PRC2 and its mark in life
    • Margueron R, Reinberg D. The Polycomb complex PRC2 and its mark in life. Nature. 2011;469(7330):343-349.
    • (2011) Nature , vol.469 , Issue.7330 , pp. 343-349
    • Margueron, R.1    Reinberg, D.2
  • 18
    • 84929049155 scopus 로고    scopus 로고
    • Epigenetics of T cells regulated by Polycomb/Trithorax molecules
    • Onodera A, Nakayama T. Epigenetics of T cells regulated by Polycomb/Trithorax molecules. Trends Mol Med. 2015;21(5):330-340.
    • (2015) Trends Mol Med. , vol.21 , Issue.5 , pp. 330-340
    • Onodera, A.1    Nakayama, T.2
  • 19
    • 78650495421 scopus 로고    scopus 로고
    • Polycomb proteins in hematologic malignancies
    • Martin-Perez D, Piris MA, Sanchez-Beato M. Polycomb proteins in hematologic malignancies. Blood. 2010;116(25):5465-5475.
    • (2010) Blood , vol.116 , Issue.25 , pp. 5465-5475
    • Martin-Perez, D.1    Piris, M.A.2    Sanchez-Beato, M.3
  • 20
    • 79955729316 scopus 로고    scopus 로고
    • Overexpression of Enhancer of zeste homolog 2 with trimethylation of lysine 27 on histone H3 in adult T-cell leukemia/lymphoma as a target for epigenetic therapy
    • Sasaki D, Imaizumi Y, Hasegawa H, et al. Overexpression of Enhancer of zeste homolog 2 with trimethylation of lysine 27 on histone H3 in adult T-cell leukemia/lymphoma as a target for epigenetic therapy. Haematologica. 2011;96(5):712-719.
    • (2011) Haematologica , vol.96 , Issue.5 , pp. 712-719
    • Sasaki, D.1    Imaizumi, Y.2    Hasegawa, H.3
  • 22
    • 77956535619 scopus 로고    scopus 로고
    • Joint Study on Predisposing Factors of ATL Development investigators. Human T-cell leukemia virus type I (HTLV-1) proviral load and disease progression in asymptomatic HTLV-1 carriers: A nationwide prospective study in Japan
    • Iwanaga M, Watanabe T, Utsunomiya A, et al; Joint Study on Predisposing Factors of ATL Development investigators. Human T-cell leukemia virus type I (HTLV-1) proviral load and disease progression in asymptomatic HTLV-1 carriers: a nationwide prospective study in Japan. Blood. 2010;116(8):1211-1219.
    • (2010) Blood , vol.116 , Issue.8 , pp. 1211-1219
    • Iwanaga, M.1    Watanabe, T.2    Utsunomiya, A.3
  • 23
    • 84901809749 scopus 로고    scopus 로고
    • CADM1 expression and stepwise downregulation of CD7 are closely associated with clonal expansion of HTLV-I-infected cells in adult T-cell leukemia/lymphoma
    • Kobayashi S, Nakano K, Watanabe E, et al. CADM1 expression and stepwise downregulation of CD7 are closely associated with clonal expansion of HTLV-I-infected cells in adult T-cell leukemia/lymphoma. Clin Cancer Res. 2014;20(11):2851-2861.
    • (2014) Clin Cancer Res. , vol.20 , Issue.11 , pp. 2851-2861
    • Kobayashi, S.1    Nakano, K.2    Watanabe, E.3
  • 24
    • 61449172037 scopus 로고    scopus 로고
    • Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
    • Huang W, Sherman BT, Lempicki RA. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc. 2009;4(1):44-57.
    • (2009) Nat Protoc , vol.4 , Issue.1 , pp. 44-57
    • Huang, W.1    Sherman, B.T.2    Lempicki, R.A.3
  • 25
    • 58549112996 scopus 로고    scopus 로고
    • Bioinformatics enrichment tools: Paths toward the comprehensive functional analysis of large gene lists
    • Huang W, Sherman BT, Lempicki RA. Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists. Nucleic Acids Res. 2009;37(1):1-13.
    • (2009) Nucleic Acids Res. , vol.37 , Issue.1 , pp. 1-13
    • Huang, W.1    Sherman, B.T.2    Lempicki, R.A.3
  • 26
    • 20144370200 scopus 로고    scopus 로고
    • OPOSSUM: Identification of over-represented transcription factor binding sites in co-expressed genes
    • Ho Sui SJ, Mortimer JR, Arenillas DJ, et al. oPOSSUM: identification of over-represented transcription factor binding sites in co-expressed genes. Nucleic Acids Res. 2005;33(10):3154-3164.
    • (2005) Nucleic Acids Res. , vol.33 , Issue.10 , pp. 3154-3164
    • Ho Sui, S.J.1    Mortimer, J.R.2    Arenillas, D.J.3
  • 27
    • 84941103248 scopus 로고    scopus 로고
    • ArrayExpress update - Simplifying data submissions
    • Kolesnikov N, Hastings E, Keays M, et al. ArrayExpress update - simplifying data submissions. Nucleic Acids Res. 2015;43(Database issue):D1113-D1116.
    • (2015) Nucleic Acids Res. , vol.43 , Issue.DATABASE ISSUE , pp. D1113-D1116
    • Kolesnikov, N.1    Hastings, E.2    Keays, M.3
  • 28
    • 84910667093 scopus 로고    scopus 로고
    • SraTailor: Graphical user interface software for processing and visualizing ChIP-seq data
    • Oki S, Maehara K, Ohkawa Y, Meno C. SraTailor: graphical user interface software for processing and visualizing ChIP-seq data. Genes Cells. 2014;19(12):919-926.
    • (2014) Genes Cells , vol.19 , Issue.12 , pp. 919-926
    • Oki, S.1    Maehara, K.2    Ohkawa, Y.3    Meno, C.4
  • 29
    • 0030931963 scopus 로고    scopus 로고
    • Stable and efficient gene transfer into the retina using an HIV-based lentiviral vector
    • Miyoshi H, Takahashi M, Gage FH, Verma IM. Stable and efficient gene transfer into the retina using an HIV-based lentiviral vector. Proc Natl Acad Sci USA. 1997;94(19):10319-10323.
    • (1997) Proc Natl Acad Sci USA , vol.94 , Issue.19 , pp. 10319-10323
    • Miyoshi, H.1    Takahashi, M.2    Gage, F.H.3    Verma, I.M.4
  • 31
    • 84875745673 scopus 로고    scopus 로고
    • Interplay between the cancer genome and epigenome
    • Shen H, Laird PW. Interplay between the cancer genome and epigenome. Cell. 2013;153(1):38-55.
    • (2013) Cell. , vol.153 , Issue.1 , pp. 38-55
    • Shen, H.1    Laird, P.W.2
  • 32
    • 84870573126 scopus 로고    scopus 로고
    • EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations
    • McCabe MT, Ott HM, Ganji G, et al. EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations. Nature. 2012;492(7427):108-112.
    • (2012) Nature , vol.492 , Issue.7427 , pp. 108-112
    • McCabe, M.T.1    Ott, H.M.2    Ganji, G.3
  • 33
    • 84863165348 scopus 로고    scopus 로고
    • Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27)
    • McCabe MT, Graves AP, Ganji G, et al. Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27). Proc Natl Acad Sci USA. 2012;109(8):2989-2994.
    • (2012) Proc Natl Acad Sci USA , vol.109 , Issue.8 , pp. 2989-2994
    • McCabe, M.T.1    Graves, A.P.2    Ganji, G.3
  • 34
    • 84877815031 scopus 로고    scopus 로고
    • EZH2 is required for germinal center formation and somatic EZH2 mutations promote lymphoid transformation
    • Béguelin W, Popovic R, Teater M, et al. EZH2 is required for germinal center formation and somatic EZH2 mutations promote lymphoid transformation. Cancer Cell. 2013;23(5):677-692.
    • (2013) Cancer Cell. , vol.23 , Issue.5 , pp. 677-692
    • Béguelin, W.1    Popovic, R.2    Teater, M.3
  • 35
    • 34249026300 scopus 로고    scopus 로고
    • High-resolution profiling of histone methylations in the human genome
    • Barski A, Cuddapah S, Cui K, et al. High-resolution profiling of histone methylations in the human genome. Cell. 2007;129(4):823-837.
    • (2007) Cell. , vol.129 , Issue.4 , pp. 823-837
    • Barski, A.1    Cuddapah, S.2    Cui, K.3
  • 36
    • 33646865180 scopus 로고    scopus 로고
    • Control of developmental regulators by Polycomb in human embryonic stem cells
    • Lee TI, Jenner RG, Boyer LA, et al. Control of developmental regulators by Polycomb in human embryonic stem cells. Cell. 2006;125(2):301-313.
    • (2006) Cell. , vol.125 , Issue.2 , pp. 301-313
    • Lee, T.I.1    Jenner, R.G.2    Boyer, L.A.3
  • 37
    • 77953742426 scopus 로고    scopus 로고
    • Downregulation of CDKN1A in adult T-cell leukemia/lymphoma despite overexpression of CDKN1A in human T-lymphotropic virus 1-infected cell lines
    • Watanabe M, Nakahata S, Hamasaki M, et al. Downregulation of CDKN1A in adult T-cell leukemia/lymphoma despite overexpression of CDKN1A in human T-lymphotropic virus 1-infected cell lines. J Virol. 2010;84(14):6966-6977.
    • (2010) J Virol. , vol.84 , Issue.14 , pp. 6966-6977
    • Watanabe, M.1    Nakahata, S.2    Hamasaki, M.3
  • 38
    • 77954952693 scopus 로고    scopus 로고
    • Downregulation of ZEB1 and overexpression of Smad7 contribute to resistance to TGF-beta1-mediated growth suppression in adult T-cell leukemia/lymphoma
    • Nakahata S, Yamazaki S, Nakauchi H, Morishita K. Downregulation of ZEB1 and overexpression of Smad7 contribute to resistance to TGF-beta1-mediated growth suppression in adult T-cell leukemia/lymphoma. Oncogene. 2010;29(29):4157-4169.
    • (2010) Oncogene , vol.29 , Issue.29 , pp. 4157-4169
    • Nakahata, S.1    Yamazaki, S.2    Nakauchi, H.3    Morishita, K.4
  • 39
    • 84927927086 scopus 로고    scopus 로고
    • Tax contributes apoptosis resistance to HTLV-1-infected T cells via suppression of Bid and Bim expression
    • Mühleisen A, Giaisi M, Köhler R, Krammer PH, Li- Weber M. Tax contributes apoptosis resistance to HTLV-1-infected T cells via suppression of Bid and Bim expression. Cell Death Dis. 2014;5:e1575.
    • (2014) Cell Death Dis. , vol.5 , pp. e1575
    • Mühleisen, A.1    Giaisi, M.2    Köhler, R.3    Krammer, P.H.4    Li-Weber, M.5
  • 40
    • 79951724657 scopus 로고    scopus 로고
    • Leukemic T cells are specifically enriched in a unique CD3 (dim) CD7(low) subpopulation of CD4(+) T cells in acute-type adult T-cell leukemia
    • Tian Y, Kobayashi S, Ohno N, et al. Leukemic T cells are specifically enriched in a unique CD3 (dim) CD7(low) subpopulation of CD4(+) T cells in acute-type adult T-cell leukemia. Cancer Sci. 2011;102(3):569-577.
    • (2011) Cancer Sci. , vol.102 , Issue.3 , pp. 569-577
    • Tian, Y.1    Kobayashi, S.2    Ohno, N.3
  • 41
    • 19944432330 scopus 로고    scopus 로고
    • Overexpression of a cell adhesion molecule, TSLC1, as a possible molecular marker for acute-type adult T-cell leukemia
    • Sasaki H, Nishikata I, Shiraga T, et al. Overexpression of a cell adhesion molecule, TSLC1, as a possible molecular marker for acute-type adult T-cell leukemia. Blood. 2005;105(3):1204-1213.
    • (2005) Blood , vol.105 , Issue.3 , pp. 1204-1213
    • Sasaki, H.1    Nishikata, I.2    Shiraga, T.3
  • 42
    • 84909995755 scopus 로고    scopus 로고
    • Epigenetic deregulation of Ellis Van Creveld confers robust Hedgehog signaling in adult T-cell leukemia
    • Takahashi R, Yamagishi M, Nakano K, et al. Epigenetic deregulation of Ellis Van Creveld confers robust Hedgehog signaling in adult T-cell leukemia. Cancer Sci. 2014;105(9):1160-1169.
    • (2014) Cancer Sci. , vol.105 , Issue.9 , pp. 1160-1169
    • Takahashi, R.1    Yamagishi, M.2    Nakano, K.3
  • 43
    • 35148867907 scopus 로고    scopus 로고
    • UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development
    • Agger K, Cloos PA, Christensen J, et al. UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development. Nature. 2007;449(7163):731-734.
    • (2007) Nature , vol.449 , Issue.7163 , pp. 731-734
    • Agger, K.1    Cloos, P.A.2    Christensen, J.3
  • 44
    • 78650062951 scopus 로고    scopus 로고
    • EZH2-mediated epigenetic silencing in germinal center B cells contributes to proliferation and lymphomagenesis
    • Velichutina I, Shaknovich R, Geng H, et al. EZH2-mediated epigenetic silencing in germinal center B cells contributes to proliferation and lymphomagenesis. Blood. 2010;116(24):5247-5255.
    • (2010) Blood , vol.116 , Issue.24 , pp. 5247-5255
    • Velichutina, I.1    Shaknovich, R.2    Geng, H.3
  • 45
    • 0032528516 scopus 로고    scopus 로고
    • Loss of function of the homeobox gene Hoxa-9 perturbs early T-cell development and induces apoptosis in primitive thymocytes
    • Izon DJ, Rozenfeld S, Fong ST, Kömüves L, Largman C, Lawrence HJ. Loss of function of the homeobox gene Hoxa-9 perturbs early T-cell development and induces apoptosis in primitive thymocytes. Blood. 1998;92(2):383-393.
    • (1998) Blood , vol.92 , Issue.2 , pp. 383-393
    • Izon, D.J.1    Rozenfeld, S.2    Fong, S.T.3    Kömüves, L.4    Largman, C.5    Lawrence, H.J.6
  • 47
    • 55949136562 scopus 로고    scopus 로고
    • Roles of the EZH2 histone methyltransferase in cancer epigenetics
    • Simon JA, Lange CA. Roles of the EZH2 histone methyltransferase in cancer epigenetics. Mutat Res. 2008;647(1-2):21-29.
    • (2008) Mutat Res. , vol.647 , Issue.1-2 , pp. 21-29
    • Simon, J.A.1    Lange, C.A.2
  • 48
    • 84921592316 scopus 로고    scopus 로고
    • Developmental control of polycomb subunit composition by GATA factors mediates a switch to non-canonical functions
    • Xu J, Shao Z, Li D, et al. Developmental control of polycomb subunit composition by GATA factors mediates a switch to non-canonical functions. Mol Cell. 2015;57(2):304-316.
    • (2015) Mol Cell. , vol.57 , Issue.2 , pp. 304-316
    • Xu, J.1    Shao, Z.2    Li, D.3
  • 49
    • 34247625135 scopus 로고    scopus 로고
    • Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells
    • Tan J, Yang X, Zhuang L, et al. Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells. Genes Dev. 2007;21(9):1050-1063.
    • (2007) Genes Dev. , vol.21 , Issue.9 , pp. 1050-1063
    • Tan, J.1    Yang, X.2    Zhuang, L.3
  • 51
    • 77950550424 scopus 로고    scopus 로고
    • HTLV-I Tax-dependent and -independent events associated with immortalization of human primary T lymphocytes
    • Bellon M, Baydoun HH, Yao Y, Nicot C. HTLV-I Tax-dependent and -independent events associated with immortalization of human primary T lymphocytes. Blood. 2010;115(12):2441-2448.
    • (2010) Blood , vol.115 , Issue.12 , pp. 2441-2448
    • Bellon, M.1    Baydoun, H.H.2    Yao, Y.3    Nicot, C.4
  • 52
    • 0025245774 scopus 로고
    • Identification of HTLV-I tax trans-activator mutants exhibiting novel transcriptional phenotypes
    • Smith MR, Greene WC. Identification of HTLV-I tax trans-activator mutants exhibiting novel transcriptional phenotypes. Genes Dev. 1990;4(11):1875-1885.
    • (1990) Genes Dev. , vol.4 , Issue.11 , pp. 1875-1885
    • Smith, M.R.1    Greene, W.C.2
  • 53
    • 34250380367 scopus 로고    scopus 로고
    • The nuclear import of the human T lymphotropic virus type I (HTLV-1) tax protein is carrier- and energy-independent
    • Tsuji T, Sheehy N, Gautier VW, Hayakawa H, Sawa H, Hall WW. The nuclear import of the human T lymphotropic virus type I (HTLV-1) tax protein is carrier- and energy-independent. J Biol Chem. 2007;282(18):13875-13883.
    • (2007) J Biol Chem. , vol.282 , Issue.18 , pp. 13875-13883
    • Tsuji, T.1    Sheehy, N.2    Gautier, V.W.3    Hayakawa, H.4    Sawa, H.5    Hall, W.W.6
  • 54
    • 84945344219 scopus 로고    scopus 로고
    • Integrated molecular analysis of adult T cell leukemia/lymphoma
    • Kataoka K, Nagata Y, Kitanaka A, et al. Integrated molecular analysis of adult T cell leukemia/lymphoma. Nat Genet. 2015;47(11):1304-1315.
    • (2015) Nat Genet. , vol.47 , Issue.11 , pp. 1304-1315
    • Kataoka, K.1    Nagata, Y.2    Kitanaka, A.3
  • 55
    • 0037126388 scopus 로고    scopus 로고
    • The interaction of HTLV-1 Tax with HDAC1 negatively regulates the viral gene expression
    • Ego T, Ariumi Y, Shimotohno K. The interaction of HTLV-1 Tax with HDAC1 negatively regulates the viral gene expression. Oncogene. 2002;21(47):7241-7246.
    • (2002) Oncogene , vol.21 , Issue.47 , pp. 7241-7246
    • Ego, T.1    Ariumi, Y.2    Shimotohno, K.3
  • 56
    • 84934969509 scopus 로고    scopus 로고
    • Novel small-molecule SIRT1 inhibitors induce cell death in adult T-cell leukaemia cells
    • Kozako T, Suzuki T, Yoshimitsu M, et al. Novel small-molecule SIRT1 inhibitors induce cell death in adult T-cell leukaemia cells. Sci Rep. 2015;5:11345.
    • (2015) Sci Rep. , vol.5 , pp. 11345
    • Kozako, T.1    Suzuki, T.2    Yoshimitsu, M.3
  • 57
    • 33646070846 scopus 로고    scopus 로고
    • A bivalent chromatin structure marks key developmental genes in embryonic stem cells
    • Bernstein BE, Mikkelsen TS, Xie X, et al. A bivalent chromatin structure marks key developmental genes in embryonic stem cells. Cell. 2006;125(2):315-326.
    • (2006) Cell. , vol.125 , Issue.2 , pp. 315-326
    • Bernstein, B.E.1    Mikkelsen, T.S.2    Xie, X.3
  • 58
    • 84889573275 scopus 로고    scopus 로고
    • Histone lysine demethylases as targets for anticancer therapy
    • Højfeldt JW, Agger K, Helin K. Histone lysine demethylases as targets for anticancer therapy. Nat Rev Drug Discov. 2013;12(12):917-930.
    • (2013) Nat Rev Drug Discov , vol.12 , Issue.12 , pp. 917-930
    • Højfeldt, J.W.1    Agger, K.2    Helin, K.3
  • 59
    • 55949124844 scopus 로고    scopus 로고
    • EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency
    • Shen X, Liu Y, Hsu Y-JJ, et al. EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency. Mol Cell. 2008;32(4):491-502.
    • (2008) Mol Cell. , vol.32 , Issue.4 , pp. 491-502
    • Shen, X.1    Liu, Y.2    Hsu, Y.-J.J.3
  • 60
    • 55949132133 scopus 로고    scopus 로고
    • Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms
    • Margueron R, Li G, Sarma K, et al. Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms. Mol Cell. 2008;32(4):503-518.
    • (2008) Mol Cell. , vol.32 , Issue.4 , pp. 503-518
    • Margueron, R.1    Li, G.2    Sarma, K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.