Syndromic versus non-syndromic sporadic gastrin-producing neuroendocrine tumors of the duodenum: Comparison of pathological features and biological behavior

Virchows Archiv

Volumn 468, Issue 3, 2016, Pages 277-287

  Rosentraeger, M Johannes ^a   Garbrecht, Nele ^a   Anlauf, Martin ^b   Raffel, Andreas ^c   Knoefel, Wolfram T ^c   Wiedenmann, Bertram ^d   Klöppel, Günter ^e  

^a UNIVERSITY OF KIEL   (Germany)

^b Gait Lab Social Pediatric Centre Children's Clinic St Vincenz Hospital   (Germany)

^c UNIVERSITY HOSPITAL DÜSSELDORF   (Germany)

^d CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^e TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

Duodenum; Gastrin production; Gastrinoma; Neuroendocrine tumors; Zollinger Ellison syndrome

Indexed keywords

GASTRIN; PROTON PUMP INHIBITOR;

ADULT; AGED; ARTICLE; CANCER SURGERY; CLINICAL ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; DISEASE ASSOCIATION; DUODENUM TUMOR; ENDOSCOPIC SURGERY; FEMALE; FOLLOW UP; GASTRIN RELEASE; GASTRINOMA; HUMAN; HUMAN TISSUE; LYMPH NODE METASTASIS; MALE; MIDDLE AGED; NEUROENDOCRINE TUMOR; OVERALL SURVIVAL; PRIORITY JOURNAL; PSAMMOMA BODY; RETROSPECTIVE STUDY; SPORADIC GASTRIN PRODUCING NEUROENDOCRINE TUMOR OF THE DUODENUM; TUMOR LOCALIZATION; TUMOR RECURRENCE; TUMOR VOLUME; VERY ELDERLY; ZOLLINGER ELLISON SYNDROME; COMPARATIVE STUDY; METABOLISM; PANCREAS TUMOR; PATHOLOGY;

ADULT; AGED; AGED, 80 AND OVER; DUODENAL NEOPLASMS; FEMALE; GASTRINOMA; GASTRINS; HUMANS; MALE; MIDDLE AGED; NEOPLASM RECURRENCE, LOCAL; NEUROENDOCRINE TUMORS; PANCREATIC NEOPLASMS; RETROSPECTIVE STUDIES;

EID: 84982170217     PISSN: 09456317     EISSN: 14322307     Source Type: Journal    
DOI: 10.1007/s00428-015-1890-9     Document Type: Article

References (39)

1. Komminoth P, Perren A, Oberg K, Rindi G, Bordi C, Klöppel G, Heitz PU (2004) Gastrinoma. In: DeLellis RA, Lloyd RV, Heitz PU, Eng C (eds) WHO classification of tumours. Pathology and genetics of tumours of endocrine organs. IARC Press, Lyon, pp 191–194
2. Zollinger RM (1987) Gastrinoma: the Zollinger-Ellison syndrome. Semin Oncol 14(3):247–252
3. Zollinger RM, Ellison EH (1955) Primary peptic ulcerations of the jejunum associated with islet cell tumors of the pancreas. Ann Surg 142(4):709–723, discussion, 724-708
4. Hoffmann KM, Furukawa M, Jensen RT (2005) Duodenal neuroendocrine tumors: classification, functional syndromes, diagnosis and medical treatment. Best Pract Res Clin Gastroenterol 19(5): 675–697
5. Capella C, Arnold R, Klimstra DS, Klöppel G, Komminoth P, Solcia E, Rindi G (2010) Neuroendocrine neoplasms of the small intestine. In: Bosman FT, Carneiro F, Hruban RH, Theise ND (eds) WHO classification of tumours of the digestive system. IARC, Lyon
6. Klöppel G (2011) Classification and pathology of gastroenteropancreatic neuroendocrine neoplasms. Endocr Relat Cancer 18(Suppl 1):S1–S16
7. Anlauf M, Perren A, Klöppel G (2007) Endocrine precursor lesions and microadenomas of the duodenum and pancreas with and without MEN1: criteria, molecular concepts and clinical significance. Pathobiology 74(5):279–284
8. Klöppel G, Perren A, Heitz PU (2004) The gastroenteropancreatic neuroendocrine cell system and its tumors: theWHO classification. Ann N YAcad Sci 1014:13–27
9. Donow C, Pipeleers-Marichal M, Schroder S, Stamm B, Heitz PU, Klöppel G (1991) Surgical pathology of gastrinoma. Site, size, multicentricity, association with multiple endocrine neoplasia type 1, and malignancy. Cancer 68(6):1329–1334
10. Weber HC, Venzon DJ, Lin JT, Fishbein VA, Orbuch M, Strader DB, Gibril F, Metz DC, Fraker DL, Norton JA (1995) Determinants of metastatic rate and survival in patients with Zollinger-Ellison syndrome: a prospective long-term study. Gastroenterology 108(6): 1637–1649
11. Anlauf M, Garbrecht N, Henopp T, Schmitt A, Schlenger R, Raffel A, Krausch M, Gimm O, Eisenberger CF, Knoefel WT, Dralle H, Komminoth P, Heitz PU, Perren A, Klöppel G (2006) Sporadic versus hereditary gastrinomas of the duodenum and pancreas: distinct clinico-pathological and epidemiological features. World J Gastroenterol 12(34):5440–5446
12. Scherübl H, Jensen RT, Cadiot G, Stolzel U, Klöppel G (2010) Neuroendocrine tumors of the small bowels are on the rise: early aspects and management. World J Gastrointest Endosc 2(10):325–334
13. Witzigmann H, Loracher C, Geissler F, Wagner T, Tannapfel A, Uhlmann D, Caca K, Hauss J, Hehl JA (2002) Neuroendocrine tumours of the duodenum. Clinical aspects, pathomorphology and therapy. Langenbecks Arch Surg 386(7):525–533
14. Stabile BE, Passaro E (1985) Benign and malignant gastrinoma. Am J Surg 149(1):144–150
15. Norton JA, Alexander HR, Fraker DL, Venzon DJ, Gibril F, Jensen RT (2003) Possible primary lymph node gastrinoma: occurrence, natural history, and predictive factors: a prospective study. Ann Surg 237(5):650–657, discussion 657-659
16. Norton JA, Fraker DL, Alexander HR, Venzon DJ, Doppman JL, Serrano J, Goebel SU, Peghini PL, Roy PK, Gibril F, Jensen RT (1999) Surgery to cure the Zollinger-Ellison syndrome. N Engl J Med 341(9):635–644
17. Lawton GP, Modlin IM (1994) Recent advances in the localization and surgical management of duodenal gastrinomas. Curr Opin Gen Surg 131–137
18. Zogakis TG, Gibril F, Libutti SK, Norton JA, White DE, Jensen RT, Alexander HR (2003) Management and outcome of patients with sporadic gastrinoma arising in the duodenum. Ann Surg 238(1):42–48
19. Norton JA, Alexander HR, Fraker DL, Venzon DJ, Gibril F, Jensen RT (2004) Does the use of routine duodenotomy (DUODX) affect rate of cure, development of liver metastases, or survival in patients with Zollinger-Ellison syndrome? Ann Surg 239(5):617–625, discussion 626
20. Capella C, Heitz PU, Capella C, Riva C, Rindi G, Sessa F, Usellini L, Chiaravalli A, Carnevali L, Solcia E (1991) Histopathology, hormone products, and clinicopathological profile of endocrine tumors of the upper small intestine: a study of 44 cases. Endocr Pathol 2:92–110
21. Anlauf M, Garbrecht N, Bauersfeld J, Schmitt A, Henopp T, Komminoth P, Heitz PU, Perren A, Klöppel G (2007) Hereditary neuroendocrine tumors of the gastroenteropancreatic system. Virchows Arch 451(Suppl 1):S29–S38
22. Anlauf M, Perren A, Meyer CL, Schmid S, Saremaslani P, Kruse ML, Weihe E, Komminoth P, Heitz PU, Klöppel G (2005) Precursor lesions in patients with multiple endocrine neoplasia type 1-associated duodenal gastrinomas. Gastroenterology 128(5): 1187–1198
23. Garbrecht N, Anlauf M, Schmitt A, Henopp T, Sipos B, Raffel A, Eisenberger CF, Knoefel WT, Pavel M, Fottner C, Musholt TJ, Rinke A, Arnold R, Berndt U, Plockinger U, Wiedenmann B, Moch H, Heitz PU, Komminoth P, Perren A, Klöppel G (2008) Somatostatin-producing neuroendocrine tumors of the duodenum and pancreas: incidence, types, biological behavior, association with inherited syndromes, and functional activity. Endocr Relat Cancer 15(1):229–241
24. Pipeleers-Marichal M, Donow C, Heitz PU, Klöppel G (1993) Pathologic aspects of gastrinomas in patients with Zollinger-Ellison syndrome with and without multiple endocrine neoplasia type I. World J Surg 17(4):481–488
25. Anlauf M, Schlenger R, Perren A, Bauersfeld J, Koch CA, Dralle H, Raffel A, Knoefel WT, Weihe E, Ruszniewski P, Couvelard A, Komminoth P, Heitz PU, Klöppel G (2006) Microadenomatosis of the endocrine pancreas in patients with and without the multiple endocrine neoplasia type 1 syndrome. Am J Surg Pathol 30(5): 560–574
26. Capella C, Solcia E, Sobin LH, Arnold R (2000) Endocrine tumours of the small intestine. In: Aaltonen LA (ed) WHO classification of tumours. Pathology and genetics of tumours of the digestive system. IARC Press, Lyon, pp 77–82
27. Campana D, Piscitelli L, Mazzotta E, Bonora M, Serra C, Salomone L, Corinaldesi R, Tomassetti P (2005) Zollinger-Ellison syndrome. Diagnosis and therapy. Minerva Med 96(3):187–206
28. Rindi G, Arnold R, Bosman FTa (2010) Nomenclature and classification of neuroendocrine neoplasms of the digestive system. In: Bosmann FT, Carneiro F, Hruban RH, Theise ND (eds) WHO classification of tumours of the digestive system. IARC, Lyon
29. Sobin LH, Gospodarowicz MK, Wittekind C (2009) TNM classification of malignant tumors, 7th edn. Wiley-Blackwell, Oxford
30. Arnold R (2007) Diagnosis and differential diagnosis of hypergastrinemia. Wien Klin Wochenschr 119(19-20):564–569
31. O’Toole D, Grossman A, Gross D, Delle Fave G, Barkmanova J, O’Connor J, Pape UF, Plockinger U (2009) ENETS consensus guidelines for the standards of care in neuroendocrine tumors: biochemical markers. Neuroendocrinology 90(2):194–202
32. Heitz PU, Komminoth P, Perren A, Klimstra DS, Dayal Y, Bordi C, Lechago J, Centeno BA, Klöppel G (2004) Pancreatic endocrine tumours: introduction. In: DeLellis RA, Lloyd RV, Heitz PU (eds) WHO classification of tumours. Pathology and genetics of tumours of endocrine organs. IARC Press, Lyon, pp 177–182
33. Sawada M, Dickinson CJ (1997) The G cell. Annu Rev Physiol 59: 273–298
34. Modlin IM, Öberg K, Chung DC, Jensen RT, de Herder WW, Thakker RV, Caplin M, Delle Fave G, Kaltsas GA, Krenning EP, Moss SF, Nilsson O, Rindi G, Salazar R, Ruszniewski P, Sundin A (2008) Gastroenteropancreatic neuroendocrine tumours. Lancet Oncol 9(1):61–72
35. Yao JC, Hassan M, Phan A, Dagohoy C, Leary C, Mares JE, Abdalla EK, Fleming JB, Vauthey JN, Rashid A, Evans DB (2008) One hundred years after “carcinoid”: epidemiology of and prognostic factors for neuroendocrine tumors in 35,825 cases in the United States. J Clin Oncol 26(18):3063–3072
36. Merchant SH, VanderJagt T, Lathrop S, Amin MB (2006) Sporadic duodenal bulb gastrin-cell tumors: association with Helicobacter pylori gastritis and long-term use of proton pump inhibitors. Am J Surg Pathol 30(12):1581–1587
37. Burke AP, Sobin LH, Federspiel BH, Shekitka KM, Helwig EB (1990) Carcinoid tumors of the duodenum. A clinicopathologic study of 99 cases. Arch Pathol Lab Med 114(7):700–704
38. Yu F, Venzon DJ, Serrano J, Goebel SU, Doppman JL, Gibril F, Jensen RT (1999) Prospective study of the clinical course, prognostic factors, causes of death, and survival in patients with long-standing Zollinger-Ellison syndrome. J Clin Oncol 17(2): 615–630
39. Jensen RT, Niederle B, Mitry E, Ramage JK, Steinmuller T, Lewington V, Scarpa A, Sundin A, Perren A, Gross D, O’Connor JM, Pauwels S, Klöppel G, Conference FC, Society ENT (2006) Gastrinoma (duodenal and pancreatic). Neuroendocrinology 84(3): 173–182