The G cell

Annual Review of Physiology

Volumn 59, Issue , 1997, Pages 273-298

  Sawada, Mitsutaka ^a   Dickinson, Chris J ^a  

^a UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

Author keywords

gastrin; growth; Helicobacter pylori; posttranslational processing; receptors; signal transduction

Indexed keywords

GASTRIN; GASTRIN RECEPTOR; SIGNAL PEPTIDE;

BACTERIAL GROWTH; ENDOPLASMIC RETICULUM; GASTRIN CELL; GASTRIN RELEASE; GOLGI COMPLEX; HELICOBACTER PYLORI; MICROVILLUS; PEPTIC ULCER; PRIORITY JOURNAL; PROTEIN PROCESSING; REVIEW; SECRETORY GRANULE; SIGNAL TRANSDUCTION;

ANIMALS; GASTRINS; HUMANS; PEPTIC ULCER; PROTEIN PROCESSING, POST-TRANSLATIONAL; RECEPTORS, CHOLECYSTOKININ; STOMACH;

EID: 0030969363     PISSN: 00664278     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.physiol.59.1.273     Document Type: Review

References (147)

1. Axon ATR. 1994. Acute infection with H. pylori. In Helicobacter pylori: Basic Mechanisms to Clinical Cure. pp. 407-12. Lancaster, England: Kluwer
2. Baldwin GS. 1994. Antiproliferative gastrin/cholecystokinin receptor antagonists target the 78-kDa gastrin-binding protein. Proc. Natl. Acad. Sci. USA 91(16):7593-97
3. Bayliss WM, Starling EH. 1902. The mechanism of pancreatic secretion. J. Physiol. 28:325-53
4. Boel E, Vuust J, Norris F, Norris K, Wind A, et al. 1983. Molecular cloning of human gastrin cDNA: evidence for evolution of gastrin by gene duplication. Proc. Natl. Acad. Sci. USA 80:2866-69
5. Bold RJ, Ishizuka J, Townsend CMJ, Thompson JC. 1994. Gastrin stimulates growth of human colon cancer cells via a receptor other than CCK-A or CCK-B. Biochem. Biophys. Res. Commun. 202(3):1222-26
6. Bradbury A, Finnie M, Smyth D. 1982. Mechanism of C-terminal amide formation by pituitary enzymes. Nature 298:686-88
7. Brand SJ, Klarlund J, Schwartz TW, Rehfeld JF. 1984. Biosynthesis of tyrosine-O-sulfated gastrins in rat antral mucosa. J. Biol. Chem. 259:13246-52
8. Bundgaard JR, Vuust J, Rehfeld JF. 1995. Tyrosine O-sulfation promotes proteolytic processing of progastrin. EMBO J. 14(13):3073-79
9. Burckhardt B, Delco F, Ensnick J, Meier R, Bauerefind P, et al. 1994. Cholecystokinin is a physiological regulator of gastric acid secretion in man. Eur. J. Clin. Invest. 24(6):370-76
10. Burgess TL, Kelly RB. 1987. Constitutive and regulated secretion of proteins. Annu. Rev. Cell. Biol. 3:243-93
11. Calam J. 1995. The somatostatin-gastrin link of Helicobacter pylori infection. Ann. Med. 27(5):569-73
12. Calam J, Dockray GJ, Walker R, Tracy HJ, Owens D. 1980. Molecular forms of gastrin in peptic ulcer: comparison of serum and tissue concentrations of G17 and G34 in gastric and duodenal ulcer subjects. Eur. J. Clin. Invest. 10:241-47
13. Chen LJ, Rosenquist GL. 1990. Enzymatic sulfation of gastrin in rat gastric mucosa. Biochem. Biophys. Res. Commun. 170:1170-76
14. Chiba T, Taminato T, Kadowaki S, Able H, Chihara K, et al. 1980. Effects of glucagon, secretin, and vasoactive intestinal polypeptide on gastric somatostatin and gastrin release from isolated perfused rat stomach. Gastroenterology 79:67-71
15. Chowdhury JR, Berkowitz JM, Praissman M, Fara JW. 1976. Effect of sulfated and non-sulfated gastrin and octapeptide-cholecystokinin on cat gall bladder in vitro. Experientia 32:1173-75
16. Ciccotosto GD, McLeish A, Hardy KJ, Shulkes A. 1995. Expression, processing and secretion of gastrin in patients with colorectal carcinoma. Gastroenterology 109:1142-53
17. Cool DR, Fenger M, Snell CR, Loh YP. 1995. Identification of the sorting signal motif within proopiomelanocortin for the regulated secretory pathway. J. Biol. Chem. 270(15):8723-29
18. DelValle J, Chiba T, Park J, Yamada T. 1993. Distinct receptors for cholecystokinin and gastrin on canine fundic D-cells. Am. J. Physiol. 264(5):G811-15
19. DelValle J, Sugano K, Yamada T. 1989. Glycine-extended processing intermediates of gastrin and cholecystokinin in human plasma. Gastroenterology 97:1159-63
20. DelValle J, Sugano K, Yamada T. 1987. Progastrin and its glycine-extended posttranslational processing intermediates in human gastrointestinal tissues. Gastroenterology 92(6):1908-12
21. i by secretagogue stimulation of canine gastric parietal cells. Am. J. Physiol. 262(3Pt 1):G420-26
22. DelValle J, Yamada T. 1990. Amino acids and amines stimulate gastrin release from canine antral G-cells via different pathways. J. Clin. Invest. 85:139-43
23. Dickinson CJ. 1995. Relationship of gastrin processing to colon cancer. Gastroenterology 109:1384-88
24. Dickinson CJ, Daugherty D, Guo Y, Hughes P, Yamada T. 1992. Molecular analysis of dibasic endoproteolytic cleavage signals. J. Biol. Chem. 267:21795-801
25. Dickinson CJ, Marino LR, Yamada T. 1990. Inhibition of the alpha-amidation of gastrin: effects on gastric acid secretion. Am. J. Physiol. 258:G810-14
26. Dickinson CJ, Sawada M, Guo YJ, Finniss S, Yamada T. 1995. Specificity of prohormone convertase endoproteolysis of progastrin in AtT-20 cells. J. Clin. Invest. 96:1425-31
27. Dickinson CJ, Takeuchi T, Guo Y-J, Stadler BT, Yamada T. 1993. Expression and processing of prohormones in nonendocrine cells. Am. J. Physiol. 264:G553-60
28. Dickinson CJ, Yamada T. 1991. Gastrinamidating enzyme in the porcine pituitary and antrum: characterization of molecular forms and substrate specificity. J. Biol. Chem. 266:334-38
29. Dockray GJ. 1973. The action of gastrin and cholecystokinin-related peptides on pancreatic secretion in the rat. Q. J. Exp. Physiol. Cogn. Med. Sci. 58:163-69
30. Dockray GJ, Vaillant C, Hopkins CR. 1978. Biosynthetic relationships of big and little gastrins. Nature 273:770-72
31. Dockray GJ, Vaillant C, Walsh JH. 1979. The neuronal origin of bombesin-like immunoreactivity in the rat gastrointestinal tract. Neuroscience 4:473-80
32. Edkins JS. 1906. The chemical mechanism of gastric secretion. J. Physiol. 34:133-44
33. Edkins JS, Tweedy M. 1909. The natural channels of absorption evoking the chemical mechanism of gastric secretion. J. Physiol. 38:263-67
34. Eipper BA, Mains RE, Glembotski CC. 1983. Identification in pituitary tissue of a peptide α-amidation activity that acts on glycine-extended peptides and requires molecular oxygen, copper and ascorbic acid. Proc. Natl. Acad. Sci. USA 80:5144-48
35. El-Omar EM, Penman ID, Ardill JES, Chittajallu RS. 1995. Helicobacter pylori infection and abnormalities of acid secretion in patients with duodenal ulcer disease. Gastroenterology 109(3):681-91
36. Evans EA, Gilmore R, Blobel G. 1986. Purification of microsomal signal peptidase as a complex. Proc. Natl. Acad. Sci. USA 83:581-85
37. Fan X, Chua A, Fan X, Keeling P. 1995. Increased gastric production of interleukin-8 and tumour necrosis factor with Helicobacter pylori infection. J. Clin. Pathol. 48(2):133-36
38. Fan X, Chua A, Shahi C, McDevitt J, Keeling P, Kelleher D. 1994. Gastric T lymphocyte responses to Helicobacter pylori in patients with H. pylori colonisation. Gut 35(10):1379-84
39. Feldman M. 1994. The acid test. Making clinical sense of the Consensus Conference on Helicobacter pylori [editorial; comment]. J. Am. Med. Assoc. 272(1):70-71
40. Feldman M, Walsh JH, Wong HC, Richardson CT. 1978. Role of gastrin heptadecapeptide in the acid secretory response to amino acids in man. J. Clin. Invest. 61:308-13
41. 2+-dependent serine protease. Proc. Natl. Acad. Sci. USA 86:1434-38
42. Glasgow RE, Kong W, Mulvihill SJ. 1996. Glycine-extended gastrin-17, but not gastrin-17-amide, promotes DNA synthesis in fetal rabbit gastric epithelial cells in vitro. Gastroenterology 110(4):A1074 (Abstr.)
43. Graham DY. 1996. Helicobacter pylori and perturbations in acid secretion: the end of the beginning. Gastroenterology 110:1647-49
44. Graham DY, Opekum A, Lew GM, Klein PD, Walsh JH. 1991. Helicobacter pylori-associated exaggerated gastrin release in duodenal ulcer patients. The effect of bombesin infusion and urea ingestion. Gastroenterology 100:1571-75
45. Greeley GHJ, Song L, Varlamov O, Leiter E, Fricker L. 1996. Localization of carboxypeptidases CP-D and CP-E in the gut and involvement of CP-E in processing progastrin. Gastroenterology 110(4):A1075(Abstr.)
46. Gregory RA, Tracy HJ. 1964. The constitution and properties of two gastrins extracted from hog antral mucosa. I. The isolation of two gastrins from hog antral mucosa. II. The properties of two gastrins isolated from hog antral mucosa. Gut 5:103-14
47. Gregory RA, Tracy HJ. 1961. The preparation and properties of gastrin. J. Physiol. 156:523-43
48. Gutzman S, Chayvialle JA, Banks WA, Rayford PL, Thompson JC. 1979. Effect of vagal stimulation on pancreatic secretion and on blood levels of gastrin, cholecystokinin, secretin, vasoactive intestinal peptide, and somatostatin. Surgery 86:329-36
49. Higashide S, Gomez G, Greeley GHJ, Townsend CM, Thompson JC. 1996. Glycine-extended gastrin potentiates gastrin-stimulated gastric acid secretion in rats. Am. J. Physiol. 33:G220-24
50. Hilsden RJ, Meddings JB, Sutherland LR. 1996. Intestinal permeability changes in response to acetylsalicylic acid in relatives of patients with Crohn's disease. Gastroenterology 110:1395-403
51. Hilsted L, Hint K, Christiansen J, Rehfeld JF. 1988. Neither glycine-extended gastrin nor the 1-13 fragment of gastrin 17 influences gastric acid secretion in humans. Gastroenterology 94:96-110
52. Hirschowitz BI, Gibson RG. 1978. Stimulation of gastrin release and gastric secretion: effect of bombesin and a non-apeptide in fistula dogs with and without fundic vagotomy. Digestion 18:227-39
53. Hirschowitz BI, Gibson RG, Molina E. 1981. Atropine suppresses gastrin release by food intact and vagotomized dogs. Gastroenterology 81:838-43
54. Hoist JJ, Jensen SL, Knuhtsen S, Nielsen OV, Rehfeld JF. 1978. Effect of vagus, gastric inhibitory polypeptide, and HCl on gastrin and somatostatin release from perfused pig antrum. Am. J. Physiol. 244:G515-22
55. Holst JJ, Ørskov C, Seier-Poulsen S. 1992. Somatostatin is an essential paracrine link in acid inhibition of gastrin secretion. Digestion 51(2):95-102
56. Hopkins RJ, Girardi LS, Turney EA. 1996. Relationship between Helicobacter pylori eradication and reduced duodenal and gastric ulcer recurrence: a review. Gastroenterology 110(4):1244-52
57. Hortin G, Folz R, Gordon JI, Strauss AW. 1986. Characterization of sites of tyrosine sulfation in proteins and criteria for predicting their occurrences. Biochem. Biophys. Res. Commun. 141:326-33
58. Huang J, O'Toole P, Doing P, Trust T. 1995. Stimulation of interleukin-8 production in epithelial cell lines by Helicobacter pylori. Infect. Immun. 63(5):1732-38
59. Johnson LR, McCormack SA, Wang J-Y. 1993. Regulation of gastrointestinal mucosal growth. In Gastrin, ed. J Walsh, pp. 285-300. New York: Raven
60. Julius D, Brake A, Blair L, Kunisawa R, Thorner J. 1984. Isolation of the putative structural gene to the lysine-arginine-cleaving endopeptidase required for processing of yeast prepro-α-factor. Cell 37:1075-89
61. +-ATPase α-subunit gene expression through a novel receptor. J. Biol. Chem. 270:11155-60
62. Kenner GW, Moore S, Ramachandran KL, Ramage R, Dockray GJ, et al. 1981. Porcine big gastrin: sequence, synthesis and immunochemical studies. Bioorg. Chem. 10:152-60
63. Kochman ML, DelValle J, Dickinson CJ, Boland CR. 1992. Post-translational processing of gastrin in neoplastic human colonie tissues. Biochem. Biophys. Res. Comm. 189:1165-69
64. Koh TJ, Nicholls PJ, Wang TC. 1996. Glycine-extended gastrin promotes growth of a human hepatoma cell line. Gastroenterology 110(4):1089
65. Kopin AS, Lee YM, McBride EW, Miller LJ, Lu M, et al. 1992. Expression cloning and characterization of the canine parietal cell gastrin receptor. Proc. Natl. Acad. Sci. USA 89(8):3605-9
66. Larssen LI, Goltermann N, De Magistris L, Rehfeld JF. 1979. Somatostatin cell processes as pathways for paracrine secretion. Science 205:1393-95
67. Levi S, Beardshall K, Swift I, Foulkes W, Playford R, et al. 1989, Antral Helicobacter pylori, hypergastrinaemia and duodenal ulcers: effect of eradicating the organism. Br. Med. J. 299:1504-5
68. Levi S, Beardshall K, Swift I, Foulkes W, Playford R, et al. 1989. Campylobacter pylori and duodenal ulcers: the gastrin link. Lancet 1:1167-68
69. Lichtenberger LM, Delansorne R, Graziani LA. 1979. Importance of amino acid uptake and decarboxylation in gastrin release from isolated G cells. Nature 295:698-700
70. Lichtenberger LM, Dial EJ, Romero JJ, Lechago J, Jarboe LA, Wolfe MM. 1995. Role of luminal ammonia in the development of gastropathy and hypergastrinemia in the rat. Gastroenterology 108:320-29
71. Madaus S, Bender H, Schusdziarra V, Keh K, Munzert G, et al. 1990. Vagally induced release of gastrin, somatostatin and bombesin-like immunoreactivity from perfused rat stomach. Effect of stimulation on frequency and cholinergic mechanism. Regul. Pep. 30:179-92
72. Marino LR, Sugano K, Yamada T. 1988. Development of gastrin synthesis and posttranslational processing mechanisms in rats. Am. J. Physiol. 254:G87-92
73. Marino LR, Takeuchi T, Dickinson CJ, Yamada T. 1991. Expression and posttranslational processing of progastrin in heterologous endocrine cell lines. J. Biol. Chem. 266:6133-36
74. Marshall BJ, Armstrong JA, McGechie DB, Glancy RJ. 1985. Attempt to fulfill Koch's postulates for pyloric campylobacter. Med. J. Aust. 142:436-39
75. Marshall BJ, Warren JR. 1984. Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. Lancet 1(8390):1311-15
76. Manindale R, Kauffman GL, Levin S, Walsh JH, Yamada T. 1982. Differential regulation of gastrin and somatostatin secretion from isolated perfused rat stomachs. Gastroenterology 83:240-44
77. Matsumoto M, Park J, Sugano K, Yamada T. 1987. Biological activity of progastrin posttranslational processing intermediates. Am. Physiol. Soc. 87:G315-19
78. McGowan CC, Clover TL, Blaser MJ. 1996. Helicobacter pylori and gastric acid: biological and therapeutic implications. Gastroenterology 110:926-38
79. McGuigan JE. 1968. Immunochemical studies with synthetic human gastrin. Gastroenterology 54:1005-11
80. Merchant JL, Dickinson CJ, Yamada T. 1994. Molecular biology of the gut: model of gastrointestinal hormones. In Physiology of the Gastrointestinal Tract, ed. LR Johnson, pp. 295-350. New York: Raven. 3rd ed.
81. Miyake A. 1995. A truncated isoform of human CCK-B/gastrin receptor generated by alternative usage of a novel exon. Biochem. Biophys. Res. Commun. 208(1):230-37
82. Naggert JK, Fricker LD, Varlamov O, Nishina PM, Rouille Y, et al. 1995. Hyperproinsulinaemia in obese fat/fat mice associated with a carboxypeptidase E mutation which reduces enzyme activity. Nat. Genet. 10(2):135-42
83. Negre F, Fagot-Revurat P, Bouisson M, Rehfeld JF, Vaysse N. 1996. Automne stimulation of AR4-2J rat pancreatic tumor cell growth by glycine-extended gastrin. Int. J. Cancer 66:653-58
84. Nemeth J, Taylor B, Pauwels S, Varro A, Dockray GJ. 1993. Identification of progastrin derived peptides in colorectal carcinoma extracts. Gut 34(1):90-95
85. Nothwehr SF, Gordon JI. 1990. Targeting of proteins into the eukaryotic secretory pathway: signal peptide structure/function relationship. BioEssays 12:479-84
86. Ohtaki T, Park J, Song I, Guo Y, Hoeltzel M, et al. 1996. Short and long isoforms of the human CCKB receptor couple to post receptor signaling pathways in a differential manner. Gastroentemlogy 110(4):A1104b (Abstr.)
87. Olbe L, Hamlet A, Dalenback J, Fandriks L. 1996. A mechanism by which Helicobacter pylori invection of the antrum contributes to the development of duodenal ulcer. Gastroenterology 110:1386-94
88. Palade G. 1975. Intracellular aspects of the process of protein synthesis. Science 189:347-58
89. Palmer DJ, Christie DL. 1992. Identification of molecular aggregates containing glycoproteins III, J, K (carboxypeptidase H) and H (Kex2-related proteases) in the soluble and membrane fractions of adrenal medullary chromaffin granules. J. Biol. Chem. 267:19806-12
90. Parsonnet J, Kim P, Yang N, Orentreich JH, Vogelman JH, Friedman GD. 1996. Gastrin and gastric adenocarcinoma: a prospective evaluation. Gastroenterology 110(4):574
91. Peters MN, Walsh JH, Ferrari J, Feldman M. 1982. Adrenergic regulation of distention-induced gastrin release in humans. Gastroenterology 82:659-63
92. Peura DA. 1996. Helicobacter pylori and ulcerogenesis. Am. J. Med. 100(5A):19-25S (Suppl.)
93. Pisegna JR, Norton JA, Slimak GG, Metz DC, Maton PN, et al. 1992. Effect of curative gastrinoma resection on gastric secretory function and antisecretory drug requirement in the Zollinger-Ellison syndrome. Gastroenterology 102:767-78
94. Porak J. 1989. Endocrine cells of the gut. In Handbook of Physiology. The Gastrointestinal System. Neural and Endocrine Biology, 6:79-96. Bethesda: Am. Physiol. Soc.
95. Pounder RE. 1996. Helicobacter pylori and gastroduodenal secretory function. Gastroenterology 110:947-49
96. Rahier J, Pauwels S, Dockray GJ. 1987. Biosynthesis of gastrin. Localization of the precursor and peptide products using electron microscopic-immunogold methods. Gastroenterology 92:1146-52
97. Rehfeld JF. 1995. Gastrin and colorectal cancer: a never-ending dispute? Gastroenterology 108:1307-09
98. Rothman JE, Orci L. 1992. Molecular dissection of the secretory pathway. Nature 355(6359):409-15
99. Rothman JE, Wieland FT. 1996. Protein sorting by transport vesicles. Science 272(5259):227-34
100. Saffouri B, Weir G, Bitar K, Grider JR, Makhlouf GM. 1980. Gastrin and sostatin secretion by perfused rat stomach: functional linkage of antrat peptides. Am. J. Physiol. 238:G495-501
101. Saffouri B, Weir G, Bitar K, Makhlouf GM. 1979. Stimulation of gastrin secretion from perfused rat stomach by somato-statin antiserum. Life Sci. 25:1749-54
102. Schepp W, Prinz C, Hakanson R, Schusdziarra V, Classen M. 1990. Bombesin-like peptides stimulate gastrin release from isolated rat G-cells. Regul. Pept. 28:241-53
103. Schiller LR, Walsh JH, Feldman M. 1980. Distension-induced gastrin release. Gastroenterology 78:912-17
104. Schmidt W, Schenk S, Nustede R, Holst J, Folsch U, Creutzfeld W. 1994. Cholecystokinin is a negative regulator of gastric acid secretion and postprandial release of gastrin in humans. Gastroenterology 107(6):1610-20
105. Schubert ML. 1991. The effect of vasoactive intestinal polypeptide on gastric acid secretion is predominantly mediated by somatostatin. Gastroenterology 100:1195-200
106. Schubert ML, Bitar KN, Makhlouf GM. 1982. Regulation of gastrin and somatostatin secretion by cholinergic and non-cholinergic intramural neurons. Am. J. Physiol. 243:G442-47
107. Schubert ML, Coy DH, Makhlouf GM. 1992. Peptone stimulates gastrin secretion from the stomach by activating bombesin/GRP and cholinergic neurons. Am. J. Physiol. 262:G685-89
108. Schubert ML, Makhlouf G. 1993. Gastrin secretion induced by distention is mediated by gastric cholinergic and vasoactive intestinal peptide neurons in rats. Gastroenterology 104:834-39
109. Schubert ML, Saffouri B, Walsh JH, Makhlouf GM. 1985. Inhibition of neurally mediated gastrin secretion by bombesin antiserum. Am. J. Physiol. 248:G456-62
110. Scopsi L, Gullo M, Rilke F, Martin S, Steiner DF. 1995. Proprotein convertases (PC1/PC3 and PC2) in normal and neoplastic tissues: their use as markers of neuroendocrine differentiation. J. Clin. Endocrinol. Metab. 80:294-301
111. Seva C, Dickinson CJ, Yamada T. 1994. Growth promoting effects of glycine-extended progastrin. Science 265:410-12
112. Seva C, Kowalski-Chauvel A, Blanchet JS, Vaysse N, Pradayrol L. 1996. Gastrin induces tyrosine phosphorylation of Shc proteins and their association with the Grb2/Sos complex. FEBS Lett. 378(1):74-78
113. Seva C, Scemama JL, Pradayrol L, Sarfati PD, Vaysse N. 1994. Coupling of pancreatic gastrin/cholecystokinin-B (GCCKB) receptors to phospholipase C and protein kinase C in AR4-2J tumoral cells. Reg. Pept. 52(1):31-38
114. Short GM, Reel GM, Doyle JW, Wolfe MM. 1985. Effect of GRP on β-adrenergic-stimulated gastrin and somatostatin release in the isolated rat stomach. Am. J. Physiol. 249:G197-202
115. Singh P, Narayan S, Adiga RB. 1994. Phosphorylation of pp62 and pp54 src-like proteins in a rat intestinal cell line in response to gastrin. Am. J .Physiol. 87:G315-19
116. Smeekens SP, Avruch AS, LaMendola J, Chan SJ, Steiner DE 1991. Identification of a cDNA encoding a second putative prohormone convertase related to PC2 in AtT20 cells and islets of Langerhans. Proc. Natl. Acad. Sci. USA 88:340-44
117. Smeekens SP, Steiner DF. 1990. Identification of a human insulinoma cDNA encoding a novel mammalian protein structurally related to the yeast dibasic processing protease Kex2. J. Biol. Chem. 265:2997-3000
118. Soll AH. 1977. Studies on the actions and interactions of secretagogues on isolated mammalian parietal cells as reflected in changes in oxygen consumption and aminopyrine uptake. Gastroenterology 73(4 Pt2):899
119. Soll AH, Yamada T, Park J, Thomas LP. 1984. Release of somatostatinlike immunoreactivity from canine fundic mucosal cells in primary culture. Am. J. Physiol. 247(5 Pt1):G558-66
120. Song I, Brown DR, Wiltshire RN, Gantz I, Trent JM, Yamada T. 1993. The human gastrin/cholecystokinin type B receptor gene: alternative splice donor site in exon 4 generates two variant mRNAs. Proc. Natl. Acad. Sci. USA 90(19):9085-89
121. Steiner DF, Smeekens SP, Ohagi S, Chan SJ. 1992. The new enzymology of precursor processing endoproteases. J. Biol. Chem. 267:23435-38
122. Stepan VM, Sawada M, Yamada T, Dickinson CJ. 1995. Glycine-extended gastrin exerts growth-promoting effects on colon cancer cell lines. Gastroenterology 110:A1122 (Abstr.)
123. Stoller TJ, Shields D. 1989. The propeptide of preprosomatostatin mediates intracellular transport and secretion of α-globin from mammalian cells. J. Cell Biol. 108:1647-55
124. Sugano K, Aponte GW, Yamada T. 1985. Identification and characterization of glycine-extended post-translational processing intermediates of progastrin in porcine stomach. J. Biol. Chem. 260(21):11724-29
125. Sugano K, Park J, Dobbins WO, Yamada T. 1987. Glycine-extended progastrin processing intermediates: accumulation in cultured G-cells and cosecretion with gastrin. Am. J. Physiol. 253(4.1):G502-7
126. Sugano K, Park J, Soll AH, Yamada T. 1987. Stimulation of gastrin release by bombesin and canine gastrin-releasing peptides. Studies with isolated canine G cells in primary culture. J. Clin. Invest. 79(3):935-42
127. Sugano K, Park J, Yamada T. 1984. Biosynthesis of gastrin: studies with isolated enriched canine antral G-cells in primary culture. Dig. Dis. Sci. 29:835
128. Tepperman BL, Walsh JH, Preshaw RM. 1972. Effect of antral denervation on gastric release by sham feeding and insulin hypoglycemia in dogs. Gastroenterology 63:973-80
129. Thorburn CM, Friedman GD, Orentreich N, Vogelman JH, Parsonnet J. 1996. High gastrin levels increase risk for colorectal carcinoma. Gastroenterology 110(4): 603
130. Todisco A, Takeuchi J, Yamada A, Urumov A, Yamada T. 1996. Molecular mechanisms for the growth factor actin of gastrin. J. Invest. Med. 40:318A (Abstr.)
131. Todisco A, Takeuchi Y, Seva C, Dickinson CJ, Yamada T. 1995. Gastrin and glycine-extended processing intermediates induce different programs of early gene activation. J. Biol. Chem. 270:28337-41
132. van Solinge WW, Neilsen FC, Friis-Hansen L, Falkmer U, Rehfeld JF. 1994. Expression but incomplete processing of progastrin in colorectal carcinomas. Gastroenterology 104:1099-107
133. Varro A, Henry J, Vaillant C, Dockray GJ. 1994. Discrimination between temperature- and brefeldin A-sensitive steps in the sulfation, phosphorylation, and cleavage of progastrin and its derivatives. J. Biol Chem. 269(32):20764-70
134. Varro A, Nemeth J, Bridson J, Lee C, Moore S, Dockray GJ. 1990. Processing of the gastrin precursor. Modulation of phosphorylated, sulfated, and amidated products. J. Biol. Chem. 265(35):21476-81
135. Varro A, Voronina S, Dockray GJ. 1995. Pathways of processing of the gastrin precursor in rat antral mucosa. J. Clin. Invest. 95(4):1642-49
136. Walsh J. 1993. Gastrin. New York: Raven. 432 pp.
137. 2+ in quiescent Swiss 3T3 cells involves a protein kinase C-independent mechanism. J. Cell Physiol. 156(2):330-40
138. Walsh JH, Yallow RS, Berson SA. 1971. The effect of atropine on plasma gastrin response to feeding. Gastroenterology 60:16-21
139. Walter P, Gilmore R, Blobel G. 1984. Protein translocation across the endoplasmic reticulum. Cell 38:5-8
140. Wang TC, Koh TJ, Varro A, Cahill R, Fox JG, Dockray GJ. 1996. Processing and functional significance of human progastrin in transgenic mice. Gastroenterology 110(4):A1132(Abstr.)
141. Wank SA. 1995. Cholecystokinin receptors. Am. J. Physiol. 269(5 Pt1):G628-46
142. Wank SA, Pisegna JR, Poirot SS. 1994. Functional significance of potential splice variants of the human cholecystokinin (CCK) B receptor. Gastroenterology 106(4):A850 (Abstr.)
143. Weigert N, Schaffer K, Schusdziarra V, Classen M, Schepp W. 1996. Gastrin secretion from primary cultures of rabbit antral G cells: stimulation by inflammatory cytokines. Gastroenterology 110:147-54
144. Wolfe MM, Jensen RT. 1987. Zollinger-Ellison syndrome. Current concepts in diagnosis and management. N. Engl. J. Med. 317(19):1200-09
145. Yalow RS, Berson SA. 1971. Future studies on the nature of immunoreactive gastrin in human plasma. Gastroenterology 60:203-14
146. Yoo OJ, Powell CT, Agarwal KL. 1982. Molecular cloning and nucleotide sequence of full-length cDNA coding for porcine gastrin. Proc. Natl. Acad. Sci. USA 79:1049-53
147. Yu DH, Noguchi M, Zhou ZC, Villanueva ML, Gardner JD, Jensen RT. 1987. Characterization of gastrin receptors on guinea pig pancreatic acini. Am. J. Physiol. 253:G793-801