Modulation of Backbone Flexibility for Effective Dissociation of Antibacterial and Hemolytic Activity in Cyclic Peptides

ACS Medicinal Chemistry Letters

Volumn 7, Issue 8, 2016, Pages 741-745

  Oddo, Alberto ^a,b   Thomsen, Thomas T ^a   Britt, Hannah M ^b   Løbner Olesen, Anders ^a   Thulstrup, Peter W ^a   Sanderson, John M ^b   Hansen, Paul R ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b DURHAM UNIVERSITY   (United Kingdom)

Author keywords

antimicrobial peptides; Cyclic peptides; flexible peptides; hemolytic activity; membrane activity

Indexed keywords

POLYPEPTIDE ANTIBIOTIC AGENT;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ANTIBIOTIC THERAPY; ARTICLE; BACTERIAL CELL WALL; BACTERIAL MEMBRANE; CIRCULAR DICHROISM; DRUG EFFICACY; DRUG POTENCY; EC50; HEMOLYSIS; HYDROPHOBICITY; LIPOPHILICITY; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL;

EID: 84982084133     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/acsmedchemlett.5b00400     Document Type: Article

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