-
1
-
-
0032736029
-
B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion
-
Dong H, Zhu G, Tamada K, et al. B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion. Nat Med 1999; 5:1365-1369.
-
(1999)
Nat Med
, vol.5
, pp. 1365-1369
-
-
Dong, H.1
Zhu, G.2
Tamada, K.3
-
2
-
-
3242677686
-
PD-L1-deficient mice show that PD-L1 on T cells, antigen-presenting cells, and host tissues negatively regulates T cells
-
Latchman YE, Liang SC, Wu Y, et al. PD-L1-deficient mice show that PD-L1 on T cells, antigen-presenting cells, and host tissues negatively regulates T cells. Proc Natl Acad Sci USA 2004; 101:10691-10696.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 10691-10696
-
-
Latchman, Y.E.1
Liang, S.C.2
Wu, Y.3
-
3
-
-
0035056017
-
CTLA-4-mediated inhibition in regulation of T cell responses: Mechanisms and manipulation in tumor immunotherapy
-
Chambers CA, Kuhns MS, Egen JG, et al. CTLA-4-mediated inhibition in regulation of T cell responses: mechanisms and manipulation in tumor immunotherapy. Annu Rev Immunol 2001; 19:565-594.
-
(2001)
Annu Rev Immunol
, vol.19
, pp. 565-594
-
-
Chambers, C.A.1
Kuhns, M.S.2
Egen, J.G.3
-
4
-
-
0028484545
-
CTLA-4 can function as a negative regulator of T cell activation
-
Walunas TL, Lenschow DJ, Bakker CY, et al. CTLA-4 can function as a negative regulator of T cell activation. Immunity 1994; 1:405-413.
-
(1994)
Immunity
, vol.1
, pp. 405-413
-
-
Walunas, T.L.1
Lenschow, D.J.2
Bakker, C.Y.3
-
5
-
-
84878699089
-
Tumor-infiltrating PD1-positive lymphocytes and FoxP3-positive regulatory T cells predict distant metastatic relapse and survival of clear cell renal cell carcinoma
-
Kang MJ, Kim KM, Bae JS, et al. Tumor-infiltrating PD1-positive lymphocytes and FoxP3-positive regulatory T cells predict distant metastatic relapse and survival of clear cell renal cell carcinoma. Transl Oncol 2013; 6:282-289.
-
(2013)
Transl Oncol
, vol.6
, pp. 282-289
-
-
Kang, M.J.1
Kim, K.M.2
Bae, J.S.3
-
6
-
-
34248586083
-
Overexpression of B7-H1 (PD-L1) significantly associates with tumor grade and postoperative prognosis in human urothelial cancers
-
Nakanishi J, Wada Y, Matsumoto K, et al. Overexpression of B7-H1 (PD-L1) significantly associates with tumor grade and postoperative prognosis in human urothelial cancers. Cancer Immunol Immunother 2007; 56:1173-1182.
-
(2007)
Cancer Immunol Immunother
, vol.56
, pp. 1173-1182
-
-
Nakanishi, J.1
Wada, Y.2
Matsumoto, K.3
-
7
-
-
10344220548
-
Costimulatory B7-H1 in renal cell carcinoma patients: Indicator of tumor aggressiveness and potential therapeutic target
-
Thompson RH, Gillett MD, Cheville JC, et al. Costimulatory B7-H1 in renal cell carcinoma patients: Indicator of tumor aggressiveness and potential therapeutic target. Proc Natl Acad Sci USA 2004; 101:17174-17179.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 17174-17179
-
-
Thompson, R.H.1
Gillett, M.D.2
Cheville, J.C.3
-
8
-
-
18544380239
-
Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion
-
Dong H, Strome SE, Salomao DR, et al. Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion. Nat Med 2002; 8:793-800.
-
(2002)
Nat Med
, vol.8
, pp. 793-800
-
-
Dong, H.1
Strome, S.E.2
Salomao, D.R.3
-
9
-
-
34848910544
-
Cytotoxic T-lymphocyte-associated antigen-4
-
Hodi FS. Cytotoxic T-lymphocyte-associated antigen-4. Clin Cancer Res 2007; 13:5238-5242.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 5238-5242
-
-
Hodi, F.S.1
-
10
-
-
84946607195
-
Nivolumab versus everolimus in advanced renal-cell carcinoma
-
Motzer RJ, Escudier B, McDermott DF, et al. Nivolumab versus everolimus in advanced renal-cell carcinoma. N Engl J Med 2015; 373:1803-1813.
-
(2015)
N Engl J Med
, vol.373
, pp. 1803-1813
-
-
Motzer, R.J.1
Escudier, B.2
McDermott, D.F.3
-
11
-
-
84959577118
-
Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy: A single-arm, multicentre, phase 2 trial
-
Rosenberg JE, Hoffman-Censits J, Powles T, et al. Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy: a single-arm, multicentre, phase 2 trial. Lancet 2016; 387:1909-1920.
-
(2016)
Lancet
, vol.387
, pp. 1909-1920
-
-
Rosenberg, J.E.1
Hoffman-Censits, J.2
Powles, T.3
-
13
-
-
84914170498
-
Harnessing the PD-1 pathway in renal cell carcinoma: Current evidence and future directions
-
Tripathi A, Drake CG, Harshman LC. Harnessing the PD-1 pathway in renal cell carcinoma: current evidence and future directions. BioDrugs 2014; 28:513-526.
-
(2014)
BioDrugs
, vol.28
, pp. 513-526
-
-
Tripathi, A.1
Drake, C.G.2
Harshman, L.C.3
-
14
-
-
58249094864
-
Genetic, immunologic, and im-munohistochemical analysis of the programmed death 1/programmed death ligand 1 pathway in human systemic lupus erythematosus
-
Bertsias GK, Nakou M, Choulaki C, et al. Genetic, immunologic, and im-munohistochemical analysis of the programmed death 1/programmed death ligand 1 pathway in human systemic lupus erythematosus. Arthritis Rheum 2009; 60:207-218.
-
(2009)
Arthritis Rheum
, vol.60
, pp. 207-218
-
-
Bertsias, G.K.1
Nakou, M.2
Choulaki, C.3
-
15
-
-
30344437313
-
CTLA4 is differentially associated with autoimmune diseases in the Dutch population
-
Zhernakova A, Eerligh P, Barrera P, et al. CTLA4 is differentially associated with autoimmune diseases in the Dutch population. Hum Genet 2005; 118:58-66.
-
(2005)
Hum Genet
, vol.118
, pp. 58-66
-
-
Zhernakova, A.1
Eerligh, P.2
Barrera, P.3
-
16
-
-
0036106276
-
An association between the CTLA4 exon 1 polymorphism and early rheumatoid arthritis with autoimmune en-docrinopathies
-
Vaidya B, Pearce SH, Charlton S, et al. An association between the CTLA4 exon 1 polymorphism and early rheumatoid arthritis with autoimmune en-docrinopathies. Rheumatology (Oxford) 2002; 41:180-183.
-
(2002)
Rheumatology (Oxford)
, vol.41
, pp. 180-183
-
-
Vaidya, B.1
Pearce, S.H.2
Charlton, S.3
-
17
-
-
13244277850
-
A regulatory polymorphism in PDCD1 is associated with susceptibility to systemic lupus erythematosus in humans
-
Prokunina L, Castillejo-Lopez C, Oberg F, et al. A regulatory polymorphism in PDCD1 is associated with susceptibility to systemic lupus erythematosus in humans. Nat Genet 2002; 32:666-669.
-
(2002)
Nat Genet
, vol.32
, pp. 666-669
-
-
Prokunina, L.1
Castillejo-Lopez, C.2
Oberg, F.3
-
18
-
-
0037648405
-
Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease
-
Ueda H, Howson JM, Esposito L, et al. Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease. Nature 2003; 423:506-511.
-
(2003)
Nature
, vol.423
, pp. 506-511
-
-
Ueda, H.1
Howson, J.M.2
Esposito, L.3
-
19
-
-
78449256966
-
Update on immunologic therapy with anti-CTLA-4 antibodies in melanoma: Identification of clinical and biological response patterns, immune-related adverse events, and their management
-
Kaehler KC, Piel S, Livingstone E, et al. Update on immunologic therapy with anti-CTLA-4 antibodies in melanoma: identification of clinical and biological response patterns, immune-related adverse events, and their management. Semin Oncol 2010; 37:485-498.
-
(2010)
Semin Oncol
, vol.37
, pp. 485-498
-
-
Kaehler, K.C.1
Piel, S.2
Livingstone, E.3
-
20
-
-
84944261579
-
Immune-related adverse events, need for systemic immunosuppression, and effects on survival and time to treatment failure in patients with melanoma treated with ipilimumab at Memorial Sloan Kettering Cancer Center
-
Horvat TZ, Adel NG, Dang TO, et al. Immune-related adverse events, need for systemic immunosuppression, and effects on survival and time to treatment failure in patients with melanoma treated with ipilimumab at Memorial Sloan Kettering Cancer Center. J Clin Oncol 2015; 33:3193-3198.
-
(2015)
J Clin Oncol
, vol.33
, pp. 3193-3198
-
-
Horvat, T.Z.1
Adel, N.G.2
Dang, T.O.3
-
21
-
-
84949951840
-
Safety profile of nivolumab (NIVO) in patients (pts) with advanced melanoma (MEL): A pooled analysis
-
Safety profile of nivolumab (NIVO) in patients (pts) with advanced melanoma (MEL): A pooled analysis. J Clin Oncol 2015; 33:. (suppl; abstr 9018).
-
(2015)
J Clin Oncol
, vol.33
, pp. 9018
-
-
-
22
-
-
84991246377
-
-
Opdivo prescribing information Bristol-Myers Squibb, January 2016
-
Opdivo prescribing information, http://packageinserts.bms.com/pi/pi-opdi-vo.pdf, Bristol-Myers Squibb, January 2016.
-
-
-
-
23
-
-
84991263597
-
-
Nivolumab, immune mediated adverse reactions management guide
-
Nivolumab, immune mediated adverse reactions management guide.
-
-
-
-
24
-
-
84936791837
-
Nivolumab versus docetaxel in advanced squamous-cell non-small-cell lung cancer
-
Brahmer J, Reckamp KL, Baas P, et al. Nivolumab versus docetaxel in advanced squamous-cell non-small-cell lung cancer. N Engl J Med 2015; 373:123-135.
-
(2015)
N Engl J Med
, vol.373
, pp. 123-135
-
-
Brahmer, J.1
Reckamp, K.L.2
Baas, P.3
-
25
-
-
84931083080
-
Nivolumab versus chemotherapy in patients with advanced melanoma who progressed after anti-CTLA-4 treatment (CheckMate 037): A randomised, controlled, open-label, phase 3 trial
-
Weber JS, D'Angelo SP, Minor D, et al. Nivolumab versus chemotherapy in patients with advanced melanoma who progressed after anti-CTLA-4 treatment (CheckMate 037): a randomised, controlled, open-label, phase 3 trial. Lancet Oncol 2015; 16:375-384.
-
(2015)
Lancet Oncol
, vol.16
, pp. 375-384
-
-
Weber, J.S.1
D'Angelo, S.P.2
Minor, D.3
-
26
-
-
84939150439
-
Expanded cohort results from CheckMate 016: A phase i study of nivolumab in combination with ipilimumab in metastatic renal cell carcinoma (mRCC)
-
Expanded cohort results from CheckMate 016: A phase I study of nivolumab in combination with ipilimumab in metastatic renal cell carcinoma (mRCC). J Clin Oncol 2015; 33:. (suppl; abstr 4516).
-
(2015)
J Clin Oncol
, vol.33
, pp. 4516
-
-
-
27
-
-
37349072460
-
Ipilimumab (anti-CTLA4 antibody) causes regression of metastatic renal cell cancer associated with enteritis and hypophysitis
-
Yang JC, Hughes M, Kammula U, et al. Ipilimumab (anti-CTLA4 antibody) causes regression of metastatic renal cell cancer associated with enteritis and hypophysitis. J Immunother 2007; 30:825-830.
-
(2007)
J Immunother
, vol.30
, pp. 825-830
-
-
Yang, J.C.1
Hughes, M.2
Kammula, U.3
-
28
-
-
84965020158
-
CheckMate 214: A phase III, randomized, open-label study of nivolumab combined with ipilimumab versus sunitinib monotherapy in patients with previously untreated metastatic renal cell carcinoma
-
CheckMate 214: A phase III, randomized, open-label study of nivolumab combined with ipilimumab versus sunitinib monotherapy in patients with previously untreated metastatic renal cell carcinoma. J Clin Oncol 2015; 33:. (suppl; abstr TPS4578).
-
(2015)
J Clin Oncol
, vol.33
, pp. TPS4578
-
-
-
29
-
-
84962144656
-
Characterisation and management of dermatologic adverse events to agents targeting the PD-1 receptor
-
Belum VR, Benhuri B, Postow MA, et al. Characterisation and management of dermatologic adverse events to agents targeting the PD-1 receptor. Eur J Cancer 2016; 60:12-25.
-
(2016)
Eur J Cancer
, vol.60
, pp. 12-25
-
-
Belum, V.R.1
Benhuri, B.2
Ma, P.3
-
30
-
-
84887621573
-
Sweet's syndrome in a patient with metastatic melanoma after ipilimumab therapy
-
Pintova S, Sidhu H, Friedlander PA, et al. Sweet's syndrome in a patient with metastatic melanoma after ipilimumab therapy. Melanoma Res 2013; 23:498-501.
-
(2013)
Melanoma Res
, vol.23
, pp. 498-501
-
-
Pintova, S.1
Sidhu, H.2
Friedlander, P.A.3
-
31
-
-
84969710115
-
Managing immune checkpoint-blocking antibody side effects
-
Postow MA. Managing immune checkpoint-blocking antibody side effects. Am Soc Clin Oncol Educ Book 2015; 76-83.
-
(2015)
Am Soc Clin Oncol Educ Book
, pp. 76-83
-
-
Postow, M.A.1
-
32
-
-
85027932675
-
Autoimmune dermatologic toxicities from immune checkpoint blockade with anti-PD-1 antibody therapy: A report on bullous skin eruptions
-
Jour G, Glitza IC, Ellis RM, et al. Autoimmune dermatologic toxicities from immune checkpoint blockade with anti-PD-1 antibody therapy: a report on bullous skin eruptions. J Cutan Pathol 2016; 43:688-696.
-
(2016)
J Cutan Pathol
, vol.43
, pp. 688-696
-
-
Jour, G.1
Glitza, I.C.2
Ellis, R.M.3
-
33
-
-
84971324112
-
Severe psoriasis flare after anti-programmed death ligand 1 (PD-L1) therapy for metastatic non-small cell lung cancer (NSCLC)
-
Chia PL, John T. Severe psoriasis flare after anti-programmed death ligand 1 (PD-L1) therapy for metastatic non-small cell lung cancer (NSCLC). J Im-munother 2016; 39:202-204.
-
(2016)
J Im-munother
, vol.39
, pp. 202-204
-
-
Chia, P.L.1
John, T.2
-
34
-
-
84949988089
-
Toxicities of the anti-PD-1 and anti-PD-L1 immune checkpoint antibodies
-
Naidoo J, Page DB, Li BT, et al. Toxicities of the anti-PD-1 and anti-PD-L1 immune checkpoint antibodies. Ann Oncol 2015; 26:2375-2391.
-
(2015)
Ann Oncol
, vol.26
, pp. 2375-2391
-
-
Naidoo, J.1
Page, D.B.2
Li, B.T.3
-
35
-
-
84898973055
-
Survival, durable tumor remission, and long-term safety in patients with advanced melanoma receiving nivolu-mab, supplementary data
-
Topalian SL, Sznol M, McDermott DF, et al. Survival, durable tumor remission, and long-term safety in patients with advanced melanoma receiving nivolu-mab, supplementary data. J Clin Oncol 2014; 32:1020-1030.
-
(2014)
J Clin Oncol
, vol.32
, pp. 1020-1030
-
-
Topalian, S.L.1
Sznol, M.2
McDermott, D.F.3
-
36
-
-
84958150171
-
Cutaneous adverse events (AEs) of antiprogrammed cell death (PD)-1 therapy in patients with metastatic melanoma: A single-institution cohort
-
e1
-
Hwang SJ, Carlos G, Wakade D, et al. Cutaneous adverse events (AEs) of antiprogrammed cell death (PD)-1 therapy in patients with metastatic melanoma: a single-institution cohort. J Am Acad Dermatol 2016; 74:455-461; e1.
-
(2016)
J Am Acad Dermatol
, vol.74
, pp. 455-461
-
-
Hwang, S.J.1
Carlos, G.2
Wakade, D.3
-
37
-
-
84939470051
-
Lichenoid dermatitis in three patients with metastatic melanoma treated with anti-PD-1 therapy
-
Joseph RW, Cappel M, Goedjen B, et al. Lichenoid dermatitis in three patients with metastatic melanoma treated with anti-PD-1 therapy. Cancer Immunol Res 2015; 3:18-22.
-
(2015)
Cancer Immunol Res
, vol.3
, pp. 18-22
-
-
Joseph, R.W.1
Cappel, M.2
Goedjen, B.3
-
39
-
-
84914148032
-
Phase i study of nivolumab in combination with ipilimumab in metastatic renal cell carcinoma (mRCC)
-
abstr 4504
-
Phase I study of nivolumab in combination with ipilimumab in metastatic renal cell carcinoma (mRCC). J Clin Oncol 2014; 32:5s. (suppl; abstr 4504).
-
(2014)
J Clin Oncol
, vol.32
, pp. 5s
-
-
-
40
-
-
84991223795
-
-
American dietetic association Crohn's-Colitis diet;
-
American dietetic association Crohn's-Colitis diet; http://www.uccs.edu/Documents/peakfood/hlthTopics/Crohns Disease Nutrition.pdf.
-
-
-
-
41
-
-
84914176528
-
Nivolumab (anti-PD-1; BMS-936558, ONO-4538) in combination with suni-tinib or pazopanib in patients (pts) with metastatic renal cell carcinoma (mRCC)
-
abstr 5010
-
Nivolumab (anti-PD-1; BMS-936558, ONO-4538) in combination with suni-tinib or pazopanib in patients (pts) with metastatic renal cell carcinoma (mRCC). J Clin Oncol 2014; 32:5s. (suppl; abstr 5010).
-
(2014)
J Clin Oncol
, vol.32
, pp. 5s
-
-
-
42
-
-
84937053577
-
Anti-PD-1-related pneumonitis during cancer immunotherapy
-
Nishino M, Sholl LM, Hodi FS, et al. Anti-PD-1-related pneumonitis during cancer immunotherapy. N Engl J Med 2015; 373:288-290.
-
(2015)
N Engl J Med
, vol.373
, pp. 288-290
-
-
Nishino, M.1
Sholl, L.M.2
Hodi, F.S.3
-
43
-
-
84929347192
-
Induction of painless thyroiditis in patients receiving programmed death 1 receptor immunotherapy for metastatic malignancies
-
Orlov S, Salari F, Kashat L, et al. Induction of painless thyroiditis in patients receiving programmed death 1 receptor immunotherapy for metastatic malignancies. J Clin Endocrinol Metab 2015; 100:1738-1741.
-
(2015)
J Clin Endocrinol Metab
, vol.100
, pp. 1738-1741
-
-
Orlov, S.1
Salari, F.2
Kashat, L.3
-
44
-
-
84876248304
-
Endocrine side effects induced by immune checkpoint inhibitors
-
Corsello SM, Barnabei A, Marchetti P, et al. Endocrine side effects induced by immune checkpoint inhibitors. J Clin Endocrinol Metab 2013; 98:1361-1375.
-
(2013)
J Clin Endocrinol Metab
, vol.98
, pp. 1361-1375
-
-
Corsello, S.M.1
Barnabei, A.2
Marchetti, P.3
-
45
-
-
79953300714
-
Anti-CTLA-4 antibody-induced Guillain-Barre syndrome in a melanoma patient
-
Wilgenhof S, Neyns B. Anti-CTLA-4 antibody-induced Guillain-Barre syndrome in a melanoma patient. Ann Oncol 2011; 22:991-993.
-
(2011)
Ann Oncol
, vol.22
, pp. 991-993
-
-
Wilgenhof, S.1
Neyns, B.2
-
46
-
-
84857517981
-
Posterior reversible encephalopathy syndrome during ipilimumab therapy for malignant melanoma
-
Maur M, Tomasello C, Frassoldati A, et al. Posterior reversible encephalopathy syndrome during ipilimumab therapy for malignant melanoma. J Clin Oncol 2012; 30:e76-e78.
-
(2012)
J Clin Oncol
, vol.30
, pp. e76-e78
-
-
Maur, M.1
Tomasello, C.2
Frassoldati, A.3
-
47
-
-
84896934432
-
Atypical neurological complications of ipilimumab therapy in patients with metastatic melanoma
-
Liao B, Shroff S, Kamiya-Matsuoka C, et al. Atypical neurological complications of ipilimumab therapy in patients with metastatic melanoma. Neuro Oncol 2014; 16:589-593.
-
(2014)
Neuro Oncol
, vol.16
, pp. 589-593
-
-
Liao, B.1
Shroff, S.2
Kamiya-Matsuoka, C.3
-
48
-
-
84879977559
-
Neurological immune-related adverse events of ipilimumab
-
Bot I, Blank CU, Boogerd W, et al. Neurological immune-related adverse events of ipilimumab. Pract Neurol 2013; 13:278-280.
-
(2013)
Pract Neurol
, vol.13
, pp. 278-280
-
-
Bot, I.1
Blank, C.U.2
Boogerd, W.3
-
49
-
-
84962409041
-
Limbic encephalitis following immunotherapy against metastatic malignant melanoma
-
Salam S, Lavin T, Turan A. Limbic encephalitis following immunotherapy against metastatic malignant melanoma. BMJ Case Rep 2016; 2016:.
-
(2016)
BMJ Case Rep
, vol.2016
-
-
Salam, S.1
Lavin, T.2
Turan, A.3
-
50
-
-
84963948616
-
Association of acute interstitial ne-phritis with programmed cell death 1 inhibitor therapy in lung cancer patients
-
[Epub ahead of print]
-
Shirali AC, Perazella MA, Gettinger S. Association of acute interstitial ne-phritis with programmed cell death 1 inhibitor therapy in lung cancer patients. Am J Kidney Dis 2016; doi: 10.1053/j.ajkd.2016.02.057. [Epub ahead of print]
-
(2016)
Am J Kidney Dis
-
-
Shirali, A.C.1
Ma, P.2
Gettinger, S.3
-
52
-
-
84977070678
-
Opportunistic infections in patients treated with immunotherapy for cancer
-
Kyi C, Hellmann MD, Wolchok JD, et al. Opportunistic infections in patients treated with immunotherapy for cancer. J Immunother Cancer 2014; 2:19.
-
(2014)
J Immunother Cancer
, vol.2
, pp. 19
-
-
Kyi, C.1
Hellmann, M.D.2
Wolchok, J.D.3
|