Anakinra Protects Against Serum Deprivation-Induced Inflammation and Functional Derangement in Islets Isolated From Nonhuman Primates

American Journal of Transplantation

Volumn 17, Issue 2, 2017, Pages 365-376

  Jin, S M ^a   Shim, W ^b,c   Oh, B J ^a,b   Oh, S H ^b   Yu, S J ^b   Choi, J M ^b   Park, H J ^a   Park, J B ^a   Kim, J H ^a,d  

^a Sungkyunkwan University School of Medicine   (South Korea)

^b Samsung Medical Center   (South Korea)

^c Ajou University   (South Korea)

^d Samsung Advanced Institute of Technology (SAIT)   (South Korea)

Author keywords

basic (laboratory) research science; diabetes; endocrinology diabetology; innate immunity; islet transplantation; islets of Langerhans; translational research science

Indexed keywords

AMYLIN; AMYLOID; ANAKINRA; CYTOKINE; GLUCOSE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INSULIN; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; INTERLEUKIN 6; OLIGOMER; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR; ANTIRHEUMATIC AGENT; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; CULTURE MEDIUM; CYTOKINE RELEASE; DRUG EFFECT; ENZYME ACTIVATION; EX VIVO STUDY; GENETIC TRANSCRIPTION; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; INSULIN RELEASE; MOUSE; NONHUMAN; PANCREAS ISLET; PANCREAS ISLET CELL FUNCTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SERUM; STAINING; STREPTOZOTOCIN-INDUCED DIABETES MELLITUS; TISSUE CULTURE; ANIMAL; BAGG ALBINO MOUSE; CELL CULTURE; CELL SURVIVAL; CHEMICALLY INDUCED; DRUG EFFECTS; HUMAN; MACACA FASCICULARIS; NUDE MOUSE; PATHOLOGY; SERUM-FREE MEDIUM; TOXICITY;

ANIMALS; ANTIRHEUMATIC AGENTS; CELL SURVIVAL; CELLS, CULTURED; CULTURE MEDIA, SERUM-FREE; HUMANS; INFLAMMATION; INTERLEUKIN 1 RECEPTOR ANTAGONIST PROTEIN; ISLETS OF LANGERHANS; MACACA FASCICULARIS; MICE; MICE, INBRED BALB C; MICE, NUDE;

EID: 84981731258     PISSN: 16006135     EISSN: 16006143     Source Type: Journal    
DOI: 10.1111/ajt.13953     Document Type: Article

References (31)

1. Boni-Schnetzler M, Boller S, Debray S, et al. Free fatty acids induce a proinflammatory response in islets via the abundantly expressed interleukin-1 receptor I. Endocrinology 2009; 150: 5218–5229.
2. Masters SL, Dunne A, Subramanian SL, et al. Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1beta in type 2 diabetes. Nat Immunol 2010; 11: 897–904.
3. Westwell-Roper C, Dai DL, Soukhatcheva G, et al. IL-1 blockade attenuates islet amyloid polypeptide-induced proinflammatory cytokine release and pancreatic islet graft dysfunction. J Immunol 2011; 187: 2755–2765.
4. Westermark GT, Davalli AM, Secchi A, et al. Further evidence for amyloid deposition in clinical pancreatic islet grafts. Transplantation 2012; 93: 219–223.
5. Marliss EB, Wollheim CB, Blondel B, et al. Insulin and glucagon release from monolayer cell cultures of pancreas from newborn rats. Eur J Clin Invest 1973; 3: 16–26.
6. Lazarow A, Wells LJ, Carpenter AM, Hegre OD, Leonard RJ, McEvoy RC. The Banting Memorial Lecture 1973: Islet differentiation, organ culture, and transplantation. Diabetes 1973; 22: 877–912.
7. Holmes MA, Clayton HA, Chadwick DR, Bell PR, London NJ, James RF. Functional studies of rat, porcine, and human pancreatic islets cultured in ten commercially available media. Transplantation 1995; 60: 854–860.
8. Avgoustiniatos ES, Scott WE 3rd, Suszynski TM, et al. Supplements in human islet culture: Human serum albumin is inferior to fetal bovine serum. Cell Transplant 2012; 21: 2805–2814.
9. Schwarznau A, Hanson MS, Sperger JM, et al. IL-1beta receptor blockade protects islets against proinflammatory cytokine induced necrosis and apoptosis. J Cell Physiol 2009; 220: 341–347.
10. Sahraoui A, Kloster-Jensen K, Ueland T, Korsgren O, Foss A, Scholz H. Anakinra and tocilizumab enhance survival and function of human islets during culture: Implications for clinical islet transplantation. Cell Transplant 2014; 23: 1199–1211.
11. Kim J, Cheon H, Jeong YT, et al. Amyloidogenic peptide oligomer accumulation in autophagy-deficient beta cells induces diabetes. J Clin Invest 2014; 124: 3311–3324.
12. Oh BJ, Oh SH, Jin SM, et al. Co-transplantation of bone marrow-derived endothelial progenitor cells improves revascularization and organization in islet grafts. Am J Transplant 2013; 13: 1429–1440.
13. Ricordi C, Lacy PE, Finke EH, Olack BJ, Scharp DW. Automated method for isolation of human pancreatic islets. Diabetes 1988; 37: 413–420.
14. Andrades P, Asiedu CK, Gansuvd B, et al. Pancreatic islet isolation variables in non-human primates (rhesus macaques). Diabetologia 2008; 51: 1236–1244.
15. Ricordi C, Gray DW, Hering BJ, et al. Islet isolation assessment in man and large animals. Acta Diabetol Lat 1990; 27: 185–195.
16. O'Brien TD, Wagner JD, Litwak KN, et al. Islet amyloid and islet amyloid polypeptide in cynomolgus macaques (Macaca fascicularis): An animal model of human non-insulin-dependent diabetes mellitus. Vet Pathol 1996; 33: 479–485.
17. Udayasankar J, Kodama K, Hull RL, et al. Amyloid formation results in recurrence of hyperglycaemia following transplantation of human IAPP transgenic mouse islets. Diabetologia 2009; 52: 145–153.
18. Potter KJ, Abedini A, Marek P, et al. Islet amyloid deposition limits the viability of human islet grafts but not porcine islet grafts. Proc Natl Acad Sci U S A 2010; 107: 4305–4310.
19. Liu C, Koeberlein B, Feldman MD, et al. Accumulation of intrahepatic islet amyloid in a nonhuman primate transplant model. Endocrinology 2012; 153: 1673–1683.
20. Potter KJ, Westwell-Roper CY, Klimek-Abercrombie AM, Warnock GL, Verchere CB. Death and dysfunction of transplanted beta-cells: Lessons learned from type 2 diabetes? Diabetes 2014; 63: 12–19.
21. Henson MS, Buman BL, Jordan K, et al. An in vitro model of early islet amyloid polypeptide (IAPP) fibrillogenesis using human IAPP-transgenic mouse islets. Amyloid 2006; 13: 250–259.
22. Marzban L, Tomas A, Becker TC, et al. Small interfering RNA-mediated suppression of proislet amyloid polypeptide expression inhibits islet amyloid formation and enhances survival of human islets in culture. Diabetes 2008; 57: 3045–3055.
23. Potter KJ, Scrocchi LA, Warnock GL, et al. Amyloid inhibitors enhance survival of cultured human islets. Biochim Biophys Acta 2009; 1790: 566–574.
24. Kerr-Conte J, Vandewalle B, Moerman E, et al. Upgrading pretransplant human islet culture technology requires human serum combined with media renewal. Transplantation 2010; 89: 1154–1160.
25. Nacher M, Estil Les E, Garcia A, et al. Human serum versus human serum albumin supplementation in human islet pretransplantation culture. In vitro and in vivo assessment. Cell Transplant 2016; 25: 343–352.
26. SoRelle JA, Itoh T, Peng H, et al. Withaferin A inhibits proinflammatory cytokine-induced damage to islets in culture and following transplantation. Diabetologia 2013; 56: 814–824.
27. Peng H, Olsen G, Tamura Y, et al. Inhibition of inflammatory cytokine-induced response in human islet cells by withaferin A. Transplant Proc 2010; 42: 2058–2061.
28. Flodstrom M, Welsh N, Eizirik DL. Cytokines activate the nuclear factor kappa B (NF-kappa B) and induce nitric oxide production in human pancreatic islets. FEBS Lett 1996; 385: 4–6.
29. Abdelli S, Ansite J, Roduit R, et al. Intracellular stress signaling pathways activated during human islet preparation and following acute cytokine exposure. Diabetes 2004; 53: 2815–2823.
30. Lee RH, Carter J, Szot GL, Posselt A, Stock P. Human albumin preserves islet mass and function better than whole serum during pretransplantation islet culture. Transplant Proc 2008; 40: 384–386.
31. Cooper DK, Casu A. The International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of porcine islet products in type 1 diabetes–chapter 4: Pre-clinical efficacy and complication data required to justify a clinical trial. Xenotransplantation 2009; 16: 229–238.