FDG-PET and NeuN-GFAP immunohistochemistry of hippocampus at different phases of the pilocarpine model of temporal lobe epilepsy

International Journal of Medical Sciences

Volumn 12, Issue 3, 2015, Pages 288-294

  Zhang, Liang ^a   Guo, Yi ^a   Hu, Haitao ^a   Wang, Jing ^b   Liu, Zhirong ^a   Gao, Feng ^a  

^a THE SECOND AFFILIATED HOSPITAL OF ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b Key Laboratory of Medical Molecular Imaging of Zhejiang Province   (China)

Author keywords

Astrocytes; Glucose uptake; MicroPET; Neurons; Pilocarpine; Temporal lobe epilepsy

Indexed keywords

FLUORODEOXYGLUCOSE F 18; GLIAL FIBRILLARY ACIDIC PROTEIN; NUCLEAR PROTEIN; PILOCARPINE; CELL NUCLEUS ANTIGEN; NERVE PROTEIN; NEUN PROTEIN, RAT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTOSIS; CELL LOSS; CONTROLLED STUDY; EPILEPTOGENESIS; GLUCOSE HYPOMETABOLISM; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; HIPPOCAMPAL CA1 REGION; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MALE; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; RAT; TEMPORAL LOBE EPILEPSY; ANIMAL; BIOSYNTHESIS; BRAIN MAPPING; EPILEPSY, TEMPORAL LOBE; HIPPOCAMPUS; HUMAN; METABOLISM; PATHOLOGY; RADIOGRAPHY;

ANIMALS; ANTIGENS, NUCLEAR; BRAIN MAPPING; EPILEPSY, TEMPORAL LOBE; FLUORODEOXYGLUCOSE F18; GLIAL FIBRILLARY ACIDIC PROTEIN; HIPPOCAMPUS; HUMANS; IMMUNOHISTOCHEMISTRY; NERVE TISSUE PROTEINS; PILOCARPINE; POSITRON-EMISSION TOMOGRAPHY; RATS;

EID: 84981719826     PISSN: 14491907     EISSN: None     Source Type: Journal    
DOI: 10.7150/ijms.10527     Document Type: Article

References (26)

1. Boling WW, Lancaster M, Kraszpulski M, Palade A, Marano G, Puce A. Fluorodeoxyglucose-positron emission tomographic imaging for the diagnosis of mesial temporal lobe epilepsy. Neurosurgery. 2008; 63: 1130-8; discussion 8.
2. O'Brien TJ, Miles K, Ware R, Cook MJ, Binns DS, Hicks RJ. The cost-effective use of 18F-FDG PET in the presurgical evaluation of medically refractory focal epilepsy. J Nucl Med. 2008; 49: 931-7.
3. Vinton AB, Carne R, Hicks RJ, Desmond PM, Kilpatrick C, Kaye AH, et al. The extent of resection of FDG-PET hypometabolism relates to outcome of temporal lobectomy. Brain. 2007; 130: 548-60.
4. Chen S, Buckmaster PS. Stereological analysis of forebrain regions in kainate-treated epileptic rats. Brain Res. 2005; 1057: 141-52.
5. Sharma AK, Jordan WH, Reams RY, Hall DG, Snyder PW. Temporal profile of clinical signs and histopathologic changes in an F-344 rat model of kainic acid- induced mesial temporal lobe epilepsy. Toxicol Pathol. 2008; 36: 932-43.
6. Joo EY, Hong SB, Han HJ, Tae WS, Kim JH, Han SJ, et al. Postoperative alteration of cerebral glucose metabolism in mesial temporal lobe epilepsy. Brain. 2005; 128: 1802-10.
7. Kuhl DE, Engel J, Jr., Phelps ME, Kowell AP. Epileptic patterns of local cerebral metabolism and perfusion in man: investigation by emission computed tomography of 18F-fluorodeoxyglucose and 13N-ammonia. Trans Am Neurol Assoc. 1978; 103: 52-3.
8. Guo Y, Gao F, Wang S, Ding Y, Zhang H, Wang J, et al. In vivo mapping of temporospatial changes in glucose utilization in rat brain during epileptogenesis: an 18F-fluorodeoxyglucose-small animal positron emission tomography study. Neuroscience. 2009; 162: 972-9.
9. Tooyama I, Bellier J-P, Park M, Minnasch P, Uemura S, Hisano T, et al. Morphologic Study of Neuronal Death, Glial Activation, and Progenitor Cell Division in the Hippocampus of Rat Models of Epilepsy. Epilepsia. 2002; 43: 39-43.
10. Gao F, Guo Y, Zhang H, Wang S, Wang J, Wu JM, et al. Anterior thalamic nucleus stimulation modulates regional cerebral metabolism: an FDG-MicroPET study in rats. Neurobiol Dis. 2009; 34: 477-83.
11. Gao F, Wang S, Guo Y, Wang J, Lou M, Wu J, et al. Protective effects of repetitive transcranial magnetic stimulation in a rat model of transient cerebral ischaemia: a microPET study. Eur J Nucl Med Mol Imaging. 2010; 37: 954-61.
12. Matsumura A, Mizokawa S, Tanaka M, Wada Y, Nozaki S, Nakamura F, et al. Assessment of microPET performance in analyzing the rat brain under different types of anesthesia: comparison between quantitative data obtained with microPET and ex vivo autoradiography. Neuroimage. 2003; 20: 2040-50.
13. Andre V, Dube C, Francois J, Leroy C, Rigoulot MA, Roch C, et al. Pathogenesis and pharmacology of epilepsy in the lithium-pilocarpine model. Epilepsia. 2007; 48 Suppl 5: 41-7.
14. Dube C, Boyet S, Marescaux C, Nehlig A. Relationship between neuronal loss and interictal glucose metabolism during the chronic phase of the lithium- pilocarpine model of epilepsy in the immature and adult rat. Exp Neurol. 2001; 167: 227-41.
15. Jupp B, Williams J, Binns D, Hicks RJ, Cardamone L, Jones N, et al. Hypometabolism precedes limbic atrophy and spontaneous recurrent seizures in a rat model of TLE. Epilepsia. 2012; 53: 1233-44.
16. Bischoff V, Deogracias R, Poirier F, Barde YA. Seizure-induced neuronal death is suppressed in the absence of the endogenous lectin Galectin-1. The Journal of neuroscience: the official journal of the Society for Neuroscience. 2012; 32: 15590-600.
17. O'Brien TJ, Newton MR, Cook MJ, Berlangieri SU, Kilpatrick C, Morris K, et al. Hippocampal atrophy is not a major determinant of regional hypometabolism in temporal lobe epilepsy. Epilepsia. 1997; 38: 74-80.
18. Theodore WH, Gaillard WD, De Carli C, Bhatia S, Hatta J. Hippocampal volume and glucose metabolism in temporal lobe epileptic foci. Epilepsia. 2001; 42: 130-2.
19. Carne RP, O'Brien TJ, Kilpatrick CJ, MacGregor LR, Hicks RJ, Murphy MA, et al. MRI-negative PET-positive temporal lobe epilepsy: a distinct surgically remediable syndrome. Brain. 2004; 127: 2276-85.
20. Represa A, Niquet J, Pollard H, Ben-Ari Y. Cell death, gliosis, and synaptic remodeling in the hippocampus of epileptic rats. J Neurobiol. 1995; 26: 413-25.
21. Belluardo N, Mudo G, Jiang XH, Condorelli DF. Induction of astroglial gene expression by experimental seizures in the rat: spatio-temporal patterns of the early stages. Glia. 1996; 16: 174-86.
22. Borges K, Gearing M, McDermott DL, Smith AB, Almonte AG, Wainer BH, et al. Neuronal and glial pathological changes during epileptogenesis in the mouse pilocarpine model. Exp Neurol. 2003; 182: 21-34.
23. Seifert G, Carmignoto G, Steinhauser C. Astrocyte dysfunction in epilepsy. Brain Res Rev. 2010; 63: 212-21.
24. Mirrione MM, Konomos DK, Gravanis I, Dewey SL, Aguzzi A, Heppner FL, et al. Microglial ablation and lipopolysaccharide preconditioning affects pilocarpine- induced seizures in mice. Neurobiol Dis. 2010; 39: 85-97.
25. Schroeter M, Dennin MA, Walberer M, Backes H, Neumaier B, Fink GR, et al. Neuroinflammation extends brain tissue at risk to vital peri-infarct tissue: a double tracer [11C]PK11195- and [18F]FDG-PET study. J Cereb Blood Flow Metab. 2009; 29: 1216-25.
26. Lee EM, Park GY, Im KC, Kim ST, Woo CW, Chung JH, et al. Changes in glucose metabolism and metabolites during the epileptogenic process in the lithium-pilocarpine model of epilepsy. Epilepsia. 2012; 53: 860-9.