Mechanisms Associated with Activation of Intracellular Metabotropic Glutamate Receptor, mGluR5

Neurochemical Research

Volumn 42, Issue 1, 2017, Pages 166-172

  Jong, Yuh Jiin I ^a   O’Malley, Karen L ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Calcium; Glutamate; GPCR; Metabotropic

Indexed keywords

2 AMINO 2 (3 CARBOXYCYCLOBUTYL) 3 (9 THIOXANTHYL)PROPIONIC ACID; 2 METHYL 6 (PHENYLETHYNYL)PYRIDINE; CALCIUM ION; CHAPERONIN 60; GLUTAMIC ACID; METABOTROPIC RECEPTOR 5;

ANIMAL CELL; ARTICLE; BRAIN MITOCHONDRION; CALCIUM CELL LEVEL; CELL BODY; CELL SURFACE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DENDRITE; EC50; FLUX ASSAY; GABAERGIC SYSTEM; IMMUNOCYTOCHEMISTRY; INTRACELLULAR MEMBRANE; NERVE CELL; NONHUMAN; PRIMARY CULTURE; PRIORITY JOURNAL; RAT; SPINAL CORD DORSAL HORN; AGONISTS; ANIMAL; CELL CULTURE; CORPUS STRIATUM; CYTOLOGY; DOSE RESPONSE; DRUG EFFECTS; INTRACELLULAR FLUID; METABOLISM; NEWBORN;

ANIMALS; ANIMALS, NEWBORN; CELLS, CULTURED; CORPUS STRIATUM; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUTAMIC ACID; INTRACELLULAR FLUID; RATS; RECEPTOR, METABOTROPIC GLUTAMATE 5;

EID: 84981504992     PISSN: 03643190     EISSN: 15736903     Source Type: Journal    
DOI: 10.1007/s11064-016-2026-6     Document Type: Article

References (34)

1. Shen B, Rosenberg B, Orlow SJ (2001) Intracellular distribution and late endosomal effects of the ocular albinism type 1 gene product: consequences of disease-causing mutations and implications for melanosome biogenesis. Traffic 2:202–211
2. Lee DK, Lança AJ, Cheng R, Nguyen T, Ji XD, Gobeil F Jr, Chemtob S, George SR, O’Dowd BF (2004) Agonist-independent nuclear localization of the Apelin, angiotensin AT1, and bradykinin B2 receptors. J Biol Chem 279:7901–7908
3. Meads MB, Medveczky PG (2004) Kaposi’s sarcoma-associated herpesvirus-encoded viral interleukin-6 is secreted and modified differently than human interleukin-6: evidence for a unique autocrine signaling mechanism. J Biol Chem 279:51793–51803
4. Rozenfeld R, Devi LA (2008) Regulation of CB1 cannabinoid receptor trafficking by theadaptor protein AP-3. FASEB J 22:2311–2322
5. Lopez VM, Decatur CL, Stamer WD, Lynch RM, McKay BS (2008) L-DOPA is an endogenous ligand for OA1. PLoS Biol 6:e236
6. Vaniotis G, Allen BG, Hébert TE (2011) Nuclear GPCRs in cardiomyocytes: an insider’s view of β-adrenergic receptor signaling Am J Physiol Heart Circ Physiol 301:H1754–H1764
7. 1 receptors regulate neuronal energy metabolism. Nat Neurosci 15:558–564
8. Tadevosyan A, Vaniotis G, Allen BG, Hébert TE, Nattel S (2012) G protein-coupled receptor signalling in the cardiac nuclear membrane: evidence and possible roles in physiological and pathophysiological function. J Physiol 590:1313–1330
9. Burgoyne T, Jolly R, Martin-Martin B, Seabra MC, Piccirillo R, Schiaffino MV, Futter CE (2013) Expression of OA1 limits the fusion of a subset of MVBs with lysosomes—a mechanism potentially involved in the initial biogenesis of melanosomes. J Cell Sci 126:5143–5152
10. Irannejad R, Tomshine JC, Tomshine JR, Chevalier M, Mahoney JP, Steyaert J, Rasmussen SG, Sunahara RK, El-Samad H, Huang B, von Zastrow M (2013) Conformational biosensors reveal GPCR signalling from endosomes. Nature 495:534–538
11. Jong YJ, Sergin I, Purgert CA, O’Malley KL (2014) Location-dependent signaling of the group 1 metabotropic glutamate receptor mGlu5. Mol Pharmacol 86:774–785
12. 2+ changes in heterologous cell types and neurons. J Biol Chem 278:28210–28219
13. Jong YJ, Kumar V, Kingston AE, Romano C, O’Malley KL (2005) Functional metabotropic glutamate receptors on nuclei from brain and primary cultured striatal neurons. Role of transporters in delivering ligand. J Biol Chem 280:30469–30480
14. 2+ release. J Biol Chem 283:14072–14083
15. Jong YJ, Kumar V, O’Malley KL (2009) Intracellular metabotropic glutamate receptor 5 (mGluR5) activates signaling cascades distinct from cell surface counterparts. J Biol Chem 284:35827–35838
16. Danbolt NC (2001) Glutamate uptake. Prog Neurobiol 65:1–105
17. Balcar VJ, Li Y (1992) Heterogeneity of high affinity uptake of l-glutamate and l-aspartate in the mammalian central nervous system. Life Sci 51:1467–1478
18. Fournier KM, Gonzalez MI, Robinson MB (2004) Rapid trafficking of the neuronal glutamate transporter, EAAC1: evidence for distinct trafficking pathways differentially regulated by protein kinase C and platelet-derived growth factor. J Biol Chem 279:34505–34513
19. − cystine/glutamate antiporter: an update on molecular pharmacology and roles within the CNS. Br J Pharmacol 165:20–34
20. Vandenberg RJ, Ryan RM (2013) Mechanisms of glutamate transport. Physiol Rev 93:1621–1657
21. − in health and disease: from molecular mechanisms to novel therapeutic opportunities. Antioxid Redox Signal 18:522–555
22. Jong YJ, Schwetye KE, O’Malley KL (2007) Nuclear localization of functional metabotropic glutamate receptor mGlu1 in HEK293 cells and cortical neurons: role in nuclear calcium mobilization and development. J Neurochem 101:458–469
23. Purgert CA, Izumi Y, Jong YJ, Kumar V, Zorumski CF, O’Malley KL (2014) Intracellular mGluR5 can mediate synaptic plasticity in the hippocampus. J Neurosci 34:4589–4598
24. Vincent K, Cornea VM, Jong YJ, Laferrière A, Kumar N, Mickeviciute A, Fung JS, Bandegi P, Ribeiro-da-Silva A, O’Malley KL, Coderre TJ (2016) Intracellular mGluR5 plays a critical role in neuropathic pain. Nat Commun 7:10604
25. Kanai Y, Hediger MA (2004) The glutamate/neutral amino acid transporter family SLC1: molecular, physiological and pharmacological aspects. Pflügers Arch 447:469–479
26. Kumar V, Fahey PG, Jong YJ, Ramanan N, O’Malley KL (2012) Activation of intracellular metabotropic glutamate receptor 5 in striatal neurons leads to up-regulation of genes associated with sustained synaptic transmission including Arc/Arg3.1 protein. J Biol Chem 287:5412–5425
27. McKenna MC (2007) The glutamate-glutamine cycle is not stoichiometric: fates of glutamate in brain. J Neurosci Res 85:3347–3358
28. Olstad E, Qu H, Sonnewald U (2007) Glutamate is preferred over glutamine for intermediary metabolism in cultured cerebellar neurons. J Cereb Blood Flow Metab 27:811–820
29. Kharazia VN, Weinberg RJ (1994) Glutamate in thalamic fibers terminating in layer IV of primary sensory cortex. J Neurosci 14:6021–6032
30. Shupliakov O, Brodin L, Cullheim S, Ottersen OP, Storm-Mathisen (1992) Immunogold quantification of glutamate in two types of excitatory synapse with different firing patterns. J Neurosci 12:3789–3803
31. Safer B (1975) The metabolic significance of the Malate-Aspartate cycle in heart. Circ Res 37:527–533
32. Olalla L, Gutiérrez A, Campos JA, Khan ZU, Alonso FJ, Segura JA, Márquez J, Aledo JC (2002) Nuclear localization of L-type glutaminase in mammalian brain. J Biol Chem 277:38939–38944
33. Olalla L, Gutiérrez A, Jiménez AJ, López-Téllez JF, Khan ZU, Pérez J, Alonso FJ, de la Rosa V, Campos-Sandoval JA, Segura JA, Aledo JC, Márquez J (2008) Expression of the scaffolding PDZ protein glutaminase-interacting protein in mammalian brain. J Neurosci Res 86:281–292
34. Lefkowitz RJ (2007) Seven transmembrane receptors: something old, something new. Acta Physiol 190:9–19