Intracellular mGluR5 can mediate synaptic plasticity in the hippocampus

Journal of Neuroscience

Volumn 34, Issue 13, 2014, Pages 4589-4598

  Purgert, Carolyn A ^a   Izumi, Yukitoshi ^a   Jong, Yuh Jiin I ^a   Kumar, Vikas ^a   Zorumski, Charles F ^a   O'Malley, Karen L ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Calcium; Hippocampus; Intracellular; LTD; mGluR5

Indexed keywords

CALCIUM ION; CELL SURFACE RECEPTOR; EXCITATORY AMINO ACID TRANSPORTER 3; METABOTROPIC RECEPTOR 5;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL FRACTIONATION; CONTROLLED STUDY; DENDRITE; ELECTROPHYSIOLOGY; HIPPOCAMPUS; IMMUNOCYTOCHEMISTRY; INTRACELLULAR MEMBRANE; MOUSE; NERVE CELL PLASTICITY; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

CALCIUM; HIPPOCAMPUS; INTRACELLULAR; LTD; MGLUR5;

ANIMALS; ANIMALS, NEWBORN; CALCIUM; CELL NUCLEUS; CELLS, CULTURED; EXCITATORY AMINO ACID AGENTS; EXCITATORY AMINO ACID TRANSPORTER 3; GLIAL FIBRILLARY ACIDIC PROTEIN; HIPPOCAMPUS; INHIBITORY POSTSYNAPTIC POTENTIALS; INTRACELLULAR FLUID; NEURONAL PLASTICITY; NEURONS; ORGAN CULTURE TECHNIQUES; RATS; RECEPTOR, METABOTROPIC GLUTAMATE 5; SIGNAL TRANSDUCTION; SUBCELLULAR FRACTIONS;

EID: 84897855255     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.3451-13.2014     Document Type: Article

References (43)

1. Bkaily G, Avedanian L, Al-Khoury J, Ahmarani L, Perreault C, Jacques D (2012) Receptors and ionic transporters in nuclear membranes: new targets for therapeutical pharmacological interventions. Can J Physiol Pharmacol 90:953-965. CrossRef Medline
2. Blandini F, Armentero MT (2012) New pharmacological avenues for the treatment of L-DOPA-induced dyskinesias in Parkinson's disease: targeting glutamate and adenosine receptors. Expert Opin Investig Drugs 21: 153-168. CrossRef Medline
3. Bramham CR, Worley PF, Moore MJ, Guzowski JF (2008) The immediate early gene arc/arg3.1: regulation, mechanisms, and function. J Neurosci 28:11760-11767. CrossRef Medline
4. Catania MV, D'Antoni S, Bonaccorso CM, Aronica E, Bear MF, Nicoletti F (2007) Group I metabotropic glutamate receptors: a role in neurodevelopmental disorders? Mol Neurobiol 35:298-307. CrossRef Medline
5. Cleva RM, Olive MF (2011) Positive allosteric modulators of type 5 metabotropic glutamate receptors (m Glu R5) and their therapeutic potential for the treatment of CNS disorders. Molecules 16:2097-2106. CrossRef Medline
6. Denis C, Saulière A, Galandrin S, Sénard JM, Galés C (2012) Probing heterotrimeric G-proteinactivation: applications to biased ligands. Curr Pharm Des 18:128-144. CrossRef Medline
7. Emery AC, Pshenichkin S, Takoudjou GR, Grajkowska E, Wolfe BB, Wroblewski JT (2010) The protective signaling of metabotropic glutamate receptor 1 Is mediated by sustained, beta-arrestin-1-dependent ERK phosphorylation. J Biol Chem 285:26041-26048. CrossRef Medline
8. Emery AC, Di Raddo JO, Miller E, Hathaway HA, Pshenichkin S, Takoudjou GR, Grajkowska E, Yasuda RP, Wolfe BB, Wroblewski JT (2012) Ligand bias at metabotropic glutamate 1a receptors: molecular determinants that distinguishβ-arrestin-mediated from G protein-mediated signaling. Mol Pharmacol 82:291-301. CrossRef Medline
9. Enz R (2012) Structure of metabotropic glutamate receptor C-terminal domains in contact with interacting proteins. Front Mol Neurosci 5:52. CrossRef Medline
10. Fagni L (2012) Diversity of metabotropic glutamate receptor-interacting proteins and pathophysiological functions. Adv Exp Med Biol. 970:63-79. CrossRef Medline
11. Gray LJ, Hannan AJ, Zhang X (2012) Metabotropic glutamate receptors as targets for novel antipsychotic treatments. Curr Pharm Biotechnol 13: 1522-1534. CrossRef Medline
12. Hanson JE, Smith Y (1999) Group I metabotropic glutamate receptors at GABAergic synpases in monkeys. J Neurosci 19:6488-6496. Medline
13. Hewavitharana T, Wedegaertner PB (2012) Non-canonical signaling and localizations of heterotrimeric G proteins. Cell Signal 24:25-34. CrossRef Medline
14. Huber KM, Kayser MS, Bear MF (2000) Role for rapid dendritic protein synthesis in hippocampal m Glu R-dependent LTD. Science 288:1254-1257. CrossRef Medline
15. Huber KM, Roder JC, Bear MF (2001) Chemical induction of m Glu R5-and protein synthesis-dependent long-term depression in hippocampal area CA1. J Neurophysiol 86:321-325. Medline
16. Hubert GW, Paquet M, Smith Y (2001) Differential subcellular localization of m Glu R1a and m Glu R5 in the rat and monkey Substantia nigra. J Neurosci 6:1838-1847. Medline
17. Izumi Y, Zorumski CF (2012) NMDA receptors, m Glu R5, and endocannabinoids are involved in a cascade leading to hippocampal long-term depression. Neuropsychopharmacology 37:609-617. CrossRef Medline
18. Izumi Y, Zarrin AR, Zorumski CF (2000) Arachidonic acid rescues hippocampal long-term potentiation blocked by group I metabotropic glutamate receptor antagonists. Neuroscience 100:485-491. CrossRef Medline
19. Jong YJ, Kumar V, Kingston AE, Romano C, O'Malley KL (2005) Functional metabotropic glutamate receptors on nuclei from brain and primary cultured striatal neurons: role of transporters in delivering ligand. J Biol Chem 280:30469-30480. CrossRef Medline
20. Jong YJ, Schwetye KE, O'Malley KL (2007) Nuclear localization of functional metabotropic glutamate receptor m Glu1 in HEK293 cells and cortical neurons: role in nuclear calcium mobilization and development. J Neurochem 101:458-469. CrossRef Medline
21. Jong YJ, Kumar V, O'Malley KL (2009) Intracellular metabotropic glutamate receptor 5 (m Glu R5) activates signaling cascades distinct from cell surface counterparts. J Biol Chem 284:35827-35838. CrossRef Medline
22. Kammermeier PJ (2012) The orthosteric agonist 2-chloro-5-hydroxyphenylglycine activates m Glu R5 and m Glu R1 with similar efficacy and potency. BMC Pharmacol 12:6. CrossRef Medline
23. Kawabata S, Tsutsumi R, Kohara A, Yamaguchi T, Nakanishi S, Okada M (1996) Control of calcium oscillations by phosphorylation of metabotropic glutamate receptors. Nature 383:89-92. CrossRef Medline
24. 2+ oscillations. J Biol Chem 280:25409-25415. CrossRef Medline
25. Krueger DD, Bear MF (2011) Toward fulfilling the promise of molecular medicine in fragile X syndrome. Annu Rev Med 62:411-429. CrossRef Medline
26. 2+ release. J Biol Chem 283:14072-14083. CrossRef Medline
27. Kumar V, Fahey PG, Jong YJ, Ramanan N, O'Malley KL (2012) Activation of intracellular metabotropic glutamate receptor 5 in striatal neurons leads to up-regulation of genes associated with sustained synaptic transmission including Arc/Arg3.1 protein. J Biol Chem 287:5412-5425. CrossRef Medline
28. Kuwajima M, Hall RA, Aiba A, Smith Y (2004) Subcellular and subsynaptic localization of group I metabotropic glutamate receptors in the moneky subthalamic nucleus. J Comp Neurol 474:589-602. CrossRef Medline
29. Lester HA, Miwa JM, Srinivasan R (2012) Psychiatric drugs bind to classical targets within early exocytotic pathways: therapeutic effects. Biol Psychiatry 72:907-915. CrossRef Medline
30. López-Bendito G, Shigemoto R, Fairén A, Luján R (2002) Differential distribution of group I metabotropic glutamate receptors during rat cortical development. Cereb Cortex 12:625-638. CrossRef Medline
31. Lujan R. Nusser Z. Roberts JD, Shigemoto R, Somogyi P (1996) Prerisynaptic location of metabotropic glutamate receptors m Glu R1 and m Glu R5 on dendrites and dendritic spines in the rat hippocampus. Eur J Neurosci 7:1488-1500. Medline
32. Mao LM, Liu XY, Zhang GC, Chu XP, Fibuch EE, Wang LS, Liu Z, Wang JQ (2008) Phosphorylation of group I metabotropic glutamate receptors (m Glu R1/5) in vitro and in vivo. Neuropharmacology 55:403-408. CrossRef Medline
33. Mitrano DA, Smith Y (2007) Comparative analysis of the subcellular and subsynaptic localization of m Glu R1a and m Glu R5 metabotropic glutamate receptors in the shell and core of the nucleus accumbens in rat and monkey. J Comp Neurol 500:788-806. CrossRef Medline
34. Mitrano DA, Arnold C, Smith Y (2008) Subcellular and subsynaptic localization of group I metabotropic glutamate receptors in the nucleus accumbens of cocaine-treated rats. Neuroscience 154:653-666. CrossRef Medline
35. Mitrano DA, Pare JF, Smith Y (2010) Ultrastructural relationships between cortical, thalamic, and amygdala glutamatergic inputs and group I metabotropic glutamate recetpors in the rat accumbens. J Comp Neurol 518:1315-1329. CrossRef Medline
36. Neyman S, Manahan-Vaughan D (2008) Metabotropic glutamate receptor 1 (m Glu R1) and 5 (m Glu R5) regulate late phases of LTP and LTD in the hippocampal CA1 region in vitro. Eur J Neurosci 27:1345-1352. CrossRef Medline
37. Nicoletti F, Bockaert J, Collingridge GL, Conn PJ, Ferraguti F, Schoepp DD, Wroblewski JT, Pin JP (2011) Metabotropic glutamate receptors: from the workbench to the bedside. Neuropharmacology 60:1017-1041. CrossRef Medline
38. 2+ changes in heterologous cell types and neurons. J Biol Chem 278:28210-28219. CrossRef Medline
39. Palmer MJ, Irving AJ, Seabrook GR, Jane DE, Collingridge GL (1997) The group I m Glu receptor agonist DHPG induces a novel form of LTD in the CA1 region of the hippocampus. Neuropharmacology 36:1517-1532. CrossRef Medline
40. Reiter E, Ahn S, Shukla AK, Lefkowitz RJ (2012) Molecular mechanism of β-arrestin-biased agonism at seven-transmembrane receptors. Annu Rev Pharmacol Toxicol. 52:179-197. CrossRef Medline
41. Romano C, Yang WL, O'Malley KL (1996) Metabotropic glutamate receptor 5 is a disulfide-linked dimer. J Biol Chem 271:28612-28616. CrossRef Medline
42. Sorensen SD, Conn PJ (2003) G protein-coupled receptor kinases regulate metabotropic glutamate receptor 5 function and expression. Neuropharmacology 44:699-706. CrossRef Medline
43. Wagner W, Brenowitz SD, Hammer JA 3rd (2011) Myosin-Va transports the endoplasmic reticulum into the dendritic spines of Purkinje neurons. Nat Cell Biol 13:40-48. CrossRef Medline