Synthesis and biological evaluation of matrine derivatives as anti-hepatocellular cancer agents

Bioorganic and Medicinal Chemistry Letters

Volumn 26, Issue 17, 2016, Pages 4267-4271

  Wu, Lichuan ^a   Liu, Shuaibing ^a   Wei, Jinrui ^a,b   Li, Dong ^a   Liu, Xu ^a   Wang, Jianyi ^a   Wang, Lisheng ^a  

^a GUANGXI UNIVERSITY   (China)

^b GUANGXI UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

Anticancer activity; Cell cycle; Hepatocarcinoma; Matrine derivatives; Migration

Indexed keywords

ANTINEOPLASTIC AGENT; MATRINE; MATRINE DERIVATIVE; NERVE CELL ADHESION MOLECULE; PROTEIN P21; PROTEIN P27; UNCLASSIFIED DRUG; UVOMORULIN; ALKALOID; CADHERIN; CYCLIN DEPENDENT KINASE INHIBITOR 1A; CYCLIN DEPENDENT KINASE INHIBITOR 1B; QUINOLIZINE DERIVATIVE;

ANTIPROLIFERATIVE ACTIVITY; ARTICLE; BEL 7402 CELL LINE; CELL MIGRATION; DOWN REGULATION; DRUG SCREENING; DRUG SYNTHESIS; G1 PHASE CELL CYCLE CHECKPOINT; HEPATOCELLULAR CARCINOMA CELL LINE; HEPG2 CELL LINE; HUMAN; HUMAN CELL; IC50; IN VITRO STUDY; LIVER CELL CARCINOMA; UPREGULATION; CELL MOTION; CELL PROLIFERATION; CELL SURVIVAL; CHEMISTRY; DRUG EFFECTS; HEP-G2 CELL LINE; LIVER TUMOR; METABOLISM; PATHOLOGY; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TUMOR CELL LINE;

ALKALOIDS; ANTINEOPLASTIC AGENTS; CADHERINS; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; CELL SURVIVAL; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLIN-DEPENDENT KINASE INHIBITOR P27; DOWN-REGULATION; DRUG SCREENING ASSAYS, ANTITUMOR; G1 PHASE CELL CYCLE CHECKPOINTS; HEP G2 CELLS; HUMANS; LIVER NEOPLASMS; QUINOLIZINES; STRUCTURE-ACTIVITY RELATIONSHIP; UP-REGULATION;

EID: 84981331856     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2016.07.045     Document Type: Article

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