LC-MS characterization of efficacy substances in serum of experimental animals treated with Sophora flavescens extracts

Biomedical Chromatography

Volumn 21, Issue 6, 2007, Pages 655-660

  Ye, Guan ^a   Zhu, Hai Yan ^a   Li, Zhi Xiong ^a   Ma, Chun Hui ^a   Fan, Ming Song ^a   Sun, Zhao Lin ^a   Huang, Cheng Gang ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Alkaloids; Efficacy substances; LC MS; Sophora flavescencs

Indexed keywords

BODY FLUIDS; DRUG PRODUCTS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; VIRUSES;

AQUEOUS EXTRACTS; EFFICACY SUBSTANCE; EXPERIMENTAL ANIMALS; HEPATITIS B VIRUS; IN-VIVO; LC-MS; MATRINE; OXYMATRINE; SOPHORA FLAVESCENCS; SOPHORA FLAVESCENS;

CELL CULTURE;

ANTIVIRUS AGENT; MATRINE; OXYMATRINE; PLANT EXTRACT; SOPHORA FLAVESCENS EXTRACT; SOPHORANOL; SOPHORIDINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIVIRAL ACTIVITY; AQUEOUS SOLUTION; ARTICLE; CELL CULTURE; CONTROLLED STUDY; DUCK; ELECTROSPRAY MASS SPECTROMETRY; HEPATITIS B VIRUS; LIQUID CHROMATOGRAPHY; NONHUMAN; SOPHORA; SOPHORA FLAVESCENS;

ANIMALIA; DUCK HEPATITIS B VIRUS; HEPATITIS B VIRUS; SOPHORA; SOPHORA FLAVESCENS;

EID: 34250643200     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.805     Document Type: Article

References (13)

1. Chen WZ, Zhang JP, Xu Q, Hu ZL, Xie WF, Zhang XR, Ma SC, Hu HP and Zhang XK. Effects of matrine on rat liver fibrosis. Academic Journal of Second Military Medical University 1996; 17(5): 424-426.
2. China Pharmacopoeia Committee. Pharmacopoeia of the People's Republic of China, Vol. 1. Chemical Industry Press: Beijing, 2005; 141.
3. Ding J, Liu J, Xue CF, Gong WD, Li YH and Zhao Y. Anti-HBV effect of TAT-HBV targeted ribonuclease. World Journal of Gastroenterology 2003; 21(9): 1525-1528.
4. Ding PL, Huang H, Zhou P and Chen DF. Quinolizidine alkaloids with anti-HBV activity from Sophora tonkinensis. Planta Medica 2006a; 72(9): 854-856.
5. Ding PL, Liao ZX, Huang H, Zhou P and Chen DF. (+)-12α-Hydroxysophocarpine, anew quinolizidine alkaloid and related anti-HBV alkaloids from Sophora flavescens. Bioorganic and Medicinal Chemistry Letters 2006b; 16(5): 1231-1235.
6. Dong PZ, Li B and Qian ZY. The inhibitory effect of matrine on human hepatitis B virus proliferation in vitro. Chinese Journal of Pharmaceutical Analysis 2005; 25(3): 331-335.
7. Hu ZL, Zhang JP, Yu XB, Lin W and Qian DH. Effect of matrine on lipopolysaccharides/D-galactosamine-induced hepatitis and tumor necrosis factor release from macrophages in vitro. China Journal of Pharmacology 1996; 17(4): 351-353.
8. Li JQ, Chen YR, Zeng MD, Lu LG, Qiu DK, Mao YM, Fan ZP and Hu J. The inhibitory effect of oxymatrine on hepatitis B virus in vitro. China Journal of Digest 2001; 21(9): 550-552.
9. Long Y, Lin XT, Zeng KL and Zhang L. Efficacy of intramuscular matrine in the treatment of chronic hepatitis B. Hepatobiliary and Pancreatic Diseases International 2004; 3(1): 69-72.
10. Miao KL, Zhang JZ, Dong Y and X YF. Research progress on the chemical compounds and pharmacology of Sophora flavescens. Natural Product Research and Development 2001; 13(2): 69-73.
11. Mosmann T. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytoxicity assays. Journal of Immunological Methods 1983; 65(1): 55-63.
12. Seeger C and Mason WS. Hepatitis B virus biology. Microbiology and Molecular Biology Reviews 2000; 64(1): 51-68.
13. Wu T, Huang H and Zhou P. The inhibitory effects of enduracidin on Hepatitis B virus in vitro. Virologica Sinica 1998; 13(1): 45-49.