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Volumn 120, Issue , 2016, Pages 97-106

Description of Loxtox protein family and identification of a new group of Phospholipases D from Loxosceles similis venom gland

Author keywords

Loxosceles; Loxosceles similis; Loxtox; NGS; Phospholipase D; RNA seq; Venom

Indexed keywords

BINDING PROTEIN; COMPLEMENTARY DNA; LOXTOX PROTEIN; PHOSPHOLIPASE D; UNCLASSIFIED DRUG; INSECT PROTEIN; LOXOSCELES VENOM; PHOSPHODIESTERASE; SPIDER VENOM;

EID: 84981275519     PISSN: 00410101     EISSN: 18793150     Source Type: Journal    
DOI: 10.1016/j.toxicon.2016.08.002     Document Type: Article
Times cited : (28)

References (73)
  • 1
    • 0026611689 scopus 로고
    • Dermonecrotic and lethal components of Loxosceles gaucho spider venom
    • Barbaro, K.C., Cardoso, J.L., Eickstedt, V.R., Mota, I., Dermonecrotic and lethal components of Loxosceles gaucho spider venom. Toxicon 30 (1992), 331–338.
    • (1992) Toxicon , vol.30 , pp. 331-338
    • Barbaro, K.C.1    Cardoso, J.L.2    Eickstedt, V.R.3    Mota, I.4
  • 3
    • 13944265640 scopus 로고    scopus 로고
    • Enzymatic characterization, antigenic cross-reactivity and neutralization of dermonecrotic activity of five Loxosceles spider venoms of medical importance in the Americas
    • Barbaro, K.C., Knysak, I., Martins, R., Hogan, C., Winkel, K., Enzymatic characterization, antigenic cross-reactivity and neutralization of dermonecrotic activity of five Loxosceles spider venoms of medical importance in the Americas. Toxicon 45 (2005), 489–499, 10.1016/j.toxicon.2004.12.009.
    • (2005) Toxicon , vol.45 , pp. 489-499
    • Barbaro, K.C.1    Knysak, I.2    Martins, R.3    Hogan, C.4    Winkel, K.5
  • 4
    • 60149084846 scopus 로고    scopus 로고
    • Molecular evolution, functional variation, and proposed nomenclature of the gene family that includes sphingomyelinase D in sicariid spider venoms
    • Binford, G.J., Bodner, M.R., Cordes, M.H.J., Baldwin, K.L., Rynerson, M.R., Burns, S.N., Zobel-Thropp, P.A., Molecular evolution, functional variation, and proposed nomenclature of the gene family that includes sphingomyelinase D in sicariid spider venoms. Mol. Biol. Evol. 26 (2009), 547–566, 10.1093/molbev/msn274.
    • (2009) Mol. Biol. Evol. , vol.26 , pp. 547-566
    • Binford, G.J.1    Bodner, M.R.2    Cordes, M.H.J.3    Baldwin, K.L.4    Rynerson, M.R.5    Burns, S.N.6    Zobel-Thropp, P.A.7
  • 5
    • 0037683720 scopus 로고    scopus 로고
    • The phylogenetic distribution of sphingomyelinase D activity in venoms of Haplogyne spiders
    • Binford, G.J., Wells, M.A., The phylogenetic distribution of sphingomyelinase D activity in venoms of Haplogyne spiders. Comp. Biochem. Physiol. - B Biochem. Mol. Biol. 135 (2003), 25–33, 10.1016/S1096-4959(03)00045-9.
    • (2003) Comp. Biochem. Physiol. - B Biochem. Mol. Biol. , vol.135 , pp. 25-33
    • Binford, G.J.1    Wells, M.A.2
  • 6
    • 84155172977 scopus 로고    scopus 로고
    • Two new phospholipase D isoforms of Loxosceles laeta: cloning, heterologous expression, functional characterization, and potential biotechnological application
    • Catalán, a., Cortes, W., Sagua, H., González, J., Araya, J.E., Two new phospholipase D isoforms of Loxosceles laeta: cloning, heterologous expression, functional characterization, and potential biotechnological application. J. Biochem. Mol. Toxicol. 25 (2011), 393–403, 10.1002/jbt.20399.
    • (2011) J. Biochem. Mol. Toxicol. , vol.25 , pp. 393-403
    • Catalán, A.1    Cortes, W.2    Sagua, H.3    González, J.4    Araya, J.E.5
  • 11
    • 84860395958 scopus 로고    scopus 로고
    • The relationship between calcium and the metabolism of plasma membrane phospholipids in hemolysis induced by brown spider venom phospholipase-D toxin
    • Chaves-Moreira, D., Souza, F.N., Fogaça, R.T.H., Mangili, O.C., Gremski, W., Senff-Ribeiro, A., Chaim, O.M., Veiga, S.S., The relationship between calcium and the metabolism of plasma membrane phospholipids in hemolysis induced by brown spider venom phospholipase-D toxin. J. Cell. Biochem. 112 (2011), 2529–2540, 10.1002/jcb.23177.
    • (2011) J. Cell. Biochem. , vol.112 , pp. 2529-2540
    • Chaves-Moreira, D.1    Souza, F.N.2    Fogaça, R.T.H.3    Mangili, O.C.4    Gremski, W.5    Senff-Ribeiro, A.6    Chaim, O.M.7    Veiga, S.S.8
  • 12
    • 0031081491 scopus 로고    scopus 로고
    • Neutralizing capacity of antibodies elicited by a non-toxic protein purified from the venom of the scorpion Tityus serrulatus
    • Chávez-Olórtegui, C., Kalapothakis, E., Ferreira, A.M., Ferreira, A.P., Diniz, C.R., Neutralizing capacity of antibodies elicited by a non-toxic protein purified from the venom of the scorpion Tityus serrulatus. Toxicon 35 (1997), 213–221.
    • (1997) Toxicon , vol.35 , pp. 213-221
    • Chávez-Olórtegui, C.1    Kalapothakis, E.2    Ferreira, A.M.3    Ferreira, A.P.4    Diniz, C.R.5
  • 14
    • 32144438835 scopus 로고    scopus 로고
    • Lateral gene transfer of a dermonecrotic toxin between spiders and bacteria
    • Cordes, M.H.J., Binford, G.J., Lateral gene transfer of a dermonecrotic toxin between spiders and bacteria. Bioinformatics 22 (2006), 264–268, 10.1093/bioinformatics/bti811.
    • (2006) Bioinformatics , vol.22 , pp. 264-268
    • Cordes, M.H.J.1    Binford, G.J.2
  • 16
    • 1642574226 scopus 로고    scopus 로고
    • Purification and characterization of loxnecrogin, a dermonecrotic toxin from Loxosceles gaucho brown spider venom
    • Cunha, R.B., Barbaro, K.C., Muramatsu, D., Portaro, F.C.V., Fontes, W., de Sousa, M.V., Purification and characterization of loxnecrogin, a dermonecrotic toxin from Loxosceles gaucho brown spider venom. J. Protein Chem. 22 (2003), 135–146.
    • (2003) J. Protein Chem. , vol.22 , pp. 135-146
    • Cunha, R.B.1    Barbaro, K.C.2    Muramatsu, D.3    Portaro, F.C.V.4    Fontes, W.5    de Sousa, M.V.6
  • 26
    • 0842313260 scopus 로고    scopus 로고
    • Prediction of proprotein convertase cleavage sites
    • Duckert, P., Brunak, S., Blom, N., Prediction of proprotein convertase cleavage sites. Protein Eng. Des. Sel. 17 (2004), 107–112, 10.1093/protein/gzh013.
    • (2004) Protein Eng. Des. Sel. , vol.17 , pp. 107-112
    • Duckert, P.1    Brunak, S.2    Blom, N.3
  • 27
    • 0032953638 scopus 로고    scopus 로고
    • Emended description of the order Chlamydiales, proposal of Parachlamydiaceae fam. nov. and Simkaniaceae fam. nov., each containing one monotypic genus, revised taxonomy of the family Chlamydiaceae, including a new genus and five new species, and standards
    • Everett, K.D., Bush, R.M., Andersen, A.A., Emended description of the order Chlamydiales, proposal of Parachlamydiaceae fam. nov. and Simkaniaceae fam. nov., each containing one monotypic genus, revised taxonomy of the family Chlamydiaceae, including a new genus and five new species, and standards. Int. J. Syst. Bacteriol. 49:Pt 2 (1999), 415–440, 10.1099/00207713-49-2-415.
    • (1999) Int. J. Syst. Bacteriol. , vol.49 , pp. 415-440
    • Everett, K.D.1    Bush, R.M.2    Andersen, A.A.3
  • 30
    • 0026729985 scopus 로고
    • Loxoscelism
    • Futrell, J.M., Loxoscelism. Am. J. Med. Sci. 304 (1992), 261–267.
    • (1992) Am. J. Med. Sci. , vol.304 , pp. 261-267
    • Futrell, J.M.1
  • 32
    • 0008958222 scopus 로고
    • The spider genus loxosceles in south America (Araneae, Scytodidae)
    • Gertsch, W.J., The spider genus loxosceles in south America (Araneae, Scytodidae). Bull. Am. Mus. Nat. Hist. 136 (1967), 117–174.
    • (1967) Bull. Am. Mus. Nat. Hist. , vol.136 , pp. 117-174
    • Gertsch, W.J.1
  • 33
    • 79952362975 scopus 로고    scopus 로고
    • Determination of sphingomyelinase-D activity of Loxosceles venoms in sphingomyelin/cholesterol liposomes containing horseradish peroxidase
    • Gomes, M.T.R., Guimarães, G., Frézard, F., Kalapothakis, E., Minozzo, J.C., Chaim, O.M., Veiga, S.S., Oliveira, S.C., Chávez-Olórtegui, C., Determination of sphingomyelinase-D activity of Loxosceles venoms in sphingomyelin/cholesterol liposomes containing horseradish peroxidase. Toxicon 57 (2011), 574–579, 10.1016/j.toxicon.2011.01.001.
    • (2011) Toxicon , vol.57 , pp. 574-579
    • Gomes, M.T.R.1    Guimarães, G.2    Frézard, F.3    Kalapothakis, E.4    Minozzo, J.C.5    Chaim, O.M.6    Veiga, S.S.7    Oliveira, S.C.8    Chávez-Olórtegui, C.9
  • 37
    • 9644272420 scopus 로고    scopus 로고
    • Loxoscelism: old obstacles, new directions
    • Hogan, C.J., Barbaro, K.C., Winkel, K., Loxoscelism: old obstacles, new directions. Ann. Emerg. Med. 44 (2004), 608–624, 10.1016/j.annemergmed.2004.08.028.
    • (2004) Ann. Emerg. Med. , vol.44 , pp. 608-624
    • Hogan, C.J.1    Barbaro, K.C.2    Winkel, K.3
  • 39
    • 67649872625 scopus 로고    scopus 로고
    • Population history in social spiders repeated: colony structure and lineage evolution in Stegodyphus mimosarum (Eresidae)
    • Johannesen, J., Wickler, W., Seibt, U., Moritz, R.F.A., Population history in social spiders repeated: colony structure and lineage evolution in Stegodyphus mimosarum (Eresidae). Mol. Ecol. 18 (2009), 2812–2818, 10.1111/j.1365-294X.2009.04238.x.
    • (2009) Mol. Ecol. , vol.18 , pp. 2812-2818
    • Johannesen, J.1    Wickler, W.2    Seibt, U.3    Moritz, R.F.A.4
  • 42
    • 0019767846 scopus 로고
    • Platelet aggregation and sphingomyelinase D activity of a purified toxin from the venom of Loxosceles reclusa
    • Kurpiewski, G., Forrester, L.J., Barrett, J.T., Campbell, B.J., Platelet aggregation and sphingomyelinase D activity of a purified toxin from the venom of Loxosceles reclusa. Biochim. Biophys. Acta 678 (1981), 467–476.
    • (1981) Biochim. Biophys. Acta , vol.678 , pp. 467-476
    • Kurpiewski, G.1    Forrester, L.J.2    Barrett, J.T.3    Campbell, B.J.4
  • 43
    • 55349126717 scopus 로고    scopus 로고
    • Nephrotoxicity caused by brown spider venom phospholipase-D (dermonecrotic toxin) depends on catalytic activity
    • Kusma, J., Chaim, O.M., Wille, A.C.M., Ferrer, V.P., Sade, Y.B., Donatti, L., Gremski, W., Mangili, O.C., Veiga, S.S., Nephrotoxicity caused by brown spider venom phospholipase-D (dermonecrotic toxin) depends on catalytic activity. Biochimie 90 (2008), 1722–1736, 10.1016/j.biochi.2008.07.011.
    • (2008) Biochimie , vol.90 , pp. 1722-1736
    • Kusma, J.1    Chaim, O.M.2    Wille, A.C.M.3    Ferrer, V.P.4    Sade, Y.B.5    Donatti, L.6    Gremski, W.7    Mangili, O.C.8    Veiga, S.S.9
  • 44
    • 27444432178 scopus 로고    scopus 로고
    • Brown recluse spider (Loxosceles reclusa) venom phospholipase D (PLD) generates lysophosphatidic acid (LPA)
    • Lee, S., Lynch, K.R., Brown recluse spider (Loxosceles reclusa) venom phospholipase D (PLD) generates lysophosphatidic acid (LPA). Biochem. J. 391 (2005), 317–323, 10.1042/BJ20050043.
    • (2005) Biochem. J. , vol.391 , pp. 317-323
    • Lee, S.1    Lynch, K.R.2
  • 45
    • 33645412600 scopus 로고    scopus 로고
    • Sobre a presença de três espécies de Loxosceles Heineken & Lowe (Araneae: Sicariidae) no município de Belo Horizonte
    • Machado, E.O., Alvares, E.S.S., de Maria, M., Kalapothakis, E., Sobre a presença de três espécies de Loxosceles Heineken & Lowe (Araneae: Sicariidae) no município de Belo Horizonte. Minas Gerais, Bras. Lundiana 6 (2005), 113–115.
    • (2005) Minas Gerais, Bras. Lundiana , vol.6 , pp. 113-115
    • Machado, E.O.1    Alvares, E.S.S.2    de Maria, M.3    Kalapothakis, E.4
  • 48
    • 32844475757 scopus 로고    scopus 로고
    • A natural anatoxin, Amm VIII, induces neutralizing antibodies against the potent scorpion alpha-toxins
    • Martin-Eauclaire, M.-F., Alami, M., Giamarchi, A., Missimilli, V., Rosso, J.-P., Bougis, P.E., A natural anatoxin, Amm VIII, induces neutralizing antibodies against the potent scorpion alpha-toxins. Vaccine 24 (2006), 1990–1996, 10.1016/j.vaccine.2005.11.016.
    • (2006) Vaccine , vol.24 , pp. 1990-1996
    • Martin-Eauclaire, M.-F.1    Alami, M.2    Giamarchi, A.3    Missimilli, V.4    Rosso, J.-P.5    Bougis, P.E.6
  • 49
    • 84879587006 scopus 로고    scopus 로고
    • A novel ICK peptide from the Loxosceles intermedia (brown spider) venom gland: cloning, heterologous expression and immunological cross-reactivity approaches
    • Matsubara, F.H., Gremski, L.H., Meissner, G.O., Constantino Lopes, E.S., Gremski, W., Senff-Ribeiro, A., Chaim, O.M., Veiga, S.S., A novel ICK peptide from the Loxosceles intermedia (brown spider) venom gland: cloning, heterologous expression and immunological cross-reactivity approaches. Toxicon 71 (2013), 147–158, 10.1016/j.toxicon.2013.05.014.
    • (2013) Toxicon , vol.71 , pp. 147-158
    • Matsubara, F.H.1    Gremski, L.H.2    Meissner, G.O.3    Constantino Lopes, E.S.4    Gremski, W.5    Senff-Ribeiro, A.6    Chaim, O.M.7    Veiga, S.S.8
  • 50
    • 84878353021 scopus 로고    scopus 로고
    • Generation and characterization of a recombinant chimeric protein (rCpLi) consisting of B-cell epitopes of a dermonecrotic protein from Loxosceles intermedia spider venom
    • Mendes, T.M., Oliveira, D., Figueiredo, L.F.M., Machado-de-Avila, R.A., Duarte, C.G., Dias-Lopes, C., Guimarães, G., Felicori, L., Minozzo, J.C., Chávez-Olortegui, C., Generation and characterization of a recombinant chimeric protein (rCpLi) consisting of B-cell epitopes of a dermonecrotic protein from Loxosceles intermedia spider venom. Vaccine 31 (2013), 2749–2755, 10.1016/j.vaccine.2013.03.048.
    • (2013) Vaccine , vol.31 , pp. 2749-2755
    • Mendes, T.M.1    Oliveira, D.2    Figueiredo, L.F.M.3    Machado-de-Avila, R.A.4    Duarte, C.G.5    Dias-Lopes, C.6    Guimarães, G.7    Felicori, L.8    Minozzo, J.C.9    Chávez-Olortegui, C.10
  • 51
    • 0032559939 scopus 로고    scopus 로고
    • Sphingomyelinase D activity of brown recluse spider (Loxosceles reclusa) venom as studied by 31P-NMR: effects on the time-course of sphingomyelin hydrolysis
    • doi:S0041-0101(97)00078-0
    • Merchant, M.L., Hinton, J.F., Geren, C.R., Sphingomyelinase D activity of brown recluse spider (Loxosceles reclusa) venom as studied by 31P-NMR: effects on the time-course of sphingomyelin hydrolysis. Toxicon 36 (1998), 537–545 doi:S0041-0101(97)00078-0.
    • (1998) Toxicon , vol.36 , pp. 537-545
    • Merchant, M.L.1    Hinton, J.F.2    Geren, C.R.3
  • 52
    • 0030992414 scopus 로고    scopus 로고
    • Effect of hyperbaric oxygen on sphingomyelinase D activity of brown recluse spider (Loxosceles reclusa) venom as studied by 31P nuclear magnetic resonance spectroscopy
    • Merchant, M.L., Hinton, J.F., Geren, C.R., Effect of hyperbaric oxygen on sphingomyelinase D activity of brown recluse spider (Loxosceles reclusa) venom as studied by 31P nuclear magnetic resonance spectroscopy. Am. J. Trop. Med. Hyg. 56 (1997), 335–338.
    • (1997) Am. J. Trop. Med. Hyg. , vol.56 , pp. 335-338
    • Merchant, M.L.1    Hinton, J.F.2    Geren, C.R.3
  • 53
    • 84981233099 scopus 로고    scopus 로고
    • Sistema nacional de notificação de agravos
    • Ministério da Saúde Brasília, Dist. Fed
    • Ministério da saúde, Sistema nacional de notificação de agravos. 2016, Ministério da Saúde, Brasília, Dist. Fed.
    • (2016)
    • Ministério da saúde1
  • 54
    • 0031981795 scopus 로고    scopus 로고
    • In vivo protection against Tityus serrulatus scorpion toxins by immunization of mice with a non-toxic protein
    • Moreira-Ferreira, A.M., Kalapothakis, E., Diniz, C.R., Chávez-Olórtegui, C., In vivo protection against Tityus serrulatus scorpion toxins by immunization of mice with a non-toxic protein. Toxicon 36 (1998), 333–339.
    • (1998) Toxicon , vol.36 , pp. 333-339
    • Moreira-Ferreira, A.M.1    Kalapothakis, E.2    Diniz, C.R.3    Chávez-Olórtegui, C.4
  • 56
    • 84898479843 scopus 로고    scopus 로고
    • Apoptosis, mast cell degranulation and collagen breakdown in the pathogenesis of loxoscelism in subcutaneously implanted sponges
    • Pereira, N.B., Campos, P.P., Parreiras, P.M., Chiarini-Garcia, H., Socarrás, T.O., Kalapothakis, E., Andrade, S.P., Moro, L., Apoptosis, mast cell degranulation and collagen breakdown in the pathogenesis of loxoscelism in subcutaneously implanted sponges. Toxicon 84 (2014), 7–18, 10.1016/j.toxicon.2014.03.003.
    • (2014) Toxicon , vol.84 , pp. 7-18
    • Pereira, N.B.1    Campos, P.P.2    Parreiras, P.M.3    Chiarini-Garcia, H.4    Socarrás, T.O.5    Kalapothakis, E.6    Andrade, S.P.7    Moro, L.8
  • 57
    • 80053345905 scopus 로고    scopus 로고
    • SignalP 4.0: discriminating signal peptides from transmembrane regions
    • Petersen, T.N., Brunak, S., von Heijne, G., Nielsen, H., SignalP 4.0: discriminating signal peptides from transmembrane regions. Nat. Methods 8 (2011), 785–786, 10.1038/nmeth.1701.
    • (2011) Nat. Methods , vol.8 , pp. 785-786
    • Petersen, T.N.1    Brunak, S.2    von Heijne, G.3    Nielsen, H.4
  • 58
    • 80051742678 scopus 로고    scopus 로고
    • The world spider catalog
    • Platnick, N., 2016. The world spider catalog. http//Res. version 17.
    • (2016)
    • Platnick, N.1
  • 60
    • 84855507378 scopus 로고    scopus 로고
    • Lack of effective anti-apoptotic activities restricts growth of Parachlamydiaceae in insect cells
    • Sixt, B.S., Hiess, B., König, L., Horn, M., Lack of effective anti-apoptotic activities restricts growth of Parachlamydiaceae in insect cells. PLoS One, 7, 2012, 10.1371/journal.pone.0029565.
    • (2012) PLoS One , vol.7
    • Sixt, B.S.1    Hiess, B.2    König, L.3    Horn, M.4
  • 61
    • 79953134751 scopus 로고    scopus 로고
    • The first record for Wolbachia in a scorpion: the parthenogenetic yellow scorpion Tityus serrulatus (Scorpiones, Buthidae)
    • Suesdek-Rocha, L., Bertani, R., da Silva, P.I. Jr., Selivon, D., The first record for Wolbachia in a scorpion: the parthenogenetic yellow scorpion Tityus serrulatus (Scorpiones, Buthidae). Rev. Ibérica Aracnol. 14 (2007), 183–184.
    • (2007) Rev. Ibérica Aracnol. , vol.14 , pp. 183-184
    • Suesdek-Rocha, L.1    Bertani, R.2    da Silva, P.I.3    Selivon, D.4
  • 63
    • 0032500898 scopus 로고    scopus 로고
    • Sphingomyelinases in the venom of the spider Loxosceles intermedia are responsible for both dermonecrosis and complement-dependent hemolysis
    • Tambourgi, D.V., Magnoli, F.C., van den Berg, C.W., Morgan, B.P., de Araujo, P.S., Alves, E.W., Da Silva, W.D., Sphingomyelinases in the venom of the spider Loxosceles intermedia are responsible for both dermonecrosis and complement-dependent hemolysis. Biochem. Biophys. Res. Commun. 251 (1998), 366–373, 10.1006/bbrc.1998.9474.
    • (1998) Biochem. Biophys. Res. Commun. , vol.251 , pp. 366-373
    • Tambourgi, D.V.1    Magnoli, F.C.2    van den Berg, C.W.3    Morgan, B.P.4    de Araujo, P.S.5    Alves, E.W.6    Da Silva, W.D.7
  • 64
    • 79957613599 scopus 로고    scopus 로고
    • MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods
    • Tamura, K., Peterson, D., Peterson, N., Stecher, G., Nei, M., Kumar, S., MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods. Mol. Biol. Evol. 28 (2011), 2731–2739, 10.1093/molbev/msr121.
    • (2011) Mol. Biol. Evol. , vol.28 , pp. 2731-2739
    • Tamura, K.1    Peterson, D.2    Peterson, N.3    Stecher, G.4    Nei, M.5    Kumar, S.6
  • 65
    • 80054863927 scopus 로고    scopus 로고
    • Loxosceles gaucho spider venom and its sphingomyelinase fraction trigger the main functions of human and rabbit platelets
    • Tavares, F.L., Peichoto, M.E., Rangel, D. de M., Barbaro, K.C., Cirillo, M.C., Santoro, M.L., Sano-Martins, I.S., Loxosceles gaucho spider venom and its sphingomyelinase fraction trigger the main functions of human and rabbit platelets. Hum. Exp. Toxicol. 30 (2011), 1567–1574, 10.1177/0960327110393761.
    • (2011) Hum. Exp. Toxicol. , vol.30 , pp. 1567-1574
    • Tavares, F.L.1    Peichoto, M.E.2    Rangel, D.D.M.3    Barbaro, K.C.4    Cirillo, M.C.5    Santoro, M.L.6    Sano-Martins, I.S.7
  • 66
    • 0027968068 scopus 로고
    • CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice
    • Thompson, J.D., Higgins, D.G., Gibson, T.J., CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res. 22 (1994), 4673–4680.
    • (1994) Nucleic Acids Res. , vol.22 , pp. 4673-4680
    • Thompson, J.D.1    Higgins, D.G.2    Gibson, T.J.3
  • 67
    • 84884383469 scopus 로고    scopus 로고
    • Differential metalloprotease content and activity of three Loxosceles spider venoms revealed using two-dimensional electrophoresis approaches
    • Trevisan-Silva, D., Bednaski, A.V., Gremski, L.H., Chaim, O.M., Veiga, S.S., Senff-Ribeiro, A., Differential metalloprotease content and activity of three Loxosceles spider venoms revealed using two-dimensional electrophoresis approaches. Toxicon 76 (2013), 11–22, 10.1016/j.toxicon.2013.08.065.
    • (2013) Toxicon , vol.76 , pp. 11-22
    • Trevisan-Silva, D.1    Bednaski, A.V.2    Gremski, L.H.3    Chaim, O.M.4    Veiga, S.S.5    Senff-Ribeiro, A.6
  • 72
    • 0036489734 scopus 로고    scopus 로고
    • Morphological and biochemical evidence of blood vessel damage and fibrinogenolysis triggered by brown spider venom. Blood Coagul
    • Zanetti, V.C., da Silveira, R.B., Dreyfuss, J.L., Haoach, J., Mangili, O.C., Veiga, S.S., Gremski, W., Morphological and biochemical evidence of blood vessel damage and fibrinogenolysis triggered by brown spider venom. Blood Coagul. Fibrinolysis 13 (2002), 135–148.
    • (2002) Fibrinolysis , vol.13 , pp. 135-148
    • Zanetti, V.C.1    da Silveira, R.B.2    Dreyfuss, J.L.3    Haoach, J.4    Mangili, O.C.5    Veiga, S.S.6    Gremski, W.7
  • 73
    • 0013776758 scopus 로고
    • Molecules as documents of evolutionary history
    • Zuckerkandl, E., Pauling, L., Molecules as documents of evolutionary history. J. Theor. Biol. 8 (1965), 357–366.
    • (1965) J. Theor. Biol. , vol.8 , pp. 357-366
    • Zuckerkandl, E.1    Pauling, L.2


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