Molecular cloning, expression, function and immunoreactivities of members of a gene family of sphingomyelinases from Loxosceles venom glands

Molecular Immunology

Volumn 41, Issue 8, 2004, Pages 831-840

  Tambourgi, Denise V ^a   Pedrosa, Matheus De F Fernandes ^a   Van Den Berg, Carmen W ^b   Gonçalves De Andrade, Rute M ^a   Ferracini, Matheus ^a   Paixão Cavalcante, Danielle ^a   Morgan, B Paul ^b   Rushmere, Neil K ^b  

^a INSTITUTO BUTANTAN   (Brazil)

^b CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

Complement system; Dermonecrosis; Hemolysis; Loxosceles intermedia; Sera cross reactivities; Sphingomyelinase genes; Spider; Venom

Indexed keywords

ANTIGEN; ANTISERUM; RECOMBINANT ANTIBODY; RECOMBINANT PROTEIN; SPHINGOMYELIN; SPHINGOMYELIN PHOSPHODIESTERASE; SPIDER VENOM;

ARTICLE; COMPARATIVE STUDY; CROSS REACTION; GENE EXPRESSION; GENE FUNCTION; HEMOLYSIS; HUMAN; HUMAN CELL; IMMUNOREACTIVITY; MOLECULAR CLONING; MULTIGENE FAMILY; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SPIDER; TOXICITY;

AMINO ACID SEQUENCE; ANIMALS; CLONING, MOLECULAR; CROSS REACTIONS; MOLECULAR SEQUENCE DATA; MULTIGENE FAMILY; PHOSPHORIC DIESTER HYDROLASES; PHYLOGENY; SPHINGOMYELIN PHOSPHODIESTERASE; SPIDER VENOMS; SPIDERS;

ARANEAE; LOXOSCELES; LOXOSCELES INTERMEDIA; LOXOSCELES LAETA;

EID: 3242700393     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2004.03.027     Document Type: Article

References (25)

1. Barretto O.C., Cardoso J.L., De Cillo D. Viscerocutaneous form of loxoscelism and erythrocyte glucose-6-phosphate deficiency. Rev. Inst. Med. Trop. Sao Paulo. 27:1985;264-267
2. Bey T.A., Walter F.G., Lober W., Schmidt J., Spark R., Schlievert P.M. Loxosceles arizonica bite associated with shock. Ann. Emerg. Med. 30:1997;701-703
3. Bucherl W. Biology and venoms of the most important South American spiders of the genera Phoneutria, Loxosceles, Lycosa, and Latrodectus. Am. Zool. 9:1969;157-159
4. Desai A., Lankford H.A., Warren J.S. Loxosceles deserta spider venom induces the expression of vascular endothelial growth factor (VEGF) in keratinocytes. Inflammation. 24:2000;1-9
5. Fernandes Pedrosa M.F., Junqueira de Azevedo I.L., Gonçalves-de- Andrade R.M., van den Berg C.W., Ramos C.R., Lee Ho P., Tambourgi D.V. Molecular cloning and expression of a functional dermonecrotic and haemolytic factor from Loxosceles laeta venom. Biochem. Biophys. Res. Commun. 298:2002;638-645
6. Frohman M.A., Dush M.K., Martin G.R. Rapid production of full-length cDNAs from rare transcripts: amplification using a single gene-specific oligonucleotide primer. Proc. Natl. Acad. Sci. U.S.A. 85:1988;8998-9002
7. Futrell J. Loxoscelism. Am. J. Med. Sci. 304:1992;261-280
8. Gatt S., Dinur T., Barenholz Y. A fluorometric determination of sphingomyelinase by use of fluorescent derivatives of sphingomyelin, and its application to diagnosis of Niemann-Pick disease. Clin. Chem. 26:1980;93-96
9. Gendron B.P. Loxosceles reclusa envenomation. Am. J. Emerg. Med. 8:1990;51-54
10. Gertsch W.J. The spider genus Loxosceles in North America, Central America and the West Indies. Am. Mus Novitates. 1907:1958;1-46
11. Gertsch W.J. The spider genus Loxosceles in South America (Araneae, Sicariidae). Bull. Amer. Mus. Nat. History. 136:1967;119-182
12. Ginsburg C.M., Weinberg A.G. Hemolytic anemia and multiorgan failure associated with localized cutaneous lesion. J. Pediatr. 112:1988;496-499
13. Kalapothakis E., Araújo S.C., Castro C.S., Mendes T.M., Gomes M.V., Mangili O.C., Gubert I.C., Chávez-Olórtegui C. Molecular cloning, expression and immunological properties of LiD1, a protein from the dermonecrotic family of Loxosceles intermedia spider venom. Toxicon. 40:2002;1691-1699
14. Kozak M. Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAs. Nucleic Acids. Res.12:1984;857-872
15. Lowry O.H., Rosenbrough N.J., Farr A.L., Randal R.J. Protein measurement with the folin phenol reagent. J. Biol. Chem. 193:1951;256-275
16. McNamara P.J., Cuevas W.A., Songer J.G. Toxic phospholipases D of Corynebacterium pseudotuberculosis, C. ulcerans and Arcanobacterium haemolyticum: cloning and sequence homology. Gene. 156:1995;113-118
17. Newlands G., Isaacson C., Martindale C. Loxoscelism in the Transvaal, South Africa. Trans. R. Soc. Trop. Med. Hyg. 76:1982;610-615
18. Schenone H., Saavedra T., Rojas A., Villarroel F. Loxoscelism in Chile. Epidemiologic, clinical and experimental studies. Rev. Inst. Med. Trop. São Paulo. 31:1989;403-415
19. Sezerino U.M., Zannin M., Coelho L.K., Gonçalves Junior J., Grando M., Mattosinho S.G., Cardoso J.L., Von Eickstedt V.R., França F.O., Barbaro K.C., Fan H.W. A clinical and epidemiological study of Loxosceles spider envenoming in Santa Catarina. Brazil. Trans. R. Soc. Trop. Med. Hyg. 92:1998;546-548
20. Tambourgi D.V., Magnoli F.C., Von Eickstedt V.R., Benedetti Z.C., Petricevich V.L., Dias Da Silva W. Incorporation of a 35-kilodalton purified protein from Loxosceles intermedia spider venom transforms human erythrocytes into activators of autologous complement alternative pathway. J. Immunol. 155:1995;4459-4466
21. Tambourgi D.V., Magnoli F.C., van den Berg C.W., Morgan B.P., de Araujo P.S., Alves E.W., Dias da Silva W. Sphingomyelinases in the venom of the spider Loxosceles intermedia are responsible for both dermonecrosis and complement-dependent hemolysis. Biochem. Biophys. Res. Commun. 251:1998a;366-373
22. Tambourgi D.V., Petricevich V.L., Magnoli F.C., Assaf S.L., Jancar S., Dias Da Silva W. Endotoxemic-like shock induced by Loxosceles spider venoms, pathological changes and putative cytokine mediators. Toxicon. 36:1998b;391-403
23. Tambourgi D.V., Morgan B.P., Gonçalves de Andrade R.M., Magnoli F.C., van den Berg C.W. Loxosceles intermedia spider envenomation induces activation of an endogenous metalloproteinase, resulting in cleavage of glycophorins from the erythrocyte surface and facilitating complement-mediated lysis. Blood. 95:2000;683-691
24. Tambourgi D.V., Silva M.S., Billington S.J., Gonçalves de Andrade R.M., Magnoli F.C., Songer J.G., van den Berg C.W. Mechanism of induction of complement susceptibility of erythrocytes by spider and bacterial sphingomyelinases. Immunology. 107:2002;93-101
25. White, J., Cardoso, J.L., Fan, H.W., 1995. Clinical toxinology of spider bites. In: Meier, J., White, J. (Eds.), Handbook of Clinical Toxinology of Animal Venoms and Poisons. CRC Press, Boca Raton, FL, pp. 259-330.