Ellagic acid confers protection against gentamicin-induced oxidative damage, mitochondrial dysfunction and apoptosis-related nephrotoxicity

Journal of Pharmacy and Pharmacology

Volumn , Issue , 2016, Pages 1222-1232

  Sepand, Mohammad Reza ^a   Ghahremani, Mohammad Hossein ^a   Razavi Azarkhiavi, Kamal ^b   Aghsami, Mehdi ^a   Rajabi, Jalil ^c   Keshavarz Bahaghighat, Hedieh ^a   Soodi, Maliheh ^d  

^a TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c AJA UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^d TARBIAT MODARES UNIVERSITY   (Iran)

Author keywords

antioxidants; apoptosis; ellagic acid; gentamicin; oxidative stress

Indexed keywords

CASPASE 3; CATALASE; CREATININE; CYTOCHROME C; ELLAGIC ACID; GENTAMICIN; GLUTATHIONE; LIPID; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE; UREA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENZYME ACTIVITY; HISTOPATHOLOGY; KIDNEY; LIPID PEROXIDATION; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; NEPHROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; RAT; RENAL PROTECTION; UREA BLOOD LEVEL;

EID: 84981249437     PISSN: 00223573     EISSN: 20427158     Source Type: Journal    
DOI: 10.1111/jphp.12589     Document Type: Article

References (51)

1. Lohr JW et al. Renal drug metabolism. Pharmacol Rev 1998; 50: 107–141.
2. Thukral SK et al. Prediction of nephrotoxicant action and identification of candidate toxicity-related biomarkers. Toxicol Pathol 2005; 33: 343–355.
3. Nagai J, Takano M. Molecular aspects of renal handling of aminoglycosides and strategies for preventing the nephrotoxicity. Drug Metab Pharmacokinet 2004; 19: 159–170.
4. Rao SC et al. One dose per day compared to multiple doses per day of gentamicin for treatment of suspected or proven sepsis in neonates. Cochrane Database Syst Rev 2006; (1): CD005091.
5. Khan SA et al. Studies on the protective effect of green tea against cisplatin induced nephrotoxicity. Pharmacol Res 2009; 60: 382–391.
6. Randjelovic P et al. Protective effect of selenium on gentamicin-induced oxidative stress and nephrotoxicity in rats. Drug Chem Toxicol 2012; 35: 141–148.
7. Tavafi M et al. Inhibitory effect of olive leaf extract on gentamicin-induced nephrotoxicity in rats. Iran J Kidney Dis 2012; 6: 25–32.
8. Banday AA et al. Time dependent effects of gentamicin on the enzymes of carbohydrate metabolism, brush border membrane and oxidative stress in rat kidney tissues. Life Sci 2008; 82: 450–459.
9. Ghaznavi R, Kadkhodaee M. Comparative effects of selective and non-selective nitric oxide synthase inhibition in gentamicin-induced rat nephrotoxicity. Arch Toxicol 2007; 81: 453–457.
10. Mutanen M et al. Berries as chemopreventive dietary constituents–a mechanistic approach with the ApcMin/+ mouse. Asia Pac J Clin Nutr 2008; 17(Suppl. 1): 123–125.
11. Barch DH et al. Ellagic acid induces transcription of the rat glutathione S-transferase-Ya gene. Carcinogenesis 1995; 16: 665–668.
12. Pari L, Sivasankari R. Effect of ellagic acid on cyclosporine A-induced oxidative damage in the liver of rats. Fundam Clin Pharmacol 2008; 22: 395–401.
13. Yan L et al. Method development and validation for pharmacokinetic and tissue distributions of ellagic acid using ultrahigh performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). Molecules 2014; 19: 18923–18935.
14. Teel RW, Martin RM. Disposition of the plant phenol ellagic acid in the mouse following oral administration by gavage. Xenobiotica 1988; 18: 397–405.
15. Larrosa M et al. Ellagitannins, ellagic acid and vascular health. Mol Aspects Med 2010; 31: 513–539.
16. Qiu Z et al. In vitro antioxidant and antiproliferative effects of ellagic acid and its colonic metabolite, urolithins, on human bladder cancer T24 cells. Food Chem Toxicol 2013; 59: 428–437.
17. Bialonska D et al. Urolithins, intestinal microbial metabolites of Pomegranate ellagitannins, exhibit potent antioxidant activity in a cell-based assay. J Agric Food Chem 2009; 57: 10181–10186.
18. Balakumar P et al. Gentamicin-induced nephrotoxicity: do we have a promising therapeutic approach to blunt it? Pharmacol Res 2010; 62: 179–186.
19. Whitley AC et al. The dietary polyphenol ellagic acid is a potent inhibitor of hOAT1. Drug Metab Dispos 2005; 33: 1097–1100.
20. Hseu YC et al. Ellagic acid protects human keratinocyte (HaCaT) cells against UVA-induced oxidative stress and apoptosis through the upregulation of the HO-1 and Nrf-2 antioxidant genes. Food Chem Toxicol 2012; 50: 1245–1255.
21. Karahan I et al. Protective effect of lycopene on gentamicin-induced oxidative stress and nephrotoxicity in rats. Toxicology 2005; 215: 198–204.
22. Atessahin A et al. Role of ellagic acid against cisplatin-induced nephrotoxicity and oxidative stress in rats. Basic Clin Pharmacol Toxicol 2007; 100: 121–126.
23. Buege JA, Aust SD. Microsomal lipid peroxidation. Methods Enzymol 1978; 52: 302–310.
24. Sepand MR et al. Effect of acetyl-L-carnitine on antioxidant status, lipid peroxidation, and oxidative damage of arsenic in rat. Biol Trace Elem Res 2016; 171: 107–115.
25. Hassani S et al. Protective effects of curcumin and vitamin E against chlorpyrifos-induced lung oxidative damage. Hum Exp Toxicol 2015; 34: 668–676.
26. Luckens MM, Davis WH. Toxicity of dieldrin and endrin to bats. Nature 1965; 207: 879–880.
27. Hosseini MJ et al. Toxicity of vanadium on isolated rat liver mitochondria: a new mechanistic approach. Metallomics 2013; 5: 152–166.
28. Pourahmad J et al. Hepatoprotective activity of angiotensin-converting enzyme (ACE) inhibitors, captopril and enalapril, against paraquat toxicity. Pestic Biochem Physiol 2011; 99: 105–110.
29. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976; 72: 248–254.
30. Razavi-Azarkhiavi K et al. Silymarin alleviates bleomycin-induced pulmonary toxicity and lipid peroxidation in mice. Pharm Biol 2014; 52: 1267–1271.
31. Esmaeili A, Niknam S. Characterization of nanocapsules containing Elaeagnus angustifolia L. extract prepared using an emulsion-diffusion process. Flavour Fragr J 2013; 28: 309–315.
32. Vauzour D et al. Polyphenols and human health: prevention of disease and mechanisms of action. Nutrients 2010; 2: 1106–1131.
33. Mingeot-Leclercq MP et al. Aminoglycosides: activity and resistance. Antimicrob Agents Chemother 1999; 43: 727–737.
34. Pedraza-Chaverri J et al. Diallyl disulfide ameliorates gentamicin-induced oxidative stress and nephropathy in rats. Eur J Pharmacol 2003; 473: 71–78.
35. Kang C et al. Protective effects of houttuynia cordata thunb. on gentamicin-induced oxidative stress and nephrotoxicity in rats. Toxicol Res 2013; 29: 61–67.
36. Ali BH, Mousa HM. Effect of dimethyl sulfoxide on gentamicin-induced nephrotoxicity in rats. Hum Exp Toxicol 2001; 20: 199–203.
37. Abdel-Raheem IT et al. Protective effect of quercetin against gentamicin-induced nephrotoxicity in rats. Biol Pharm Bull 2009; 32: 61–67.
38. Del Rio D et al. A review of recent studies on malondialdehyde as toxic molecule and biological marker of oxidative stress. Nutr Metab Cardiovasc Dis 2005; 15: 316–328.
39. Wu G et al. Glutathione metabolism and its implications for health. J Nutr 2004; 134: 489–492.
40. Hassoun EA et al. The modulatory effects of ellagic acid and vitamin E succinate on TCDD-induced oxidative stress in different brain regions of rats after subchronic exposure. J Biochem Mol Toxicol 2004; 18: 196–203.
41. Parlakpinar H et al. Protective role of caffeic acid phenethyl ester (cape) on gentamicin-induced acute renal toxicity in rats. Toxicology 2005; 207: 169–177.
42. Chao PC et al. Anti-inflammatory and anti-coagulatory activities of caffeic acid and ellagic acid in cardiac tissue of diabetic mice. Nutr Metab (Lond) 2009; 6: 33.
43. Chen YC et al. Leptin reduces gentamicin-induced apoptosis in rat renal tubular cells via the PI3K-Akt signaling pathway. Eur J Pharmacol 2011; 658: 213–218.
44. Regec AL et al. Effect of gentamicin on the lysosomal system of cultured human proximal tubular cells. Endocytotic activity, lysosomal pH and membrane fragility. Biochem Pharmacol 1989; 38: 2527–2534.
45. Morales AI et al. Metformin prevents experimental gentamicin-induced nephropathy by a mitochondria-dependent pathway. Kidney Int 2010; 77: 861–869.
46. Antonsson B. Bax and other pro-apoptotic Bcl-2 family “killer-proteins” and their victim the mitochondrion. Cell Tissue Res 2001; 306: 347–361.
47. Martinez-Salgado C et al. Gentamicin treatment induces simultaneous mesangial proliferation and apoptosis in rats. Kidney Int 2004; 65: 2161–2171.
48. Walker PD, Shah SV. Gentamicin enhanced production of hydrogen peroxide by renal cortical mitochondria. Am J Physiol 1987; 253(4 Pt 1): C495–C499.
49. Lee JY et al. Protective effect of metformin on gentamicin-induced vestibulotoxicity in rat primary cell culture. Clin Exp Otorhinolaryngol 2014; 7: 286–294.
50. Ho CC et al. Ellagic acid induces apoptosis in TSGH8301 human bladder cancer cells through the endoplasmic reticulum stress- and mitochondria-dependent signaling pathways. Environ Toxicol 2014; 29: 1262–1274.
51. Alfredsson CF et al. Ellagic acid induces a dose- and time-dependent depolarization of mitochondria and activation of caspase-9 and -3 in human neuroblastoma cells. Biomed Pharmacother 2014; 68: 129–135.