Method development and validation for pharmacokinetic and tissue distributions of ellagic acid using ultrahigh performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS)

Molecules

Volumn 19, Issue 11, 2014, Pages 18923-18935

  Yan, Linlin ^a   Yin, Peipei ^a   Ma, Chao ^a   Liu, Yujun ^a  

^a BEIJING FORESTRY UNIVERSITY   (China)

Author keywords

Ellagic acid; Pharmacokinetics; Solid phase extraction; Tissue distribution; UPLC MS MS

Indexed keywords

ELLAGIC ACID;

ANIMAL; CHEMISTRY; FEMALE; FRUIT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ORAL DRUG ADMINISTRATION; PHYSIOLOGY; PROCEDURES; RAT; SPRAGUE DAWLEY RAT; TANDEM MASS SPECTROMETRY; TISSUE DISTRIBUTION; VEGETABLE;

ADMINISTRATION, ORAL; ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ELLAGIC ACID; FEMALE; FRUIT; RATS; RATS, SPRAGUE-DAWLEY; TANDEM MASS SPECTROMETRY; TISSUE DISTRIBUTION; VEGETABLES;

EID: 84912060379     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules191118923     Document Type: Article

References (15)

1. Larrosa, M.; García-Conesa, M.T.; Espín, J.C.; Tomás-Barberán, F.A. Ellagitannins, ellagic acid and vascular health. Mol. Asp. Med. 2010, 31, 513-539
2. Larrosa, M.; García-Conesa, M.T.; Espín, J.C.; Tomás-Barberán, F.A. Bioavailability and metabolism of ellagic acid and ellagitannins. In Flavonoids and Related Compounds: Bioavailability and Function, 1st ed.; Spencer, J.P.E., Crozier, A., Eds.; CRC Press Inc: Boca Raton, FL, USA, 2012; pp. 183-195
3. Aguilera-Carbo, A.; Augur, C.; Prado-Barragan, L.A.; Favela-Torres, E.; Aguilar, C.N. Microbial production of ellagic acid and biodegradation of ellagitannins. Appl. Microbiol. Biot. 2008, 78, 189-199
4. Doyle, B.; Griffiths, L.A. The metabolism of ellagic acid in the rat. Xenobiotica 1980, 10, 247-256
5. Boukharta, M.; Jalbert, G.; Castonguay, A. Biodistribution of ellagic acid and dose-related inhibition of lung tumorigenesis in A/J mice. Nutr. Cancer 1992, 18, 181-189
6. Lei, F.; Xing, D.M.; Xiang, L.; Zhao, Y.N.; Wang, W.; Zhang, L.J.; Du, L.J. Pharmacokinetic study of ellagic acid in rat after oral administration of pomegranate leaf extract. J. Chromatogr. B 2003, 796, 189-194
7. Seeram, N.P.; Lee, R.; Heber, D. Bioavailability of ellagic acid in human plasma after consumption of ellagitannins from pomegranate (Punica granatum L.) juice. Clin. Chim. Acta 2004, 348, 63-68
8. Stoner, G.D.; Sardo, C.; Apseloff, G.; Mullet, D.; Wargo, W.; Pound, V.; Singh, A.; Sanders, J.; Aziz, R.; Casto, B.; et al. Pharmacokinetics of anthocyanins and ellagic acid in healthy volunteers fed freeze-dried black raspberries daily for 7 days. J. Clin. Pharmacol. 2005, 45, 1153-1164
9. Espín, J.C.; Larrosa, M.; García-Conesa, M.T.; Tomás-Barberán, F.A. Biological significance of urolithins, the gut microbial ellagic acid-derived metabolites: The evidence so far. Evid. Based Complement. Altern. Med. 2013, 2013, doi:10.1155/2013/270418
10. Smart, R.C.; Huang, M.T.; Chang, R.L.; Sayer, J.M.; Jerina, D.M.; Conney, A.H. Disposition of the naturally occurring antimutagenic plant phenol, ellagic acid, and its synthetic derivatives, 3-O-decylellagic acid and 3,3'-di-O-methylellagic acid in mice. Carcinogenesis 1986, 7, 1663-1667
11. Mattila, P.; Kumpulainen, J. Determination of free and total phenolic acids in plant-derived foods by HPLC with diode-array detection. J. Agric. Food Chem. 2002, 50, 3660-3667
12. Krishna, V.N.; Meyyanathan, S.N.; Gowramma, B.; Babu, B.; Elango, K. Development and validation of LC-APCI-MS method for the estimation of ellagic acid in fresh and processed fruit products. J. Appl. Pharm. Sci. 2013, 3, 8-12
13. Whitley, A.C.; Stoner, G.D.; Darby, M.V.; Walle, T. Intestinal epithelial cell accumulation of the cancer preventive polyphenol ellagic acid-extensive binding to protein and DNA. Biochem. Pharmacol. 2003, 66, 907-915
14. Murugan, V.; Mukherjee, K.; Maiti, K.; Mukherjee, P.K. Enhanced oral bioavailability and antioxidant profiles of ellagic acid by phospholipids. J. Agric. Food Chem. 2009, 57, 4559-4565
15. Li, T.; Hu, L.; Zhang, M.; Sun, J.; Qiu, Y.; Rui, J.; Yang, X. A sensitive UPLC-MS/MS method for simultaneous determination of eleven bioactive components of Tong-Xie-Yao-Fang decoction in rat biological matrices. J. Chromatogr. B 2014, 944, 90-100.