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1
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39749113080
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Clonal integration of a polyomavirus in human Merkel cell carcinoma
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This study discovers the presence of MCPyV in 80% of MCC tumors and suggests MCPyV is a contributing factor to MCC tumorigenesis.
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1•• Feng, H., Shuda, M., Chang, Y., Moore, P.S., Clonal integration of a polyomavirus in human Merkel cell carcinoma. Science 319 (2008), 1096–1100 This study discovers the presence of MCPyV in 80% of MCC tumors and suggests MCPyV is a contributing factor to MCC tumorigenesis.
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Science
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Feng, H.1
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2
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Pathologic nodal evaluation improves prognostic accuracy in Merkel cell carcinoma: analysis of 5823 cases as the basis of the first consensus staging system
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2 Lemos, B.D., Storer, B.E., Iyer, J.G., Phillips, J.L., Bichakjian, C.K., Fang, L.C., Johnson, T.M., Liegeois-Kwon, N.J., Otley, C.C., Paulson, K.G., et al. Pathologic nodal evaluation improves prognostic accuracy in Merkel cell carcinoma: analysis of 5823 cases as the basis of the first consensus staging system. J Am Acad Dermatol 63 (2010), 751–761.
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Lemos, B.D.1
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3
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3 Lemos, B., Nghiem, P., Merkel cell carcinoma: more deaths but still no pathway to blame. J Invest Dermatol 127 (2007), 2100–2103.
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4 Weinstock, M.A., Gardstein, B., Twenty-year trends in the reported incidence of mycosis fungoides and associated mortality. Am J Public Health 89 (1999), 1240–1244.
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5
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5 Engels, E.A., Frisch, M., Goedert, J.J., Biggar, R.J., Miller, R.W., Merkel cell carcinoma and HIV infection. Lancet 359 (2002), 497–498.
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Engels, E.A.1
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6
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84925547275
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6 Locke, F.L., Rollison, D.E., Sondak, V.K., Merkel cell carcinoma and immunosuppression: what we still need to know. J Natl Cancer Inst, 2015, 107.
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Locke, F.L.1
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7
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84863116134
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Merkel cell carcinoma: a virus-induced human cancer
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This review discusses the genomic organization of MCPyV, the molecular biology and pathology of both MCPyV and MCC, and the epidemiology of MCPyV and MCC.
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7•• Chang, Y., Moore, P.S., Merkel cell carcinoma: a virus-induced human cancer. Annu Rev Pathol 7 (2012), 123–144 This review discusses the genomic organization of MCPyV, the molecular biology and pathology of both MCPyV and MCC, and the epidemiology of MCPyV and MCC.
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Annu Rev Pathol
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Chang, Y.1
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8
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68249144369
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Human Merkel cell polyomavirus infection II. MCV is a common human infection that can be detected by conformational capsid epitope immunoassays
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This study shows that, although it was previously unrecognized, MCPyV infection is widespread in the human population, and that MCC patients have elevated MCPyV IgG response compared to controls.
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8• Tolstov, Y.L., Pastrana, D.V., Feng, H., Becker, J.C., Jenkins, F.J., Moschos, S., Chang, Y., Buck, C.B., Moore, P.S., Human Merkel cell polyomavirus infection II. MCV is a common human infection that can be detected by conformational capsid epitope immunoassays. Int J Cancer 125 (2009), 1250–1256 This study shows that, although it was previously unrecognized, MCPyV infection is widespread in the human population, and that MCC patients have elevated MCPyV IgG response compared to controls.
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Tolstov, Y.L.1
Pastrana, D.V.2
Feng, H.3
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Moschos, S.6
Chang, Y.7
Buck, C.B.8
Moore, P.S.9
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9
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77956506650
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Merkel cell polyomavirus and two previously unknown polyomaviruses are chronically shed from human skin
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This study isolated complete, wild-type cloned genomes of MCPyV, and also discovered the existence of two previously unknown polyomaviruses, human polyomavirus-6 and human polyomavirus-7.
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9•• Schowalter, R.M., Pastrana, D.V., Pumphrey, K.A., Moyer, A.L., Buck, C.B., Merkel cell polyomavirus and two previously unknown polyomaviruses are chronically shed from human skin. Cell Host Microbe 7 (2010), 509–515 This study isolated complete, wild-type cloned genomes of MCPyV, and also discovered the existence of two previously unknown polyomaviruses, human polyomavirus-6 and human polyomavirus-7.
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Cell Host Microbe
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, pp. 509-515
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Schowalter, R.M.1
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Buck, C.B.5
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10
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84862522999
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Human skin microbiota: high diversity of DNA viruses identified on the human skin by high throughput sequencing
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10 Foulongne, V., Sauvage, V., Hebert, C., Dereure, O., Cheval, J., Gouilh, M.A., Pariente, K., Segondy, M., Burguière, A., Manuguerra, J.-C., et al. Human skin microbiota: high diversity of DNA viruses identified on the human skin by high throughput sequencing. PLoS ONE, 7, 2012, e38499.
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PLoS ONE
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Foulongne, V.1
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11
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11 Kean, J.M., Rao, S., Wang, M., Garcea, R.L., Seroepidemiology of human polyomaviruses. PLoS Pathog, 5, 2009, e1000363.
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Kean, J.M.1
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12
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70349693465
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Quantitation of human seroresponsiveness to Merkel cell polyomavirus
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12 Pastrana, D.V., Tolstov, Y.L., Becker, J.C., Moore, P.S., Chang, Y., Buck, C.B., Quantitation of human seroresponsiveness to Merkel cell polyomavirus. PLoS Pathog, 5, 2009, e1000578.
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Pastrana, D.V.1
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Buck, C.B.6
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13
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78951478101
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Serological evidence of Merkel cell polyomavirus primary infections in childhood
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13 Chen, T., Hedman, L., Mattila, P.S., Jartti, T., Ruuskanen, O., Soderlund-Venermo, M., Hedman, K., Serological evidence of Merkel cell polyomavirus primary infections in childhood. J Clin Virol 50 (2011), 125–129.
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Chen, T.1
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14
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77954638804
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Update on human polyomaviruses and cancer
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F.V.W. George Academic Press George K [Chapter 1]
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14 Gjoerup, O., Chang, Y., Update on human polyomaviruses and cancer. George, F.V.W., (eds.) Advances in Cancer Research, vol 106, 2010, Academic Press, George K, 1–51 [Chapter 1].
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Gjoerup, O.1
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15
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80052273419
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Taxonomical developments in the family Polyomaviridae
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15 Johne, R., Buck, C.B., Allander, T., Atwood, W.J., Garcea, R.L., Imperiale, M.J., Major, E.O., Ramqvist, T., Norkin, L.C., Taxonomical developments in the family Polyomaviridae. Arch Virol 156 (2011), 1627–1634.
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Johne, R.1
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Major, E.O.7
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16
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55849098118
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T antigen mutations are a human tumor-specific signature for Merkel cell polyomavirus
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This article shows that LT antigen is truncated in MCC tumor cells, eliminating viral DNA replication capacity by removing the origin binding and helicase domains, preventing autoactivation of integrated virus replication that would threaten cell survival.
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16•• Shuda, M., Feng, H., Kwun, H.J., Rosen, S.T., Gjoerup, O., Moore, P.S., Chang, Y., T antigen mutations are a human tumor-specific signature for Merkel cell polyomavirus. Proc Natl Acad Sci U S A 105 (2008), 16272–16277 This article shows that LT antigen is truncated in MCC tumor cells, eliminating viral DNA replication capacity by removing the origin binding and helicase domains, preventing autoactivation of integrated virus replication that would threaten cell survival.
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Shuda, M.1
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Gjoerup, O.5
Moore, P.S.6
Chang, Y.7
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17
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84881103245
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Identification of an overprinting gene in Merkel cell polyomavirus provides evolutionary insight into the birth of viral genes
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This article identifies an overprinting gene, alternate LT ORF (ALTO), in MCPyV and other polyomaviruses.
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17•• Carter, J.J., Daugherty, M.D., Qi, X., Bheda-Malge, A., Wipf, G.C., Robinson, K., Roman, A., Malik, H.S., Galloway, D.A., Identification of an overprinting gene in Merkel cell polyomavirus provides evolutionary insight into the birth of viral genes. Proc Natl Acad Sci U S A 110 (2013), 12744–12749 This article identifies an overprinting gene, alternate LT ORF (ALTO), in MCPyV and other polyomaviruses.
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Proc Natl Acad Sci U S A
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Carter, J.J.1
Daugherty, M.D.2
Qi, X.3
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Wipf, G.C.5
Robinson, K.6
Roman, A.7
Malik, H.S.8
Galloway, D.A.9
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18
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84883349000
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The Merkel cell polyomavirus minor capsid protein
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18 Schowalter, R.M., Buck, C.B., The Merkel cell polyomavirus minor capsid protein. PLoS Pathog, 9, 2013, e1003558.
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Schowalter, R.M.1
Buck, C.B.2
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19
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70249101039
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Merkel cell polyomavirus expression in merkel cell carcinomas and its absence in combined tumors and pulmonary neuroendocrine carcinomas
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19 Busam, K.J., Jungbluth, A.A., Rekthman, N., Coit, D., Pulitzer, M., Bini, J., Arora, R., Hanson, N.C., Tassello, J.A., Frosina, D., et al. Merkel cell polyomavirus expression in merkel cell carcinomas and its absence in combined tumors and pulmonary neuroendocrine carcinomas. Am J Surg Pathol 33 (2009), 1378–1385.
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Busam, K.J.1
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Arora, R.7
Hanson, N.C.8
Tassello, J.A.9
Frosina, D.10
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20
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77953787613
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Merkel cell polyomavirus-infected Merkel cell carcinoma cells require expression of viral T antigens
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This article shows that viral T antigen expression is necessary for the maintenance of MCPyV-positive MCC. This study provides direct evidence that MCPyV is the infectious cause of MCPyV-positive MCC.
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20• Houben, R., Shuda, M., Weinkam, R., Schrama, D., Feng, H., Chang, Y., Moore, P.S., Becker, J.C., Merkel cell polyomavirus-infected Merkel cell carcinoma cells require expression of viral T antigens. J Virol 84 (2010), 7064–7072 This article shows that viral T antigen expression is necessary for the maintenance of MCPyV-positive MCC. This study provides direct evidence that MCPyV is the infectious cause of MCPyV-positive MCC.
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J Virol
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Houben, R.1
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Feng, H.5
Chang, Y.6
Moore, P.S.7
Becker, J.C.8
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21
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68249146060
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Human Merkel cell polyomavirus infection I. MCV T antigen expression in Merkel cell carcinoma, lymphoid tissues and lymphoid tumors
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21 Shuda, M., Arora, R., Kwun, H.J., Feng, H., Sarid, R., Fernandez-Figueras, M.T., Tolstov, Y., Gjoerup, O., Mansukhani, M.M., Swerdlow, S.H., et al. Human Merkel cell polyomavirus infection I. MCV T antigen expression in Merkel cell carcinoma, lymphoid tissues and lymphoid tumors. Int J Cancer 125 (2009), 1243–1249.
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Shuda, M.1
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22
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22 Shuda, M., Kwun, H.J., Feng, H., Chang, Y., Moore, P.S., Human Merkel cell polyomavirus small T antigen is an oncoprotein targeting the 4E-BP1 translation regulator. J Clin Invest 121 (2011), 3623–3634.
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Shuda, M.1
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23
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Improved detection suggests all Merkel cell carcinomas harbor Merkel polyomavirus
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23 Rodig, S.J., Cheng, J., Wardzala, J., DoRosario, A., Scanlon, J.J., Laga, A.C., Martinez-Fernandez, A., Barletta, J.A., Bellizzi, A.M., Sadasivam, S., et al. Improved detection suggests all Merkel cell carcinomas harbor Merkel polyomavirus. J Clin Invest 122 (2012), 4645–4653.
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Rodig, S.J.1
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24
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84873467040
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24 Amber, K., McLeod, M.P., Nouri, K., The Merkel cell polyomavirus and its involvement in Merkel cell carcinoma. Dermatol Surg 39 (2013), 232–238.
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Amber, K.1
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25
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Distinct merkel cell polyomavirus molecular features in tumour and non tumour specimens from patients with merkel cell carcinoma
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25 Laude, H.C., Jonchere, B., Maubec, E., Carlotti, A., Marinho, E., Couturaud, B., Peter, M., Sastre-Garau, X., Avril, M.F., Dupin, N., et al. Distinct merkel cell polyomavirus molecular features in tumour and non tumour specimens from patients with merkel cell carcinoma. PLoS Pathog, 6, 2010, e1001076.
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Laude, H.C.1
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26
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26 de Biase, D., Ragazzi, M., Asioli, S., Eusebi, V., Extracutaneous Merkel cell carcinomas harbor polyomavirus DNA. Hum Pathol 43 (2012), 980–985.
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de Biase, D.1
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27
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Merkel cell carcinoma of the skin: pathological and molecular evidence for a causative role of MCV in oncogenesis
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27 Sastre-Garau, X., Peter, M., Avril, M.F., Laude, H., Couturier, J., Rozenberg, F., Almeida, A., Boitier, F., Carlotti, A., Couturaud, B., et al. Merkel cell carcinoma of the skin: pathological and molecular evidence for a causative role of MCV in oncogenesis. J Pathol 218 (2009), 48–56.
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Sastre-Garau, X.1
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28
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28 Hodgson, N.C., Merkel cell carcinoma: changing incidence trends. J Surg Oncol 89 (2005), 1–4.
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29
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This review discusses MCPyV biology and the unique features that distinguish MCPyV from other polyomaviruses.
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29•• Grundhoff, A., Fischer, N., Merkel cell polyomavirus, a highly prevalent virus with tumorigenic potential. Curr Opin Virol 14 (2015), 129–137 This review discusses MCPyV biology and the unique features that distinguish MCPyV from other polyomaviruses.
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Grundhoff, A.1
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30
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30 Wendzicki, J.A., Moore, P.S., Chang, Y., Large T and small T antigens of Merkel cell polyomavirus. Curr Opin Virol 11 (2015), 38–43.
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Wendzicki, J.A.1
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31
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31 Spurgeon, M.E., Lambert, P.F., Merkel cell polyomavirus: a newly discovered human virus with oncogenic potential. Virology 435 (2013), 118–130.
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32
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High-affinity Rb binding, p53 inhibition, subcellular localization, and transformation by wild-type or tumor-derived shortened Merkel cell polyomavirus large T antigens
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32 Borchert, S., Czech-Sioli, M., Neumann, F., Schmidt, C., Wimmer, P., Dobner, T., Grundhoff, A., Fischer, N., High-affinity Rb binding, p53 inhibition, subcellular localization, and transformation by wild-type or tumor-derived shortened Merkel cell polyomavirus large T antigens. J Virol 88 (2014), 3144–3160.
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Borchert, S.1
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Fischer, N.8
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33
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83955161771
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An intact retinoblastoma protein-binding site in Merkel cell polyomavirus large T antigen is required for promoting growth of Merkel cell carcinoma cells
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33 Houben, R., Adam, C., Baeurle, A., Hesbacher, S., Grimm, J., Angermeyer, S., Henzel, K., Hauser, S., Elling, R., Brocker, E.B., et al. An intact retinoblastoma protein-binding site in Merkel cell polyomavirus large T antigen is required for promoting growth of Merkel cell carcinoma cells. Int J Cancer 130 (2012), 847–856.
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Houben, R.1
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34
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84928429167
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Merkel cell polyomavirus small T antigen is oncogenic in transgenic mice
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This article demonstrates transforming activity of MCPyV sT antigen in vivo using a panel of transgenic mouse models. The result implicates sT antigen as an oncogenic driver in MCC.
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34• Verhaegen, M.E., Mangelberger, D., Harms, P.W., Vozheiko, T.D., Weick, J.W., Wilbert, D.M., Saunders, T.L., Ermilov, A.N., Bichakjian, C.K., Johnson, T.M., et al. Merkel cell polyomavirus small T antigen is oncogenic in transgenic mice. J Invest Dermatol, 2014 This article demonstrates transforming activity of MCPyV sT antigen in vivo using a panel of transgenic mouse models. The result implicates sT antigen as an oncogenic driver in MCC.
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J Invest Dermatol
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Verhaegen, M.E.1
Mangelberger, D.2
Harms, P.W.3
Vozheiko, T.D.4
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36
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36 Houben, R., Schrama, D., Becker, J.C., Molecular pathogenesis of Merkel cell carcinoma. Exp Dermatol 18 (2009), 193–198.
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37
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84881238348
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Merkel cell polyomavirus large T antigen disrupts host genomic integrity and inhibits cellular proliferation
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PMCID: PMC3957940 This article shows that the helicase-containing region of the MCPyV LT activates host DNA damage responses and enhanced p53 phosphorylation, thus contributing to the full-length LT antitumorigenic activity.
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37• Li, J., Wang, X., Diaz, J., Tsang, S.H., Buck, C.B., You, J., Merkel cell polyomavirus large T antigen disrupts host genomic integrity and inhibits cellular proliferation. J Virol 87 (2013), 9173–9188 PMCID: PMC3957940 This article shows that the helicase-containing region of the MCPyV LT activates host DNA damage responses and enhanced p53 phosphorylation, thus contributing to the full-length LT antitumorigenic activity.
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J Virol
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