Human Merkel cell polyomavirus infection II. MCV is a common human infection that can be detected by conformational capsid epitope immunoassays

International Journal of Cancer

Volumn 125, Issue 6, 2009, Pages 1250-1256

  Tolstov, Yanis L ^a   Pastrana, Diana V ^b   Feng, Huichen ^a   Becker, Jürgen C ^c   Jenkins, Frank J ^d   Moschos, Stergios ^d   Chang, Yuan ^a   Buck, Christopher B ^b   Moore, Patrick S ^a  

^a UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c UNIVERSITY HOSPITAL WÜRZBURG   (Germany)

^d UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Enzyme linked immunosorbent assay; Merkel cell carcinoma; Merkel cell polyomavirus; Serologic assay; Virus like particles

Indexed keywords

EPITOPE; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN M ANTIBODY;

ADOLESCENT; ADULT; AGE DISTRIBUTION; AGED; ANTIBODY BLOOD LEVEL; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; HISTIOCYTOSIS X; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOBLOTTING; INFANT; INTERMETHOD COMPARISON; MERKEL CELL POLYOMAVIRUS; MERKEL CELL TUMOR; NONHUMAN; NUCLEOTIDE SEQUENCE; PEPTIDE MAPPING; POLYOMA VIRUS; PREVALENCE; PRIORITY JOURNAL; SEROLOGY; SYSTEMIC LUPUS ERYTHEMATOSUS; VERTICAL TRANSMISSION; VIRUS CAPSID; VIRUS DETECTION; VIRUS GENE; VIRUS INFECTION; VIRUS LIKE AGENT; VIRUS TRANSMISSION; VP1 GENE; VP2 GENE;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANTIBODIES, VIRAL; BK VIRUS; CAPSID PROTEINS; CARCINOMA, MERKEL CELL; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITOPES; HUMANS; IMMUNOGLOBULIN G; MIDDLE AGED; MOLECULAR CONFORMATION; POLYOMAVIRUS; POLYOMAVIRUS INFECTIONS; SKIN NEOPLASMS; TUMOR VIRUS INFECTIONS;

EID: 68249144369     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.24509     Document Type: Article

References (27)

1. Dinh V, Feun L, Elgart G, Savaraj N. Merkel cell carcinomas. Hematol Oncol Clin North Am 2007;21:527-44.
2. Engels EA, Frisch M, Goedert JJ, Biggar RJ, Miller RW. Merkel cell carcinoma and HIV infection. Lancet 2002;359:497-8.
3. Feng H, Taylor JL, Benos PV, Newton R, Waddell K, Lucas SB, Chang Y, Moore PS. Human transcriptome subtraction by using short sequence tags to search for tumor viruses in conjunctival carcinoma. J Virol 2007;81:11332-40.
4. Feng H, Shuda M, Chang Y, Moore PS. Clonal integration of a polyomavirus in human Merkel cell carcinoma. Science 2008;319:1096-100.
5. Foulongne V, Kluger N, Dereure O, Brieu N, Guillot B, Segondy M. Merkel cell polyomavirus and Merkel cell carcinoma. Fr Emerg Infect Dis 2008;14:1491-3.
6. Ridd K, Yu S, Bastian BC. The presence of polyomavirus in nonmelanoma skin cancer in organ transplant recipients is rare. J Invest Dermatol 2009;129:250-2.
7. Becker JC, Houben R, Ugurel S, Trefzer U, Pfohler C, Schrama D. MC polyomavirus is frequently present in Merkel cell carcinoma of European patients. J Invest Dermatol 2009;129:248-50.
8. Kassem A, Schopflin A, Diaz C, Weyers W, Stickeler E, Werner M, Zur Hausen A. Frequent detection of Merkel cell polyomavirus in human Merkel cell carcinomas and identification of a unique deletion in the VP1 gene. Cancer Res 2008;68:5009-13.
9. Buck CB, Lowy DR. Getting stronger: the relationship between a newly identified virus and Merkel cell carcinoma. J Invest Dermatol 2009;129:9-11.
10. Shuda M, Feng H, Kwun HJ, Rosen ST, Gjoerup O, Moore PS, Chang Y. T antigen mutations are a human tumor-specific signature for Merkel cell polyomavirus. Proc Natl Acad Sci USA 2008;105:16272-7.
11. Shuda M, Arora R, Kwun HJ, Feng HC, Sarid R, Fernández-Figueras MT, Tolstov Y, Gjoerup O, Mansukhani M, Swerdlow SH, Chaudhary PM, Kirkwood JM, et al. Human Merkel cell polyomavirus infection. I. MCV T antigen expression in Merkel cell carcinoma, lymphoid tissues and lymphoid tumors. Int J Cancer 2009. DOI: 10.1002/ijc.24510.
12. Viscidi RP, Clayman B. Serological cross reactivity between polyomavirus capsids. Adv Exp Med Biol 2006;577:73-84.
13. Poulin DL, DeCaprio JA. Is there a role for SV40 in human cancer? J Clin Oncol 2006;24:4356-65.
14. Laney AS, Peters JS, Manzi SM, Kingsley LA, Chang Y, Moore PS. Use of a multiantigen detection algorithm for diagnosis of Kaposi's sarcoma-associated herpesvirus infection. J Clin Microbiol 2006;44: 3734-41.
15. Pastrana DV, Buck CB, Pang YY, Thompson CD, Castle PE, FitzGerald PC, Kruger Kjaer S, Lowy DR, Schiller JT. Reactivity of human sera in a sensitive, high-throughput pseudovirus-based papillomavirus neutralization assay for HPV16 and HPV18. Virology 2004;321: 205-16.
16. Bauer PH, Bronson RT, Fung SC, Freund R, Stehle T, Harrison SC, Benjamin TL. Genetic and structural analysis of a virulence determinant in polyomavirus VP1. J Virol 1995;69:7925-31.
17. Lenz P, Day PM, Pang YY, Frye SA, Jensen PN, Lowy DR, Schiller JT. Papillomavirus-like particles induce acute activation of dendritic cells. J Immunol 2001;166:5346-55.
18. Buck CB, Pastrana DV, Lowy DR, Schiller JT. Efficient intracellular assembly of papillomaviral vectors. J Virol 2004;78:751-7.
19. Buck CB, Pastrana DV, Lowy DR, Schiller JT. Generation of HPV pseudovirions using transfection and their use in neutralization assays. Methods Mol Med 2005;119:445-62.
20. Giraud G, Ramqvist T, Ragnarsson-Olding B, Dalianis T. DNA from BK virus and JC virus and from KI, WU and MC polyomaviruses as well as from simian virus 40 is not detected in non-UV-light-associated primary malignant melanomas of mucous membranes. J Clin Microbiol 2008;46:3595-8.
21. Garneski KM, DeCaprio JA, Nghiem P. Does a new polyomavirus contribute to Merkel cell carcinoma? Genome Biol 2008;9:228.
22. Bialasiewicz S, Lambert SB, Whiley DM, Nissen MD, Sloots TP. Merkel cell polyomavirus DNA in respiratory specimens from children and adults. Emerg Infect Dis 2009;15:492-4.
23. Goh S, Lindau C, Tiveljung-Lindell A, Allander T. Merkel cell polyomavirus in respiratory tract secretions. Emerg Infect Dis 2009;15: 489-91.
24. Stolt A, Sasnauskas K, Koskela P, Lehtinen M, Dillner J. Seroepidemiology of the human polyomaviruses. J Gen Virol 2003;84(Pt 6): 1499-504.
25. Allander T, Andreasson K, Gupta S, Bjerkner A, Bogdanovic G, Persson MA, Dalianis T, Ramqvist T, Andersson B. Identification of a third human polyomavirus. J Virol 2007;81:4130-6.
26. Gaynor AM, Nissen MD, Whiley DM, Mackay IM, Lambert SB, Wu G, Brennan DC, Storch GA, Sloots TP, Wang D. Identification of a novel polyomavirus from patients with acute respiratory tract infections. PLoS Pathog 2007;3:e64.
27. Koutsky LA, Ault KA, Wheeler CM, Brown DR, Barr E, Alvarez FB, Chiacchierini LM, Jansen KU. A controlled trial of a human papillomavirus type 16 vaccine. N Engl J Med 2002;347:1645-51.