Cardiac protective effects of moringa oleifera seeds in spontaneous hypertensive rats

American Journal of Hypertension

Volumn 29, Issue 7, 2016, Pages 873-881

  Randriamboavonjy, Joseph I ^a,b,c   Loirand, Gervaise ^a,b,c   Vaillant, Nathalie ^a,b   Lauzier, Benjamin ^a,b   Derbré, Sévérine ^d   Michalet, Serge ^e   Pacaud, Pierre ^a,b   Tesse, Angela ^a,b  

^a CNRS   (France)

^b UNIVERSITÉ DE NANTES   (France)

^c L INSTITUT DU THORAX   (France)

^d UNIVERSITÉ D'ANGERS   (France)

^e Centre D' tude des Substances Naturelles (CESN)   (France)

Author keywords

Blood pressure; Cardiac hypertrophy; Fibrosis; Hypertension

Indexed keywords

CARDIOVASCULAR AGENT; MORINGA OLEIFERA EXTRACT; MORINGA OLEIFERA SEED EXTRACT; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROSTACYCLIN; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; PLANT MEDICINAL PRODUCT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE; CONTROLLED STUDY; DIASTOLE; DRUG EFFECT; ECHOCARDIOGRAPHY; HEART FUNCTION; HEART HEMODYNAMICS; HEART LEFT VENTRICLE HYPERTROPHY; HEART LEFT VENTRICLE WALL; HEART MUSCLE FIBROSIS; HEART MUSCLE RELAXATION; HEART OUTPUT; HEART PROTECTION; HEART RATE; HEMODYNAMIC PARAMETERS; HISTOLOGY; HYPERTENSION; IN VIVO STUDY; ISOVOLUMETRIC RELAXATION TIME; MALE; MORINGA OLEIFERA; NONHUMAN; OUTCOME ASSESSMENT; PLANT SEED; POWDER; PRIORITY JOURNAL; PROSTAGLANDIN BLOOD LEVEL; PROTEIN EXPRESSION; RAT; RECEPTOR UPREGULATION; SPONTANEOUSLY HYPERTENSIVE RAT; TELEMETRY; TIME; ANIMAL; CARDIAC MUSCLE; COMPLICATION; EVALUATION STUDY; HEART DISEASE; LIPID METABOLISM; METABOLISM; PHYTOTHERAPY; WISTAR KYOTO RAT;

ANIMALS; BLOOD PRESSURE; ECHOCARDIOGRAPHY; HEART DISEASES; HEART RATE; HYPERTENSION; LIPID METABOLISM; MALE; MORINGA OLEIFERA; MYOCARDIUM; PHYTOTHERAPY; PLANT PREPARATIONS; PPAR ALPHA; PPAR DELTA; RATS, INBRED SHR; RATS, INBRED WKY; SEEDS;

EID: 84981165198     PISSN: 08957061     EISSN: 19417225     Source Type: Journal    
DOI: 10.1093/ajh/hpw001     Document Type: Article

References (39)

1. Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL Jr, Jones DW, Materson BJ, Oparil S, Wright JT Jr, Roccella EJ. Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Hypertension 2003; 42:1206-1252.
2. McCarty R, Kopin IJ. Alterations in plasma catecholamines and behavior during acute stress in spontaneously hypertensive and Wistar-Kyoto normotensive rats. Life Sci 1978; 22:997-1005.
3. Kokubo M, Uemura A, Matsubara T, Murohara T. Noninvasive evaluation of the time course of change in cardiac function in spontaneously hypertensive rats by echocardiography. Hypertens Res 2005; 28:601-609.
4. Barger PM, Kelly DP. PPAR signaling in the control of cardiac energy metabolism. Trends Cardiovasc Med 2000; 10:238-245.
5. Ralay Ranaivo H, Rakotoarison O, Tesse A, Schott C, Randriantsoa A, Lobstein A, Andriantsitohaina R. Cedrelopsis grevei induced hypotension and improved endothelial vasodilatation through an increase of Cu/Zn SOD protein expression. Am J Physiol Heart Circ Physiol 2004; 286:H775-H781.
6. Mingorance C, Andriantsitohaina R, Alvarez de Sotomayor M. Cedrelopsis grevei improves endothelial vasodilatation in aged rats through an increase of NO participation. J Ethnopharmacol 2008; 117:76-83.
7. Rakotomalala G, Agard C, Tonnerre P, Tesse A, Derbré S, Michalet S, Hamzaoui J, Rio M, Cario-Toumaniantz C, Richomme P, Charreau B, Loirand G, Pacaud P. Extract from Mimosa pigra attenuates chronic experimental pulmonary hypertension. J Ethnopharmacol 2013; 148:106-116.
8. Morimitsu Y, Hayashi K, Nakagawa Y, Horio F, Uchida K, Osawa T. Antiplatelet and anticancer isothiocyanates in Japanese domestic horseradish, wasabi. Biofactors 2000; 13:271-276.
9. Siddhuraju P, Becker K. Antioxidant properties of various solvent extracts of total phenolic constituents from three different agroclimatic origins of drumstick tree (Lam). J. Agric Food Chem 2003; 15:2144-2155.
10. Fahey JW. Moringa oleifera: a review of the medical evidence for its nutritional, therapeutic and prophylactic properties. Tree Life J 2005; 1:5.
11. Ogbunugafor HA, Eneh FU, Ozumba AN, Igwo-Ezikpe MN, Okpuzor J, Igwilo IO, Adenekan SO, Oneykwelu OA. Physico-chemical and antioxidant properties in Moringa oleifera seed oil. Pak J Nutr 2011; 10:409-414.
12. Hayward R, Lien CY. Echocardiographic evaluation of cardiac structure and function during exercise training in the developing Sprague-Dawley rat. J Am Assoc Lab Anim Sci 2011; 50:454-461.
13. Robinson E, Grieve DJ. Significance of peroxisome proliferator-activated receptors in the cardiovascular system in health and disease. Pharmacol Ther 2009; 122:246-263.
14. Tesse A, Andriantsitohaina R, Ragot T. PPAR? activity in cardiovascular diseases: a potential pharmacological target. PPAR Res 2009; 2009:745821.
15. Giannoglou GD, Chatzizisis YS, Zamboulis C, Parcharidis GF, Mikhailidis DP, Louridas GE. Elevated HR and atherosclerosis: an overview of the pathogenetic mechanisms. Int J Cardiol 2008; 126:302-312.
16. Fox K, Borer JS, Camm AJ, Danchin N, Ferrari R, Lopez Sendon JL, Steg PG, Tardif JC, Tavazzi L, Tendera M; Heart Rate Working Group. Resting heart rate in cardiovascular disease. JACC 2007; 50:823-830.
17. Cook S, Togni M, Schaub MC, Wenaweser P, Hess OM. High heart rate: a cardiovascular risk factor? Eur Heart J 2006; 27:2387-2393.
18. Ijarotimi OS, Adeoti OA, Ariyo O. Comparative study on nutrient composition, phytochemical, and functional characteristics of raw, germinated, and fermented Moringa oleifera seed flour. Food Sci Nutr 2013; 1:452-463.
19. Ajibade TO, Arowolo R, Olayemi FO. Phytochemical screening and toxicity studies on the methanol extract of the seeds of Moringa oleifera. J Complement Integr Med 2013; 10:11-16.
20. Jansakul C, Wun-Noi A, Croft K, Byrne I. Pharmacological studies of thiocarbamate glycosides isolated from Moringa oleifera. J Sci Soc Thailand 1997; 23:335-346.
21. Kääb S, Dixon J, Duc J, Ashen D, Näbauer M, Beuckelmann DJ, Steinbeck G, McKinnon D, Tomaselli GF. Molecular basis of transient outward potassium current downregulation in human heart failure: a decrease in Kv4.3 mRNA correlates with a reduction in current density. Circulation 1998; 98:1383-1393.
22. Sharma GV, Woods PA, Lindsey N, O'Connell C, Connolly L, Joseph J, McIntyre KM. Noninvasive monitoring of left ventricular enddiastolic pressure reduces rehospitalization rates in patients hospitalized for heart failure: a randomized controlled trial. J Card Fail 2011; 17:718-725.
23. Prunier F, Gaertner R, Louedec L, Michel JB, Mercadier JJ, Escoubet B. Doppler echocardiographic estimation of left ventricular end-diastolic pressure after MI in rats. Am J Physiol Heart Circ Physiol 2002; 283:H346-H352.
24. Mukherjee D, Sen S. Collagen phenotypes during development and regression of myocardial hypertrophy in spontaneously hypertensive rats. Circ Res 1990; 67:1474-1480.
25. Huang Y, Zhang H, Shao Z, O'Hara KA, Kopilas MA, Yu L, Netticadan T, Anderson HD. Suppression of endothelin-1-induced cardiac myocyte hypertrophy by PPAR agonists: role of diacylglycerol kinase zeta. Cardiovasc Res 2011; 90:267-275.
26. Sarma S, Ardehali H, Gheorghiade M. Enhancing the metabolic substrate: PPAR-alpha agonists in heart failure. Heart Fail Rev 2012; 17:35-43.
27. Gao F, Liang Y, Wang X, Lu Z, Li L, Zhu S, Liu D, Yan Z, Zhu Z. TRPV1 activation attenuates high-salt diet-induced cardiac hypertrophy and fibrosis through PPAR-? upregulation. PPAR Res 2014; 2014:491963.
28. Barish GD, Narkar VA, Evans RM. PPAR delta: a dagger in the heart of the metabolic syndrome. J Clin Invest 2006; 116:590-597.
29. He T, Chen L, Chen Y, Han Y, Yang WQ, Jin MW. In vivo and in vitro protective effects of pentamethylquercetin on cardiac hypertrophy. Cardiovasc Drugs Ther 2012; 26:109-120.
30. Liu J, Wang P, Luo J, Huang Y, He L, Yang H, Li Q, Wu S, Zhelyabovska O, Yang Q. Peroxisome proliferator-activated receptor ?/? activation in adult hearts facilitates mitochondrial function and cardiac performance under pressure-overload condition. Hypertension 2011; 57:223-230.
31. Herranz-López M, Barrajón-Catalán E, Segura-Carretero A, Menéndez JA, Joven J, Micol V. Lemon verbena (Lippia citriodora) polyphenols alleviate obesity-related disturbances in hypertrophic adipocytes through AMPK-dependent mechanisms. Phytomedicine 2015; 22:605-614.
32. Agouni A, Lagrue-Lak-Hal AH, Mostefai HA, Tesse A, Mulder P, Rouet P, Desmoulin F, Heymes C, Martínez MC, Andriantsitohaina R. Red wine polyphenols prevent metabolic and cardiovascular alterations associated with obesity in Zucker fatty rats (Fa/Fa). PLoS One 2009; 4:e5557.
33. Galisteo M, Sánchez M, Vera R, González M, Anguera A, Duarte J, Zarzuelo A. A diet supplemented with husks of Plantago ovata reduces the development of endothelial dysfunction, hypertension, and obesity by affecting adiponectin and TNF-alpha in obese Zucker rats. J Nutr 2005; 135:2399-2404.
34. Sarr M, Chataigneau M, Martins S, Schott C, El Bedoui J, Oak MH, Muller B, Chataigneau T, Schini-Kerth VB. Red wine polyphenols prevent angiotensin II-induced hypertension and endothelial dysfunction in rats: role of NADPH oxidase. Cardiovasc Res 2006; 71:794-802.
35. Thandapilly SJ, Wojciechowski P, Behbahani J, Louis XL, Yu L, Juric D, Kopilas MA, Anderson HD, Netticadan T. Resveratrol prevents the development of pathological cardiac hypertrophy and contractile dysfunction in the SHR without lowering blood pressure. Am J Hypertens 2010; 23:192-196.
36. Fiedler B, Wollert KC. Interference of antihypertrophic molecules and signaling pathways with the Ca2+-calcineurin-NFAT cascade in cardiac myocytes. Cardiovasc Res 2004; 63:450-457.
37. Molkentin JD. Calcineurin-NFAT signaling regulates the cardiac hypertrophic response in coordination with the MAPKs. Cardiovasc Res 2004; 63:467-475.
38. Wilkins BJ, Molkentin JD. Calcium-calcineurin signaling in the regulation of cardiac hypertrophy. Biochem Biophys Res Commun 2004; 322:1178-1191.
39. Zou Y, Yamazaki T, Nakagawa K, Yamada H, Iriguchi N, Toko H, Takano H, Akazawa H, Nagai R, Komuro I. Continuous blockade of L-type Ca2+ channels suppresses activation of calcineurin and development of cardiac hypertrophy in spontaneously hypertensive rats. Hypertens Res 2002; 25:117-124.