Vitamin D metabolism varies among women in different reproductive states consuming the same intakes of vitamin D and related nutrients

Journal of Nutrition

Volumn 146, Issue 8, 2016, Pages 1537-1545

  Park, Heyjun ^a   Brannon, Patsy M ^a   West, Allyson A ^a   Yan, Jian ^a   Jiang, Xinyin ^a   Perry, Cydne A ^a   Malysheva, Olga V ^a   Mehta, Saurabh ^a   Caudill, Marie A ^a  

^a Cornell University ^*  (United States)

Author keywords

1,25 dihydroxyvitamin D; 24,25 dihydroxyvitamin D; 25(OH)2D ratio; 25(OH)D:24; 25 hydroxyvitamin D; Epi 25(OH)D3; Free 25(OH)D; Lactation; Pregnancy; Vitamin D; Vitamin D requirements

Indexed keywords

24,25 DIHYDROXYVITAMIN D; 25 HYDROXYVITAMIN D; BIOLOGICAL MARKER; CALCITRIOL; CALCIUM; CHOLINE; PHOSPHORUS; VITAMIN D; VITAMIN D BINDING PROTEIN; COLECALCIFEROL;

ADULT; ARTICLE; CONTROLLED STUDY; FEEDING; FEMALE; HUMAN; MAJOR CLINICAL STUDY; NUTRIENT; PREGNANT WOMAN; QUANTITATIVE ANALYSIS; RANDOMIZED CONTROLLED TRIAL; REPRODUCTIVE HEALTH; VITAMIN BLOOD LEVEL; VITAMIN D METABOLISM; VITAMIN INTAKE; VITAMIN SUPPLEMENTATION; BLOOD; CALORIC INTAKE; DIET; DIETARY SUPPLEMENT; LACTATION; PHYSIOLOGY; PREGNANCY; REPRODUCTION;

ADULT; BIOMARKERS; CHOLECALCIFEROL; DIET; DIETARY SUPPLEMENTS; ENERGY INTAKE; FEMALE; HUMANS; LACTATION; PREGNANCY; REPRODUCTION; VITAMIN D; VITAMIN D-BINDING PROTEIN;

EID: 84980335349     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.3945/jn.116.229971     Document Type: Article

References (39)

1. Brannon PM, Picciano MF. Vitamin D in pregnancy and lactation in humans. Annu Rev Nutr 2011;31:89-115.
2. De-Regil LM, Palacios C, Ansary A, Kulier R, Peña-Rosas JP. Vitamin D supplementation for women during pregnancy. Cochrane Database Syst Rev 2012:CD008876.
3. Saraf R, Morton SM, Camargo CA, Grant CC. Global summary of maternal and newborn vitamin D status-a systematic review. Matern Child Nutr 2015;25:1-22.
4. Wagner CL, Taylor SN, Johnson DD, Hollis BW. The role of vitamin D in pregnancy and lactation: emerging concepts. Womens Health (Lond Engl) 2012;8:323-40.
5. Aghajafari F, Nagulesapillai T, Ronksley PE, Tough SC,Beirne M, Rabi DM. Association between maternal serum 25-hydroxyvitamin D level and pregnancy and neonatal outcomes: systematic review and meta-analysis of observational studies. BMJ 2013;346:f1169.
6. Institute of Medicine Committee to Review Dietary Reference Intakes for Vitamin D and Calcium; Ross AC, Taylor CL, Yaktine AL, Valle HD (editors). Dietary reference intakes for calcium and vitamin D. Washington (DC): National Academies Press; 2011.
7. Papapetrou PD. The interrelationship of serum 1,25-dihydroxyvitamin D, 25-hydroxyvitamin D and 24,25-dihydroxyvitamin D in pregnancy at term: a meta-analysis. Hormones (Athens) 2010;9:136-44.
8. Bikle DD, Gee E, Halloran B, Haddad JG. Free 1,25-dihydroxyvitamin D levels in serum from normal subjects, pregnant subjects, and subjects with liver disease. J Clin Invest 1984;74:1966-71.
9. Cross NA, Hillman LS, Allen SH, Krause GF, Vieira NE. Calcium homeostasis and bone metabolism during pregnancy, lactation, and postweaning: a longitudinal. Am J Clin Nutr 1995;61:514-23.
10. Ardawi MS, Nasrat HA, Aqueel HS. Calcium-regulating hormones and parathyroid hormone-related peptide in normal human pregnancy and postpartum: a longitudinal study. Eur J Endocrinol 1997;137:402-9.
11. Ritchie LD, Fung EB, Halloran BP, Turnlund JR, Van Loan MD, Cann CE, King JC. A longitudinal study of calcium homeostasis during human pregnancy and lactation and after resumption of menses. Am J Clin Nutr 1998;67:693-701.
12. Wilson SG, Retallack RW, Kent JC, Worth GK, Gutteridge DH. Serum free 1,25-dihydroxyvitamin D and the free 1,25-dihydroxyvitamin D index during a longitudinal study of human pregnancy and lactation. Clin Endocrinol (Oxf) 1990;32:613-22.
13. More C, Bettembuk HP, Bhattoa P, Balogh A. The effects of pregnancy and lactation on bone mineral density. Osteoporos Int2001;12:732-7.
14. Sanchez PA, Idrisa A, Bobzom DN, Airede A, Hollis BW, Liston DE, Jones DD, Dasgupta A, Glew RH. Calcium and vitamin D status of pregnant teenagers in Maiduguri, Nigeria. J Natl Med Assoc 1997; 89:805-11.
15. Morley R, Carlin JB, Pasco JA, Wark JD. Maternal 25-hydroxyvitamin D and parathyroid hormone concentrations and offspring birth size. J Clin Endocrinol Metab 2006;91:906-12.
16. Zhang JY, Lucey AJ, Horgan R, Kenny LC, Kiely M. Impact of pregnancy on vitamin D status: a longitudinal study. Br J Nutr 2014;112:1081-7.
17. Sowers M, Zhang D, Hollis BW, Shapiro B, Janney CA, Crutchfield M, Anthony Schork M, Stanczyk F, Randolph J. Role of calciotrophic hormones in calcium mobilization of lactation. Am J Clin Nutr 1998;67:284-91.
18. Hoogenboezem T, Degenhart HJ, De Muinck Keizer-Schrama SM, Bouillon R, Grose WF, Hackeng WH, Visser HK. Vitamin D metabolism in breast-fed infants and their mothers. Pediatr Res 1989;25:623-8.
19. Wagner D, Hanwell HE, Schnabl K, Yazdanpanah M, Kimball S, Fu L, Sidhom G, Rousseau D, Cole DEC, Vieth R. The ratio of serum 24,25-dihydroxyvitamin D3 to 25-hydroxyvitamin D3 is predictive of 25-hydroxyvitamin D3 response to vitamin D3 supplementation. J Steroid Biochem Mol Biol 2011;126:72-7.
20. Kaufmann M, Gallagher JC, Peacock M, Schlingmann KP, Konrad M, DeLuca HF, Sigueiro R, Lopez B, Mourino A, Maestro M, et al. Clinical utility of simultaneous quantitation of 25-hydroxyvitamin D and 24,25-dihydroxyvitamin D by LC-MS/MS involving derivatization with DMEQ-TAD. J Clin Endocrinol Metab 2014; 99:2567-74.
21. Cashman KD, Hayes A, Galvin K, Merkel J, Jones G, Kaufmann M, Hoofnagle AN, Carter GD, Durazo-Arvizu RA, Sempos CT. Significance of serum 24,25-dihydroxyvitamin D in the assessment of vitamin D status: a double-edged sword? Clin Chem 2015; 61:636-45.
22. Berg AH, Powe CE, Evans MK, Wenger J, Ortiz G, Zonderman AB, Suntharalingam P, Lucchesi K, Powe NR, Karumanchi SA, et al. 24,25-Dihydroxyvitamin D3 and vitamin D status of communitydwelling black and white Americans. Clin Chem 2015;61:877-84.
23. Schwartz JB, Lai J, Lizaola B, Kane L, Markova S, Weyland P, Terrault NA, Stotland N, Bikle D. A comparison of measured and calculated free 25(OH) vitamin D levels in clinical populations. J Clin Endocrinol Metab 2014;99:1631-7.
24. Schleicher RL, Encisco SE, Chaudhary-Webb M, Paliakov E, McCoy LF, Pfeiffer CM. Isotope dilution ultra performance liquid chromatography-tandem mass spectrometry method for simultaneous measurement of 25-hydroxyvitamin D2, 25-hydroxyvitamin D3 and 3-epi-25-hydroxyvitamin D3 in human serum. Clin Chim Acta 2011;412:1594-9.
25. Cashman KD, Kinsella M, Walton J, Flynn A, Hayes A, Lucey A, Seamans KM, Kiely M. The 3 epimer of 25-hydroxycholecalciferol is present in the circulation of the majority of adults in a nationally representative sample and has endogenous origins. J Nutr 2014;144: 1050-7.
26. Yan J, Jiang X, West AA, Perry CA, Malysheva OV, Devapatla S, Pressman E, Vermeylen F, Stabler SP, Allen RH, et al. Maternal choline intake modulates maternal and fetal biomarkers of choline metabolism in humans. Am J Clin Nutr 2012;95:1060-71.
27. West AA, Yan J, Perry CA, Jiang X, Malysheva OV, Caudill MA. Folatestatus response to a controlled folate intake in nonpregnant, pregnant, and lactating women. Am J Clin Nutr 2012;96:789-800.
28. Bikle DD, Gee E, Halloran B, Kowalski MA, Ryzen E, Haddad JG. Assessment of the free fraction of 25-hydroxyvitamin. J Clin Endocrinol Metab 1986;63:954-9.
29. Bolland MJ, Grey AB, Ames RW, Horne AM, Mason BH, Wattie DJ, Gamble GD, Bouillon R, Reid IR. Age-, gender-, and weight-related effects on levels of 25-hydroxyvitamin D are not mediated by vitamin D binding protein. Clin Endocrinol (Oxf) 2007;67:259-64.
30. Lundgren S, Carling T, Hjälm G, Juhlin C, Rastad J, Pihlgren U, Rask L, Akerström GHP. Tissue distribution of human gp330/megalin, a putative Ca(2+)-sensing protein. J Histochem Cytochem 1997; 45:383-92.
31. Kalkwarf HJ, Specker BL, Heubi JE, Vieira NE, Yergey AL. Intestinal calcium absorption and after weaning. Am J Clin Nutr 1996;63:526-31.
32. Hollis BW, Johnson D, Hulsey TC, Ebeling M, Wagner CL. Vitamin D supplementation during pregnancy: double-blind, randomized clinical trial of safety and effectiveness. J Bone Miner Res 2011; 26:2341-57.
33. Powe CE, Ricciardi C, Berg AH, Erdenesanaa D, Collerone G, Ankers E, Wenger J, Karumanchi SA, Thadhani R, Bhan I. Vitamin D-binding protein modifies the vitamin D-bone mineral density relationship. J Bone Miner Res 2011;26:1609-16.
34. Johnsen MS, Grimnes G, Figenschau Y, Torjesen PA, Almas B, Jorde R. Serum free and bio-available 25-hydroxyvitamin D correlate better with bone density than serum total 25-hydroxyvitamin D. Scand J Clin Lab Invest 2014;74:177-83.
35. Novakovic B, Sibson M, Ng HK, Manuelpillai U, Rakyan V, Down T, Beck S, Fournier T, Evain-Brion D, Dimitriadis E, et al. Placenta-specific methylation of the vitamin D 24-hydroxylase gene: implications for feedback autoregulation of active vitamin D levels at the fetomaternal interface. J Biol Chem 2009;284:14838-48.
36. Liu NQ, Hewison M. Vitamin D, the placenta and pregnancy. Arch Biochem Biophys 2012;523:37-47.
37. Møller UK, Streym Sv, Jensen LT, Mosekilde L, Schoenmakers I, Nigdikar S, Rejnmark L. Increased plasma concentrations of vitamin D metabolites and vitamin D binding protein in women using hormonal contraceptives: a cross-sectional study. Nutrients 2013;5:3470-80.
38. Zehnder D, Evans KN, Kilby MD, Bulmer JN, Innes BA, Stewart PM, Hewison M. The ontogeny of 25-hydroxyvitamin D(3) 1alphahydroxylase expression in human placenta and decidua. Am J Pathol 2002;161:105-14.
39. Ma R, Gu Y, Zhao S, Sun J, Groome LJ,Wang Y. Expressions of vitamin D metabolic components VDBP, CYP2R1, CYP27B1, CYP24A1, and VDR in placentas from normal and preeclamptic pregnancies. Am J Physiol Endocrinol Metab 2012;303:E928-35.