Clinical utility of simultaneous quantitation of 25-hydroxyvitamin D and 24,25-dihydroxyvitamin D by LC-MS/MS involving derivatization with DMEQ-TAD

Journal of Clinical Endocrinology and Metabolism

Volumn 99, Issue 7, 2014, Pages 2567-2574

  Kaufmann, Martin ^a   Gallagher, J Christopher ^b   Peacock, Munro ^c   Schlingmann, Karl Peter ^d   Konrad, Martin ^d   DeLuca, Hector F ^e   Sigueiro, Rita ^f   Lopez, Borja ^f   Mourino, Antonio ^f   Maestro, Miguel ^f   St Arnaud, René ^g   Finkelstein, Joel S ^h   Cooper, Donald P ⁱ   Jones, Glenville ^a  

^a QUEEN S UNIVERSITY   (Canada)

^b CREIGHTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY HOSPITAL MÜNSTER   (Germany)

^e UNIVERSITY OF WISCONSIN MADISON   (United States)

^f UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

^g MCGILL UNIVERSITY   (Canada)

^h MASSACHUSETTS GENERAL HOSPITAL   (United States)

ⁱ WATERS CORPORATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

24,25 DIHYDROXYVITAMIN D; 25 HYDROXYVITAMIN D; 4 [2 (6,7 DIMETHOXY 4 METHYL 3,4 DIHYDROQUINOXALINYL)ETHYL] 1,2,4 TRIAZOLINE 3,5 DIONE; PLACEBO; TRIAZOLINE DERIVATIVE; UNCLASSIFIED DRUG; VITAMIN D;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DERIVATIZATION; FEMALE; HUMAN; HYPERCALCEMIA; KNOCKOUT MOUSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; QUALITY CONTROL; RANDOMIZED CONTROLLED TRIAL (TOPIC); SERUM; STANDARD; TANDEM MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; VITAMIN D DEFICIENCY; VITAMIN D INTOXICATION;

24,25-DIHYDROXYVITAMIN D 3; ANIMALS; BLOOD CHEMICAL ANALYSIS; CHROMATOGRAPHY, LIQUID; DIETARY SUPPLEMENTS; FEMALE; HUMANS; HYPERCALCEMIA; MICE; MICE, KNOCKOUT; PREDICTIVE VALUE OF TESTS; QUINOXALINES; TANDEM MASS SPECTROMETRY; TRIAZOLES; VITAMIN D; VITAMIN D DEFICIENCY;

EID: 84904060100     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2013-4388     Document Type: Article

References (36)

1. Jones G. Metabolism and biomarkers of vitamin D. Scand J Clin Lab Invest Suppl. 2012;243:7-13.
2. Jones G, Strugnell S, DeLuca HF. Current understanding of the molecular actions of vitamin D. Physiol Rev. 1998;78:1193-1231. (Pubitemid 28491953)
3. Holick MF. Vitamin D deficiency. N Engl J Med. 2007;357:266-281.
4. 3. Semin Dial. 2007;20:316-324.
5. IOM (Institute of Medicine). Dietary Reference Intakes for Ca and Vitamin D. Washington, DC: The National Academies of Science; 2011.
6. Carter GD. 25-Hydroxyvitamin D: a difficult analyte. Clin Chem. 2012;58:486-488.
7. Schlingmann KP, Kaufmann M, Weber S, et al. Mutations in CYP24A1 and idiopathic infantile hypercalcemia. N Engl J Med. 2011;365:410-421.
8. 3-24- hydroxylase (CYP24A1): its important role in the degradation of vitamin D. Arch Biochem Biophys. 2012;523:9-18.
9. Haddad JG Jr, Min C, Walgate J, Hahn T. Competition by 24,25-dihydroxycholecalciferol in the competitive protein binding radioassay of 25-hydroxycalciferol. J Clin Endocrinol Metab. 1976;43:712-715.
10. Cunningham J, Coldwell RD, Jones G, Tenenhouse HS, Trafford DJ, Makin HL. Plasma 24,25-dihydroxyvitamin D3 concentrations in X-linked hypophosphatemic mice: studies using mass fragmentographic and radioreceptor assays. J Bone Miner Res. 1990;5:173-177. (Pubitemid 20121645)
11. Makin HLJ, Jones G, Kaufmann M, Calverley M. Analysis of vitamins D, their metabolites, analogues. In: Makin HLJ, Gower DB, eds. Steroid Analysis. 2nd ed. London: Springer (Chapman, Hall); 2010:967-1094.
12. Singh RJ, Taylor RL, Reddy GS, Grebe SK. C-3 epimers can account for a significant proportion of total circulating 25-hydroxyvitamin Din infants, complicating accurate measurement and interpretation of vitamin D status. J Clin Endocrinol Metab. 2006;91:3055-3061. (Pubitemid 44271755)
13. Wang Z, Senn T, Kalhorn T, et al. Simultaneous measurement of plasma vitamin D(3) metabolites, including 4β,25-dihydroxyvitamin D(3), using liquid chromatography-tandem mass spectrometry. Anal Biochem. 2011;418:126-133.
14. Gallagher JC, Sai A, Templin T 2nd, Smith L. Dose response to vitamin D supplementation in postmenopausal women: a randomized trial. Ann Intern Med. 2012;156:425-427.
15. Gallagher JC, Peacock M, Yalamanchili V, Smith LM. Effects of vitamin D supplementation in older African American women. J Clin Endocrinol Metab. 2013;98:1137-1146.
16. Gallagher JC, Jindal PS, Smith LM. Vitamin D supplementation in young White and African American women. J Bone Miner Res. 2014:29:173-181.
17. Zhu J, Ochalek JT, Kaufmann M, Jones G, DeLuca HF. CYP2R1 is a major, but not exclusive, contributor to 25-hydroxyvitamin D production in vivo. Proc Natl Acad Sci USA. 2013;110:15650-15655.
18. 3 in the blood and tissues of the 25-hydroxyvitamin D-24-hydroxylase (CYP24A1) null mouse. Endocrinology. 2005;146:825-834.
19. 2. J Org Chem. 1986;51:1264-1268.
20. 3. J Steroid Biochem Mol Biol. 2010;121:43-45.
21. 3 in human plasma by liquid chromatography-mass spectrometry employing derivatization with a Cookson-type reagent. Biol Pharm Bull. 2001;24:738-743.
22. Aronov PA, Hall LM, Dettmer K, Stephensen CB, Hammock BD. Metabolic profiling of major vitamin D metabolites using Diels-Alder derivatization and ultra-performance liquid chromatographytandem mass spectrometry. Anal Bioanal Chem. 2008;391:1917-1930.
23. Wagner D, Hanwell HE, Schnabl K, et al. The ratio of serum 24,25-dihydroxyvitamin D(3) to 25-hydroxyvitamin D(3) is predictive of 25-hydroxyvitamin D(3) response to vitamin D(3) supplementation. J Steroid Biochem Mol Biol. 2011;126(3-5):72-77.
24. Kobold U. Approaches to measurement of vitamin D concentrations-mass spectrometry. Scand J Clin Lab Invest Suppl. 2012;243:54-59.
25. 3 is a novel and sensitive measure of predicting vitamin D deficiency. Paper presented at: Annual Meeting of the American Society for Bone and Mineral Research; October 4-7, 2013; Baltimore, MD.
26. Strathmann FG, Sadilkova K, Laha TJ, et al. 3-epi-25 hydroxyvitamin D concentrations are not correlated with age in a cohort of infants and adults. Clin Chim Acta. 2012;413:203-206.
27. Lensmeyer G, Poquette M, Wiebe D, Binkley N. The C-3 epimer of 25-hydroxyvitamin D(3) is present in adult serum. J Clin Endocrinol Metab. 2012;97:163-168.
28. Nesterova G, Malicdan MC, Yasuda K, et al. 1,25-(OH)2D-24 Hydroxylase (CYP24A1) deficiency as a cause of nephrolithiasis. Clin J Am Soc Nephrol. 2013;8:649-657.
29. Meusburger E, Mundlein A, Zitt E, Obermayer-Pietsch, Zotlot D, Lhotta K. Medullary nephrocalcinosis in an adult patient with idiopathic infantile hypercalcemia and a novel CYP24A1 mutation. Clin Kidney J. 2013;6(2):211-215.
30. Jones G. Pharmacokinetics of vitamin D toxicity. Am J Clin Nutr. 2008;88:582S-586S.
31. 3 or 25-hydroxyvitamin D3 intakes. Arch Biochem Biophys. 1980;202:43-53.
32. Horst RL. Exogenous versus endogenous recovery of 25-hydroxyvitamins D2 and D3 in human samples using high-performance liquid chromatography and the DiaSorin LIAISON Total-D Assay. J Steroid Biochem Mol Biol. 2010;121(1-2):180- 182.
33. Janssen MJ, Wielders JP, Bekker CC, et al. Multicenter comparison study of current methods to measure 25-hydroxyvitamin D in serum. Steroids. 2012;77:1366-1372.
34. 2. Clin Chim Acta. 2013;415:54-58.
35. Netzel BC, Cradic KW, Bro ET, et al. Increasing liquid chromatography-tandem mass spectrometry throughput by mass tagging: a sample-multiplexed high-throughput assay for 25-hydroxyvitamin D2 and D3. Clin Chem. 2011;57:431-440.
36. Hedman CJ, Wiebe DA, Dey S, Plath J, Kemnitz JW, Ziegler TE. Development of a sensitive LC/MS/MS method for vitamin D metabolites: 1,25 dihydroxyvitamin D2&3 measurement using a novel derivatizing agent. J Chromatography B. 2014;953-954:62-67.